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1. 发明申请

WO2007061737A2 FUSED BICYCLIC mTOR INHIBITORS 审中-公开
标题翻译：熔融双相mTOR抑制剂
公开(公告)号：WO2007061737A2
公开(公告)日：2007-05-31
申请号：PCT/US2006/044461
申请日：2006-11-15
申请人： OSI PHARMACEUTICALS, INC. , CHEN, Xin , COATE, Heather , CREW, Andrew-Philip , DONG, Han-Qing , HONDA, Ayako , MULVIHILL, Mark, Joseph , TAVARES, Paula, A., R. , WANG, Jing , WERNER, Douglas, S. , MULVIHILL, Kristen, Michelle , SIU, Kam, W. , PANICKER, Bijoy , BHARADWAJ, Apoorba , ARNOLD, Lee, D. , JIN, Meizhong , VOLK, Brian , WENG, Qinghua , BEARD, James, David
发明人： CHEN, Xin , COATE, Heather , CREW, Andrew-Philip , DONG, Han-Qing , HONDA, Ayako , MULVIHILL, Mark, Joseph , TAVARES, Paula, A., R. , WANG, Jing , WERNER, Douglas, S. , MULVIHILL, Kristen, Michelle , SIU, Kam, W. , PANICKER, Bijoy , BHARADWAJ, Apoorba , ARNOLD, Lee, D. , JIN, Meizhong , VOLK, Brian , WENG, Qinghua , BEARD, James, David
CPC分类号： C07D487/04 , A61K31/5025 , C07D253/07 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14
摘要： Compounds represented by Formula (I) or a pharmaceutically acceptable salt thereof, are inhibitors of mTOR and useful in the treatment of cancer.
摘要翻译：由式（I）表示的化合物或其药学上可接受的盐是mTOR的抑制剂，可用于治疗癌症。

2. 发明申请

WO2006107756A1 PYRROLO [2,3-D] IMIDAZOLES FOR THE TREATMENT OF HYPERPROLIFERATIVE DISORDERS 审中-公开
标题翻译： PYRROLO [2,3-D]用于治疗高反应性疾病的咪唑
公开(公告)号：WO2006107756A1
公开(公告)日：2006-10-12
申请号：PCT/US2006/011961
申请日：2006-03-30
申请人： OSI PHARMACEUTICALS, INC. , CREW, Andrew, Philip , DONG, Han-Qing , PANICKER, Bijoy
发明人： CREW, Andrew, Philip , DONG, Han-Qing , PANICKER, Bijoy
IPC分类号： C07D487/04 , A61K31/4188 , A61P35/00
CPC分类号： C07D487/04
摘要： Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of tumors and cancers.
摘要翻译：式（I）：或其药学上可接受的盐或N-氧化物可用于治疗肿瘤和癌症。

3. 发明申请

WO2005097800A1 6,6-BICYCLIC RING SUBSTITUTED HETEROBICYCLIC PROTEIN KINASE INHIBITORS 审中-公开
标题翻译： 6,6-双环环取代的杂环蛋白激酶抑制剂
公开(公告)号：WO2005097800A1
公开(公告)日：2005-10-20
申请号：PCT/US2005/010606
申请日：2005-03-31
申请人： OSI PHARMACEUTICALS, INC. , ARNOLD, Lee, D. , CESARIO, Cara , COATE, Heather , CREW, Andrew, Philip , DONG, Hanqing , FOREMAN, Kenneth , HONDA, Ayako , LAUFER, Radoslaw , LI, An-Hu , MULVIHILL, Kristen, Michelle , MULVIHILL, Mark, Joseph , NIGRO, Anthony , PANICKER, Bijoy , STEINIG, Arno, G. , SUN, Yingchuan , WENG, Qinghua , WERNER, Douglas, S. , WYLE, Michael, J. , ZHANG, Tao
发明人： ARNOLD, Lee, D. , CESARIO, Cara , COATE, Heather , CREW, Andrew, Philip , DONG, Hanqing , FOREMAN, Kenneth , HONDA, Ayako , LAUFER, Radoslaw , LI, An-Hu , MULVIHILL, Kristen, Michelle , MULVIHILL, Mark, Joseph , NIGRO, Anthony , PANICKER, Bijoy , STEINIG, Arno, G. , SUN, Yingchuan , WENG, Qinghua , WERNER, Douglas, S. , WYLE, Michael, J. , ZHANG, Tao
IPC分类号： C07D487/04
CPC分类号： C07F5/025 , C07D471/04 , C07D487/04
摘要： Compounds of the formula (I) and pharmaceutically acceptable salts thereof, wherein X I , X 2 , X 3 , X 4 , X 5 , X 6 , X 7 , R 1 , and Q 1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asthma, disease and conditions of the immune system, disease and conditions of the central nervous system.
摘要翻译：式（I）化合物及其药学上可接受的盐，其中XI，X 2，X 3，X 4，X 5，X 6，X 7，R 1和Q 1如本文所定义，抑制IGF-1R酶，可用于治疗和/或预防过度增生性疾病如癌症，炎症，牛皮癣，过敏/哮喘，免疫系统的疾病和病症，中枢神经系统的疾病和病症。

