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1. 发明申请

WO2017218796A1 METABOLIC LABELING AND MOLECULAR ENHANCEMENT OF BIOLOGICAL MATERIALS USING BIOORTHOGONAL REACTIONS 审中-公开
标题翻译：生物材料的代谢标记和分子增强利用生物正交反应
公开(公告)号：WO2017218796A1
公开(公告)日：2017-12-21
申请号：PCT/US2017/037710
申请日：2017-06-15
申请人： OTT, Harald C. , REN, Xi , BLOOM, Jordan P. , RAJAB, Konrad T.
发明人： OTT, Harald C. , REN, Xi , BLOOM, Jordan P. , RAJAB, Konrad T.
IPC分类号： A61K9/14 , A61K31/715 , C12N5/07 , C12N5/02 , C12N5/00 , A61N1/30 , C07D233/88
摘要： The present application provides methods of functionalizing an organ or tissue of a mammal by administering a nutrient (e.g., peracetylated N-azido galactosamine Ac4GalNAz) to the mammal or by culturing an organ or tissue in a bioreactor containing such nutrient. The present application also provides methods of selectively functionalizing extracellular matrix (ECM) of an organ or tissue of a mammal by administering a nutrient (e.g., peracetylated N-azido galactosamine Ac4GalNAz) to the mammal. In some aspects, the present application provides a decellularized scaffold of a mammalian organ or tissue comprising an extracellular matrix, wherein the extracellular matrix of the decellularized scaffold is functionalized with a chemical group that is reactive in a bioorthogonal chemical reaction, such as an azide chemical group. The present application also provides biological prosthetic mesh and mammalian organs and tissues for transplantation prepared according to the methods of the application.
摘要翻译：本申请提供了通过向哺乳动物施用营养物（例如，过乙酰化的N-叠氮基半乳糖胺Ac 4 GalNAz）或通过在生物反应器中培养器官或组织来功能化哺乳动物的器官或组织的方法，这种营养素。本申请还提供了通过向哺乳动物施用营养物（例如，全乙酰化的N-叠氮基半乳糖胺Ac 4 GalNAz）来选择性功能化哺乳动物器官或组织的细胞外基质（ECM）的方法。在一些方面，本申请提供了包含细胞外基质的哺乳动物器官或组织的脱细胞支架，其中脱细胞支架的细胞外基质用在生物正交化学反应中具有反应性的化学基团例如叠氮化物化学组。本申请还提供了根据本申请方法制备的用于移植的生物假体网和哺乳动物器官和组织。

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