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1. 发明申请

WO2009009688A1 DELIVERY SYSTEM 审中-公开
标题翻译：输送系统
公开(公告)号：WO2009009688A1
公开(公告)日：2009-01-15
申请号：PCT/US2008/069690
申请日：2008-07-10
申请人： OSTEOTECH, INC. , WEI, Guobao , BEHNAM, Keyvan , FORSYTH, Nanette , WINTERBOTTOM, John , BEISSER, James , BOYCE, Todd, M. , BERVEN, Sigurd , BETZ, Randal , O'BRIEN, Michael , SHELEKOV, Alexis
发明人： WEI, Guobao , BEHNAM, Keyvan , FORSYTH, Nanette , WINTERBOTTOM, John , BEISSER, James , BOYCE, Todd, M. , BERVEN, Sigurd , BETZ, Randal , O'BRIEN, Michael , SHELEKOV, Alexis
IPC分类号： A61L24/00 , A61L27/56
CPC分类号： A61F2/2846 , A61B17/7097 , A61B17/7098 , A61F2/0095 , A61F2/28 , A61F2/4455 , A61F2/4601 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/285 , A61F2002/30588 , A61F2002/30738
摘要： A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust, the release of the substance.
摘要翻译：提供了将物质或材料输送到手术部位的覆盖物。其中提供的物质的覆盖物可以被称为递送系统。通常，覆盖物可以是能够至少部分地保留其中提供的物质的单室或多室结构，直到覆盖物被放置在手术部位。放置时，覆盖物可以促进物质或周围材料的转移。例如，物质可以被主动地或被动地释放到手术部位。覆盖物可以参与，控制或以其他方式调节物质的释放。

2. 发明申请

WO2009120248A1 DELIVERY SYSTEM ATTACHMENT 审中-公开
标题翻译：交付系统附件
公开(公告)号：WO2009120248A1
公开(公告)日：2009-10-01
申请号：PCT/US2008/088293
申请日：2008-12-24
申请人： OSTEOTECH, INC. , WEI, Guobao , BEHNAM, Keyvan , FORSYTH, Nanette , WINTERBOTTOM, John , BEISSER, James , BOYCE, Todd, M. , ATTAWIA, Mohamed , RICHARDS, Cristy, J. , SHIMP, Lawrence
发明人： WEI, Guobao , BEHNAM, Keyvan , FORSYTH, Nanette , WINTERBOTTOM, John , BEISSER, James , BOYCE, Todd, M. , ATTAWIA, Mohamed , RICHARDS, Cristy, J. , SHIMP, Lawrence
IPC分类号： A61M37/00
CPC分类号： A61M35/00
摘要： A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust, the release of the substance.
摘要翻译：提供了将物质或材料输送到手术部位的覆盖物。其中提供的物质的覆盖物可以被称为递送系统。通常，覆盖物可以是能够至少部分地保留其中提供的物质的单室或多隔室结构，直到将覆盖物放置在手术部位。放置时，覆盖物可以促进物质或周围材料的转移。例如，物质可以被主动地或被动地释放到手术部位。覆盖物可以参与，控制或以其他方式调节物质的释放。

3. 发明申请

WO2009009684A1 DELIVERY SYSTEM 审中-公开
标题翻译：输送系统
公开(公告)号：WO2009009684A1
公开(公告)日：2009-01-15
申请号：PCT/US2008/069681
申请日：2008-07-10
申请人： OSTEOTECH, INC. , WEI, Guobao , BEHNAM, Keyvan , FORSYTH, Nanette , WINTERBOTTOM, John , BEISSER, James , BOYCE, Todd, M.
发明人： WEI, Guobao , BEHNAM, Keyvan , FORSYTH, Nanette , WINTERBOTTOM, John , BEISSER, James , BOYCE, Todd, M.
IPC分类号： A61L24/00 , A61L27/56
CPC分类号： A61F2/2846 , A61B17/7097 , A61B17/7098 , A61F2/0095 , A61F2/28 , A61F2/4455 , A61F2/4601 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/285 , A61F2002/30588 , A61F2002/30738
摘要： A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust, the release of the substance.
摘要翻译：提供了用于将物质或材料输送到手术部位的覆盖物。其中提供有物质的覆盖物可以被称为递送系统。通常，覆盖物可以是能够至少部分地保留设置在其中的物质直到覆盖物被置于手术部位处的单隔室或多隔室结构。放置后，覆盖物可以促进物质或周围物质的转移。例如，该物质可以被释放（主动或被动）到手术部位。覆盖物可以参与，控制或调整物质的释放。

