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1. 发明申请

US20070092894A1 Methods and kits for detecting single nucleotide polymorphisms of chromosome implicated in premature canities 审中-公开
标题翻译：用于检测涉及早产儿的染色体单核苷酸多态性的方法和试剂盒
公开(公告)号：US20070092894A1
公开(公告)日：2007-04-26
申请号：US11486062
申请日：2006-07-14
申请人： Olivier De Lacharriere , Jean-Louis Blouin , Claire Deloche , Stylianos Antonarakis , Emmanouil Dermitzakis
发明人： Olivier De Lacharriere , Jean-Louis Blouin , Claire Deloche , Stylianos Antonarakis , Emmanouil Dermitzakis
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6886 , C12Q2600/172
摘要： Methods and kits for diagnosing a predisposition to premature canities in an individual are disclosed. A method for diagnosing a predisposition to premature canities in an individual comprises detecting at least one SNP marker of the human chromosome 9, selected from the group consisting of rs306534, rs3739902, rs575916, and rs365297. A kit for diagnosing a predisposition to premature canities comprises a means for detecting in a sample of human genetic material, the allele of a SNP marker of the human chromosome 9 selected from the markers rs306534, rs3739902, rs575916 and rs365297; and a positive or negative control.
摘要翻译：公开了用于诊断个体早产儿倾向的方法和试剂盒。用于诊断个体早产性易感性的方法包括检测选自rs306534，rs3739902，rs575916和rs365297的人染色体9的至少一个SNP标记。用于诊断早产性易感性的试剂盒包括在人类遗传物质的样品中检测选自标记rs306534，rs3739902，rs575916和rs365297的人染色体9的SNP标记的等位基因的方法; 和正或负控制。

2. 发明申请

US20070065389A1 Genes from chromosomes 3, 5 and 11 involved in premature canities 审中-公开
标题翻译：来自染色体3,5和11的基因涉及早衰
公开(公告)号：US20070065389A1
公开(公告)日：2007-03-22
申请号：US11583512
申请日：2006-10-18
申请人： Olivier De Lacharriere , Jean-Louis Blouin , Claire Deloche , Stylianos Antonarakis
发明人： Olivier De Lacharriere , Jean-Louis Blouin , Claire Deloche , Stylianos Antonarakis
IPC分类号： A61K8/73 , C12Q1/68 , A61K48/00
CPC分类号： A61Q5/10 , A61K8/35 , A61K48/00 , A61Q19/04 , C12Q1/6883 , C12Q2600/148 , C12Q2600/156 , C12Q2600/172
摘要： The disclosure provides a cosmetic or therapeutic method for combating canities and/or stimulating natural pigmentation and/or treating a pigmentation disorder comprising administering at least one polynucleotide fragment comprising 18 consecutive nucleotides, the sequence of which corresponds to all or part of a gene on human chromosome 3 selected from KIAA1042, CCK, CACNA1D, ARHGEF3 and AL133097 genes, or the sequence of which corresponds to all or part of a gene on human chromosome 5 selected from the KLHL3, HNRPA0, CDC25C, EGR1, C5orf7, LOC51308, ETF1, HSPA9B, PDCHA1 to PDCHA13, CSF1R, RPL7, PDGFRB, TCOF1, AL133039, CD74, RPS14, NDST1, G3BP, GLRA1, C5orf3, MFAP3, GALNT10 and FLJ117151 genes, or the sequence of which corresponds to all or part of a gene or human chromosome 11 selected from the GUCY1A2, CUL5, ACAT1, NPAT, ATM, AF035326, AF035327m A0035328m BC029536, FLJ20535, DRD2, ENS303941, IGSF4, LOC1092, BC010946, TAGLN, PCSK7 and ENS300650 genes, and diagnostic methods employing same.
摘要翻译：本公开提供了一种用于对抗癌症和/或刺激天然色素沉着和/或治疗色素沉着病症的化妆品或治疗方法，其包括施用至少一种包含18个连续核苷酸的多核苷酸片段，其中所述多核苷酸片段的序列对应于人的全部或部分基因染色体3选自KIAA1042，CCK，CACNA1D，ARHGEF3和AL133097基因，或其序列对应于选自KLHL3，HNRPA0，CDC25C，EGR1，C5orf7，LOC51308，ETF1，HSPA9B的人染色体5上的全部或部分基因，PDCHA1至PDCHA13，CSF1R，RPL7，PDGFRB，TCOF1，AL133039，CD74，RPS14，NDST1，G3BP，GLRA1，C5orf3，MFAP3，GALNT10和FLJ117151基因，或其序列对应于全部或部分基因或人染色体 11选自GUCY1A2，CUL5，ACAT1，NPAT，ATM，AF035326，AF035327m A0035328m BC029536，FLJ20535，DRD2，ENS303941，IGSF4，LOC1092，BC010946，TAGLN，PCSK7和ENS300650基因，以及采用相同

