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1. 发明申请

WO2006014012A2 AROMATIC COMPOUND 审中-公开
标题翻译：芳香化合物
公开(公告)号：WO2006014012A2
公开(公告)日：2006-02-09
申请号：PCT/JP2005/014611
申请日：2005-08-03
申请人： OTSUKA PHARMACEUTICAL CO., LTD. , FUKUSHIMA, Tae , MATSUMURA, Shuji , TAKEMURA, Noriaki , SATOU, Hideaki , ITO, Nobuaki , SHITSUTA, Takuya , TSUTSUI, Hironori , TANAKA, Michinori , KAN, Keizo , NAGAO, Hitoshi , WATANABE, Kenji , TAI, Kuninori , NAKAGAWA, Takashi , TAKASU, Hideki , SAKAMOTO, Makoto , MIYAJIMA, Keisuke , YAMADA, Satoshi , KOJIMA, Yutaka , YASUMURA, Koichi , OHI, Naoto , OKUNO, Mitsuhiro , SUGIYAMA, Kazuhisa , KIYONO, Kunihiko , SUZUKI, Takashi , AKAMATSU, Seiji , KODAMA, Takeshi , YANAGIHARA, Yasuo , SUMIDA, Takumi
发明人： FUKUSHIMA, Tae , MATSUMURA, Shuji , TAKEMURA, Noriaki , SATOU, Hideaki , ITO, Nobuaki , SHITSUTA, Takuya , TSUTSUI, Hironori , TANAKA, Michinori , KAN, Keizo , NAGAO, Hitoshi , WATANABE, Kenji , TAI, Kuninori , NAKAGAWA, Takashi , TAKASU, Hideki , SAKAMOTO, Makoto , MIYAJIMA, Keisuke , YAMADA, Satoshi , KOJIMA, Yutaka , YASUMURA, Koichi , OHI, Naoto , OKUNO, Mitsuhiro , SUGIYAMA, Kazuhisa , KIYONO, Kunihiko , SUZUKI, Takashi , AKAMATSU, Seiji , KODAMA, Takeshi , YANAGIHARA, Yasuo , SUMIDA, Takumi
IPC分类号： C07D295/192 , C07D317/58 , C07D211/46 , C07D211/58 , C07D213/75
CPC分类号： C07C229/18 , C07C205/38 , C07C217/90 , C07C233/45 , C07C233/75 , C07C271/58 , C07C275/34 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D211/46 , C07D211/58 , C07D211/62 , C07D211/70 , C07D213/75 , C07D239/42 , C07D241/20 , C07D295/185 , C07D295/192 , C07D317/58 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention provides a novel compound, which has an excellent effect of suppressing the generation of collagen and less side effects, with being excellent in terms of safety. The compound of the present invention is represented by the following general formula (1): [wherein X 1 represents a nitrogen atom or a group -CH=; R 1 represents a group -Z-R 6 , wherein Z represents a group -CO-, a group -CH(OH)-, or the like, and R 6 represents a 5- to 15-membered monocyclic, dicyclic, or tricyclic, saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms, or sulfur atoms; R 2 represents a hydrogen atom, a halogen atom or a lower alkylene group; Y represents a group -O-, a group -CO-, a group -CH(OH)-, a lower alkylene group, or the like; and (A) represents a group or the like, wherein R 3 represents a hydrogen atom, a lower alkoxy group, or the like, p represents 1 or 2, and R 4 represents an imidazolyl lower alkyl group or the like.
摘要翻译：本发明提供了一种新颖的化合物，其具有优异的抑制胶原产生的效果和较少的副作用。本发明的化合物由下列通式（1）表示：其中X 1表示氮原子或基团-CH =; R 1表示基团-ZR 6，其中Z表示-CO-基团，-CH（OH） - 基等基团，R“ 6表示具有1至4个氮原子，氧原子或硫原子的5至15元单环，二环或三环饱和或不饱和杂环基; R 2表示氢原子，卤素原子或低级亚烷基; Y表示基团-O-，基团-CO-，基团-CH（OH） - ，低级亚烷基基团等; 和（A）表示基团等，其中R 3表示氢原子，低级烷氧基等，p表示1或2，R 4 O >表示咪唑基低级烷基等。

