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1. 发明申请

US20070051824A1 Nozzles for electrospray ionization and methods of fabricating them 审中-公开
标题翻译：用于电喷雾电离的喷嘴及其制造方法
公开(公告)号：US20070051824A1
公开(公告)日：2007-03-08
申请号：US10546117
申请日：2004-02-19
申请人： Olle Larsson , Toni Sigmundsson , Michael Read , Ove Ohman
发明人： Olle Larsson , Toni Sigmundsson , Michael Read , Ove Ohman
IPC分类号： B05B5/025
CPC分类号： H01J49/167 , H01J49/0018
摘要： A nozzle chip (3) for ejecting a liquid such as in an electrospray device is built from a substrate chip having grooves (5, 7) on a top surface. A lid (25) is attached to the top surface closing the grooves to form channels one of which has an open outlet end (9). At the outlet end a nozzle is formed at or attached and it has an outlet opening from which the liquid is to be ejected. Alignment recesses (13, 15) are made at edges of the substrate chip and they are accurately positioned in relation to the outlet opening, the alignment recesses allowing an accurate mounting of nozzle chip giving the outlet opening of the nozzle a reproducible position in the device where it is to be used. At the outlet end a recess (17) in the substrate chip can be provided and the nozzle can then be located in the recess to mechanically protect it.
摘要翻译：用于喷射诸如电喷雾装置中的液体的喷嘴芯片（3）由在顶表面上具有凹槽（5,7）的衬底芯片构成。盖（25）附接到顶表面，封闭沟槽以形成通道，其中一个具有开放的出口端（9）。在出口处，喷嘴形成在或附接并且具有出口，液体从该出口开始喷出。对准凹槽（13,15）在基片的边缘处形成，并且它们相对于出口开口精确定位，所述对准凹槽允许精确地安装喷嘴芯片，使得喷嘴的出口开口在该装置中可再现的位置在哪里使用。在出口端，可以设置衬底芯片中的凹部（17），然后可以将喷嘴定位在凹部中以机械地保护其。

2. 发明申请

US20070267217A1 Method for manufacturing a miniaturized three-dimensional electric component 有权
标题翻译：微型三维电气部件的制造方法
公开(公告)号：US20070267217A1
公开(公告)日：2007-11-22
申请号：US11888571
申请日：2007-07-31
申请人： Tapani Ryhanen , Hans Scheck , Ove Ohman , Olle Larsson , Michael Read , Tomas Lindstrom
发明人： Tapani Ryhanen , Hans Scheck , Ove Ohman , Olle Larsson , Michael Read , Tomas Lindstrom
IPC分类号： H01S4/00 , H05K1/16
CPC分类号： H01S4/00 , H01C17/06 , H01F17/0033 , H01F27/2804 , H01F27/2895 , H01F41/04 , H01F41/041 , H01F41/08 , H05K1/0272 , H05K1/165 , H05K3/0014 , H05K3/107 , H05K3/205 , H05K3/4614 , H05K2201/0379 , H05K2201/09036 , H05K2201/09118 , H05K2201/09981 , H05K2203/0108 , H05K2203/0594 , H05K2203/1105 , H05K2203/135 , Y10T29/49071 , Y10T29/49073 , Y10T29/49146 , Y10T29/49172 , Y10T29/49176 , Y10T29/4922
摘要： Manufacturing of miniaturised three-dimensional electric components are presented, as well as components manufactured by the methods. The manufacturing methods comprise micro-replication of at least one master structure, e.g. via a mould structure, in at least one polymer layer onto which layer at least one conductive path is provided.
摘要翻译：提出了小型化三维电气部件的制造以及通过这些方法制造的部件。制造方法包括至少一个主结构的微复制，例如。通过模具结构，在至少一个聚合物层中，至少一个导电路径被设置在该层上。