3. 发明申请

US20050214821A1 Chromosome 6 and 9 genes involved in premature canities 审中-公开
标题翻译：染色体6和9基因涉及早产儿
公开(公告)号：US20050214821A1
公开(公告)日：2005-09-29
申请号：US11031012
申请日：2005-01-10
申请人： Olivier De Lacharriere , Jean-Louis Blouin , Claire Deloche , Stylianos Antonarakis
发明人： Olivier De Lacharriere , Jean-Louis Blouin , Claire Deloche , Stylianos Antonarakis
IPC分类号： C12Q1/68 , A61K7/06 , A61K7/11
CPC分类号： C12Q1/6883 , C12Q2600/148 , C12Q2600/156 , C12Q2600/172
摘要： The invention provides a cosmetic or therapeutic method for combating canities and/or stimulating natural pigmentation and/or treating a pigmentation disorder comprising administering at least one polynucleotide fragment comprising 18 consecutive nucleotides, the sequence of which corresponds to all or part of a gene on human chromosome 9 selected from the group consisting of the FREQ, NT_030046.18, NT_030046.17, GTF3C5, CEL, CELL, FS, ABO, BARHL1, DDX31, GTF3C4 and Q96MA6 genes, or the sequence of which corresponds to all or part of a gene on human chromosome 6 selected from the HLAG, NT_007592.445, NT_007592.446, NT_007592.506, NT_007592.507, NT_007592.508, HSPA1B, G8, NEU1, NG22, BAT8, HLA-DMB, HLA-DMA, BRD2, HLA-DQA1, HLA-DQA2, NT_007592.588, GRM4, RNF23, FLJ22638, NT_007592.459 and NT_007592.457 genes, and diagnostic methods employing same.
摘要翻译：本发明提供了一种用于对抗癌症和/或刺激天然色素沉着和/或治疗色素沉着病症的化妆品或治疗方法，其包括施用至少一种包含18个连续核苷酸的多核苷酸片段，其序列对应于人的全部或部分基因染色体9选自FREQ，NT_030046.18，NT_030046.17，GTF3C5，CEL，CELL，FS，ABO，BARHL1，DDX31，GTF3C4和Q96MA6基因，或其序列对应于全部或部分选自HLAG，NT_007592.445，NT_007592.446，NT_007592.506，NT_007592.507，NT_007592.508，HSPA1B，G8，NEU1，NG22，BAT8，HLA-DMB，HLA-DMA，BRD2， HLA-DQA1，HLA-DQA2，NT_007592.588，GRM4，RNF23，FLJ22638，NT_007592.459和NT_007592.457基因，以及采用其的诊断方法。