2. 发明申请

WO2009057811A2 HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF 审中-公开
标题翻译：杂环化合物及其药物组合物
公开(公告)号：WO2009057811A2
公开(公告)日：2009-05-07
申请号：PCT/JP2008/070153
申请日：2008-10-29
申请人： OTSUKA PHARMACEUTICAL CO., LTD. , SUMIDA, Takumi , TABUSA, Fujio , SEKIGUCHI, Kazuo , KODAMA, Takeshi , YASUMURA, Koichi , KOJIMA, Yutaka , MOTOYAMA, Masaaki , MIYAJIMA, Keisuke , YOSHIDA, Kenji , KAN, Keizo , SAKAMOTO, Makoto , TAKASU, Hideki , NAKAGAWA, Takashi , OHI, Naoto , HARADA, Yasuo , HASHIMOTO, Norikazu , MATSUYAMA, Hironori , IIDA, Masatoshi , FUJITA, Shigekazu , FUKUSHIMA, Tae
发明人： SUMIDA, Takumi , TABUSA, Fujio , SEKIGUCHI, Kazuo , KODAMA, Takeshi , YASUMURA, Koichi , KOJIMA, Yutaka , MOTOYAMA, Masaaki , MIYAJIMA, Keisuke , YOSHIDA, Kenji , KAN, Keizo , SAKAMOTO, Makoto , TAKASU, Hideki , NAKAGAWA, Takashi , OHI, Naoto , HARADA, Yasuo , HASHIMOTO, Norikazu , MATSUYAMA, Hironori , IIDA, Masatoshi , FUJITA, Shigekazu , FUKUSHIMA, Tae
IPC分类号： C07D401/12 , C07D403/12 , A61K31/444 , A61K31/506 , A61P1/16
CPC分类号： C07D401/12 , C07D403/12
摘要： The present invention provides a heterocyclic compound represented by General Formula (1): wherein R 1 is a group R 5 -Z 1 -, etc., Z 1 is a lower alkylene group, etc., and R 5 is a group represented by General Formula; wherein R 13 is a hydrogen atom, etc., m is an integer from 1 to 5; R 2 is a hydrogen atom: Y is CH or N: A 1 is a heterocyclic ring selected from the group consisting of indolediyl groups, wherein the heterocyclic ring may have at least one substituent: T is a group -CO-, etc.: R 3 is a hydrogen atom, etc.: R 4 is a lower alkyl group optionally substituted by one or more hydroxy groups, etc.: R 3 and R 4 , together with the nitrogen atom to which they bind, may bind to each other and form a 5- to 10-membered saturated heterocyclic ring, wherein the heterocyclic ring may have at least one substituent. The heterocyclic compound of the present invention has excellent effects of suppressing the production of collagen and/or treating tumors.
摘要翻译：本发明提供了由通式（1）表示的杂环化合物：其中R 1是基团R 5 -Z 1， 1 - 等，Z 1是低级亚烷基等，R 5是由通式表示的基团; 其中R 13为氢原子等，m为1至5的整数; R 2是氢原子：Y是CH或N：A 1是选自吲哚二基的杂环，其中该杂环可至少具有一个取代基：T为基团-CO-等：R 3为氢原子等：R 4为任选被一个或两个取代基取代的低级烷基或更多的羟基等：R 3和R 4与它们所结合的氮原子一起可以相互连接并形成5至10元环，其中杂环可以具有至少一个取代基。本发明的杂环化合物具有抑制胶原产生和/或治疗肿瘤的优异效果。

