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1. 发明授权

US07807437B2 Variants of hepatitis B virus resistant against some nucleoside analogues, but sensitive to others, and uses thereof 有权
标题翻译：乙型肝炎病毒对某些核苷类似物具有抗性但对其他人敏感的变体及其用途
公开(公告)号：US07807437B2
公开(公告)日：2010-10-05
申请号：US11375580
申请日：2006-03-15
申请人： Oliver Schildgen , Martin Vogel , Bertfried Matz , Juergen Rockstroh , Rolf Kaiser , Martin Daeumer , Martin Helm , Lutwin Weitner , Carl Knud Schewe , Wolfram Gerlich
发明人： Oliver Schildgen , Martin Vogel , Bertfried Matz , Juergen Rockstroh , Rolf Kaiser , Martin Daeumer , Martin Helm , Lutwin Weitner , Carl Knud Schewe , Wolfram Gerlich
IPC分类号： C12N7/00
CPC分类号： C12N7/00 , C07K14/005 , C12N9/1276 , C12N2730/10121 , C12N2730/10122 , C12Q1/706 , C12Q2600/156 , G01N33/5761 , G01N2333/02
摘要： The present invention relates generally to the field of Hepatitis B variants exhibiting a reduced sensitivity to nucleoside analogues both in vivo and in vitro. More in particular, reverse transcriptase mutant rt I233V is provided. Present invention provides assays and methods for detecting such variant, which assays are useful in monitoring anti-viral therapeutic regimes and adjusting patient therapy. A diagnostic kit for detecting the presence of an HBV variant in a biological sample has also been described. Finally, the use of a pharmaceutical composition to cure a subject suffering from a HBV infection, which HBV is resistant to lamuvidine and/or adefovir has been provided, which pharmaceutical composition comprises the nucleoside analogue tenofovir.
摘要翻译：本发明一般涉及在体内和体外对核苷类似物的敏感性降低的乙型肝炎变体领域。更具体地，提供逆转录酶突变体rt I233V。本发明提供了用于检测这种变体的测定和方法，该测定法可用于监测抗病毒治疗方案并调整患者治疗。还描述了用于检测生物样品中HBV变异体的存在的诊断试剂盒。最后，已经提供了使用药物组合物治疗HBV感染的受试者，其HBV对lamvvidine和/或阿德福韦有抗性，该药物组合物包含核苷类似物替诺福韦。

2. 发明申请

US20070042356A1 Variants of hepatitis B virus resistant against some nucleoside analogues, but sensitive to others, and uses thereof 有权
标题翻译：乙型肝炎病毒对某些核苷类似物具有抗性但对其他人敏感的变体及其用途
公开(公告)号：US20070042356A1
公开(公告)日：2007-02-22
申请号：US11375580
申请日：2006-03-15
申请人： Oliver Schildgen , Martin Vogel , Bertfried Matz , Juergen Rockstroh , Rolf Kaiser , Martin Daeumer , Martin Helm , Lutwin Weitner , Carl Schewe , Wolfram Gerlich
发明人： Oliver Schildgen , Martin Vogel , Bertfried Matz , Juergen Rockstroh , Rolf Kaiser , Martin Daeumer , Martin Helm , Lutwin Weitner , Carl Schewe , Wolfram Gerlich
IPC分类号： C12Q1/70 , C07H21/04 , A61K31/7072 , C07K14/02 , C12N15/86 , C12N7/01
CPC分类号： C12N7/00 , C07K14/005 , C12N9/1276 , C12N2730/10121 , C12N2730/10122 , C12Q1/706 , C12Q2600/156 , G01N33/5761 , G01N2333/02
摘要： The present invention relates generally to the field of Hepatitis B variants exhibiting a reduced sensitivity to nucleoside analogues both in vivo and in vitro. More in particular, reverse transcriptase mutant rt I233V is provided. Present invention provides assays and methods for detecting such variant, which assays are useful in monitoring anti-viral therapeutic regimes and adjusting patient therapy. A diagnostic kit for detecting the presence of an HBV variant in a biological sample has also been described. Finally, the use of a farmaceutical composition to cure a subject suffering from a HBV infection, which HBV is resistant to lamuvidine and/or adefovir has been provided, which farmaceutical composition comprises the nucleoside analogue tenofovir.
摘要翻译：本发明一般涉及在体内和体外对核苷类似物的敏感性降低的乙型肝炎变体领域。更具体地，提供逆转录酶突变体rt I233V。本发明提供了用于检测这种变体的测定和方法，该测定法可用于监测抗病毒治疗方案并调整患者治疗。还描述了用于检测生物样品中HBV变异体的存在的诊断试剂盒。最后，提供了一种药物组合物治疗患有HBV感染的受试者，其HBV对lamvvidine和/或阿德福韦具有抗性，该药物组合物包含核苷类似物替诺福韦。

