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1. 发明申请

US20130066223A1 Vehicle Interlocking System and Method Based on Detection of Analytes in Exhaled Breath 审中-公开
标题翻译：基于呼气呼气分析仪检测的车辆联锁系统及方法
公开(公告)号：US20130066223A1
公开(公告)日：2013-03-14
申请号：US13416956
申请日：2012-03-09
申请人： Olof Beck , Bo Hammarlund
发明人： Olof Beck , Bo Hammarlund
IPC分类号： A61B5/08
CPC分类号： G01N33/497 , G01N21/658 , G01N21/7703
摘要： A drug interlock for vehicles based on exhaled breath directed onto said SERS-active substrate, wherein a detected drug substance in exhaled breath of a subject locks said vehicle from use for at least a pre-determined time or a repeated exhaled breath test where no drugs are detected. A collecting surface has a Surface Enhanced Raman Spectroscopy (SERS)-active layer that comprises at least one SERS-active material. The collecting surface is arranged as an outer surface of a waveguide for contact with exhaled breath, such that at least traces of said at least one drug substance in said exhaled breath can contact said SERS-active layer for read-out of a Raman shift spectrum that is detected in-situ for said detecting the presence or determining the quantitative amount of said at least one drug substance from said exhaled breath.
摘要翻译：一种用于基于呼出呼吸的针对所述SERS活性基质的车辆的药物互锁，其中受试者的呼出气中检测到的药物物质将所述车辆使用至少预定时间或重复呼出呼气试验，其中没有药物被检测到。收集表面具有包含至少一种SERS活性材料的表面增强拉曼光谱（SERS）活性层。收集表面被布置为用于与呼出气体接触的波导的外表面，使得所述呼出的呼吸中的至少一种药物物质的至少痕迹可接触所述SERS活性层以读出拉曼位移谱其被现场检测，用于从所述呼出的呼吸中检测存在或确定所述至少一种药物的定量。

2. 发明授权

US09977011B2 Portable sampling device and method for sampling drug substances from exhaled breath 有权
公开(公告)号：US09977011B2
公开(公告)日：2018-05-22
申请号：US14003915
申请日：2012-03-09
申请人： Bo Hammarlund
发明人： Olof Beck , Bo Hammarlund
IPC分类号： G01N33/497 , A61B5/08 , A61B5/091 , A61B5/097 , A61B5/00 , B29C65/46 , B29C65/66 , B29K23/00 , B29K33/04 , B29K105/00
CPC分类号： G01N33/497 , A61B5/082 , A61B5/091 , A61B5/097 , A61B5/4845 , B29C65/46 , B29C65/665 , B29K2023/10 , B29K2033/04 , B29K2105/256 , B29K2105/258 , G01N2033/4975
摘要： A portable drug sampling device for handheldly collecting a sample from exhaled breath of a subject for further sensor based analysis. The device comprising: a housing (406) comprising at least one inlet (407) and at least one outlet (408) for the exhaled breath to exit through, and a sampling membrane (302) arranged in the housing. A tubular element (40) having a mouthpiece section (401) for the subject to exhale into, and a saliva trap section comprising baffles (103) to create a non-straight gas flow path for letting aerosols pass through the tubular element. The sampling membrane (302) is arranged to collect the aerosols from the exhaled breath. The portable drug testing device further comprises a volume collecting element (208).

