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1. 发明申请

WO2008119765A1 METHOD OF NUCLEIC ACID ANALYSIS TO ANALYZE THE METHYLATION PATTERN OF CPG ISLANDS IN DIFFERENT SAMPLES 审中-公开
标题翻译：核酸分析方法分析不同样品中CPG岛的甲基化模式
公开(公告)号：WO2008119765A1
公开(公告)日：2008-10-09
申请号：PCT/EP2008/053748
申请日：2008-03-28
申请人： ORYZON GENOMICS, S.A. , MAES, Tamara , DURANY TURK, Olga , AIBAR DURÁN, Elena
发明人： MAES, Tamara , DURANY TURK, Olga , AIBAR DURÁN, Elena
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6855 , C12Q1/6809 , C12Q1/6827 , C12Q2521/331 , C12Q2525/143 , C12Q2525/191
摘要： Methods and kits are disclosed for determining the methylation of nucleic acids. The methods and kits can be used for the diagnosis and prognosis of diseases. The method and kits can be used to identify biomarkers. The method and kits relate to fragmenting a nucleic acid sample, ligating adaptors to the ends of the nucleic fragments obtained, amplifying the fragments that include both adaptors using specific primers based on the adaptors, labeling of the amplified fragments by in vitro transcription and determining the methylation state of the sample.
摘要翻译：公开了用于确定核酸甲基化的方法和试剂盒。方法和试剂盒可用于疾病的诊断和预后。该方法和试剂盒可用于鉴定生物标志物。该方法和试剂盒涉及将核酸样品碎裂，将获得的核酸片段的末端连接到衔接子上，使用基于衔接子的特异性引物扩增包括两个衔接子的片段，通过体外转录标记扩增片段并确定样品的甲基化状态。

2. 发明申请

WO2010063754A1 PROCEDURE FOR THE DIAGNOSIS OR PROGNOSIS OF LUNG CANCER AND A KIT FOR PERFORMING SAID PROCEDURE 审中-公开
标题翻译：肺癌诊断或预防程序及实施程序的工具包
公开(公告)号：WO2010063754A1
公开(公告)日：2010-06-10
申请号：PCT/EP2009/066218
申请日：2009-12-02
申请人： ONCNOSIS PHARMA AIE , MAES, Tamara , AIBAR DURÁN, Elena , DURANY TURK, Olga , MONTUENGA BADÍA, Luís , PÍO OSÉS, Rubén , BLANCO BARRENECHEA, David , PAJARES VILLANDIEGO, María José
发明人： MAES, Tamara , AIBAR DURÁN, Elena , DURANY TURK, Olga , MONTUENGA BADÍA, Luís , PÍO OSÉS, Rubén , BLANCO BARRENECHEA, David , PAJARES VILLANDIEGO, María José
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6809 , C12Q1/6886 , C12Q2600/158
摘要： Said procedure comprises determining the amount of the CEACAM1 -1 isoform in a sample isolated from an individual, where said isoform contains, consecutively, exons 1, 2 and 6 of the gene encoding for CEACAM1; so that if the amount of said isoform is greater than that determined in a control sample, this is indicative that the individual has developed the disease, risks developing it or has a bad prognosis. The present invention also refers to a kit to carry out the diagnosis and/or prognosis procedure comprising suitable means for determining the amount of the CEACAM1 -1 isoform present in the sample to be analysed Advantageously, with procedure and kit based on the detection of CEACAM1 - 1 it is achieved a better precision in the diagnosis and patient's condition.
摘要翻译：所述方法包括确定从个体分离的样品中的CEACAM1-1同种型的量，其中所述同种型连续地包含编码CEACAM1的基因的外显子1,2和6; 所以如果所述异构体的量大于对照样品中所测定的量，则这表明个体已经发展出疾病，发展中的风险或预后不良。本发明还涉及用于实施诊断和/或预后程序的试剂盒，其包括用于确定待分析样品中存在的CEACAM1-1同种型的量的合适方法有利的是，使用基于CEACAM1检测的程序和试剂盒 - 1在诊断和患者状况方面实现更好的准确性。