3. 发明申请

WO2007066784A2 MEDICINAL DRUG 审中-公开
标题翻译：药物药物
公开(公告)号：WO2007066784A2
公开(公告)日：2007-06-14
申请号：PCT/JP2006/324610
申请日：2006-12-04
申请人： OTSUKA PHARMACEUTICAL CO., LTD. , MATSUYAMA, Hironori , OHNISHI, Kenji , NAKAGAWA, Takashi , TAKASU, Hideki , SAKAMOTO, Makoto , HIGUCHI, Kumi , MIYAJIMA, Keisuke , YAMADA, Satoshi , MOTOYAMA, Masaaki , KOJIMA, Yutaka , YASUMURA, Koichi , KODAMA, Takeshi , OTSUJI, Shun , KAN, Keizo , SUMIDA, Takumi
发明人： MATSUYAMA, Hironori , OHNISHI, Kenji , NAKAGAWA, Takashi , TAKASU, Hideki , SAKAMOTO, Makoto , HIGUCHI, Kumi , MIYAJIMA, Keisuke , YAMADA, Satoshi , MOTOYAMA, Masaaki , KOJIMA, Yutaka , YASUMURA, Koichi , KODAMA, Takeshi , OTSUJI, Shun , KAN, Keizo , SUMIDA, Takumi
CPC分类号： A61K31/496 , A61K31/495
摘要： An object of the present invention is to provide a medicinal drug much improved in anti tumor activity and excellent in safety. According to the present invention, there is provided a medicinal drug containing a compound represented by the following general formula (1) or a salt thereof as an active ingredient: [Formula 1] wherein X 1 represents a nitrogen atom or a group -CH=, R 1 represents a group -Z-R 6 , in which Z represents a group -CO-, a group -CH(OH)- or the like, R 6 represents a 5- to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R 2 represents a hydrogen atom or a halogen atom, Y represents a group -O-, a group -CO-, a group -CH(OH)- or a lower alkylene group, and A represents [Formula 2] wherein R 3 represents a hydrogen atom, a lower alkoxy group or the like, p represents 1 or 2, R 4 represents an imidazolyl lower alkyl group or the like.
摘要翻译：本发明的目的在于提供一种抗肿瘤活性大大提高，安全性优异的药用药物。根据本发明，提供了含有下述通式（1）表示的化合物或其盐作为活性成分的药物：[1]其中X 1代表氮原子或基团-CH =，R 1表示基团-ZR 6，其中Z表示基团-CO-，基团-CH（OH） - 或 R 6表示具有1至4个氮原子，氧原子或硫原子的5至15元单环，二环或三环饱和或不饱和杂环基，R 2， SUP>表示氢原子或卤素原子，Y表示-O-基团，-CO-基团，-CH（OH）基或低级亚烷基，A表示[式2]其中R ^{3表示氢原子，低级烷氧基等，p表示1或2，R 4表示咪唑基低级烷基等。}