4. 发明申请

US20050208010A1 Genes from Chromosome 3, 5 and 11 involved in premature canities 审中-公开
标题翻译：来自染色体3,5和11的基因涉及早衰
公开(公告)号：US20050208010A1
公开(公告)日：2005-09-22
申请号：US11031033
申请日：2005-01-10
申请人： Olivier De Lacharriere , Jean-Louis Blouin , Claire Deloche , Stylianos Antonarakis
发明人： Olivier De Lacharriere , Jean-Louis Blouin , Claire Deloche , Stylianos Antonarakis
IPC分类号： A61K8/35 , A61K48/00 , A61Q5/10 , A61Q19/04 , C12Q1/68 , A61K7/06 , A61K7/11
CPC分类号： A61Q5/10 , A61K8/35 , A61K48/00 , A61Q19/04 , C12Q1/6883 , C12Q2600/148 , C12Q2600/156 , C12Q2600/172
摘要： The invention provides a cosmetic or therapeutic method for combating canities and/or stimulating natural pigmentation and/or treating a pigmentation disorder comprising administering at least one polynucleotide fragment comprising 18 consecutive nucleotides, the sequence of which corresponds to all or part of a gene on human chromosome 3 selected from KIAA 042, CCK, CACNA1D, ARHGEF3 and AL133097 genes, or the sequence of which corresponds to all or part of a gene on human chromosome 5 selected from the KLHL3, HNRPA0, CDC25C, EGR1, C5orf6, C5orf7, LOC51308, ETF1, HSPA9B, PCDHA1 to PCDHA13, CSF1R, RPL7, PDGFRB, TCOF1, AL133039, CD74, RPS14, NDST1, G3BP, GLRA1, C5orf3, MFAP3, GALNT10 and FLJ 117151 genes, or the sequence of which corresponds to all or part of a gene on human chromosome 11 selected from the GUCY1A2, CUL5, ACAT1, NPAT, ATM, AF035326, AF035327, AF035328, BC029536, FLJ20535, DRD2, ENS303941, IGSF4, LOC51092, BC010946, TAGLN, PCSK7 and ENS300650 genes, and diagnostic methods employing same.
摘要翻译：本发明提供了一种用于对抗癌症和/或刺激天然色素沉着和/或治疗色素沉着病症的化妆品或治疗方法，其包括施用至少一种包含18个连续核苷酸的多核苷酸片段，其序列对应于人的全部或部分基因染色体3选自KIAA 042，CCK，CACNA1D，ARHGEF3和AL133097基因，或其序列对应于选自KLHL3，HNRPA0，CDC25C，EGR1，C5orf6，C5orf7，LOC51308等的人类染色体5上的全部或部分基因。 ETF1，HSPA9B，PCDHA1至PCDHA13，CSF1R，RPL7，PDGFRB，TCOF1，AL133039，CD74，RPS14，NDST1,3GBP，GLRA1，C5orf3，MFAP3，GALNT10和FLJ 117151基因，或其序列对应于全部或部分基因，选自GUCY1A2，CUL5，ACAT1，NPAT，ATM，AF035326，AF035327，AF035328，BC029536，FLJ20535，DRD2，ENS303941，IGSF4，LOC51092，BC010946，TAGLN，PCSK7和ENS300650基因的人染色体11基因和诊断方法用同样的

5. 发明申请

US20090239312A1 Chromosome 6 and 9 Genes Involved in Premature Canities 审中-公开
标题翻译：染色体6和9基因涉及早产性
公开(公告)号：US20090239312A1
公开(公告)日：2009-09-24
申请号：US12474244
申请日：2009-05-28
申请人： Olivier De Lacharriere , Jean-Louis Blouin , Claire Deloche , Stylianos Antonarakis
发明人： Olivier De Lacharriere , Jean-Louis Blouin , Claire Deloche , Stylianos Antonarakis
IPC分类号： G01N33/566
CPC分类号： C12Q1/6883 , C12Q2600/148 , C12Q2600/156 , C12Q2600/172
摘要： The invention provides a cosmetic or therapeutic method for combating canities and/or stimulating natural pigmentation and/or treating a pigmentation disorder comprising administering at least one polynucleotide fragment comprising 18 consecutive nucleotides, the sequence of which corresponds to all or part of a gene on human chromosome 9 selected from the group consisting of the FREQ, NT_030046.18, NT_030046.17, GTF3C5, CEL, CELL, FS, ABO, BARBLI, DDX31, GTF3C4 and Q96MA6 genes, or the sequence of which corresponds to all or part of a gene on human chromosome 6 selected from the HLAG, NT_007592.445, NT_007592.446, NT_007592.506, NT_007592.507, NT_007592.508, HSPA1 B, G8, NEU1, NG22, BAT8, HLA-DMB, HLA-DMA, BRD2, HLA-DQA1, HLA-DQA2, NT_007592.588, GRM4, RNF23, FLJ22638, NT_007592.459 and NT_007592.457 genes, and diagnostic methods employing same.
摘要翻译：本发明提供了一种用于对抗癌症和/或刺激天然色素沉着和/或治疗色素沉着病症的化妆品或治疗方法，其包括施用至少一种包含18个连续核苷酸的多核苷酸片段，其序列对应于人的全部或部分基因染色体9选自FREQ，NT_030046.18，NT_030046.17，GTF3C5，CEL，CELL，FS，ABO，BARBLI，DDX31，GTF3C4和Q96MA6基因，或其序列对应于全部或部分选自HLAG，NT_007592.445，NT_007592.446，NT_007592.506，NT_007592.507，NT_007592.508，HSPA1B，G8，NEU1，NG22，BAT8，HLA-DMB，HLA-DMA，BRD2的人6号染色体上的基因，HLA-DQA1，HLA-DQA2，NT_007592.588，GRM4，RNF23，FLJ22638，NT_007592.459和NT_007592.457基因以及使用其的诊断方法。

