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1. 发明专利

PL2569314T3 Skondensowane bicykliczne inhibitory kinazy 未知
公开(公告)号：PL2569314T3
公开(公告)日：2017-02-28
申请号：PL11721678
申请日：2011-05-16
申请人： OSI PHARMACEUTICALS LLC
发明人： MULVIHILL MARK J , STEINIG ARNO G , CREW ANDREW PHILIP , JIN MEIZHONG , KLEINBERG ANDREW , LI AN-HU , WANG JING
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00

2. 发明专利

AU2011252784A1 Fused bicyclic kinase inhibitors 未知
公开(公告)号：AU2011252784A1
公开(公告)日：2012-09-13
申请号：AU2011252784
申请日：2011-05-16
申请人： OSI PHARMACEUTICALS LLC
发明人： MULVIHILL MARK J , STEINIG ARNO G , CREW ANDREW PHILIP , JIN MEIZHONG , KLEINBERG ANDREW , LI AN-HU , WANG JING
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
摘要： Compounds of Formula I, as shown below and defined herein: (I) pharmaceutically acceptable salts thereof, synthesis, intermediates, formulations, and methods of disease treatment therewith, including treatment of cancers, such as tumors driven at least in part by at least one of RON, MET or ALK. This Abstract is not limiting of the invention.

3. 发明专利

CA2790847A1 FUSED BICYCLIC KINASE INHIBITORS 未知
公开(公告)号：CA2790847A1
公开(公告)日：2011-11-17
申请号：CA2790847
申请日：2011-05-16
申请人： OSI PHARMACEUTICALS LLC
发明人： MULVIHILL MARK J , STEINIG ARNO G , CREW ANDREW PHILIP , JIN MEIZHONG , KLEINBERG ANDREW , LI AN-HU , WANG JING
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
摘要： Compounds of Formula I, as shown below and defined herein: (I) pharmaceutically acceptable salts thereof, synthesis, intermediates, formulations, and methods of disease treatment therewith, including treatment of cancers, such as tumors driven at least in part by at least one of RON, MET or ALK. This Abstract is not limiting of the invention.

