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1. 发明申请

WO0247732A2 METHOD OF MAKING DEMINERALIZED BONE PARTICLES 审中-公开
标题翻译：制造脱矿骨粒子的方法
公开(公告)号：WO0247732A2
公开(公告)日：2002-06-20
申请号：PCT/US0148384
申请日：2001-12-14
申请人： OSTEOTECH INC , MORRIS JOHN , SHIMP LAWRENCE A , PETERSEN KENNETH C , MANRIQUE ALBERT , KAES DAVID , SCARBOROUGH NELSON L , DOWD MICHAEL
发明人： MORRIS JOHN , SHIMP LAWRENCE A , PETERSEN KENNETH C , MANRIQUE ALBERT , KAES DAVID , SCARBOROUGH NELSON L , DOWD MICHAEL
IPC分类号： A61L27/00 , A61L27/36 , A61L
CPC分类号： A61L27/3847 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L27/3691 , A61L2430/02 , A61L2430/40
摘要： Demineralized bone particles are obtained by demineralizing whole bone and thereafter subdividing the demineralized bone to provide the demineralized bone particles.
摘要翻译：脱矿骨颗粒通过将全骨去矿物质并随后细分脱矿骨以提供去矿物质骨颗粒而获得。

2. 发明专利

EA001263B1 ПРОТОЧНАЯ СИСТЕМА ПОД ДАВЛЕНИЕМ И СПОСОБ ОБРАБОТКИ ЖИДКОСНО-ПРОНИЦАЕМЫХ ЗАГОТОВОК, ТАКИХ КАК КОСТИ 未知
公开(公告)号：EA001263B1
公开(公告)日：2000-12-25
申请号：EA199900850
申请日：1998-03-11
申请人： OSTEOTECH INC
发明人： SCARBOROUGH NELSON L , MORRIS JOHN W , RUSSEL JAMES L , DOWD MICHAEL
IPC分类号： B08B5/02 , A61L2/00 , A61L27/00 , A61L27/36 , B08B3/02
摘要： Заявленыпроточнаясистемаподдавлениеми способееприменениядляконтактас внутреннимобъемомжидкостно-проницаемых, например, пористыхзаготовок. Системавключаеткамерунагнетаниядавленияжидкости, имеющуювходнойпатрубоки отверстие, выполненноев однойизстеноккамеры. Вотверстиирасположеноуплотнение, обеспечивающеежидкостно-непроницаемуюгерметизациювокругвнешнейповерхностизаготовки, котораяимеетнеравномернуюформуповерхности. Жидкостьподдавлениемподаютв камерунагнетания, иобеспечиваютпрохождениежидкостичерезвнутреннийкаркасзаготовки. Впредпочтительномвариантереализациизаготовкойявляетсякостьилиеефрагмент, ижидкостьпроходитотвнутреннейчастикостик наружнойчастикостичерезсосудыи пористуюструктурукостидлятого, чтобыудалитькровь, костныймозги/илипрочиенекостныесоставныечастиизкости. Вкачествеальтернативыможновыбратьжидкостьдлядеконтаминациии/илидеминерализациикости, окрашиваниякостидляулучшениявизуализациимикрососудистойсистемыкостиилипропитыванияфармакологическимиреагентами (антибиотиками, факторамиростакостии т.п.) так, чтобыкостьмогласлужитьсистемойподачи.

3. 发明专利

NO994502A 未知
公开(公告)号：NO994502A
公开(公告)日：1999-11-17
申请号：NO994502
申请日：1999-09-17
申请人： OSTEOTECH INC
发明人： SCARBOROUGH NELSON L , MORRIS JOHN W , RUSSELL JAMES L , DOWD MICHAEL
IPC分类号： B08B5/02 , A61L2/00 , A61L27/00 , A61L27/36 , B08B3/02 , A61L
CPC分类号： A61F2/4644 , A61F2/28 , A61F2002/4646 , A61K35/32 , A61L2/0088 , A61L2/18 , A61L27/36 , A61L27/3608 , A61L27/3683 , Y10S623/923
摘要： A pressure flow system and method for its use are provided for contacting the interior of a fluid permeable, e.g., porous, workpiece. The system includes a fluid pressure chamber having an inlet port and an opening formed in one of the chamber walls. An adjustable seal capable of providing a fluid-tight seal about the exterior of a workpiece having a non-uniform surface is positioned within the opening. Fluid under pressure is supplied to the pressure chamber to force fluid to flow through the internal matrix of the workpiece. In a preferred embodiment, the workpiece is a bone or a section thereof, and the fluid is forced to flow from the endosteal portion of bone to the periosteal portion of bone through the vasculature and porous structure of the bone to remove blood, bone marrow and/or other non-bone constituent(s) from the bone. Alternatively, the fluid can be chosen to decontaminate and/or demineralize the bone, to stain the bone to improve visualization of the bone microvasculature or to impregnate with pharmacological agents (antibiotics, bone growth factors, etc.) so that bone can act as a delivery system.