3. 发明授权

US5984534A Method and device for waveguide connection 失效
标题翻译：用于波导连接的方法和装置
公开(公告)号：US5984534A
公开(公告)日：1999-11-16
申请号：US823388
申请日：1997-03-24
申请人： H.ang.kan Elderstig , Olle Larsson , Goran Palmskog , Ove Ohman
发明人： H.ang.kan Elderstig , Olle Larsson , Goran Palmskog , Ove Ohman
IPC分类号： H01P5/00 , G02B6/36 , G02B6/42
CPC分类号： G02B6/3696 , G02B6/4201 , G02B6/4214 , G02B6/4243 , G02B6/4246 , G02B6/3636 , G02B6/3652 , G02B6/3692 , G02B6/4238 , G02B6/4239
摘要： Replicated polymeric microstructures have been used in the fabrication of optofiber waveguide connections, with the intention of simplifying the production of such connections, and therewith greatly reduce manufacturing costs. Fabrication is commenced from a silicon chip in which there has been etched grooves whose cross-sectional shape has been adapted to accommodate waveguides, such as optofibers. Firstly, the silicon chip is replicated, by plating the silicon chip with nickel for instance. The replication then serves as a model for producing a plastic copy of the silicon chip. This method of manufacture is able to produce waveguide accommodating grooves (2), such as optofiber accommodating grooves, to a very high degree of accuracy. Furthermore, the method provides a high degree of freedom in the configuration of the grooves, and also enables branched grooves for receiving branched fibres to be produced. The waveguide connection can then be used with a waveguide, such as an optofiber, together with a light transmitter or light receiver.
摘要翻译：复制的聚合物微结构已经用于制造光纤波导连接，其目的是简化这种连接的生产，从而大大降低制造成本。制造从其中已经蚀刻了凹槽的硅芯片开始，其横截面形状已经适于容纳波导，例如光电二极管。首先，通过例如用镍电镀硅芯片来复制硅芯片。然后，该复制物用作产生硅芯片的塑料副本的模型。这种制造方法能够以非常高的精度制造波导容纳槽（2），例如光纤容纳槽。此外，该方法在槽的构造中提供高度的自由度，并且还能够制造用于接收分支纤维的分支槽。然后可以将波导连接与光传输器或光接收器一起用于波导，例如光纤。

4. 发明授权

US07829799B2 Method for manufacturing a miniaturized three-dimensional electric component 有权
标题翻译：微型三维电气部件的制造方法
公开(公告)号：US07829799B2
公开(公告)日：2010-11-09
申请号：US11888571
申请日：2007-07-31
申请人： Tapani Ryhänen , Hans Otto Scheck , Ove Öhman , Olle Larsson , Michael Read , Tomas Lindström
发明人： Tapani Ryhänen , Hans Otto Scheck , Ove Öhman , Olle Larsson , Michael Read , Tomas Lindström
IPC分类号： H01R13/502
CPC分类号： H01S4/00 , H01C17/06 , H01F17/0033 , H01F27/2804 , H01F27/2895 , H01F41/04 , H01F41/041 , H01F41/08 , H05K1/0272 , H05K1/165 , H05K3/0014 , H05K3/107 , H05K3/205 , H05K3/4614 , H05K2201/0379 , H05K2201/09036 , H05K2201/09118 , H05K2201/09981 , H05K2203/0108 , H05K2203/0594 , H05K2203/1105 , H05K2203/135 , Y10T29/49071 , Y10T29/49073 , Y10T29/49146 , Y10T29/49172 , Y10T29/49176 , Y10T29/4922
摘要： Manufacturing of miniaturised three-dimensional electric components are presented, as well as components manufactured by the methods. The manufacturing methods comprise micro-replication of at least one master structure, e.g. via a mould structure, in at least one polymer layer onto which layer at least one conductive path is provided.
摘要翻译：提出了小型化三维电气部件的制造以及通过这些方法制造的部件。制造方法包括至少一个主结构的微复制，例如。通过模具结构，在至少一个聚合物层中，至少一个导电路径被设置在该层上。