4. 发明申请

WO2007067537A1 PYRROLOPYRIDINE KINASE INHIBITING COMPOUNDS 审中-公开
标题翻译：吡咯啉激酶抑制化合物
公开(公告)号：WO2007067537A1
公开(公告)日：2007-06-14
申请号：PCT/US2006/046391
申请日：2006-12-05
申请人： OSI PHARMACEUTICALS, INC. , DONG, Han-qing , FOREMAN, Kenneth , LI, An-Hu , MULVIHILL, Mark, Joseph , PANICKER, Bijoy , STEINIG, Arno, G. , STOLZ, Kathryn, M. , WENG, Qinghua , JIN, Meizhong , VOLK, Brian , WANG, Jing , WANG, Ti , BEARD, James, D.
发明人： DONG, Han-qing , FOREMAN, Kenneth , LI, An-Hu , MULVIHILL, Mark, Joseph , PANICKER, Bijoy , STEINIG, Arno, G. , STOLZ, Kathryn, M. , WENG, Qinghua , JIN, Meizhong , VOLK, Brian , WANG, Jing , WANG, Ti , BEARD, James, D.
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04
摘要： Compounds represented by Formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, are inhibitors of least one of the Ab1, Aurora-A, BIk, c-Raf, cSRC, Src, PRK2, FGFR3, Flt3, Lck, Mekl, PDK-1, GSK3β, EGFR, p70S6K, BMX, SGK, CaMKII, Tie-2, IGF-IR, Ron, Met, and KDR kinases in animals, including humans, for the treatment and/or prevention of various diseases and conditions such as cancer.
摘要翻译：由式（I）表示的化合物或其立体异构体或其药学上可接受的盐是至少一种Ab1，Aurora-A，BIk，c-Raf，cSRC，Src，PRK2，FGFR3，Flt3，Lck，Mekl，PDK -1，GSK3β，EGFR，p70S6K，BMX，SGK，CaMKII，Tie-2，IGF-1R，Ron，Met和KDR激酶，用于治疗和/或预防各种疾病和病症，癌症。

5. 发明申请

WO2006017443A2 ARYL-AMINO SUBSTITUTED PYRROLOPYRIMIDINE MULTI-KINASE INHIBITING COMPOUNDS 审中-公开
标题翻译： ARYL-AMINO取代的吡咯并咪唑多激酶抑制化合物
公开(公告)号：WO2006017443A2
公开(公告)日：2006-02-16
申请号：PCT/US2005/027274
申请日：2005-08-01
申请人： OSI PHARMACEUTICALS, INC. , AHMED, Saleh , BARBA, Oscar , BLOXHAM, Jason , DAWSON, Graham , GATTRELL, William , KITCHIN, John , PEGG, Neil, Anthony , SABA, Imaad , SHADIQ, Shazia , SMITH, Colin, Peter, Sambrook , SMYTH, Don , STEINIG, Arno, G. , WILKES, Robin , FOREMAN, Kenneth , WENG, Qinghua, Felix , STOLZ, Kathryn , TAVARES, Paula , PANICKER, Bijoy , LI, An-Hu , DONG, Hanqing , MA, Lifu , COX, Matthew
发明人： AHMED, Saleh , BARBA, Oscar , BLOXHAM, Jason , DAWSON, Graham , GATTRELL, William , KITCHIN, John , PEGG, Neil, Anthony , SABA, Imaad , SHADIQ, Shazia , SMITH, Colin, Peter, Sambrook , SMYTH, Don , STEINIG, Arno, G. , WILKES, Robin , FOREMAN, Kenneth , WENG, Qinghua, Felix , STOLZ, Kathryn , TAVARES, Paula , PANICKER, Bijoy , LI, An-Hu , DONG, Hanqing , MA, Lifu , COX, Matthew
IPC分类号： A61K31/519 , C07D487/02
CPC分类号： C07D471/02 , C07D487/02 , C07D487/04
摘要： Compounds represented by Formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, are inhibitors of least two of the Abl, Aurora-A, Blk, c-Raf, cSRC, Src, PRK2, FGFR3, Flt3, Lck, Mekl, PDK-1, GSK3ß, EGFR, p70S6K, BMX, SGK, CaMKII, Tie-2, IGF-lR, Ron, Ret, and KDR kinases in animals, including humans, for the treatment and/or prevention of various diseases and conditions such as cancer.
摘要翻译：由式（I）表示的化合物或其立体异构体或其药学上可接受的盐是Abl，Aurora-A，Blk，c-Raf，cSRC，Src，PRK2，FGFR3，Flt3，Lck，Mekl，PDK中的至少两种的抑制剂 -1，GSK3β，EGFR，p70S6K，BMX，SGK，CaMKII，Tie-2，IGF-1R，Ron，Ret和KDR激酶，用于治疗和/或预防各种疾病和病症，癌症。

