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1. 发明专利

JPH11292790A THERAPEUTIC AGENT FOR RENAL DISEASE 失效
公开(公告)号：JPH11292790A
公开(公告)日：1999-10-26
申请号：JP10108198
申请日：1998-04-13
申请人： OTSUKA PHARMA FACTORY INC
发明人： OKA TATSUZO , ASAKI KOZO , YAMAOKA IPPEI
IPC分类号： A61K38/00 , A61K35/22 , A61K45/00 , A61P13/02 , A61P15/00 , A61P43/00 , A61K35/23
摘要： PROBLEM TO BE SOLVED: To obtain the subject therapeutic agent containing an expression inhibitor for a perchloric acid-soluble protein as an active ingredient, capable of promoting the proliferation of uriniferous tubuliform cells and useful for treating renal diseases. SOLUTION: This therapeutic agent containing an expression inhibitor for a perchloric acid-soluble protein(PSP) as an active ingredient is obtained. The expression inhibitor for the PSP is capable of inhibiting the expression of the PSP in uriniferous tubuliform cells and is preferably a PSP derived from a human kidney or its derivative. The PSP is a protein extracted with perchloric acid and having 14 kDa molecular weight and can be extracted and purified from a biological tissue. A substance in which a part of the amino acid sequence of the PSP is deleted or substituted with other amino acids, etc., is cited as the PSP derivative. The therapeutic agent is used together with a filler, an extender, etc., and can be converted into a pharmaceutical preparation composition. The active ingredient is contained in an amount of preferably 1-70 wt.% in the pharmaceutical preparation. The daily dose thereof administered is preferably 0.01 μg to 10 mg based on 1 kg body weight expressed in terms of the PSP.

2. 发明专利

JP2019019105A 筋痙攣閾値増強剤审中-公开
公开(公告)号：JP2019019105A
公开(公告)日：2019-02-07
申请号：JP2017141035
申请日：2017-07-20
申请人： OTSUKA PHARMA FACTORY INC
发明人： NOSAKA KAZUNORI , YEN WIN LO , KATO HARUYASU , MIKI SHINYA , YAMAOKA IPPEI , SAKASHITA MASAKI
IPC分类号： A61K31/195 , A23L2/38 , A23L2/52 , A23L21/10 , A23L33/125 , A23L33/16 , A61K31/7004 , A61K33/06 , A61K33/14 , A61K33/42 , A61P21/00 , A61P43/00
摘要：【課題】本発明は、日常的に手軽に飲食品等として摂取することにより、筋痙攣を抑制および/または防止することのできる剤を提供することを目的とする。【解決手段】本発明は、ナトリウムイオンとブドウ糖とを特定のモル比の範囲で含有し、ナトリウムイオン、カリウムイオン、マグネシウムイオン、リンおよび有機酸を特定範囲で含有する筋痙攣閾値増強剤に関する。【選択図】なし

3. 发明专利

JP2002087980A SODIUM ION-DISCHARGING STIMULATOR AND FOOD CONTAINING THE SAME 失效
公开(公告)号：JP2002087980A
公开(公告)日：2002-03-27
申请号：JP2000271867
申请日：2000-09-07
申请人： OTSUKA PHARMA FACTORY INC
发明人： YAMAOKA IPPEI , KAMISAKO TAKUJI , KOBAYASHI MASARU
IPC分类号： A23L2/38 , A23L1/30 , A23L1/304 , A23L2/52 , A61K36/02 , A61P3/12 , A61K35/80
摘要： PROBLEM TO BE SOLVED: To provide a sodium ion-discharging stimulator capable of discharging excessively taken sodium chloride extracorporeally in a positive and safe manner, and a food containing the stimulator. SOLUTION: The sodium ion-discharge stimulator containing at least one kind out of a water extract and a hot water extract of a Phaeophyceae plant (Laminaria, Kjellmaniella and Myrionema, Nemacystis are excluded), and their metal salts (sodium salt is excluded) as an active ingredient, and the food containing the same.