3. 发明申请

WO2008119767A2 METHOD OF NUCLEIC ACID ANALYSIS. 审中-公开
标题翻译：核酸分析方法。
公开(公告)号：WO2008119767A2
公开(公告)日：2008-10-09
申请号：PCT/EP2008/053752
申请日：2008-03-28
申请人： ORYZON GENOMICS, S. A. , MAES, Tamara , DURANY TURK, Olga , AIBAR DURÁN, Elena
发明人： MAES, Tamara , DURANY TURK, Olga , AIBAR DURÁN, Elena
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886
摘要： Method of nucleic acid analysis comprising the stages of synthesis of a first complementary DNA strand from a messenger RNA using compound primers, synthesis of a second DNA strand, labeling by in vitro transcription of an RNA polymerase, and determination of the presence of splicing events in the sample.The said invention has application, for example, in analyzing differential splicing events and in diagnosing diseases.
摘要翻译：使用化合物引物合成来自信使RNA的第一互补DNA链的步骤的核酸分析方法，第二DNA链的合成，RNA聚合酶的体外转录标记和剪接事件的存在的确定所述发明例如用于分析差分拼接事件和诊断疾病中的应用。

4. 发明申请

WO2006134185A1 MÉTODO PARA DIAGNOSTICAR LA ENFERMEDAD DE ALZHEIMER 审中-公开
标题翻译：阿尔茨海默病诊断方法
公开(公告)号：WO2006134185A1
公开(公告)日：2006-12-21
申请号：PCT/ES2006/000255
申请日：2006-05-17
申请人： LABORATORIOS INDAS, S.A. , FERRER ABIZANDA, Isidro , BARRACHINA CASTILLO, Marta , SUBIRADA SOLÉ, Francisco , DURANY TURK, Olga, María , BUESA ARJOL, Carlos, Manuel , MAES, Tamara
发明人： FERRER ABIZANDA, Isidro , BARRACHINA CASTILLO, Marta , SUBIRADA SOLÉ, Francisco , DURANY TURK, Olga, María , BUESA ARJOL, Carlos, Manuel , MAES, Tamara
IPC分类号： C07K14/705
CPC分类号： G01N33/6896 , C07K14/4711 , C12Q1/6883 , C12Q2600/112 , C12Q2600/158 , G01N2800/2821
摘要： La presente invención se refiere a un método para diagnosticar y/o pronosticar la enfermedad de Alzheimer mediante la determinación del nivel de expresión de un gen que codifica un marcador lisosomal.
摘要翻译：本发明涉及一种用于诊断和/或预后阿尔茨海默病的方法，其包括测定编码溶酶体标记物的基因的表达水平。

5. 发明申请

WO2012107499A1 LYSINE DEMETHYLASE INHIBITORS FOR MYELOPROLIFERATIVE OR LYMPHOPROLIFERATIVE DISEASES OR DISORDERS 审中-公开
标题翻译：赖氨酸脱乙酰酶抑制剂用于放射性免疫抑制剂或淋巴细胞增生性疾病或疾病
公开(公告)号：WO2012107499A1
公开(公告)日：2012-08-16
申请号：PCT/EP2012/052145
申请日：2012-02-08
申请人： ORYZON GENOMICS S.A. , FYFE, Matthew Colin Thor , MAES, Tamara , MARTINELL PEDEMONTE, Marc , TIRAPU FERNÁNDEZ DE LA CUESTA, Iñigo
发明人： FYFE, Matthew Colin Thor , MAES, Tamara , MARTINELL PEDEMONTE, Marc , TIRAPU FERNÁNDEZ DE LA CUESTA, Iñigo
IPC分类号： A61K31/135 , A61P35/02
CPC分类号： A61K31/495 , A61K31/00 , A61K31/135 , A61K31/145 , A61K31/164 , A61K31/165 , A61K31/40 , A61K31/44 , A61K31/4965 , A61K45/06 , C07C215/64 , C07C237/20 , C07C311/13 , C07D207/14 , C07D213/38 , C07D241/04
摘要： The present invention relates to methods and compositions for the treatment or prevention of diseases and disorder associated with myeloproliferative and lymphoproliferative disorders. In particular, the invention relates to an LSD1 inhibitor for use in treating or preventing diseases and disorder associated with myeloproliferative and lymphoproliferative disorders.
摘要翻译：本发明涉及用于治疗或预防与骨髓增生和淋巴组织增生性疾病相关的疾病和病症的方法和组合物。特别地，本发明涉及用于治疗或预防与骨髓增生和淋巴组织增生性疾病相关的疾病和病症的LSD1抑制剂。