3. 发明申请

US20140366609A1 Portable Sampling Device and Method for Sampling Drug Substances From Exhaled Breath 有权
标题翻译：便携式取样装置及呼气呼吸药物抽样方法
公开(公告)号：US20140366609A1
公开(公告)日：2014-12-18
申请号：US14003915
申请日：2012-03-09
申请人： Bo Hammarlund
发明人： Olof Beck , Bo Hammarlund
IPC分类号： G01N33/497 , B29C65/66 , B29C65/46 , A61B5/097 , A61B5/08
CPC分类号： G01N33/497 , A61B5/082 , A61B5/091 , A61B5/097 , A61B5/4845 , B29C65/46 , B29C65/665 , B29K2023/10 , B29K2033/04 , B29K2105/256 , B29K2105/258 , G01N2033/4975
摘要： A portable drug sampling device for handheldly collecting a sample from exhaled breath of a subject for further sensor based analysis. The device comprising: a housing (406) comprising at least one inlet (407) and at least one outlet (408) for the exhaled breath to exit through, and a sampling membrane (302) arranged in the housing. A tubular element (40) having a mouthpiece section (401) for the subject to exhale into, and a saliva trap section comprising baffles (103) to create a non-straight gas flow path for letting aerosols pass through the tubular element. The sampling membrane (302) is arranged to collect the aerosols from the exhaled breath. The portable drug testing device further comprises a volume collecting element (208).
摘要翻译：一种便携式药物采样装置，用于从用于进一步基于传感器的分析的呼吸呼吸中手持收集样品。该装置包括：壳体（406），其包括至少一个入口（407）和用于呼出的呼吸排出的至少一个出口（408）以及布置在壳体中的取样膜（302）。管状元件（40）具有用于受试者呼出的吸口部分（401）和包括挡板（103）的唾液陷阱部分，以产生用于使气溶胶通过管状元件的非直线气流通道。取样膜（302）布置成从呼出的呼吸中收集气溶胶。便携式药物检测装置还包括容积收集元件（208）。

4. 发明申请

US20060100420A1 5-hydroxytryptophol (5-HTOL) derivatives, antibodies, immunoassays and detection of recent alcohol consumption 审中-公开
标题翻译： 5-羟色胺（5-HTOL）衍生物，抗体，免疫测定和检测近期饮酒
公开(公告)号：US20060100420A1
公开(公告)日：2006-05-11
申请号：US10420931
申请日：2003-04-23
申请人： Ragnhild Brandt , Olof Beck , Anders Helander , Rose-Marie Jonsson , Eric Unger , Stefan Borg , Eva Akerblom
发明人： Ragnhild Brandt , Olof Beck , Anders Helander , Rose-Marie Jonsson , Eric Unger , Stefan Borg , Eva Akerblom
IPC分类号： C07K16/00
CPC分类号： C07H17/02 , C07K16/44 , Y10T436/14 , Y10T436/145555 , Y10T436/17 , Y10T436/173845 , Y10T436/203332 , Y10T436/25
摘要： Antibody specific for a 5-HTOL compound. A glucuronide with 5-hydroxytryptophol (5-HTOL) characterized in that it comprises the structure of the β-glucuronide between the 5-hydroxy group of 5-HTOL and D-glucopyranosiduronic acid. An immunoassay and a diagnostic method utilizing the immunoassay wherein a 5-hydroxytryptophol (5-HTOL) compound is determined by the use of an antibody specific for a 5-HTOL compound is used.
摘要翻译：针对5-HTOL化合物的抗体。具有5-羟基吡啶（5-HTOL）的葡糖苷酸的特征在于其包含5-羟基与5-羟基吡喃糖苷二糖酸的5-羟基之间的β-葡糖苷酸的结构。使用免疫测定法和诊断方法，其中使用5-羟色胺（5-HTOL）化合物通过使用对5-HTOL化合物特异的抗体来测定。

5. 发明申请

US20120212735A1 System and Method for Detection of Analytes in Exhaled Breath 有权
公开(公告)号：US20120212735A1
公开(公告)日：2012-08-23
申请号：US13394979
申请日：2010-09-09
申请人： Göran Palmskog , Olof Beck , Per Ola Andersson
发明人： Göran Palmskog , Olof Beck , Per Ola Andersson
IPC分类号： G01J3/44
CPC分类号： G01N21/658 , A61B5/082 , A61B5/412 , G01J3/44 , G01N33/497
摘要： A sensor for detecting a drug substance (15) from exhaled breath of a subject in-situ. Its collecting surface has a Surface Enhanced Raman Spectroscopy (SERS)-active layer (14) of a SERS-active material. The collecting surface is arranged as an outer surface of a waveguide (12) for contact with exhaled breath, such that at least traces of said drug substance (15) in said exhaled breath can contact said SERS-active layer for read-out of a Raman shift spectrum.

