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1. 发明申请

WO2007084609A2 POROUS OSTEOIMPLANT 审中-公开
公开(公告)号：WO2007084609A2
公开(公告)日：2007-07-26
申请号：PCT/US2007/001325
申请日：2007-01-19
申请人： OSTEOTECH, INC. , SHIMP, Larry , WINTERBOTTOM, John , KAES, David, R. , BELANEY, Ryan, M. , BHATTACHARYYA, Subhabrata
发明人： SHIMP, Larry , WINTERBOTTOM, John , KAES, David, R. , BELANEY, Ryan, M. , BHATTACHARYYA, Subhabrata
IPC分类号： A61F2/28
CPC分类号： A61L27/56 , A61F2/28 , A61F2002/30062 , A61F2002/30677 , A61F2210/0004 , A61F2310/00293 , A61F2310/00359 , A61F2310/00365 , A61L27/446 , A61L27/46
摘要： The invention is directed toward porous composites for application to a bone defect site to promote new bone growth. The inventive porous composites comprise a biocompatible polymer and a plurality of particles of bone-derived material, inorganic material, bone substitute material or composite material. In certain embodiments, the porous composites are prepared using a method that includes a supercritical fluid (e.g., supercritical carbon dioxide) treatment. The invention also discloses methods of using these composites as bone void fillers.
摘要翻译：本发明涉及用于骨缺损部位以促进新骨生长的多孔复合材料。本发明的多孔复合材料包括生物相容性聚合物和多种骨源材料，无机材料，骨替代材料或复合材料的颗粒。在某些实施方案中，使用包括超临界流体（例如超临界二氧化碳）处理的方法制备多孔复合材料。本发明还公开了使用这些复合材料作为骨空隙填料的方法。

2. 发明申请

WO2004067050A1 TISSUE PATHOGEN INACTIVATION/REMOVAL PROCESS 审中-公开
标题翻译：组织病原体失活/去除过程
公开(公告)号：WO2004067050A1
公开(公告)日：2004-08-12
申请号：PCT/US2004/002404
申请日：2004-01-27
申请人： OSTEOTECH, INC. , SHIMP, Larry , DEAN, Sheldon , MARTINS, Daniel
发明人： SHIMP, Larry , DEAN, Sheldon , MARTINS, Daniel
IPC分类号： A61L2/00
CPC分类号： A61L2/0088 , A61F2/28 , A61F2002/2835 , A61F2002/302 , A61F2002/4646 , A61F2002/4649 , A61F2230/0065 , A61L2/0011
摘要： Bone such as cortical or cancellous bone or connective tissue are centrifuged as a solution is applied to the tissue in a continuous process. The centrifuge creates forces, which cause the flowing solution to penetrate substantially all of the cavities of the tissue. The solution, which may be alcohol, a detergent, an oxidizer, or a surfactant, with or without water, flushes the cavities of the tissue and removes and inactivates viral and bacterial contaminants. In a second embodiment, bone or connective tissue is centrifuged in a batch process to remove contaminants from cavities in the tissue by first spinning the tissue dry and then submerging the tissue in a viral/bacteria cleansing solution and centrifuging the submerged tissue and solution at a sufficiently high speed and radius from the spin axis to create substantially high G forces on the tissue and solution to force the solution into and through the tissue cavities. The solution with the flushed contaminants is then removed from the vicinity of the tissue. In a further embodiment, an enzyme is centrifuged with the tissue to digest lipids and proteins which are then removed with a flushing solution which may also inactivate viral and bacterial contaminants. In yet a further embodiment, the centrifuge can be used to infuse biologically and/or structurally useful materials into the tissue. Further, the lipids and proteins may be removed by a chemically active agent such as oxo anions.
摘要翻译：将诸如皮层或松质骨或结缔组织的骨骼以连续过程施用于组织的方式进行离心分离。离心机产生的力使流动的溶液基本上渗透组织的所有空腔。该溶液可以是醇，洗涤剂，氧化剂或表面活性剂，含或不含水，冲洗组织的空腔并除去和灭活病毒和细菌污染物。在第二实施方案中，骨或结缔组织通过间歇过程离心以从组织中的空腔移除污染物，方法是首先将组织旋干，然后将组织浸没在病毒/细菌清洁溶液中，并将浸没的组织和溶液在从旋转轴线足够高的速度和半径以在组织和溶液上产生基本上高的G力，以迫使溶液进入并穿过组织空腔。然后将冲掉污染物的溶液从组织附近除去。在另一个实施方案中，用组织离心酶以消化脂质和蛋白质，然后用冲洗溶液除去脂质和蛋白质，所述冲洗溶液也可灭活病毒和细菌污染物。在又一个实施例中，离心机可用于将生物和/或结构上有用的材料输注到组织中。此外，脂质和蛋白质可以通过化学活性剂如氧代阴离子除去。

3. 发明公开

EP1976459A2 POROUS OSTEOIMPLANT 审中-公开
标题翻译：多孔骨植入
公开(公告)号：EP1976459A2
公开(公告)日：2008-10-08
申请号：EP07718026.3
申请日：2007-01-19
申请人： Osteotech, Inc.,
发明人： SHIMP, Larry , WINTERBOTTOM, John , KAES, David, R. , BELANEY, Ryan, M. , BHATTACHARYYA, Subhabrata
IPC分类号： A61F2/28
CPC分类号： A61L27/56 , A61F2/28 , A61F2002/30062 , A61F2002/30677 , A61F2210/0004 , A61F2310/00293 , A61F2310/00359 , A61F2310/00365 , A61L27/446 , A61L27/46
摘要： The invention is directed toward porous composites for application to a bone defect site to promote new bone growth. The inventive porous composites comprise a biocompatible polymer and a plurality of particles of bone-derived material, inorganic material, bone substitute material or composite material. In certain embodiments, the porous composites are prepared using a method that includes a supercritical fluid (e.g., supercritical carbon dioxide) treatment. The invention also discloses methods of using these composites as bone void fillers.

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