3. 发明专利

DE1072460C2 Vorrichtung an Musikinstrumenten 未知
公开(公告)号：DE1072460C2
公开(公告)日：1960-06-15
申请号：DE1072460
申请日：1958-09-20
申请人： MARTIN VOGEL
发明人： Martin Vogel

4. 发明授权

US08828289B2 Free-radical-polymerisable fixing mortar having silane additives 有权
标题翻译：具有硅烷添加剂的自由基聚合固定砂浆
公开(公告)号：US08828289B2
公开(公告)日：2014-09-09
申请号：US13515636
申请日：2010-11-16
申请人： Jurgen Grun , Martin Vogel , Clemens Schmidt , Christian Schlenk , Christian Weinelt
发明人： Jurgen Grun , Martin Vogel , Clemens Schmidt , Christian Schlenk , Christian Weinelt
IPC分类号： E04B1/35 , C04B26/16 , C04B28/06 , C04B28/04 , C04B26/06 , C04B26/32 , C04B26/18 , C04B26/14 , C04B111/00 , C04B103/00
CPC分类号： C04B26/32 , C04B16/065 , C04B24/42 , C04B26/06 , C04B26/14 , C04B26/16 , C04B26/18 , C04B28/04 , C04B28/06 , C04B2103/0047 , C04B2111/00715 , C04B24/2641 , C04B40/065 , C04B24/281 , C04B24/282 , C04B24/283
摘要： Two-component or multi-component fixing mortar, based on a free-radical-hardening unsaturated reactive resin, for embedding anchoring means in mortar in holes or crevices, which fixing mortar includes silanes which may or may not have reactive groups capable of participating in the polymerization with a synthetic resin based on free-radical-hardening unsaturated reactive resins but do in any case have Si-bonded hydrolysable groups, and, physically separate therefrom, a hardener.
摘要翻译：基于自由基硬化的不饱和反应性树脂的双组分或多组分固定砂浆用于将锚固装置嵌入孔或缝隙中的砂浆中，固定砂浆包括可能具有或不具有能够参与的反应性基团的硅烷使用基于自由基硬化不饱和反应性树脂的合成树脂的聚合，但是在任何情况下都具有Si键合的可水解基团，并且与其物理上分离出固化剂。

5. 发明申请

US20120247985A1 FREE-RADICAL-POLYMERISABLE FIXING MORTAR HAVING SILANE ADDITIVES 有权
标题翻译：具有硅烷添加剂的自由可聚合固定木糖
公开(公告)号：US20120247985A1
公开(公告)日：2012-10-04
申请号：US13515636
申请日：2010-11-16
申请人： Jurgen Grun , Martin Vogel , Clemens Schmidt , Christian Schlenk , Christian Weinelt
发明人： Jurgen Grun , Martin Vogel , Clemens Schmidt , Christian Schlenk , Christian Weinelt
IPC分类号： B65D25/08 , C08K5/5415 , C08K5/5435 , E04B1/35 , C08K5/548 , C08G77/00 , C08K5/5425 , B65D85/84 , C08L33/06 , C08K5/544
CPC分类号： C04B26/32 , C04B16/065 , C04B24/42 , C04B26/06 , C04B26/14 , C04B26/16 , C04B26/18 , C04B28/04 , C04B28/06 , C04B2103/0047 , C04B2111/00715 , C04B24/2641 , C04B40/065 , C04B24/281 , C04B24/282 , C04B24/283
摘要： Two-component or multi-component fixing mortar, based on a free-radical-hardening unsaturated reactive resin, for embedding anchoring means in mortar in holes or crevices, which fixing mortar includes silanes which may or may not have reactive groups capable of participating in the polymerisation with a synthetic resin based on free-radical-hardening unsaturated reactive resins but do in any case have Si-bonded hydrolysable groups, and, physically separate therefrom, a hardener.
摘要翻译：基于自由基硬化的不饱和反应性树脂的双组分或多组分固定砂浆用于将锚固装置嵌入孔或缝隙中的砂浆中，固定砂浆包括可能具有或不具有能够参与的反应性基团的硅烷使用基于自由基硬化的不饱和反应性树脂的合成树脂进行聚合，但是在任何情况下都具有硅键合的可水解基团，并与其物理分离，由硬化剂构成。