6. 发明申请

US20120302907A1 System and Method for Drug Detection in Exhaled Breath 审中-公开
标题翻译：呼出气体药物检测系统及方法
公开(公告)号：US20120302907A1
公开(公告)日：2012-11-29
申请号：US13394609
申请日：2010-09-09
申请人： Göran Palmskog , Olof Beck
发明人： Göran Palmskog , Olof Beck
IPC分类号： A61B5/097
摘要： A portable system (10) is disclosed for collecting a sample from exhaled breath of a subject. Drug substance in the exhaled breath are detected or determined. The sample is collected for further analysis using mass-spectroscopy. The system comprises a sampling unit (14) and a housing (12) arranged to hold the sampling unit (14), the sampling unit (14) is adapted to collect non-volatile and volatile compounds of the at least one drug substance from the exhaled breath from the subject. The housing (12) has at least one inlet (15) for the subject to exhale into the housing (12) to the sampling unit (14) and at least one outlet (16) for the exhaled breath to exit through.
摘要翻译：公开了一种便携式系统（10），用于从受试者的呼出气中收集样品。呼出呼吸中的药物被检测或确定。收集样品以进行质谱分析。该系统包括一个采样单元（14）和一个布置成保持采样单元（14）的壳体（12），采样单元（14）适于从该采样单元（14）收集至少一种药物的非挥发性和挥发性化合物呼气从主题。壳体（12）具有至少一个入口（15），用于受试者呼出到采样单元（14）的壳体（12）和用于呼出的呼吸的至少一个出口（16）通过。

7. 发明授权

US06608178B1 5-hydroxytryptophol (5-HTOL) derivatives, antibodies, immunoassays and detection of recent alcohol consumption 失效
标题翻译： 5-羟色胺（5-HTOL）衍生物，抗体，免疫测定和检测近期酒精消费
公开(公告)号：US06608178B1
公开(公告)日：2003-08-19
申请号：US09326647
申请日：1999-06-07
申请人： Ragnhild Brandt , Olof Beck , Anders Helander , Rose-Marie Jonsson , Eric Unger , Stefan Borg , Eva Akerblom
发明人： Ragnhild Brandt , Olof Beck , Anders Helander , Rose-Marie Jonsson , Eric Unger , Stefan Borg , Eva Akerblom
IPC分类号： C07K1644
CPC分类号： C07H17/02 , C07K16/44 , Y10T436/14 , Y10T436/145555 , Y10T436/17 , Y10T436/173845 , Y10T436/203332 , Y10T436/25
摘要： Antibody specific for a 5-HTOL compound. A glucuronide with 5-hydroxytryptophol (5-HTOL) characterized in that it comprises the structure of the &bgr;-glucuronide between the 5-hydroxy group of 5-HTOL and D-glucopyranosiduronic acid. An immunoassay and a diagnostic method utilizing the ummunoassay wherein a 5-hydroxytryptophol (5-HTOL) compound is determined by the use of an antibody specific for a 5-HTOL compound is used.
摘要翻译：针对5-HTOL化合物的抗体。具有5-羟基吡啶（5-HTOL）的葡糖苷酸的特征在于其包含5-羟基与5-羟基吡喃糖苷二糖酸的5-羟基之间的β-葡糖苷酸的结构。使用其中通过使用对5-HTOL化合物特异的抗体来测定5-羟色胺（5-HTOL）化合物的免疫测定和诊断方法。