6. 发明授权

US06509014B1 Therapeutic/cosmetic compositions comprising CGRP antagonists for treating skin redness/rosacea/discreet erythema 有权
标题翻译：包含用于治疗皮肤发红/红斑痤疮/谨慎性红斑的CGRP拮抗剂的治疗/美容组合物
公开(公告)号：US06509014B1
公开(公告)日：2003-01-21
申请号：US09318237
申请日：1999-05-25
申请人： Olivier De Lacharriere , Lionel Breton
发明人： Olivier De Lacharriere , Lionel Breton
IPC分类号： A61K39395
CPC分类号： A61K39/3955 , A61K38/225 , Y10S424/809
摘要： Skin redness, rosacea and/or discreet erythema afflicting a mammalian, notably human patient, are therapeutically treated by administrating to such patient a therapeutically/cosmetically effective amount of at least one CGRP antagonist, advantageously in combinatory immixture with at least one antagonist of a neuropeptide other than CGRP, e.g., a substance P antagonist, and/or at least one inflammation mediator antagonist.
摘要翻译：影响哺乳动物，特别是人类患者的皮肤红肿，红斑痤疮和/或谨慎性红斑，通过向该患者施用治疗/化妆有效量的至少一种CGRP拮抗剂，有利地与至少一种神经肽拮抗剂的组合性固定除CGRP外，例如物质P拮抗剂和/或至少一种炎症介质拮抗剂。

7. 发明授权

US06241993B1 Therapeutic/cosmetic compositions comprising bradykinin antagonists for treating sensitive human skin 失效
公开(公告)号：US06241993B1
公开(公告)日：2001-06-05
申请号：US09087803
申请日：1998-06-01
申请人： Lionel Breton , Olivier De Lacharriere
发明人： Lionel Breton , Olivier De Lacharriere
IPC分类号： A61K748
CPC分类号： A61K8/64 , A61K8/37 , A61K8/63 , A61K8/671 , A61K2800/70 , A61K2800/75 , A61Q1/14 , A61Q17/00 , A61Q17/02 , A61Q19/00 , A61Q19/004 , A61Q19/005 , A61Q19/08 , Y10S514/844 , Y10S514/846 , Y10S514/936 , Y10S514/944
摘要： Topically applicable pharmaceutical/dermatological/cosmetic compositions well suited for the therapeutic treatment or care of sensitive human skin, hair, mucous membranes, nails and/or the scalp, in particular for reducing or avoiding the skin-irritant side effects of a variety of bioactive agents, for example the &agr;-hydroxy and &bgr;-hydroxy acids, comprise a therapeutically/cosmetically effective amount of at least one bradykinin antagonist.

8. 发明授权

US06169069A Therapeutic/cosmetic compositions comprising CGRP antagonists for treating the eyes or eyelids 失效
标题翻译：包含用于治疗眼睛或眼睑的CGRP拮抗剂的治疗/化妆品组合物
公开(公告)号：US06169069A
公开(公告)日：2001-01-02
申请号：US08623576
申请日：1996-03-28
申请人： Olivier De Lacharriere , Lionel Breton
发明人： Olivier De Lacharriere , Lionel Breton
IPC分类号： A61K3800
CPC分类号： A61K38/225 , A61K39/3955 , Y10S514/844
摘要： Ocular and/or palpebral pruritus and/or ocular and/or palpebral pain and/or ocular and/or palpebral dysaesthesia afflicting a mammalian, notably human patient, are therapeutically treated by administering to such patient a therapeutically/cosmetically effective amount of at least one CGRP antagonist, advantageously in combinatory immixture with at least one antagonist of a neuropeptide other than CGRP, e.g., a substance P antagonist, and/or at least one inflammation mediator antagonist; the subject compositions are also well suited for making up and/or caring for human eyes, eyelashes and/or eyelids, especially sensitive eyes and eyelids.
摘要翻译：影响哺乳动物，特别是人类患者的眼睛和/或睑板瘙痒和/或眼睛和/或睑部疼痛和/或眼睑和/或睑部麻醉感受物通过向该患者施用治疗/化妆有效量的至少一种 CGRP拮抗剂，有利地与除CGRP以外的神经肽的至少一种拮抗剂（例如物质P拮抗剂）和/或至少一种炎症介质拮抗剂的组合性混合物中; 主题组合物也非常适合于补充和/或照顾人眼，睫毛和/或眼睑，特别是敏感的眼睛和眼皮。