4. 发明专利

JP2001002581A PHOSPHORUS ABSORPTION INHIBITOR AND SODIUM ION ABSORPTION INHIBITOR AND THERAPEUTIC AGENT AND FOOD CONTAINING THE SAME 失效
公开(公告)号：JP2001002581A
公开(公告)日：2001-01-09
申请号：JP17860699
申请日：1999-06-24
申请人： NISSHIN SPINNING , OTSUKA PHARMA FACTORY INC
发明人： SATOU TAKAYA , UEHARA TSUTOMU , YAMAOKA IPPEI , ASAKI KOZO , KAMISAKO TAKUJI , KOBAYASHI MASARU , KORI HIDEAKI
IPC分类号： A23L1/30 , A23L1/308 , A61K31/00 , A61K31/715 , A61K31/737 , A61K36/02 , A61P7/00 , A61P43/00 , A61K35/80
摘要： PROBLEM TO BE SOLVED: To obtain the subject inhibitors, therapeutic agent and food, each capable of effectively inhibiting the absorption into the human body of phosphorus or common salt existing in excess inside the body, thereby of positively and safely secreting such phosphorus or common salt out of the body. SOLUTION: This phosphorus absorption inhibitor comprises as active ingredient a water extract or hot water extract from red algae with a molecular weight of >10,000. The 2nd objective sodium ion absorption inhibitor comprises as active ingredient a water extract or hot water extract from red algae (except λ-carrageenan). The 3rd objective therapeutic agent or prophylactic comprises as active ingredient either one of the above inhibitors and is intended for diseases caused by the excessive presence of phosphorus or common salt in the human body or diseases requiring the intake limitation of phosphorus or common salt. The 4th objective food contains either one of the above inhibitors.

5. 发明专利

JPH10130154A LIFE PROLONGATION RATIO IMPROVER FOR NEPHRITIS PATIENT 失效
公开(公告)号：JPH10130154A
公开(公告)日：1998-05-19
申请号：JP28644696
申请日：1996-10-29
申请人： OTSUKA PHARMA FACTORY INC , KAO CORP
发明人： YONEKAWA MOTOKI , YAMAOKA IPPEI , HASHIMOTO KINJI , SAKASHITA EIJI , KORI HIDEAKI , KONDO AKIHIRO , AMIYA TSUYOSHI
IPC分类号： A61K31/78 , A61P13/02 , A61P15/00
摘要： PROBLEM TO BE SOLVED: To obtain the subject improver having bettering effects on life prolongation ratio of nephritis parient and excellent in safety by oral intake, containing an acrylic water absorbing resin as an active ingredient. SOLUTION: This improver for life prolongation ratio for nephritis patient contains an acrylic water-absorbing resin selected from a polymer comprising an acrylic monomer preferably of the formula CH2 =CR COOR (R is methyl; R is H or a metal atom) as an essential constitutent unit and a cross-linked material of the polymer as an active ingredient. A alkaline (earth) metal may be cited as a metal to form a metal salt. In the improver, the acrylic water- absorbing resin in a state of powder, bead, flake or gel may be orally administered in the form as it is or made in to tablet, granule or capsule by using a medicine carrier. The daily dose is about 5-20g calculated as the amount of the active ingredient.

6. 发明专利

JP2000264844A NUTRITIVE COMPOSITION FOR KIDNEY DISEASE PATIENT 失效
公开(公告)号：JP2000264844A
公开(公告)日：2000-09-26
申请号：JP2000002493
申请日：2000-01-11
申请人： OTSUKA PHARMA FACTORY INC
发明人： ASAKI KOZO , YAMAOKA IPPEI , KOBAYASHI MASARU , KAMISAKO TAKUJI
IPC分类号： A23L33/00 , A61K31/20 , A61K31/23 , A61K31/70 , A61K38/00 , A61P13/12 , A23L1/29
摘要： PROBLEM TO BE SOLVED: To obtain the subject composition which improves the nutritive states of kidney disease patients and is useful for preventing arteriosclerosis and cardiovascular diseases caused by the arteriosclerosis by specifying the compounding ratio of three large nutriments (lipid, protein, carbohydrate). SOLUTION: This composition contains (A) lipids (for example, rice bran oil, fish oil), (B) proteins (for example, casein calcium, gelatin) and/or their hydrolyzates, and (C) carbohydrates (for example, dextrin) in amounts of 35-70%, 8-15% and