4. 发明专利

ES2652440T3 Inhibidores de proteína cinasa heterobicíclicos sustituidos con anillo 6,6-bicíclico 未知
公开(公告)号：ES2652440T3
公开(公告)日：2018-02-02
申请号：ES09156987
申请日：2005-03-31
申请人： OSI PHARMACEUTICALS LLC
发明人： ARNOLD LEE D , CESARIO CARA , COATE HEATHER , CREW ANDREW PHILIP , DONG HANQING , FOREMAN KENNETH , HONDA AYAKO , LAUFER RADOSLAW , LI AN-HU , MULVIHILL KRISTEN MICHELLE , MULVIHILL MARK JOSEPH , NIGRO ANTHONY , PANICKER BIJOY , STEINIG ARNO G , SUN YINGCHUAN , WENG QINGHUA , WERNER DOUGLAS S , WYLE MICHAEL J , ZHANG TAO
IPC分类号： C07D487/04 , A61K31/437 , A61K31/4985 , A61K31/5025 , A61K31/519 , A61K31/53 , A61P11/06 , A61P17/06 , A61P25/00 , A61P35/00 , C07D471/04
摘要： Un compuesto representado por la Fórmula I: **(Ver fórmula)** o una sal farmacéuticamente aceptable del mismo, en donde: X2 y X4 son N; X1 y X5 son C-(E1)aa; X3, X6, y X7 son C; o X3 y X5 son N; X1 y X2 son C-(E1)aa; X4, X6, y X7 son C; o X2, X3, y X5 son N; X1 es C-(E1)aa; X4, X6 y X7 son C; o X2, X4, y X5 son N; X1 es C-(E1)aa; X3, X6 y X7 son C; Q1 es **(Ver fórmula)** en donde: X14, X15, y X16 son N; X11, X12, y X13 son C-(E11)bb; o X14 y X15 son N; X11, X12, X13, y X16 son C-(E11)bb; o X14 y X16 son N; X11, X12, X13, y X15 son C-(E11)bb; o X15 y X16 son N; X11, X12, X13, y X14 son C-(E11)bb; o X14 es N; X11, X12, X13, X15, y X16 son C-(E11)bb; o X15 es N; X11, X12, X13, X14, y X16 son C-(E11)bb; o X16 es N; X11, X12, X13, X14, y X15 son C-(E11)bb; a menos que se indique otra cosa, R1 está ausente, alquilo C0-10, cicloalquilo C3-10, bicicloalquilo C5-10, arilo, heteroarilo, aralquilo, heteroaralquilo, heterociclilo, heterobicicloalquilo C5-10, espiroalquilo, o heteroespiroalquilo, cualquiera de los cuales está opcionalmente sustituido por uno o más sustituyentes G11 independientes; cada uno de E1, E11, G1, y G41 es independientemente halo, -CF3, -OCF3, -OR2, -NR2R3(R2a)j1, -C(>=O)R2, -CO2R2, -CONR2R3, -NO2, -CN, -S(O)j1R2, -SO2NR2R3, -NR2C(>=O)R3, -NR2C(>=O)OR3, -NR2C(>=O)NR3R2a, -NR2S(O)j1R3, - C(>=S)OR2, -C(>=O)SR2, -NR2C(>=NR3)NR2aR3a, -NR2C(>=NR3)OR2a, -NR2C(>=NR3)SR2a, -OC(>=O)OR2, - OC(>=O)NR2R3, -OC(>=O)SR2, -SC(>=O)OR2, -SC(>=O)NR2R3, alquilo C0-10, alquenilo C2-10, alquinilo C2-10, alcoxi C1- 10-alquilo C1-10, alcoxi C1-10-alquenilo C2-10, alcoxi C1-10-alquinilo C2-10, alquiltio C1-10-alquilo C1-10, alquiltio C1-10- alquenilo C2-10, alquiltio C1-10-alquinilo C2-10, cicloalquilo C3-8, cicloalquenilo C3-8, cicloalquil C3-8-alquilo C1-10, cicloalquenil C3-8-alquilo C1-10, cicloalquil C3-8-alquenilo C2-10, cicloalquenil C3-8-alquenilo C2-10, cicloalquil C3-8- alquinilo C2-10, cicloalquenil C3-8-alquinilo C2-10, heterociclil-alquilo C0-10, heterociclil-alquenilo C2-10, o heterociclil alquinilo C2-10, cualquiera de los cuales está opcionalmente sustituido con uno o más sustituyentes independientes halo, oxo, -CF3, -OCF3, -OR222, -NR222R333(R222a)j1a, -C(>=O)R222, -CO2R222, -C(>=O)NR222R333, - NO2, -CN, -S(O)j1aR222, -SO2NR222R333, -NR222C(>=O)R333, -NR222C(>=O)OR333, -NR222C(>=O)NR333R222a, - NR222S(O)j1aR333, -C(>=S)OR222, -C(>=O)SR222, -NR222C(>=NR333)NR222aR333a, -NR222C(>=NR333)OR222a, - NR222C(>=NR333)SR222a, -OC(>=O)OR222, -OC(>=O)NR222R333, -OC(>=O)SR222, -SC(>=O)OR222, o -SC(>=O)NR222R333; ...

5. 发明专利

BR112012028674A2 inibidores de quinase bicíclica fundida 未知
公开(公告)号：BR112012028674A2
公开(公告)日：2016-08-16
申请号：BR112012028674
申请日：2011-05-16
申请人： OSI PHARMACEUTICALS LLC
发明人： LI AN-HU , KLEINBERG ANDREW , CREW ANDREW PHILIP , STEINIG ARNO G , WANG JIN , MULVIHILL MARK J , JIN MEIZHONG
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
摘要： inibidores de quinase bicíclica fundida. a presente invenção refere-se a compostos da fórmula i, como mostrado abaixo e definidos aqui: são farmaticais aceitáveis dos mesmos, síntese, intermediários, formulações e processos de tratamento de doenças com os mesmos, incluindo tratamento de cânceres, tais como tumores controlados pelo menos em parte por pelo menos um de ron, met ou alk. este resumo não é limitante da invenção.