4. 发明申请

WO2008157495A2 BONE MATRIX COMPOSITIONS AND METHODS 审中-公开
标题翻译：骨基质组合物和方法
公开(公告)号：WO2008157495A2
公开(公告)日：2008-12-24
申请号：PCT/US2008/067121
申请日：2008-06-16
申请人： OSTEOTECH, INC. , BEHNAM, Keyvan , WEI, Guobao , FORSYTH, Nanette , BOYCE, Todd, M. , SHIMP, Lawrence, A.
发明人： BEHNAM, Keyvan , WEI, Guobao , FORSYTH, Nanette , BOYCE, Todd, M. , SHIMP, Lawrence, A.
IPC分类号： A61L27/36
CPC分类号： A61K35/00 , A61F2/28 , A61F2002/30059 , A61F2310/00359 , A61K35/32 , A61L27/3604 , A61L27/3608 , A61L27/3683 , A61L27/3695 , A61L27/3834 , A61L27/54 , A61L2430/02 , A61L2430/40
摘要： Osteoinductive compositions and implants having increased biological activities, and methods for their production, are provided. The biological activities that may be increased include, but are not limited to, bone forming; bone healing; osteoinductive activity, osteogenic activity, chondrogenic activity, wound healing activity, neurogenic activity, contraction-inducing activity, mitosisinducing activity, differentiation-inducing activity, chemotactic activity, angiogenic or vasculogenic activity, and exocytosis or endocytosis-inducing activity. In one embodiment, a method for producing an osteoinductive composition comprises providing partially demineralized bone, treating the partially demineralized bone to disrupt the collagen structure of the bone, and optionally providing a tissue-derived extract and adding the tissue-derived extract to the partially demineralized bone. In another embodiment, an implantable osteoinductive and osteoconductive composition comprises partially demineralized bone, wherein the collagen structure of the bone has been disrupted, and, optionally, a tissue-derived extract.
摘要翻译：提供具有增加的生物活性的骨诱导组合物和植入物及其生产方法。可能增加的生物活性包括但不限于骨形成; 骨愈合; 骨诱导活性，成骨活性，软骨形成活性，伤口愈合活性，神经源性活性，收缩诱导活性，有丝分裂诱导活性，分化诱导活性，趋化活性，血管生成或血管发生活性，以及胞吐作用或内吞诱导活性。在一个实施方案中，用于产生骨诱导性组合物的方法包括提供部分去矿物质的骨，处理所述部分去矿物质的骨以破坏所述骨的胶原结构，以及任选地提供组织衍生的提取物，并将所述组织衍生的提取物加入到部分去矿物质骨。在另一个实施方案中，可植入的骨诱导和骨传导性组合物包含部分脱矿质骨，其中所述骨的胶原结构已被破坏，并且任选地包含组织衍生的提取物。

5. 发明申请

WO2008157492A3 OSTEOINDUCTIVE DEMINERALIZED CANCELLOUS BONE 审中-公开
公开(公告)号：WO2008157492A3
公开(公告)日：2008-12-24
申请号：PCT/US2008/067117
申请日：2008-06-16
申请人： OSTEOTECH, INC. , BEHNAM, Keyvan , FORSYTH, Nanette , RUSSELL, James , WINTERBOTTOM, John, M. , BOYCE, Todd, M.
发明人： BEHNAM, Keyvan , FORSYTH, Nanette , RUSSELL, James , WINTERBOTTOM, John, M. , BOYCE, Todd, M.
IPC分类号： A61L27/36
摘要： An osteoinductive demineralized bone matrix, corresponding osteoimplants, and methods for making the osteoinductive demineralized bone matrix are disclosed. The osteoinductive demineralized bone matrix may be prepared by providing demineralized bone and altering the collagenous structure of the bone. The osteoinductive demineralized bone matrix may also be prepared by providing demineralized bone and compacting the bone, for example via mechanical compaction, grinding into a particulate, or treatment with a chemical. Additives such as growth factors or bioactive agents may be added to the osteoinductive demineralized bone matrix. The osteoinductive demineralized bone matrix may form an osteogenic osteoimplant. The osteoimplant, when implanted in a mammalian body, may induce at the locus of the implant the full developmental cascade of endochondral bone formation including vascularization, mineralization, and bone marrow differentiation. The osteoinductive demineralized bone matrix may also be used as a delivery device to administer bioactive agents.