7. 发明专利

JPH1070970A HOT WATER EXTRACT OF NEMACYSTUS DECIPIENS 失效
公开(公告)号：JPH1070970A
公开(公告)日：1998-03-17
申请号：JP16378397
申请日：1997-06-20
申请人： NISSHIN SPINNING , OTSUKA PHARMA FACTORY INC
发明人： SATOU TAKAYA , UEHARA TSUTOMU , YAMAOKA IPPEI , ASAKI KOZO , KORI HIDEAKI
IPC分类号： A23L1/30 , A23L17/60 , A61K36/02 , A61P3/06 , A61P9/12 , A61P35/00 , A23L1/337 , A61K35/80
摘要： PROBLEM TO BE SOLVED: To obtain a hot water extract of Nemacystus decipiens capable of adsorbing sodium ion in the alimentary canal and improving the discharge thereof and useful for prevention, treatment, etc., of disease caused by surplus ingestion of common salt by making a molecular weight over a prescribed value. SOLUTION: This hot water extract of Nemacystus decipiens is obtained by subjecting the Nemacystus decipiens, e.g. Tinocladia crassa to an extraction treatment by using a hot water of 80-90 deg.C for 30min to 3hr and dialyzing the extract to remove a material having lower molecular weight, and has >=30,000 molecular weight, preferably 50,000-500,000 weight average molecular weight, 50-90% content of neutral sugar and 3-17% content of sulfide. A food, an adsorbent of a sodium ion, an accelerator of discharge of the sodium ion and a preventing or treating agent for a disease caused by surplus ingestion of common salt are obtained by using the hot water extract of the Nemacystus decipiens as an active ingredient.

8. 发明专利

JPH1059851A GUANIDINE COMPOUND REDUCING AGENT AND WATER AND POTASSIUM ION ADSORBENT 失效
公开(公告)号：JPH1059851A
公开(公告)日：1998-03-03
申请号：JP25638796
申请日：1996-09-27
申请人： OTSUKA PHARMA FACTORY INC , KAO CORP
发明人： YONEKAWA MOTOKI , YAMAOKA IPPEI , HASHIMOTO KINJI , SAKASHITA EIJI , KORI HIDEAKI , KONDO AKIHIRO , AMIYA TSUYOSHI
IPC分类号： A61M1/14 , A61K31/78 , A61M1/36 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To obtain the subject medicine effective for patients with acute and chronic renal insufficiency, receiving hemodialysis and reduced in liver function, having a new action, by using a specific resin as an active ingredient. SOLUTION: This reducing agent comprises an acrylic water-absorbing resin as an active ingredient. An alkaline earth metal acrylate- or methacrylate-based polymer or a self cross-linking type metal acrylate-based polymer is preferable as the acrylic water-absorbing resin. Preferably, these metal salts comprise at least partially a calcium ion (with the proviso that a potassium salt is omitted in the case of a potassium ion adsorbent). The medicine reduces a guanidine compound accumulated in the body of a patient, discharges the compound out of the body together with water accumulated in the body without by hemodialysis and also potassium ion accumulated in the body.

9. 发明专利

AU2016350158A1 Novel citric acid derivative 未知
公开(公告)号：AU2016350158A1
公开(公告)日：2018-05-24
申请号：AU2016350158
申请日：2016-11-01
申请人： ADABIO CO LTD , OTSUKA PHARMA FACTORY INC
发明人： HIRAISHI KATSUYA , JIMMA FUMIE , SOMA HIROYUKI , ADACHI TARO , ADACHI MASAKAZU , YAMAOKA IPPEI , KAGAWA TOMOHIRO
IPC分类号： C07C235/12 , A23L33/105 , A61K31/197 , A61K31/341 , A61P1/18 , C07C231/02 , C07D207/416 , C07D405/04
摘要： Compounds (citric acid derivatives) represented by formulae (1) and (2) are novel compounds that have hepatic disorder inhibitory effect, and are able to be used as hepatic disorder inhibitors and food additives. (In the formulae, R

10. 发明专利

CA3004153A1 PROPHYLACTIC AND/OR THERAPEUTIC AGENT FOR NAFLD/NASH 未知
公开(公告)号：CA3004153A1
公开(公告)日：2017-06-01
申请号：CA3004153
申请日：2016-11-25
申请人： OTSUKA PHARMA FACTORY INC , ADABIO CO LTD
发明人： HIRAISHI KATSUYA , JIMMA FUMIE , SOMA HIROYUKI , ADACHI TARO , ADACHI MASAKAZU , YAMAOKA IPPEI , KAGAWA TOMOHIRO
IPC分类号： A61K36/736 , A23L33/105 , A61P1/16 , A61P43/00
摘要： A prophylactic and/or therapeutic agent for non-alcoholic fatty liver disease (NAFLD), in particular non-alcoholic steatohepatitis (NASH), said prophylactic and/or therapeutic agent comprising a concentrate of Japanese plum (Prunus mume) juice or a processed product thereof. The prophylactic and/or therapeutic agent, which is obtained with the use of ingredients contained in a plant or a processed product thereof, has a high safety and can be easily taken. It was confirmed that hepatic fibrosis can be ameliorated by orally administering a concentrate of Japanese plum juice or a processed product thereof to streptozocin (STZ)-induced NAFLD model mice and STZ-induced NASH model mice.

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