6. 发明专利

MX2012013206A INHIBIDORES DE QUINASA BICICLICA FUSIONADA. 未知
公开(公告)号：MX2012013206A
公开(公告)日：2012-12-17
申请号：MX2012013206
申请日：2011-05-16
申请人： OSI PHARMACEUTICALS LLC
发明人： CREW ANDREW PHILIP , STEINIG ARNO G , JIN MEIZHONG , WANG JING , KLEINBERG ANDREW , MULVIHILL MARK J , LI AN-HU
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
摘要： Compuestos de fórmula I, como se muestra abajo y define aquí: (ver Fórmula) sales farmacéuticamente aceptables de los mismos, síntesis, intermedios, formulaciones y métodos de tratamiento de enfermedad, incluyendo el tratamiento de cánceres, tales como tumores impulsados por lo menos en parte por al menos uno de RON, MET o ALK.

7. 发明专利

SG184822A1 FUSED BICYCLIC KINASE INHIBITORS 未知
公开(公告)号：SG184822A1
公开(公告)日：2012-12-28
申请号：SG2012075495
申请日：2011-05-16
申请人： OSI PHARMACEUTICALS LLC
发明人： MULVIHILL MARK J , STEINIG ARNO G , CREW ANDREW PHILIP , JIN MEIZHONG , KLEINBERG ANDREW , LI AN-HU , WANG JING
摘要： Compounds of Formula I, as shown below and defined herein: (I) pharmaceutically acceptable salts thereof, synthesis, intermediates, formulations, and methods of disease treatment therewith, including treatment of cancers, such as tumors driven at least in part by at least one of RON, MET or ALK. This Abstract is not limiting of the invention.

8. 发明专利

ZA201208489B FUSED BICYCLIC KINASE INHIBITORS 未知
公开(公告)号：ZA201208489B
公开(公告)日：2013-09-25
申请号：ZA201208489
申请日：2012-11-12
申请人： OSI PHARMACEUTICALS LLC
发明人： MULVIHILL MARK J , STEINIG ARMO G , CREW ANDREW PHILIP , JIN MEIZHONG , KLEINBERG ANDREW , LI AN-HU , WANG JING
IPC分类号： C07D20060101 , A61K20060101 , A61P20060101
摘要： Compounds of Formula I, as shown below and defined herein: pharmaceutically acceptable salts thereof, synthesis, intermediates, formulations, and methods of disease treatment therewith, including treatment of cancers, such as tumors driven at least in part by at least one of RON, MET or ALK. This Abstract is not limiting of the invention.

9. 发明专利

ES2395835T3 Inhibidores de la proteína quinasa bicíclicos 未知
公开(公告)号：ES2395835T3
公开(公告)日：2013-02-15
申请号：ES06844779
申请日：2006-12-04
申请人： OSI PHARM INC , OSI PHARMACEUTICALS LLC
发明人： CREW ANDREW PHILIP , DONG HAN-QING , MULVIHILL MARK JOSEPH , WERNER DOUGLAS S , KADALBAJOO MRIDULA , LAUFER RADOSLAW
IPC分类号： C07D487/04 , A61K31/4985 , A61P29/00 , A61P31/00 , A61P35/00
摘要： Un compuesto de Fórmula I: o una sal farmacéuticamente aceptable del mismo, en la que: R1 es -OR4, -NR4R5, -C(>=O)R4, -CO2R4, -CONR4R5, -NO2, -CN, -S(O)j1R4, -SO 2NR4R5, -NR4C(>=O)R5, -NR4C(>=O)OR5, -NR4C(>=O)NR5R5a, -NR4S(O)j1R5, -C(>=S)OR4, -C(>=O)SR4, -NR4C(>=NR5)NR4aR5a, -NR4C(>=NR5)OR4a, -NR4C(>=NR5)SR4a, -OC(>=O)OR5, -OC(>=O)NR4R5, -OC(>=O)SR4, -SC(>=O)OR4 o -SC(>=O)NR4R5;cada uno de R2 y R3 es hidrógeno; X1 es -C-E1; X2 es -C-E1; X3 y X5 son N o -N-(E1)aa cada uno de X4, X6 y X7 es C; Q1 aril-alquilo C0-10, aril-alquenilo C2-10, aril-alquinilo C2-10, hetaril-alquilo C0-10, hetaril-alquenilo C2-10 o hetarilalquiniloC2-10, cualquiera de los cuales está opcionalmente sustituido con uno o más sustituyentes G11 independientes; o Q1 es uno cualquiera de los siguientes.

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