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1. 发明申请

WO2007092941A3 SERS NANOTAG ASSAYS 审中-公开
标题翻译： SERS NANOTAG测试
公开(公告)号：WO2007092941A3
公开(公告)日：2008-10-16
申请号：PCT/US2007061878
申请日：2007-02-08
申请人： OXONICA INC , NATAN MICHAEL , PENN SHARRON GAYNOR , CROMER REMY , SHA MICHAEL , XU HONGXIA , DOERING WILLIAM E
发明人： NATAN MICHAEL , PENN SHARRON GAYNOR , CROMER REMY , SHA MICHAEL , XU HONGXIA , DOERING WILLIAM E
IPC分类号： C07H21/04 , G01N33/53
CPC分类号： G01N21/658 , B82Y5/00 , C12Q1/6816 , G01N33/54373 , Y10T436/143333 , C12Q2537/125 , C12Q2563/131 , C12Q2563/143 , C12Q2565/632
摘要： Methods and systems for the use of Surface Enhanced Raman Scattering nanotags (SERS nanotags) to create homogeneous (no-wash), heterogeneous or sequence detection assay platforms. In certain embodiments the SERS nanotags are used in combination with magnetic particles. Multiplexed assay platforms are also disclosed. In certain embodiments, the assay is useful for clinical proteomics. Assay platforms suitable for use within a biological matrix, for example within whole blood or serum are also disclosed. The assay formats described herein may be used to detect any analyte of interest including but not limited to the detection of cells, viruses, bacteria, proteins, DNA, RNA, or small molecules in any type of biological (animal or plant kingdom) or environmental samples including but not limited to whole blood or serum, occult samples, urine, feces, air, drinking water, phage, any organism, multicellular clumps of cells, for example, cancer tissue homogenate.
摘要翻译：使用表面增强拉曼散射纳米标签（SERS纳米标签）的方法和系统，以创建均质（非洗涤），异质或序列检测测定平台。在某些实施方案中，SERS纳米颗粒与磁性颗粒结合使用。还公开了多重测定平台。在某些实施方案中，该测定可用于临床蛋白质组学。还公开了适用于生物基质，例如全血或血清中的测定平台。本文描述的测定形式可用于检测感兴趣的任何分析物，包括但不限于检测任何类型的生物（动物或植物界）或环境中的细胞，病毒，细菌，蛋白质，DNA，RNA或小分子样品包括但不限于全血或血清，隐匿样品，尿液，粪便，空气，饮用水，噬菌体，任何生物，细胞多细胞团，例如癌组织匀浆。

2. 发明申请

WO2007090058A2 LATERAL FLOW IMMUNOASSAY WITH ENCAPSULATED DETECTION MODALITY 审中-公开
标题翻译：侧向流动免疫测定具有掩蔽检测模式
公开(公告)号：WO2007090058A2
公开(公告)日：2007-08-09
申请号：PCT/US2007061136
申请日：2007-01-26
申请人： OXONICA INC , NATAN MICHAEL , CROMER REMY , DOERING WILLIAM , CORISH PETER
发明人： NATAN MICHAEL , CROMER REMY , DOERING WILLIAM , CORISH PETER
IPC分类号： G01N33/53
CPC分类号： G01N33/54386 , G01N33/54346
摘要： A lateral flow immunoassay featuring encapsulated metal particles. The encapsulated particles may use SERS nanotags as the detection modality. The use of encapsulated particles as a detection modality, in particular encapsulated SERS tags increases the sensitivity of an LFI prepared for visual reading and introduces the ability to obtain substantially more sensitive qualitative results or quantitative results through the analysis of a SERS spectrum read from an LFI prepared in accordance with the present invention. The use of SERS as detection modality also enhances the ability of an LFI device to be used for a multiplexed test. Other aspects of the present invention include LFI devices specifically configured to test whole blood, a reader for the detection and interpretation of a multiplexed assay and the hardware and software components used to implement the reader.
摘要翻译：侧向流动免疫测定，具有封装的金属颗粒。封装的颗粒可以使用SERS纳米颗粒作为检测模式。使用封装的颗粒作为检测模式，特别是封装的SERS标签增加了用于视觉阅读的LFI的灵敏度，并且通过分析从LFI读取的SERS光谱引入获得显着更敏感的定性结果或定量结果的能力根据本发明制备。使用SERS作为检测模式也增强了LFI设备用于复用测试的能力。本发明的其他方面包括专门用于测试全血的LFI装置，用于检测和解释多重测定的读取器以及用于实现读取器的硬件和软件组件。

3. 发明专利

BRPI0510116A 未知
公开(公告)号：BRPI0510116A
公开(公告)日：2007-09-25
申请号：BRPI0510116
申请日：2005-04-25
申请人： OXONICA INC
发明人： NATAN MICHAEL , PENN SHARRON GAYNOR , FREEMAN R GRIFFITH , CHAKAPORAVA GABRIELA S , DOERING WILLIAM E , WALTON IAN D
IPC分类号： C25D5/02
摘要： New method for the preparation of improved Surface Enhanced Spectroscopy- Active Composite Nanoparticles (SACNs), which can be covalently or non-covalently affixed to entities of interest for the purpose of quantification, location, identification, tracking, and diagnosis, are described.

4. 发明专利

AT382471T 未知
公开(公告)号：AT382471T
公开(公告)日：2008-01-15
申请号：AT00968555
申请日：2000-10-02
申请人： OXONICA INC
发明人： NATAN MICHAEL , MALLOUK THOMAS
IPC分类号： B32B5/16 , G01N27/62 , A61K39/12 , B01J13/00 , B01J19/00 , B01L3/00 , B22F1/00 , B82B1/00 , C25D1/04 , C40B40/06 , C40B70/00 , G01N13/10 , G01N21/47 , G01N21/64 , G01N33/543 , G06K7/00 , G06K9/32 , G06K19/06 , G06T1/00 , G06T7/00 , H01F1/00
摘要： Freestanding particles comprising a plurality of segments, wherein the particle length is from 20 nm to 50 mum and the particle width is form 5 nm to 50 mum.

5. 发明公开

EP1977242A4 LATERAL FLOW IMMUNOASSAY WITH ENCAPSULATED DETECTION MODALITY 有权转让
标题翻译：克罗斯河免疫测试封装ERKENNUNGSMODALITÄT
公开(公告)号：EP1977242A4
公开(公告)日：2009-03-25
申请号：EP07762849
申请日：2007-01-26
申请人： OXONICA INC
发明人： NATAN MICHAEL , CROMER REMY , DOERING WILLIAM , CORISH PETER
IPC分类号： G01N33/53
CPC分类号： G01N33/54386 , G01N33/54346
摘要： A lateral flow immunoassay featuring encapsulated metal particles. The encapsulated particles may use SERS nanotags as the detection modality. The use of encapsulated particles as a detection modality, in particular encapsulated SERS tags increases the sensitivity of an LFI prepared for visual reading and introduces the ability to obtain substantially more sensitive qualitative results or quantitative results through the analysis of a SERS spectrum read from an LFI prepared in accordance with the present invention. The use of SERS as detection modality also enhances the ability of an LFI device to be used for a multiplexed test. Other aspects of the present invention include LFI devices specifically configured to test whole blood, a reader for the detection and interpretation of a multiplexed assay and the hardware and software components used to implement the reader.

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