6. 发明申请

WO2009115313A1 METHOD AND COMPOSITION FOR METHYLATION ANALYSIS 审中-公开
标题翻译：甲基化分析方法与组合
公开(公告)号：WO2009115313A1
公开(公告)日：2009-09-24
申请号：PCT/EP2009/002003
申请日：2009-03-18
申请人： ORYZON GENOMICS, S.A. , MAES, Tamara , DURANNY-TURK, Olga , AIBAR-DURAN, Elena
发明人： MAES, Tamara , DURANNY-TURK, Olga , AIBAR-DURAN, Elena
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827 , C12Q2565/501 , C12Q2525/191
摘要： Described are methods and compositions useful to detect DNA methylation for, e.g., characterizing the methylation status or methylation profile of DNA. The methods can be used to examine the methylation status/profile of a specific promoter/CpG island and/or a plurality of promoters/CpG islands. The compositions can be used to assess the DNA methylation of genomic DNA. The methods are useful in various applications including the diagnosis and prognosis of diseases having altered DNA methylation patterns or for biomarker discovery. The invention can be used to identify specific biomarkers associated with phenotypes and for establishing methylation fingerprints (e.g., patterns, status, profiles, or the methylome). Methylation patterns, status, profiles, and the methylome as determined by the methods can be associated with phenotypes (prognosis, diagnosis, response to therapeutics, etc.). The methods and compositions are further useful for determining genome-wide methylation patterns.
摘要翻译：描述了可用于检测DNA甲基化以用于例如表征DNA的甲基化状态或甲基化分布的方法和组合物。该方法可用于检查特异性启动子/ CpG岛和/或多个启动子/ CpG岛的甲基化状态/谱。该组合物可用于评估基因组DNA的DNA甲基化。该方法可用于各种应用，包括具有改变的DNA甲基化模式或用于生物标志物发现的疾病的诊断和预后。本发明可用于鉴定与表型相关的特异性生物标志物和用于建立甲基化指纹（例如，模式，状态，谱或甲基化）。通过方法测定的甲基化模式，状态，特征和甲基化可以与表型（预后，诊断，对治疗的反应等）相关。方法和组合物进一步用于确定全基因组甲基化模式。

7. 发明申请

WO2005100594A1 A METHOD FOR SELECTIVELY DETECTING SUBSETS OF NUCLEIC ACID MOLECULES 审中-公开
标题翻译：一种选择性检测核酸分子的方法
公开(公告)号：WO2005100594A1
公开(公告)日：2005-10-27
申请号：PCT/EP2005/003787
申请日：2005-04-14
申请人： ORYZON GENOMICS, S.A. , MAES, Tamara , HAMPSON, Richard , BENITO AMENGUAL, Maria del Mar
发明人： MAES, Tamara , HAMPSON, Richard , BENITO AMENGUAL, Maria del Mar
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6809 , C12Q1/6827 , C12Q2525/186 , C12Q2521/514 , C12Q2521/307
摘要： Method for selectively detecting nucleic acid molecules comprising structural aberrations that are capable of being converted into nicks comprising generating linear nucleic acids from a selected nucleic acid substrate population; denaturing and re-annealing the linear nucleic acids to form nucleic acid duplexes; masking the nucleic acid duplex termini and internal structural aberrations with a masking component; modifying the masked nucleic acids by introducing nicks therein using at least an enzyme possessing endonuclease activity;labelling the modified nucleic acids with labelled nucleotides via nucleic acid nick translation with at least an enzyme displaying a nucleic acid polymerase activity; and selecting and identifying the labelled nucleic acid.
摘要翻译：用于选择性检测核酸分子的方法，所述核酸分子包含能够转化成缺口的结构畸变，包括从选定的核酸底物群体产生线性核酸; 使线性核酸变性并重新退火以形成核酸双链体; 用掩蔽组分掩蔽核酸双链体末端和内部结构畸变; 通过使用至少一种具有核酸内切酶活性的酶在其中引入缺口来修饰所述掩蔽的核酸;用至少一种显示核酸聚合酶活性的酶的核酸切口平移标记经标记的核苷酸的经修饰的核酸; 并选择和鉴定标记的核酸。