5. 发明申请

US20100227797A1 USE OF CYCLOLIGNANS FOR THE TREATMENT OF TYPE 2 DIABETES AND AS CONTRACEPTIVES 审中-公开
标题翻译： CYCLOLIGNANS用于治疗2型糖尿病和作为承诺的使用
公开(公告)号：US20100227797A1
公开(公告)日：2010-09-09
申请号：US12279986
申请日：2007-02-23
申请人： Magnus Axelson , Olof Danielsson , Mario-Alexander Economou , Olle Larsson
发明人： Magnus Axelson , Olof Danielsson , Mario-Alexander Economou , Olle Larsson
IPC分类号： A61K38/28 , A61P3/10 , A61P27/06 , A61P37/06 , A61P15/18 , A61P13/12 , A61K31/365 , A61K31/567
CPC分类号： A61K31/36 , A61K31/365
摘要： There is disclosed use of certain cyclolignans for prophylaxis or treatment of diabetes mellitus type 2, nephropathy, retinopathy, macular degeneration, retinopathy of prematurity, central retinal vein occlusion, branch retinal vein occlusion, rubeotic glaucoma, thyroid eye disease, corneal graft rejection and corneal chemical burns; and for contraception. Preferred compounds are picropodophyllin, deoxypicropodophyllin and anhydropicropodophyllol. There is also described a method of treatment of an eye disease.
摘要翻译：公开了某些环烯霉素用于预防或治疗2型糖尿病，肾病，视网膜病变，黄斑变性，早产儿视网膜病变，视网膜中央静脉阻塞，视网膜分支静脉闭塞，眼球性青光眼，甲状腺眼病，角膜移植排斥和角膜的预防或治疗化学灼伤和避孕。优选的化合物是鬼臼苦草素，脱氧叶酸和脱水鸟嘌呤。还描述了治疗眼部疾病的方法。

6. 发明授权

US07709526B2 Use of cyclolignans and new cyclolignans 失效
标题翻译：使用环烷基和新的环烷基
公开(公告)号：US07709526B2
公开(公告)日：2010-05-04
申请号：US11346294
申请日：2006-02-03
申请人： Olle Larsson , Magnus Axelson
发明人： Olle Larsson , Magnus Axelson
IPC分类号： A61K31/335 , C07D317/70
CPC分类号： C07D493/04 , A61K31/34 , A61K31/36 , A61K31/365 , C07D317/54 , C07D317/70
摘要： Compounds which inhibit the insulin-like growth factor-1 receptor (IGF-1 R) and methods for using them for treating IGF-1 R dependent diseases, such as cancer.
摘要翻译：抑制胰岛素样生长因子-1受体（IGF-1R）的化合物及其用于治疗IGF-1R依赖性疾病如癌症的方法。

7. 发明申请

US20060111363A1 Treatment of uveal melanoma 审中-公开
标题翻译：治疗葡萄膜黑素瘤
公开(公告)号：US20060111363A1
公开(公告)日：2006-05-25
申请号：US10531967
申请日：2003-10-20
申请人： Charlotta All-Ericsson , Olle Larsson
发明人： Charlotta All-Ericsson , Olle Larsson
IPC分类号： A61K31/506
CPC分类号： A61K31/506
摘要： The present invention pertains to the use of the Compound I of the following formula or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for the treatment of uveal melanoma.
摘要翻译：本发明涉及下式的化合物I或其药学上可接受的盐在制备用于治疗葡萄膜黑素瘤的药物中的用途。

8. 发明授权

US06402389B1 Angled opto-mechanical device 失效
标题翻译：角度光学机械装置
公开(公告)号：US06402389B1
公开(公告)日：2002-06-11
申请号：US08848238
申请日：1997-04-29
申请人： Odd Steijer , Christer Moll , Bengt Lindström , Christian Vieider , Paul Eriksen , Jan-Åke Engstrand , Olle Larsson , Håkan Elderstig
发明人： Odd Steijer , Christer Moll , Bengt Lindström , Christian Vieider , Paul Eriksen , Jan-Åke Engstrand , Olle Larsson , Håkan Elderstig
IPC分类号： G02B638
CPC分类号： G02B6/3829 , G02B6/3839 , G02B6/3865 , G02B6/3885
摘要： The present invention relates to an angled opto-mechanical connector (10) and to a manufacturing process for the same. The connector (10) comprises a fixture (1) with straight and parallel grooves (2, 3) of two sizes running on the upper side of the fixture (1) from a first fixture side (1a) to a second fixture side (1b). A lid (4) is fastened above the fixture (1). Fibre ends (8a) of optical fibres (8) are placed in the capillaries which are formed between the smaller grooves (2) of the fixture and the lid (4) in such a way that they stick out through the side of the fixture (1b). A plastic capsule (11) encloses the fixture (1), the lid (4) and the fibres (8) completely or partially. The fibres (8) stick out from the plastic capsule (11) in a direction separated from that defined by the grooves of the fixture. The connector (10) can also have an opto-mechanical interface of the above mentioned type at its other end (10b).
摘要翻译：本发明涉及一种成角度的光机械连接器（10）及其制造方法。连接器（10）包括具有从第一固定侧（1a）到第二固定侧（1b）在固定装置（1）的上侧上延伸的具有两个尺寸的直的和平行的凹槽（2,3）的固定装置（1））。盖（4）被紧固在固定装置（1）上方。将光纤（8）的纤维端部（8a）放置在毛细管中，毛细管形成在固定装置的较小凹槽（2）和盖子（4）之间，使得它们穿过固定装置的侧面 1b）。塑料胶囊（11）完全或部分地包围固定装置（1），盖子（4）和纤维（8）。纤维（8）沿与固定装置的凹槽所限定的方向分开的方向从塑料胶囊（11）伸出。连接器（10）在其另一端（10b）上也可以具有上述类型的光机械接口。