8. 发明授权

US10520439B2 System and method for drug detection in exhaled breath 有权
公开(公告)号：US10520439B2
公开(公告)日：2019-12-31
申请号：US13394609
申请日：2010-09-09
申请人： Göran Palmskog , Olof Beck
发明人： Göran Palmskog , Olof Beck
IPC分类号： A61B5/08 , G01N21/65 , G01J3/44 , A61B5/00 , G01N33/497
摘要： A portable system (10) is disclosed for collecting a sample from exhaled breath of a subject. Drug substance in the exhaled breath are detected or determined. The sample is collected for further analysis using mass-spectroscopy. The system comprises a sampling unit (14) and a housing (12) arranged to hold the sampling unit (14), the sampling unit (14) is adapted to collect non-volatile and volatile compounds of the at least one drug substance from the exhaled breath from the subject. The housing (12) has at least one inlet (15) for the subject to exhale into the housing (12) to the sampling unit (14) and at least one outlet (16) for the exhaled breath to exit through.

9. 发明授权

US08368883B2 System and method for detection of analytes in exhaled breath 有权
标题翻译：用于检测呼气中分析物的系统和方法
公开(公告)号：US08368883B2
公开(公告)日：2013-02-05
申请号：US13394979
申请日：2010-09-09
申请人： Göran Palmskog , Olof Beck , Per Ola Andersson
发明人： Göran Palmskog , Olof Beck , Per Ola Andersson
IPC分类号： G01J3/44
CPC分类号： G01N21/658 , A61B5/082 , A61B5/412 , G01J3/44 , G01N33/497
摘要： A sensor for detecting a drug substance (15) from exhaled breath of a subject in-situ. Its collecting surface has a Surface Enhanced Raman Spectroscopy (SERS)-active layer (14) of a SERS-active material. The collecting surface is arranged as an outer surface of a waveguide (12) for contact with exhaled breath, such that at least traces of said drug substance (15) in said exhaled breath can contact said SERS-active layer for read-out of a Raman shift spectrum.
摘要翻译：一种用于从现场呼出的呼吸气体检测药物（15）的传感器。其收集表面具有SERS-活性材料的表面增强拉曼光谱（SERS）活性层（14）。收集表面被布置为用于与呼出的呼吸接触的波导（12）的外表面，使得所述呼出的呼吸中的至少痕量的所述药物（15）可以接触所述SERS活性层以读出拉曼位移谱。

10. 发明申请

US20070276133A1 5-hydroxytryptophol (5-HTOL) derivatives, antibodies, immunoassays and detection of recent alcohol consumption 审中-公开
标题翻译： 5-羟色胺（5-HTOL）衍生物，抗体，免疫测定和检测近期饮酒
公开(公告)号：US20070276133A1
公开(公告)日：2007-11-29
申请号：US11648892
申请日：2007-01-03
申请人： Ragnhild Brandt , Olof Beck , Anders Helander , Rose-Marie Jonsson , Eric Unger , Stefan Borg , Eva Akerblom
发明人： Ragnhild Brandt , Olof Beck , Anders Helander , Rose-Marie Jonsson , Eric Unger , Stefan Borg , Eva Akerblom
IPC分类号： C07H17/02
CPC分类号： C07H17/02 , C07K16/44 , Y10T436/14 , Y10T436/145555 , Y10T436/17 , Y10T436/173845 , Y10T436/203332 , Y10T436/25
摘要： Antibody specific for a 5-HTOL compound. A glucuronide with 5-hydroxytryptophol (5-HTOL) characterized in that it comprises the structure of the β-glucuronide between the 5-hydroxy group of 5-HTOL and D-glucopyranosiduronic acid. An immunoassay and a diagnostic method utilizing the immunoassay wherein a 5-hydroxytryptophol (5-HTOL) compound is determined by the use of an antibody specific for a 5-HTOL compound is used.
摘要翻译：针对5-HTOL化合物的抗体。具有5-羟基吡啶（5-HTOL）的葡糖苷酸的特征在于其包含5-羟基与5-羟基吡喃糖苷二糖酸的5-羟基之间的β-葡糖苷酸的结构。使用免疫测定法和诊断方法，其中使用5-羟色胺（5-HTOL）化合物通过使用对5-HTOL化合物特异的抗体来测定。

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