8. 发明申请

WO2012156531A2 LYSINE DEMETHYLASE INHIBITORS FOR INFLAMMATORY DISEASES OR CONDITIONS 审中-公开
标题翻译：用于炎症性疾病或病症的赖氨酸脱乙酰酶抑制剂
公开(公告)号：WO2012156531A2
公开(公告)日：2012-11-22
申请号：PCT/EP2012/059377
申请日：2012-05-21
申请人： ORYZON GENOMICS, S.A. , MAES, Tamara , MARTINELL PEDEMONTE, Marc , CASTRO-PALOMINO LARIA, Julio César
发明人： MAES, Tamara , MARTINELL PEDEMONTE, Marc , CASTRO-PALOMINO LARIA, Julio César
IPC分类号： A61K31/135 , A61K31/165 , A61K31/18 , A61K31/40 , A61K31/44 , A61K31/495 , A61P7/02
CPC分类号： C07D295/192 , A61K31/135 , A61K31/165 , A61K31/18 , A61K31/40 , A61K31/44 , A61K31/4418 , A61K31/495 , A61K45/06 , C07C215/64 , C07C237/06 , C07C311/08 , C07D207/14 , C07D213/38
摘要： The invention relates to methods and compositions for the treatment or prevention of inflammation and inflammatory diseases or conditions. In particular, the invention relates to an LSD l inhibitor for use in treating or preventing inflammation and inflammatory diseases or conditions.
摘要翻译：本发明涉及用于治疗或预防炎症和炎性疾病或病症的方法和组合物。特别地，本发明涉及用于治疗或预防炎症和炎性疾病或病症的LSD1抑制剂。

9. 发明申请

WO2012107498A1 LYSINE DEMETHYLASE INHIBITORS FOR MYELOPROLIFERATIVE DISORDERS 审中-公开
标题翻译：赖氨酸二甲酯酶抑制剂对骨髓增生异常的治疗作用
公开(公告)号：WO2012107498A1
公开(公告)日：2012-08-16
申请号：PCT/EP2012/052144
申请日：2012-02-08
申请人： ORYZON GENOMICS S.A. , BAKER, Jonathan, Alleman , CASTRO PALOMINO, Julio , FYFE, Matthew, Colin, Thor , MAES, Tamara , MARTINELL PEDEMONTE, Marc
发明人： BAKER, Jonathan, Alleman , CASTRO PALOMINO, Julio , FYFE, Matthew, Colin, Thor , MAES, Tamara , MARTINELL PEDEMONTE, Marc
IPC分类号： A61K31/135 , A61P35/02
CPC分类号： C07D295/195 , A61K31/00 , A61K31/131 , A61K31/135 , A61K31/138 , A61K31/15 , A61K31/164 , A61K31/18 , A61K31/40 , A61K31/4418 , A61K31/495 , A61K45/06 , C07D207/14 , C07D213/38
摘要： The invention relates to methods and compositions for the treatment or prevention of diseases and disorders associated with myeloproliferative disorders. In particular, the invention relates to an LSD 1 inhibitor for use in treating or preventing Philadelphia chromosome negative myeloproliferative disorders.
摘要翻译：本发明涉及用于治疗或预防与骨髓增殖性疾病相关的疾病和病症的方法和组合物。具体而言，本发明涉及用于治疗或预防费城染色体阴性骨髓增殖性疾病的LSD1抑制剂。

10. 发明申请

WO2007104816A2 MÉTODO DE ANÁLISIS DE ÁCIDOS NUCLEICOS 审中-公开
标题翻译：分析核酸的方法
公开(公告)号：WO2007104816A2
公开(公告)日：2007-09-20
申请号：PCT/ES2007/000146
申请日：2007-03-13
申请人： ORYZON GENOMICS, S.A. , MAES, Tamara , AIBAR DURAN, Elena
发明人： MAES, Tamara , AIBAR DURAN, Elena
IPC分类号： C12Q1/68
CPC分类号： C12Q1/683 , C12Q1/6855 , C12Q2565/501 , C12Q2525/143 , C12Q2521/301
摘要： Método de análisis de ácidos nucleicos, que comprende las etapas de fraccionamiento del ácido nucleico, ligación de adaptadores y amplificación del ácido nucleico y una etapa de transcripción in vitro. Dicha invención tiene aplicación en el campo del análisis genómico de organismos mediante el uso de micromatrices de ADN.
摘要翻译：分析核酸的方法，其包括分离核酸，结合衔接子和扩增核酸以及体外转录步骤的步骤。所述发明通过使用DNA微阵列应用于生物体的基因组分析领域。

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