6. 发明申请

WO2010093959A9 DELIVERY SYSTEMS, TOOLS, AND METHODS OF USE 审中-公开
公开(公告)号：WO2010093959A9
公开(公告)日：2010-08-19
申请号：PCT/US2010/024144
申请日：2010-02-12
申请人： OSTEOTECH, INC. , BETZ, Randal, R. , BODEN, Scott , GUPTA, Munish, Chandra , O'BRIEN, Michael, F. , SANDHU, Harvinder , SHELOKOV, Alexis , SYBERT, Daryl, R. , VACCARO, Alexander , WEI, Guobao , BOYCE, Todd, M. , COHEN, Robert , RICHARDS, Cristy , SHIMP, Lawrence, A.
发明人： BETZ, Randal, R. , BODEN, Scott , GUPTA, Munish, Chandra , O'BRIEN, Michael, F. , SANDHU, Harvinder , SHELOKOV, Alexis , SYBERT, Daryl, R. , VACCARO, Alexander , WEI, Guobao , BOYCE, Todd, M. , COHEN, Robert , RICHARDS, Cristy , SHIMP, Lawrence, A.
IPC分类号： A61F2/28 , A61F2/44 , A61L27/36 , A61L27/54 , A61F2/46 , A61L2/02 , A61L2/03 , A61L2/04 , A61L2/08 , A61L2/14
摘要： A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust the release of the substance. In various embodiments, the covering is suitable for a variety of procedure specific uses. Implantation tools may be provided for placing the covering at a surgical site. Kits may be provided including variously sized or shaped coverings and one or more tools for use in placing the covering.

7. 发明申请

WO2010093950A1 DELIVERY SYSTEM CARTRIDGE 审中-公开
标题翻译：交货系统盒
公开(公告)号：WO2010093950A1
公开(公告)日：2010-08-19
申请号：PCT/US2010/024134
申请日：2010-02-12
申请人： OSTEOTECH, INC. , WEI, Guobao , BOYCE, Todd, M. , SHIMP, Lawrence, A.
发明人： WEI, Guobao , BOYCE, Todd, M. , SHIMP, Lawrence, A.
IPC分类号： A61F2/28 , A61F2/44 , A61L27/36 , A61L27/54
CPC分类号： A61B17/8819 , A61B17/823 , A61B17/8825 , A61B2017/8813 , A61F2/30 , A61F2/4603 , A61F2002/0086 , A61F2002/2825 , A61F2002/2835 , A61F2002/30059 , A61F2002/30064 , A61F2002/3007 , A61F2002/30072 , A61F2002/30588 , A61F2002/30677 , A61F2002/3068 , A61F2002/3093 , A61F2002/30971 , A61F2002/4623 , A61F2002/4627 , A61F2250/0068 , A61F2310/00592 , A61F2310/00958 , A61F2310/0097
摘要： A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. In some embodiments, the covering may be configured and sized for receipt by an implant device. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust the release of the substance.
摘要翻译：提供了将物质或材料输送到手术部位的覆盖物。其中提供的物质的覆盖物可以被称为递送系统。通常，覆盖物可以是能够至少部分地保留其中提供的物质的单室或多隔室结构，直到将覆盖物放置在手术部位。在一些实施例中，覆盖物可被配置和定尺寸以便由植入装置接收。放置时，覆盖物可以促进物质或周围材料的转移。例如，物质可以被主动地或被动地释放到手术部位。覆盖物可以参与，控制或以其他方式调节物质的释放。

8. 发明申请

WO2010093955A9 SEGMENTED DELIVERY SYSTEM 审中-公开
公开(公告)号：WO2010093955A9
公开(公告)日：2010-08-19
申请号：PCT/US2010/024140
申请日：2010-02-12
申请人： OSTEOTECH,INC. , WEI, Guobao , BOYCE, Todd, M. , COHEN, Robert , RICHARDS, Cristy , SHIMP, Lawrence, A.
发明人： WEI, Guobao , BOYCE, Todd, M. , COHEN, Robert , RICHARDS, Cristy , SHIMP, Lawrence, A.
IPC分类号： A61F2/28 , A61F2/44 , A61L27/36 , A61L27/54 , A61F2/46 , A61L2/02 , A61L2/03 , A61L2/08 , A61L2/14
摘要： A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust the release of the substance. In various embodiments, the covering may be formed of a collagen material and is suitable for a variety of procedure specific uses.