4. 发明申请

WO2011093524A1 DI - SUBSTITUTED PYRIDINE DERIVATIVES AS ANTICANCERS 审中-公开
标题翻译：二取代的吡啶衍生物作为抗癌剂
公开(公告)号：WO2011093524A1
公开(公告)日：2011-08-04
申请号：PCT/JP2011/052302
申请日：2011-01-28
申请人： OTSUKA PHARMACEUTICAL CO., LTD. , TAKASU, Hideki , FUJITA, Shigekazu , OHTSUKA, Shinya , HIROSE, Toshiyuki , SATO, Yosuke , YAMADA, Satoshi , MIYAJIMA, Keisuke , SAKAI, Koji , KOJIMA, Yutaka , SEKIGUCHI, Kazuo , YANAGIHARA, Yasuo , SUZUKI, Takashi , TANAKA, Hideo , SUGIYAMA, Kazuhisa , OKUNO, Mitsuhiro , SUMIDA, Takumi
发明人： TAKASU, Hideki , FUJITA, Shigekazu , OHTSUKA, Shinya , HIROSE, Toshiyuki , SATO, Yosuke , YAMADA, Satoshi , MIYAJIMA, Keisuke , SAKAI, Koji , KOJIMA, Yutaka , SEKIGUCHI, Kazuo , YANAGIHARA, Yasuo , SUZUKI, Takashi , TANAKA, Hideo , SUGIYAMA, Kazuhisa , OKUNO, Mitsuhiro , SUMIDA, Takumi
IPC分类号： C07D213/69 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12 , A61K31/44 , A61K31/4439 , A61K31/4545 , A61K31/4725 , A61K31/443 , A61K31/496 , A61P35/00
CPC分类号： C07D213/69 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要： The present invention provides a novel compound having an excellent antitumor effect. The compound of the present invention is represented by the following general formula (1) wherein R 1 and R 2 are aryl or the like; A is lower alkylene; Ring X is optionally substituted arylene; E is bond or lower alkenylene; Ring Y is optionally substituted heterocycloalkylene containing one or more nitrogen atoms, one of which is attached to the adjacent carbonyl group; G is -NH-G 2 -, -N(lower alkyl)-G 2 -, -NH-CH 2 -G 2 -, -N(lower alkyl)-CH 2 -G 2 - or -CH 2 -G 2 -, [wherein G 2 binds to R 2 , G 2 -R 2 is bond-R 2 , phenylene-G 3 -R 2 , phenylene-G 4 -O-R 2 , phenylene-G 5 -NH-R 2 , phenylene-G 6 -N(lower alkyl)-R 2 or quinolinediyl-O-R 2 , the phenylene of said phenylene-cotnaining groups being optionally substituted with one or more substituents; G 3 -R 2 is -O-lower alkylene-R 2 or the like; G 4 -O- is lower alkylene-O- or the like; G 5 is lower alkylene; G 6 is lower alkylene].
摘要翻译：本发明提供了具有优异抗肿瘤效果的新型化合物。本发明的化合物由以下通式（1）表示：其中R1和R2是芳基等; A是低级亚烷基; 环X是任选取代的亚芳基; E是键或低级亚烯基; 环Y是含有一个或多个氮原子的任选取代的杂环亚烷基，其中一个与相邻的羰基连接; G是-NH-G 2 - ， - N（低级烷基）-G 2 - ， - NH-CH 2 -G

5. 发明申请

WO2012046825A1 4- (METHYLAMINOPHENOXY) PYRDIN- 3 - YL - BENZAMIDE DERIVATIVES FOR TREATING CANCER 审中-公开
标题翻译： 4-（甲基氨基苯氧基）PYRDIN-3-YL-治疗癌症的苯甲酰胺衍生物
公开(公告)号：WO2012046825A1
公开(公告)日：2012-04-12
申请号：PCT/JP2011/073165
申请日：2011-10-03
申请人： OTSUKA PHARMACEUTICAL CO., LTD. , NAKAGAWA, Takashi , SAKAMOTO, Makoto , YAMAGUCHI, Kazuya , TERAUCHI, Yuki , SHIRAKURA, Masamichi , HARADA, Yasuo , KOJIMA, Yutaka , SUMIDA, Takumi
发明人： NAKAGAWA, Takashi , SAKAMOTO, Makoto , YAMAGUCHI, Kazuya , TERAUCHI, Yuki , SHIRAKURA, Masamichi , HARADA, Yasuo , KOJIMA, Yutaka , SUMIDA, Takumi
IPC分类号： A61K31/44 , C07D213/75 , A61P35/00
CPC分类号： C07D213/75 , C07D213/76
摘要： The present invention provides a novel compound having an excellent antitumor effect, stability and metabolic stability. The compound of the present invention is represented by the following general formula (1) wherein R 1 represents a halogen atom, an aryl group, an aryloxy group or a lower alkyl group optionally substituted with one or more halogen atoms; R 2 represents a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group; and; m represents an integer of 1 to 3; provided that when m represents 2 or 3, R 1 s are the same or different.
摘要翻译：本发明提供了具有优异的抗肿瘤效果，稳定性和代谢稳定性的新型化合物。本发明化合物由以下通式（1）表示，其中R 1表示卤素原子，芳基，芳氧基或任选被一个或多个卤素原子取代的低级烷基; R2表示氢原子，卤素原子，低级烷基或低级烷氧基; 和; m表示1〜3的整数，条件是当m表示2或3时，R 1相同或不同。

