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1. 发明申请

WO2009120300A3 METHOD OF TREATING DEGENERATIVE DISEASES 审中-公开
标题翻译：治疗退行性疾病的方法
公开(公告)号：WO2009120300A3
公开(公告)日：2009-11-26
申请号：PCT/US2009001813
申请日：2009-03-24
申请人： ORTHOLOGIC CORP , CARNEY DARRELL H , STEER RANDOLPH C
发明人： CARNEY DARRELL H , STEER RANDOLPH C
IPC分类号： A61K38/48 , A61P17/00 , A61P25/16 , A61P25/28 , A61P27/06
CPC分类号： A61K38/4833
摘要： Agonists of a non-proteolytically activated receptor can be used in methods for treating a disease or disorder in a subject. The methods comprise administering to the subject a therapeutically effective amount of an agonist, wherein the disease or disorder is scleroderma, macular degeneration, diabetic retinopathy, Huntington's disease, Parkinson's disease, closed head trauma, glaucoma, optic neuritis or allograft vasculopathy.
摘要翻译：非蛋白水解活化受体的激动剂可用于治疗受试者的疾病或病症的方法。所述方法包括向受试者施用治疗有效量的激动剂，其中所述疾病或病症是硬皮病，黄斑变性，糖尿病性视网膜病变，亨廷顿舞蹈病，帕金森病，闭合性头部创伤，青光眼，视神经炎或同种异体移植血管病变。

2. 发明申请

WO2008036387A3 METHOD OF TREATING ENDOTHELIAL DYSFUNCTION 审中-公开
标题翻译：治疗内皮功能障碍的方法
公开(公告)号：WO2008036387A3
公开(公告)日：2008-12-04
申请号：PCT/US2007020445
申请日：2007-09-21
申请人： ORTHOLOGIC CORP , TEXAS A & M UNIV SYS , CARNEY DARRELL H , OLSZEWSKA-PAZDRAK BARBARA , FOSSUM THERESA W
发明人： CARNEY DARRELL H , OLSZEWSKA-PAZDRAK BARBARA , FOSSUM THERESA W
IPC分类号： A61K38/48 , A61P9/08 , A61P9/10 , C12N9/74
CPC分类号： A61K38/10 , A61K38/16 , A61K38/18 , A61K38/4833 , C12N9/6429 , C12Y304/21005
摘要： Endothelial dysfunction (ED) is associated with a number of diseases and disorders. Agonists of the non-proteolytically activated thrombin receptor can be used in methods to treat ED or ED-related diseases and disorders.
摘要翻译：内皮功能障碍（ED）与许多疾病和病症有关。非蛋白水解活化凝血酶受体的激动剂可用于治疗ED或ED相关疾病和病症的方法。

3. 发明申请

WO2008036387A8 METHOD OF TREATING ENDOTHELIAL DYSFUNCTION 审中-公开
标题翻译：治疗内皮功能障碍的方法
公开(公告)号：WO2008036387A8
公开(公告)日：2008-06-26
申请号：PCT/US2007020445
申请日：2007-09-21
申请人： ORTHOLOGIC CORP , TEXAS A & M UNIV SYS , CARNEY DARRELL H , OLSZEWSKA-PAZDRAK BARBARA , FOSSUM THERESA W
发明人： CARNEY DARRELL H , OLSZEWSKA-PAZDRAK BARBARA , FOSSUM THERESA W
IPC分类号： A61K38/36 , A61K39/395 , A61P3/10 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/06 , A61P13/12 , A61P15/10 , A61P19/02 , A61P29/00 , A61P39/00
CPC分类号： A61K38/10 , A61K38/16 , A61K38/18 , A61K38/4833 , C12N9/6429 , C12Y304/21005
摘要： Endothelial dysfunction (ED) is associated with a number of diseases and disorders. Agonists of the non-proteolytically activated thrombin receptor can be used in methods to treat ED or ED-related diseases and disorders.
摘要翻译：内皮功能障碍（ED）与许多疾病和病症有关。非蛋白水解活化的凝血酶受体的激动剂可用于治疗ED或ED相关疾病和病症的方法中。