9. 发明授权

US5858024A Composition for dyeing keratin fibres containing a substance P antagonist 失效
标题翻译：用于染色含有P物质拮抗剂的角蛋白纤维的组合物
公开(公告)号：US5858024A
公开(公告)日：1999-01-12
申请号：US716534
申请日：1996-09-19
申请人： Olivier De Lacharriere , Lionel Breton , Genevieve Loussouarn
发明人： Olivier De Lacharriere , Lionel Breton , Genevieve Loussouarn
IPC分类号： A61K8/00 , A61K8/19 , A61K8/20 , A61K8/31 , A61K8/33 , A61K8/41 , A61K8/49 , A61K8/64 , A61K8/97 , A61K8/99 , A61Q5/00 , A61Q5/10 , A61K7/13
CPC分类号： A61K8/20 , A61K8/64 , A61K8/97 , A61K8/99 , A61Q5/10 , A61K2800/70
摘要： The invention relates to a composition, in particular a cosmetic composition, and more particularly one for dyeing keratin fibers, this composition containing at least one substance P antagonist in order to reduce or even eliminate the irritant effects of the dyes and/or pigments and/or dye precursors used during this dyeing. The substance P antagonist may form part of the dye composition itself or may be contained in a composition which is applied prior to the application of the dye composition.
摘要翻译：本发明涉及一种组合物，特别是化妆品组合物，更特别地涉及用于染色角蛋白纤维的组合物，该组合物含有至少一种物质P拮抗剂，以减少或甚至消除染料和/或颜料的刺激性影响和/ 或在染色期间使用的染料前体。物质P拮抗剂可以形成染料组合物本身的一部分，或者可以包含在施用染料组合物之前施用的组合物中。

10. 发明授权

US5851556A Use of a salt of an alkaline-earth metal as TNF-A or substance P inhibitor in a topical composition and composition obtained 失效
标题翻译：在局部组合物和组合物中使用碱土金属盐作为TNF-A或物质P抑制剂
公开(公告)号：US5851556A
公开(公告)日：1998-12-22
申请号：US630326
申请日：1996-04-10
申请人： Lionel Breton , Olivier De Lacharriere
发明人： Lionel Breton , Olivier De Lacharriere
IPC分类号： A61K8/19 , A61K8/36 , A61K8/365 , A61K8/44 , A61K33/00 , A61K33/06 , A61K33/14 , A61Q19/00 , A61K33/32
CPC分类号： A61Q19/005 , A61K33/00 , A61K33/06 , A61K33/14 , A61K8/19 , A61K8/36 , A61K8/365 , A61K8/44 , A61Q19/00
摘要： The invention relates to the use of a salt of an alkaline-earth metal in a cosmetic, pharmaceutical, veterinary and/or dermatological composition for treating, in particular, sensitive skins. It relates, in addition, to the use of a salt of an alkaline-earth metal for preventing and/or combating rosacea and/or skin irritation and/or dartre and/or pudic erythema and/or dysesthetic sensation and/or sensation of inflammation and/or pruritus of the skin and/or of the mucous membranes. The salt is in particular strontium nitrate or chloride.
摘要翻译：本发明涉及在化妆品，药物，兽医和/或皮肤病学组合物中用于治疗特别是敏感皮肤的碱土金属盐的用途。此外，还涉及使用碱土金属的盐来预防和/或防治酒渣鼻和/或皮肤刺激和/或呕吐和/或红斑和/或躁动症和/或炎症感觉和/或皮肤和/或粘膜的瘙痒。该盐特别是硝酸锶或氯化锶。

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