9. 发明申请

WO2007084725A2 INJECTABLE AND MOLDABLE BONE SUBSTITUTE MATERIALS 审中-公开
标题翻译：可注射和可修复的骨代替材料
公开(公告)号：WO2007084725A2
公开(公告)日：2007-07-26
申请号：PCT/US2007/001540
申请日：2007-01-19
申请人： OSTEOTECH, INC. , WINTERBOTTOM, John , KAES, David, R. , TUNC, Deger, C. , BOYCE, Todd, M. , KNAACK, David , RUSSELL, James , BHATTACHARYYA, Subhabrata
发明人： WINTERBOTTOM, John , KAES, David, R. , TUNC, Deger, C. , BOYCE, Todd, M. , KNAACK, David , RUSSELL, James , BHATTACHARYYA, Subhabrata
IPC分类号： A61F2/28
CPC分类号： A61F2/28 , A61F2002/2835 , A61F2002/30062 , A61F2002/30677 , A61F2210/0004 , A61F2310/00293 , A61F2310/00359 , A61F2310/00365 , A61L27/446 , A61L27/46 , A61L27/48 , A61L27/56 , A61L27/58 , A61L2400/06 , A61L2400/08 , A61L2430/02
摘要： An osteoimplant composite comprising a plurality of particles of an inorganic material, a bone substitute material, a bone-derived material, or any combination thereof; and a polymer material with which the particles are combined. The composite is either naturally moldable or flowable, or it can be made moldable or settable. After implantation, the composite may be set to provide mechanical strength to the implant. The inventive composite have the advantage of being able to fill irregularly shape implantation site while at the same time being settable to provide the mechanical strength required for most orthopedic applications. The invention also provides methods of using and preparing the moldable and flowable composites.
摘要翻译：一种植物复合材料，其包含多种无机材料颗粒，骨替代材料，骨衍生材料或其任何组合; 以及与颗粒结合的聚合物材料。复合材料可以自然地模塑或流动，或者它可以是可模制的或可设定的。植入后，可以将复合材料设置成为植入物提供机械强度。本发明的复合材料具有能够填充不规则形状的植入部位的优点，同时可设置为提供大多数矫形应用所需的机械强度。本发明还提供了使用和制备可模制和可流动的复合材料的方法。

10. 发明申请

WO2004069890A2 POLYURETHANES FOR OSTEOIMPLANTS 审中-公开
标题翻译：聚氨酯泡沫塑料
公开(公告)号：WO2004069890A2
公开(公告)日：2004-08-19
申请号：PCT/US2004/003233
申请日：2004-02-04
申请人： OSTEOTECH, INC. , KNAACK, David , WINTERBOTTOM, John, M. , KAES, David , BOYCE, Todd, M. , SHIMP, Lawrence, A.
发明人： KNAACK, David , WINTERBOTTOM, John, M. , KAES, David , BOYCE, Todd, M. , SHIMP, Lawrence, A.
IPC分类号： C08G
CPC分类号： A61L27/3608 , A61L27/18 , A61L27/46 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2300/426 , A61L2430/02 , C08G18/10 , C08G18/36 , C08G18/3878 , C08G18/3882 , C08G18/6484 , C08G18/73 , C08G18/771 , C08G18/798 , C08G2230/00 , C08L75/04
摘要： biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.
摘要翻译：生物基聚氨酯及其制备方法。聚氨酯通过可生物降解的多异氰酸酯（例如赖氨酸二异氰酸酯）与任选羟基化的生物分子反应形成聚氨酯。形成的聚合物可以与陶瓷和/或骨颗粒结合以形成可用作骨样植入物的复合物。

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