4. 发明申请

WO2009120307A3 METHOD OF TREATING PERIPHERAL ARTERIAL DISEASE 审中-公开
标题翻译：治疗周围动脉疾病的方法
公开(公告)号：WO2009120307A3
公开(公告)日：2009-11-19
申请号：PCT/US2009001822
申请日：2009-03-24
申请人： ORTHOLOGIC CORP , TEXAS A & M UNIV SYS , CARNEY DARRELL H , OLSZEWSKA-PAZDRAK BARBARA , FOSSUM THERESA W
发明人： CARNEY DARRELL H , OLSZEWSKA-PAZDRAK BARBARA , FOSSUM THERESA W
IPC分类号： A61K38/04 , A61K38/16 , A61P9/10
CPC分类号： A61K38/04 , A61K38/16
摘要： An agonist of a non-proteolytically activated thrombin receptor can be used in a method for treating peripheral arterial disease. The agonist can be a thrombin peptide derivative. In some embodiments, the peripheral arterial disease is characterized by intermittent claudication. The thrombin peptide derivatives to be used in the methods can have amino acid sequences similar to a region of thrombin. Usually, the thrombin peptide derivatives are 12-23 amino acid residues in length. In some cases, the thrombin peptide derivatives are dimers, and in particular, dimers that result from formation of a disulfide bond between two cysteine residues of peptide monomers.
摘要翻译：非蛋白水解活化的凝血酶受体激动剂可用于治疗外周动脉疾病的方法中。激动剂可以是凝血酶肽衍生物。在一些实施方案中，外周动脉疾病的特征在于间歇性跛行。用于该方法的凝血酶肽衍生物可具有与凝血酶区域相似的氨基酸序列。通常，凝血酶肽衍生物的长度为12-23个氨基酸残基。在一些情况下，凝血酶肽衍生物是二聚体，特别是由肽单体的两个半胱氨酸残基之间形成二硫键而产生的二聚体。

5. 发明申请

WO2004014937A3 THROMBIN PEPTIDE DERIVATIVES 审中-公开
标题翻译：脑啡肽衍生物
公开(公告)号：WO2004014937A3
公开(公告)日：2005-02-17
申请号：PCT/US0320635
申请日：2003-07-01
申请人： UNIV TEXAS , CARNEY DARRELL H
发明人： CARNEY DARRELL H
IPC分类号： A61K38/00 , A61K38/48 , C07K20060101 , C12N9/74
CPC分类号： C12N9/6429 , A61K38/00 , C12Y304/21005
摘要： Disclosed are thrombin peptide derivatives comprising a polypeptide having the amino acid sequence SEQ ID NO. 2: Arg-Gly-Asp-Ala-Xaa-Gly-Asp-Ser-Gly-Gly-Pro-Phe-Val, or a C-terminal truncated fragment of the polypeptide having at least six amino acids. Xaa is alanine, glycine, serine, or an S-protected cysteine. Zero, one, two, or three amino acids in the polypeptide or polypeptide fragment differ from the corresponding position of SEQ ID NO. 2. Also disclosed are methods of treating a subject in need of treatment with a thrombin receptor agonist. The methods comprise the step of administering an effective amount of the thrombin peptide derivative described above.
摘要翻译：公开了包含具有氨基酸序列SEQ ID NO.1的多肽的凝血酶肽衍生物。 2：Arg-Gly-Asp-Ala-Xaa-Gly-Asp-Ser-Gly-Gly-Pro-Phe-Val或具有至少6个氨基酸的多肽的C末端截短的片段。 Xaa是丙氨酸，甘氨酸，丝氨酸或S-保护的半胱氨酸。多肽或多肽片段中的一个，一个，两个或三个氨基酸不同于SEQ ID NO：还公开了治疗需要用凝血酶受体激动剂治疗的受试者的方法。所述方法包括施用有效量的上述凝血酶肽衍生物的步骤。