6. 发明申请

US20100294676A1 SYNTHETIC MORTAR COMPOSITION 审中-公开
标题翻译：合成麦芽糖组合物
公开(公告)号：US20100294676A1
公开(公告)日：2010-11-25
申请号：US12445621
申请日：2007-09-20
申请人： Jürgen Grün , Markus Semmler , Christian Schlenk , Martin Vogel
发明人： Jürgen Grün , Markus Semmler , Christian Schlenk , Martin Vogel
IPC分类号： B65D71/00 , C08K3/00
CPC分类号： C09D5/34 , C04B26/06 , C04B26/10 , C04B40/065 , C04B40/0666 , C04B2111/00715 , C09J11/04 , C04B7/00 , C04B14/06 , C04B14/28 , C04B38/10
摘要： A multi-component synthetic resin system, its use for securing fixing elements and a method for its preparation, and further embodiments mentioned in the description based on this invention, the multi-component synthetic resin system including one or more finely distributed gases in at least one of its components. Application is primarily in the construction industry.
摘要翻译：多组分合成树脂体系，其固定元件的固定用途及其制备方法以及基于本发明的说明书中提到的其它实施方案，所述多组分合成树脂体系至少包含一种或多种精细分布的气体其中一个组件。申请主要在建筑行业。

7. 发明授权

US5663224A Process for preparing an aqueous dispersion 失效
标题翻译：制备水性分散体的方法
公开(公告)号：US5663224A
公开(公告)日：1997-09-02
申请号：US801989
申请日：1991-12-03
申请人： William David Emmons , Martin Vogel , Edward C. Kostansek , Jack C. Thibeault , Peter R. Sperry , Chao-Jen Chung
发明人： William David Emmons , Martin Vogel , Edward C. Kostansek , Jack C. Thibeault , Peter R. Sperry , Chao-Jen Chung
IPC分类号： C08J3/03 , C08J3/205 , C08J3/215 , C08K3/00 , C08L101/00 , C09D5/02 , C09J11/04 , C09J201/00 , D21H19/40 , C08K5/54
CPC分类号： D21H19/40 , C08J3/215 , C09D5/024
摘要： Inorganic material particles are dispersed in an aqueous medium with surface charge adjusting additives to give a moderately stable slurry or pigment grind. The dispersion can be used to prepare fully formulated compositions. Products formulated using the aqueous dispersion can be prepared to give the same performance as products including inorganic material dispersed with conventional polyelectrolyte pigment dispersants, but with higher levels of inorganic material, or superior performance properties with like levels of inorganic material.
摘要翻译：将无机材料颗粒分散在具有表面电荷调节添加剂的水性介质中，得到适度稳定的浆料或颜料研磨。分散体可用于制备完全配制的组合物。使用水分散体配制的产品可以制备成与包括用常规聚电解质颜料分散剂分散的无机材料的产品相同的性能，但是具有较高水平的无机材料或具有相似水平的无机材料的优异性能。

8. 发明授权

US5510422A Synthesis of latex capsules 失效
公开(公告)号：US5510422A
公开(公告)日：1996-04-23
申请号：US467642
申请日：1995-06-06
申请人： Robert M. Blankenship , Ronald W. Novak , Clarence J. Neyhart , Martin Vogel , Alexander Kowalski
发明人： Robert M. Blankenship , Ronald W. Novak , Clarence J. Neyhart , Martin Vogel , Alexander Kowalski
IPC分类号： C08F2/22 , C08F2/44 , C08F265/02 , C08F267/06 , C08J3/12 , B32B27/30
CPC分类号： C08J3/12 , C08F265/02 , C08J3/126 , C09D7/125 , C09D7/1291 , C08J2333/12 , C08J2433/12 , Y10T428/2989
摘要： The present invention is concerned with core and shell polymeric particles having microvoids in the core and one or more channels connecting the microvoids to the exterior of the particle. These particles, or LCAPs are produced by forming a core of polymeric acid, encasing the core in a shell polymer permeable to base, and then neutralizing the core such that the core swells, causing the shell to "explode" in a controlled fashion. This controlled explosion causes channels to form in the shell.These particles can be used as control release devices for target compounds, to impart reinforcing properties to acrylic films, as an opacifying agent in coating compositions, and as a supplement or replacement of part or all of the pigmentary material or extenders that would otherwise be used in such coating compositions.