6. 发明申请

WO2008002619A2 SOLDER BALL SOCKET CONNECTOR 审中-公开
标题翻译：焊接球窝接头
公开(公告)号：WO2008002619A2
公开(公告)日：2008-01-03
申请号：PCT/US2007/014939
申请日：2007-06-27
申请人： MOLEX INCORPORATED , KOJIMA, Yutaka
发明人： KOJIMA, Yutaka
IPC分类号： H05K7/10
CPC分类号： H05K7/1069
摘要： A socket connector utilizes contacts that have a shape similar to an inverted ohm sign and which have two flexible contact arms located at one end thereof for contacting elements such as solder balls. The other end of the contact have a closed end and the contacts may be slotted in increase their flexibility or they may be solid.
摘要翻译：插座连接器使用具有类似于反向欧姆标志的形状的触点，并且在其一端具有两个柔性接触臂，用于接触诸如焊球的元件。触点的另一端具有封闭端，并且触点可以开槽以增加它们的柔性，或者它们可以是固体。

7. 发明申请

WO2009065051A1 LATCHING CONNECTOR 审中-公开
标题翻译：连接器
公开(公告)号：WO2009065051A1
公开(公告)日：2009-05-22
申请号：PCT/US2008/083656
申请日：2008-11-14
申请人： MOLEX INCORPORATED , KOJIMA, Yutaka
发明人： KOJIMA, Yutaka
IPC分类号： H01R13/627 , H01R13/633 , H01R13/66
CPC分类号： H01R13/6335 , H01R13/6272 , H01R13/6275 , H01R13/665
摘要： A latching connector for use with electronic devices provides a latching member with at least one hook that engages a locking hole in a counterpart receptacle, and which can be easily de-latched from the counterpart receptacle. The hook passes completely through the locking hole and into a recess in a portion of the latching connector to further secure the locking mechanism to lock the latching connector into engagement with the receptacle but may be released by way of a ramp and lobe mechanism in the latching connector. The ramp and lobe mechanism converts horizontal movement of a pull tab-like actuator into vertical movement of a latching member such that the hook is lifted upward and disengaged from the receptacle.
摘要翻译：一种用于电子设备的闭锁连接器提供了一种闩锁构件，其具有与配对插座中的锁定孔接合的至少一个钩，并且可以容易地从配对插座脱锁。钩完全穿过锁定孔并进入锁定连接器的一部分中的凹槽中，以进一步固定锁定机构以锁定闩锁连接器与插座接合，但是可以通过闩锁中的斜坡和凸角机构来释放连接器。斜面和凸角机构将拉片状致动器的水平运动转换成锁定构件的垂直运动，使得钩向上提起并与容器脱离接合。