9. 发明授权

US06173098B2 Opto-mechanical device 失效
标题翻译：光机械装置
公开(公告)号：US06173098B2
公开(公告)日：2001-01-09
申请号：US08848618
申请日：1997-04-29
申请人： Odd Steijer , Christer Moll , Bengt Lindström , Christian Vieider , Paul Eriksen , Jan-Åke Engstrand , Olle Larsson , Håkan Elderstig
发明人： Odd Steijer , Christer Moll , Bengt Lindström , Christian Vieider , Paul Eriksen , Jan-Åke Engstrand , Olle Larsson , Håkan Elderstig
IPC分类号： G02B638
CPC分类号： G02B6/3865 , G02B6/3839 , G02B6/3885
摘要： The present invention relates to a manufacturing method for an opto-mechanical connector (10) and to the connector itself. The invention includes that a fixture (1) is manufactured with straight and parallel grooves (2,3) running on the upper side of the fixture (1) from a first fixture side (1a) to a second fixture side (1b), and which grooves (2,3) are intended partly for optical fibers and partly for guide pins. A lid (4) is attached above the fixture (1), whereafter optical fibers (8) from, for example, a fiber ribbon cable (6) are introduced into the grooves (2) intended for the fibers from the first fixture side (1a) so that the fiber ends (8) extend out through the second fixture side (1b). Guide pins (9) are furthermore introduced into the grooves (3) intended for the guide pins. The structure obtained (fixture (1), lid (4), fiber ends (8) and guide pins (9)) is completely or partially enclosed by a plastic capsule (11).
摘要翻译：本发明涉及一种用于光机械连接器（10）和连接器本身的制造方法。本发明包括一种固定装置（1）制造成具有从第一固定侧（1a）到第二固定侧（1b）在固定装置（1）的上侧上延伸的直的和平行的槽（2,3），以及哪些槽（2,3）部分用于光纤，部分用于导向销。盖子（4）安装在固定装置（1）的上方，然后从例如纤维带状电缆（6）的光纤（8）从第一夹具侧引入预定用于纤维的凹槽（2） 1a）使得纤维端部（8）延伸穿过第二固定侧（1b）。引导销（9）进一步被引入用于引导销的凹槽（3）中。获得的结构（固定装置（1），盖子（4），纤维端部和引导销（9））被塑料胶囊（11）完全或部分地包围。

10. 发明授权

US08389747B2 Use of specific cyklolignans 有权
标题翻译：使用特定的cyklolignans
公开(公告)号：US08389747B2
公开(公告)日：2013-03-05
申请号：US12508218
申请日：2009-07-23
申请人： Olle Larsson , Magnus Axelson
发明人： Olle Larsson , Magnus Axelson
IPC分类号： C07D307/77 , C07D317/70
CPC分类号： C07D493/04 , A61K31/34 , A61K31/36 , A61K31/365 , C07D317/54 , C07D317/70
摘要： The invention refers to the use of specific cyclolignans, wherein the carbon atoms in positions 9 and 9′ have cis configuration, for inhibition of the insulin-like growth factor-1 receptor. Said compounds can be used for treatment of IGF-1R dependent diseases, such as cancer, psoriasis, artherosclerosis and acromegaly. A preferred compound is picropodophyllin.
摘要翻译：本发明涉及使用特定的环烯霉素，其中9和9'位的碳原子具有顺式构型，用于抑制胰岛素样生长因子-1受体。所述化合物可用于治疗IGF-1R依赖性疾病，例如癌症，牛皮癣，动脉粥样硬化和肢端肥大症。优选的化合物是鬼臼苦茶。

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