9. 发明授权

US4970241A Multi-stage opacifying polymer particles containing non-polymeric acid absorbed therein 失效
标题翻译：含有非聚合酸的多级不透明聚合物颗粒被吸收
公开(公告)号：US4970241A
公开(公告)日：1990-11-13
申请号：US382612
申请日：1989-07-19
申请人： Alexander Kowalski , Martin Vogel
发明人： Alexander Kowalski , Martin Vogel
IPC分类号： C08F285/00 , C08J9/28 , C09D7/12
CPC分类号： C08J9/28 , C08F285/00 , C09D7/1291 , Y10S525/902
摘要： Multi-stage polymer particles containing one or more void space(s) therein are produced by sequential emulsion polymerization of an essentially low-acid earlier polymer stage, encapsulation of said low-acid polymer stage with at least a final polymer stage, contacting said polymer particles with a non-polymeric carboxylic acid or anhydride to permit the acid or anhydride to be absorbed into said low-acid polymer stage and swelling the polymer particles by contacting the particles with an aqueous base. The low-acid polymer stage is formed by emulsion polymerizing a monomer system comprising ethylenically unsaturated monomer(s) and containing less than 5% by weight of monomer(s) containing acid functionality. The low-acid polymer stage is swubsequently encapsulated by one or more polymer stages by emulsion polymerizing ethylenically unsaturated monomer(s) in the presence of the low-acid polymer stage. The final stage has a glass transition temperature (Tg) of about 50.degree. C. or greater, and the total polymer stages having a Tg of about 50.degree. C. or greater comprise about 60% or more by weight of the polymer particles. A non-polymeric carboxylic acid or anhydride is absorbed into the polymer particles and the resultant particles are contacted with base at a pH sufficient to swell the particles with water at a temperature near or above the Tg of the neat polymer or plasticized polymer of the final polymer stage. When dried the particles contain void space(s) therein which produce(s) opacity in compositions in which the particles are contained.
摘要翻译：在其中含有一个或多个空隙空间的多级聚合物颗粒通过基本上低酸的较早聚合物阶段的顺序乳液聚合制备，所述低酸聚合物阶段至少包含最终聚合物阶段，使所述聚合物接触具有非聚合羧酸或酸酐的颗粒，以允许酸或酸酐被吸收到所述低酸聚合物阶段中，并通过使颗粒与碱水溶液接触来使聚合物颗粒膨胀。通过乳液聚合包含烯属不饱和单体并且含有少于5重量％的含有酸官能团的单体的单体体系形成低酸聚合物阶段。低酸聚合物阶段通过在低酸聚合物阶段的存在下通过乳液聚合烯键式不饱和单体而被一个或多个聚合物阶段封装。最终阶段具有约50℃或更高的玻璃化转变温度（Tg），并且具有约50℃或更高Tg的总聚合物阶段包含约60重量％或更多的聚合物颗粒。非聚合的羧酸或酸酐被吸收到聚合物颗粒中，并且所得颗粒在足以在最终纯净聚合物或增塑聚合物的Tg附近或更高的温度下用水溶胀颗粒的pH与碱接触聚合物阶段。当干燥时，颗粒中含有空隙空间，其中含有颗粒的组合物中产生不透明度。

10. 发明申请

US20130000839A1 EPOXIDE-BASED FIXING MORTAR HAVING SILANE ADDITIONS 有权
标题翻译：基于环氧化物的固定木糖具有硅烷添加剂
公开(公告)号：US20130000839A1
公开(公告)日：2013-01-03
申请号：US13634905
申请日：2011-03-02
申请人： Jurgen Grun , Martin Vogel , Clemens Schmidt , Christian Schlenk
发明人： Jurgen Grun , Martin Vogel , Clemens Schmidt , Christian Schlenk
IPC分类号： C08G59/14 , C08L63/02 , C08K5/548 , B32B37/12 , C08K5/544 , C08K5/5415 , B65D25/04 , C08L63/04 , C08G59/16
CPC分类号： C04B40/065 , C04B26/14 , C04B28/02 , C04B28/04 , C04B2111/00715 , C04B24/281 , C04B24/42
摘要： The invention relates to a fixing mortar system for embedding anchoring means in mortar in holes or crevices, based on one or more hardening epoxy-based reactive resins, characterised in that it includes silanes which may or may not have reactive groups capable of participating in the polymerisation with a synthetic resin based on the hardening epoxy-based reactive synthetic resin(s) but which in any case have Si-bonded hydrolysable groups, and to related inventive subject matter such as processes, kits and uses.
摘要翻译：本发明涉及一种基于一种或多种硬化型环氧基反应性树脂将锚固装置嵌入到孔或缝隙中的砂浆中的固定砂浆系统，其特征在于，其包括硅烷，其可以具有或可以不具有能够参与基于硬化环氧基反应性合成树脂，但在任何情况下具有Si键合的可水解基团的合成树脂的聚合，以及相关的发明主题，例如方法，试剂盒和用途。

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