8. 发明申请

WO2007106562A1 SEALED PLUG CONNECTOR 审中-公开
标题翻译：密封插头连接器
公开(公告)号：WO2007106562A1
公开(公告)日：2007-09-20
申请号：PCT/US2007/006542
申请日：2007-03-15
申请人： MOLEX INCORPORATED , KOJIMA, Yutaka , HASEGAWA, Yuichi , MIZUMURA, Akinori , YAGI, Masanori
发明人： KOJIMA, Yutaka , HASEGAWA, Yuichi , MIZUMURA, Akinori , YAGI, Masanori
IPC分类号： H01R43/24
CPC分类号： H01R13/521 , B29C45/14377 , B29C45/14639 , H01R13/035 , H01R43/24 , H05K1/119 , H05K3/107 , H05K3/182
摘要： An improved moisture impervious connector utilizes a molded body portion that has conductive terminals plated thereon in order not to create any spaces within any sort of terminal-receiving cavities. A flexible sealing member is supported by the body portion crosswise to the terminals to provide a seal to the connector for an opening into which it is inserted.
摘要翻译：一种改进的不透水连接器利用其上镀有导电端子的成型体部分，以便在任何类型的端子容纳腔内不产生空间。柔性密封构件由主体部分支撑在与端子交叉的位置处，以向连接器提供用于其插入的开口的密封。

9. 发明申请

WO2004040714A1 MEMORY CARD ADAPTER FOR CONNECTING A MINIATURE CARD TO A STANDARD CARD CONNECTOR, ALONG WITH A METHOD OF FABRICATING SAME 审中-公开
标题翻译：用于将微型卡连接到标准卡连接器的存储卡适配器，以及制造相同的方法
公开(公告)号：WO2004040714A1
公开(公告)日：2004-05-13
申请号：PCT/US2003/031881
申请日：2003-10-08
申请人： MOLEX INCORPORATED , KOJIMA, Yutaka , HIRATA, Hideyuki
发明人： KOJIMA, Yutaka , HIRATA, Hideyuki
IPC分类号： H01R31/06
CPC分类号： G06K19/077 , G06K19/07732 , G06K19/07741 , H01R24/62 , H01R31/06 , H01R2107/00 , Y10S439/945 , Y10S439/946
摘要： An adapter, along with a method of fabricating the adapter, for a memory card connector to enable a miniature memory card to be inserted into a larger, standard memory card connector. A two-part housing is provided of a size and shape to simulate a standard memory card. The housing includes a base housing part defining a substantial portion of an inner cavity for receiving a miniature memory card. An inner housing part is separate from and independent of the base housing part. A plurality of terminals are mounted on the inner housing part to define a subassembly which is mounted on the base housing part. Each terminal includes a first contact portion at one end thereof for engaging an appropriate contact on the standard memory card connector. Each terminal includes a second contact portion at an opposite end thereof for engaging an appropriate contact of the miniature memory card.
摘要翻译：
适配器以及制造适配器的方法，用于存储卡连接器，以使小型存储卡能够插入更大的标准存储卡连接器中。提供两部分的外壳，其大小和形状可以模拟标准的存储卡。该壳体包括基座壳体部分，该基座壳体部分限定用于接收微型存储卡的内腔的大部分。内部壳体部分与基座壳体部分分开并且独立。多个端子安装在内壳体部分上以限定安装在基壳体部分上的子组件。每个端子包括位于其一端的第一接触部分，用于接合标准存储卡连接器上的适当触点。每个端子在其相对端包括一个第二接触部分，用于接合微型存储卡的适当触点。

10. 发明申请

WO2003021719A3 MEMORY CARD CONNECTOR WITH ESD PROTECTION AND CARD LOCKING DEVICE 审中-公开
公开(公告)号：WO2003021719A3
公开(公告)日：2003-03-13
申请号：PCT/US2002/027046
申请日：2002-08-23
申请人： MOLEX INCORPORATED , KOJIMA, Yutaka
发明人： KOJIMA, Yutaka
IPC分类号： H01R12/22
摘要： A memory card connector includes a housing for receiving a memory card movable in an insertion direction to an inserted position. The housing mounts a plurality of terminals having contact portions for engaging contacts on at least one side of the memory card. A one-piece metal electrostatic discharge (ESD) terminal is mounted on the housing. The ESD terminal includes an ESD portion for engaging the memory card before the contacts on the card engage the contact portions of the terminals, along with a lock portion for engaging the memory card to maintain the card in its inserted position.

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