6. 发明申请

WO2006034016A1 (ARYLAMIDOANILINO) NITROETHYLENE COMPOUNDS 审中-公开
标题翻译：（ARYLAMIDOANILINO）硝基乙烯化合物
公开(公告)号：WO2006034016A1
公开(公告)日：2006-03-30
申请号：PCT/US2005/033128
申请日：2005-09-15
申请人： OSI PHARMACEUTICALS, INC. , CREW, Andrew , LI, An-Hu , PANICKER, Bijoy
发明人： CREW, Andrew , LI, An-Hu , PANICKER, Bijoy
IPC分类号： C07D409/12 , C07D409/14 , A61K31/4709 , A61P35/00
CPC分类号： C07D409/12 , C07D409/14
摘要： Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, wherein A, Q, Y, R 1 , R 2 , and R 5 are defined herein, are useful in the treatment of tumors and cancers such as mastocytosis/mast cell leukemia, gastrointestinal stromal tumors (GIST), germ cell tumors, small cell lung carcinoma (SCLC), sinonasal natural killer/T-cell lymphoma, testicular cancer (seminoma), thyroid carcinoma, malignant melanoma, ovarian carcinoma, adenoid cystic carcinoma, acute myelogenous leukemia (AML), breast carcinoma, pediatric T-cell acute lymphoblastic leukemia, neuroblastoma, mast cell leukemia, angiosarcoma, anaplastic large cell lymphoma, endometrial carcinoma, and prostate carcinoma..
摘要翻译：由式（I）表示的化合物或其药学上可接受的盐或N-氧化物，其中A，Q，Y，R 1，R 2和R 2 在本文中定义的可用于治疗肿瘤和癌症如肥大细胞增多症/肥大细胞白血病，胃肠道间质瘤（GIST），生殖细胞肿瘤，小细胞肺癌（SCLC），鼻窦自然杀伤/ T细胞淋巴瘤，睾丸癌（精原细胞瘤），甲状腺癌，恶性黑素瘤，卵巢癌，腺样囊性癌，急性骨髓性白血病（AML），乳腺癌，儿科T细胞急性淋巴细胞白血病，成神经细胞瘤，肥大细胞白血病，血管肉瘤，间变性大细胞淋巴瘤，子宫内膜癌和前列腺癌。

7. 发明申请

WO2006047574A1 (2-CARBOXAMIDO)(3-AMINO) THIOPHENE COMPOUNDS 审中-公开
标题翻译：（2-羧基甲酰胺）（3-氨基）噻吩化合物
公开(公告)号：WO2006047574A1
公开(公告)日：2006-05-04
申请号：PCT/US2005/038520
申请日：2005-10-25
申请人： OSI PHARMACEUTICALS, INC. , BLOXHAM, Jason , CREW, Andrew , HONDA, Ayako , LI, An-hu , PANICKER, Bijoy , TARDIBONO, Lawrence , WYNNE, Graham
发明人： BLOXHAM, Jason , CREW, Andrew , HONDA, Ayako , LI, An-hu , PANICKER, Bijoy , TARDIBONO, Lawrence , WYNNE, Graham
IPC分类号： C07D409/12 , C07D409/14 , A61K31/47 , A61P35/00
CPC分类号： A61K31/381 , A61K31/437 , A61K31/4436 , A61K31/4709 , A61K31/4745 , A61K45/06 , C07D409/12 , C07D409/14 , C07D471/04 , A61K2300/00
摘要： Amidoaryl/amidoheteroaryl substituted thiophenes, further substituted with a heteroarylmethylamino group, are useful in the treatment of cancer.
摘要翻译：进一步被杂芳基甲基氨基取代的酰胺芳基/酰胺基芳基取代的噻吩可用于治疗癌症。