4. 发明专利

CA2446410A1 PRESSURE FLOW SYSTEM AND METHOD FOR TREATING A FLUID PERMEABLE WORKPIECE SUCH AS BONE 未知
公开(公告)号：CA2446410A1
公开(公告)日：1998-09-24
申请号：CA2446410
申请日：1998-03-11
申请人： OSTEOTECH INC
发明人： DOWD MICHAEL , RUSSELL JAMES L , MORRIS JOHN W , SCARBOROUGH NELSON L
IPC分类号： A61B17/56 , A61L2/18 , A61L27/36 , A61L27/58
摘要： A pressure flow system and method for its use are provided for contacting th e interior of a fluid permeable, e.g., porous, workpiece. The system includes a fluid pressu re chamber having an inlet port and an opening formed in one of the chamber walls. An adjustable seal capable of providing a fluid-tight seal about the exterior of a workpiece having a non-uniform surface is positioned within the opening. Fluid under pressure is supplied t o the pressure chamber to force fluid to flow through the internal matrix of the workpiece. In a preferred embodiment, the workpiece is a bone or a section thereof, and the fluid is forced to flow from the endosteal portion of bone to the periosteal portion of bone through the vasculature and porous structure of the bone to remove blood, bone marrow and/or other non bone constituent(s) from the bone. Alternatively, the fluid can be chosen to decontaminate and/or demineralize the bone, to stain the bone to improve visualization of the bon e microvasculature or to impregnate with pharmacological agents (antibiotics, bone growth factors, etc.) so that bone can act as a delivery system.

5. 发明专利

CA2243365C PROCESS AND APPARATUS FOR PRODUCING FLEXIBLE SHEETS FROM DEMINERALIZED, ELONGATE, BONE PARTICLES 未知
公开(公告)号：CA2243365C
公开(公告)日：2006-07-25
申请号：CA2243365
申请日：1997-01-16
申请人： OSTEOTECH INC
发明人： DOWD MICHAEL , DAUGHERTY MARK , SCARBOROUGH NELSON , MCMICKLE JACK
IPC分类号： A61L27/00 , A61F2/28 , A61F2/30 , A61F2/46 , A61L27/36
摘要： A process for fabricating shaped material from demineralized bone particl es includes the steps of applying a liquid slurry of demineralized bone particl es to a support, removing excess liquid from the demineralized bone particles to provide a coherent shaped mass of demineralized bone particles (50), and warming the shaped mas s of demineralized bone particles at a predetermined temperature and for a predetermined time period (60). The resultant bone mass exhibits enhanced tensile strength and minimal bone particle disassociation upon rehydration thereby improving product handling and application at the operative site.

6. 发明专利

ES2207820T3 未知
公开(公告)号：ES2207820T3
公开(公告)日：2004-06-01
申请号：ES98911575
申请日：1998-03-11
申请人： OSTEOTECH INC
发明人： SCARBOROUGH NELSON L , MORRIS JOHN W , RUSSELL JAMES L , DOWD MICHAEL
IPC分类号： B08B5/02 , A61L2/00 , A61L27/00 , A61L27/36 , B08B3/02

7. 发明专利

DE69819883D1 未知
公开(公告)号：DE69819883D1
公开(公告)日：2003-12-24
申请号：DE69819883
申请日：1998-03-11
申请人： OSTEOTECH INC
发明人： SCARBOROUGH L , MORRIS W , RUSSELL L , DOWD MICHAEL
IPC分类号： B08B5/02 , A61L2/00 , A61L27/00 , A61L27/36 , B08B3/02

8. 发明专利

AT254485T 未知
公开(公告)号：AT254485T
公开(公告)日：2003-12-15
申请号：AT98911575
申请日：1998-03-11
申请人： OSTEOTECH INC
发明人： SCARBOROUGH NELSON L , MORRIS JOHN W , RUSSELL JAMES L , DOWD MICHAEL
IPC分类号： B08B5/02 , A61L2/00 , A61L27/00 , A61L27/36 , B08B3/02

9. 发明专利

CA2431030A1 METHOD OF MAKING DEMINERALIZED BONE PARTICLES 未知
公开(公告)号：CA2431030A1
公开(公告)日：2002-06-20
申请号：CA2431030
申请日：2001-12-14
申请人： OSTEOTECH INC
发明人： DOWD MICHAEL , KAES DAVID , SCARBOROUGH NELSON L , MANRIQUE ALBERT , MORRIS JOHN , PETERSEN KENNETH C , SHIMP LAWRENCE A
IPC分类号： A61L27/00 , A61L27/36
摘要： Demineralized bone particles are obtained by demineralizing whole bone and thereafter subdividing the demineralized bone to provide the demineralized bone particles.

10. 发明公开

EP0880345A4 PROCESS AND APPARATUS FOR PRODUCING FLEXIBLE SHEETS FROM DEMINERALIZED, ELONGATE, BONE PARTICLES 失效
标题翻译：方法和设备生产柔性薄膜FROM DEMINARALISIERTEN，拉长骨粒
公开(公告)号：EP0880345A4
公开(公告)日：2002-07-17
申请号：EP97901455
申请日：1997-01-16
申请人： OSTEOTECH INC
发明人： DOWD MICHAEL , SCARBOROUGH NELSON , DAUGHERTY MARK , MCMICKLE JACK
IPC分类号： A61F2/28 , A61F2/30 , A61F2/46 , A61L27/36 , A61L27/00
CPC分类号： A61L27/3691 , A61F2/28 , A61F2/3094 , A61F2/4644 , A61F2002/30957 , A61F2002/4649 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L27/3687 , A61L2430/40 , Y10S623/901 , Y10S623/919
摘要： A process for fabricating shaped material from demineralized bone particles includes the steps of applying a liquid slurry of demineralized bone particles to a support, removing excess liquid from the demineralized bone particles to provide a coherent shaped mass of demineralized bone particles (50), and warming the shaped mass of demineralized bone particles at a predetermined temperature and for a predetermined time period (60). The resultant bone mass exhibits enhanced tensile strength and minimal bone particle disassociation upon rehydration thereby improving product handling and application at the operative site.

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