8. 发明申请

WO2011016863A2 METHODS AND USES OF CYTOCHROME P450 INHIBITORS 审中-公开
标题翻译：细胞色素P450抑制剂的方法和用途
公开(公告)号：WO2011016863A2
公开(公告)日：2011-02-10
申请号：PCT/US2010/002175
申请日：2010-08-05
申请人： ANGION BIOMEDICA CORP. , OEHLEN, Lambertus, J., W., M. , PANICKER, Bijoy
发明人： OEHLEN, Lambertus, J., W., M. , PANICKER, Bijoy
IPC分类号： A61K31/4164 , A61K31/4192 , A61K31/4196 , A61K31/045 , A61P11/00
CPC分类号： A61K31/4172 , A61K31/045 , A61K31/4164 , A61K31/4192 , A61K31/4196
摘要： Methods are provided for treating or preventing chronic obstructive pulmonary diseases such as emphysema, and fibrotic diseases including heart, liver, kidney and vascular diseases, by administering to a subject a pharmaceutical composition comprising a compound that inhibits cytochrome P450RA or CYP26.
摘要翻译：通过向受试者施用包含抑制细胞色素P450RA或CYP26的化合物的药物组合物，提供治疗或预防慢性阻塞性肺疾病如肺气肿和包括心脏，肝脏，肾脏和血管疾病在内的纤维化疾病的方法。

9. 发明申请

WO2011002520A2 SMALL MOLECULE INHIBITORS OF PARP ACTIVITY 审中-公开
标题翻译：小分子PARP活性分子抑制剂
公开(公告)号：WO2011002520A2
公开(公告)日：2011-01-06
申请号：PCT/US2010/001893
申请日：2010-07-02
申请人： ANGION BIOMEDICA CORP. , PANICKER, Bijoy , LIM, Dong, Sung , SMITH, David, E.
发明人： PANICKER, Bijoy , LIM, Dong, Sung , SMITH, David, E.
IPC分类号： C07D403/04 , A61K31/4184 , A61P21/00
CPC分类号： C07D403/04 , C07D401/04
摘要： Componds and pharmaceutical compositions are provided that inhibit the activity of poly ADP- ribose synthetase (PARP). Such compounds are useful in the treatment of various diseases, conditions and injuries such as stroke, myocardial infarction, ischemia-perfusion injury in various organs, traumatic brain injury, atherosclerosis, inflammatory diseases and cancer.
摘要翻译：提供了抑制多聚ADP-核糖合成酶（PARP）活性的化合物和药物组合物。这类化合物可用于治疗各种疾病，病症和损伤，例如中风，心肌梗塞，各种器官的缺血灌注损伤，创伤性脑损伤，动脉粥样硬化，炎性疾病和癌症。

10. 发明申请

WO2010005580A2 METHODS AND COMPOSITIONS OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY 审中-公开
标题翻译：细胞生长因子（散射因子）活性的小分子调节剂的方法和组成
公开(公告)号：WO2010005580A2
公开(公告)日：2010-01-14
申请号：PCT/US2009/004014
申请日：2009-07-09
申请人： ANGION BIOMEDICA CORP. , CAI, Weizhong , NARAYAN, Prakash , PANICKER, Bijoy , SMITH, David, E.
发明人： CAI, Weizhong , NARAYAN, Prakash , PANICKER, Bijoy , SMITH, David, E.
IPC分类号： A61K31/415 , A61K47/34 , A61K31/4155 , A61P1/16 , A61P25/28
CPC分类号： C07D409/14 , A61K9/0019 , A61K9/145 , A61K9/146 , A61K9/1652 , A61K9/19 , A61K9/4866 , A61K31/415 , A61K31/4155 , C07D231/12 , C07D405/06 , C07D405/14 , C07D409/06
摘要： The present invention provides compositions and formulations of compounds having formula (I) and pharmaceutically acceptable derivatives thereof, wherein p, R 1 , R 2 and B are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of injuries, conditions or diseases in which HGF/SF or the activities thereof, or agonists or antagonists thereof have a therapeutically useful role. In addition, methods are provided for treating such diseases or diseases starting at a time after the onset of the injury, condition or disease.
摘要翻译：本发明提供具有式（I）的化合物及其药学上可接受的衍生物的组合物和制剂，其中p，R 1，R 2和B如本文中一般和本领域和亚类所述，并且另外提供其药物组合物，以及用于其用于治疗HGF / SF或其活性或其激动剂或拮抗剂具有治疗有用作用的许多损伤，病症或疾病中的任何一种。此外，提供了用于治疗在损伤，病症或疾病发作后的时间开始的这些疾病或疾病的方法。

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