6. 发明申请

WO2004005317A3 THROMBIN PEPTIDE DERIVATIVE DIMERS 审中-公开
标题翻译：凝血酶肽衍生物二聚体
公开(公告)号：WO2004005317A3
公开(公告)日：2004-09-30
申请号：PCT/US0320626
申请日：2003-07-01
申请人： UNIV TEXAS , CARNEY DARRELL H
发明人： CARNEY DARRELL H
IPC分类号： C12N9/74 , C07K5/00 , A61K38/00 , A61K38/16 , C07K5/10
CPC分类号： C12N9/6429 , A61K38/00 , C12Y304/21005
摘要： Disclosed are thrombin peptide derivative dimers comprising two polypeptides having the amino acid sequence SEQ ID NO. 2: Arg-Gly-Asp-Ala-Cys-Glu-Gly-Asp-Ser-Gly-Gly-Pro-Phe-Val, or a C-terminal truncated fragment of the polypeptide having at least six amino acids. Zero, one, two, or three amino acids in the polypeptide or polypeptide fragment differ from the corresponding position of SEQ ID NO. 2. Also disclosed are methods of treating a subject in need of treatment with a thrombin receptor agonist. The methods comprise the step of administering an effective amount of the thrombin peptide derivative described above.
摘要翻译：公开了包含两种具有氨基酸序列SEQ ID NO.2的多肽的凝血酶肽衍生物二聚体。 2：Arg-Gly-Asp-Ala-Cys-Glu-Gly-Asp-Ser-Gly-Gly-Pro-Phe-Val或具有至少六个氨基酸的多肽的C-末端截短片段。多肽或多肽片段中的零个，一个，两个或三个氨基酸不同于SEQ ID NO.1的相应位置。还公开了治疗需要用凝血酶受体激动剂治疗的受试者的方法。该方法包括施用有效量的上述凝血酶肽衍生物的步骤。

7. 发明申请

WO0207748A3 STIMULATION OF CARTILAGE GROWTH WITH AGONISTS OF THE NON-PROTEOLYTICALLY ACTIVATED THROMBIN RECEPTOR 审中-公开
标题翻译：使用非保守激活的硫蛋白受体激动剂刺激生长
公开(公告)号：WO0207748A3
公开(公告)日：2002-09-12
申请号：PCT/US0122668
申请日：2001-07-19
申请人： UNIV TEXAS , CARNEY DARRELL H , CROWTHER ROGER S , STIERNBERG JANET , BERGMANN JOHN
发明人： CARNEY DARRELL H , CROWTHER ROGER S , STIERNBERG JANET , BERGMANN JOHN
IPC分类号： C12N9/74 , A61K35/32 , A61K38/00 , A61K38/17 , A61K38/46 , A61K38/48 , A61K45/00 , A61K47/34 , A61L27/00 , A61L27/18 , A61L27/22 , A61L27/54 , A61P17/02 , A61P19/00 , A61P19/02 , A61P19/08 , A61P43/00 , C12N5/06 , C12N15/00 , A61L27/14 , A61L27/38 , C12N5/08
CPC分类号： A61K38/4833 , A61K38/465 , A61L27/18 , A61L27/227 , A61L27/54 , A61L2300/25 , A61L2300/252 , A61L2300/40 , A61L2300/412 , A61L2430/06 , C08L67/04
摘要： Disclosed is a method of stimulating cartilage growth, repair or regeneration at a site in a subject in need of such growth, repair or regeneration. The method comprises the step of administering a therapeutically effective amount of an agonist of the non-proteolytically activated thrombin receptor to the site. Also disclosed is a method of stimulating the proliferation and expansion of chrondrocytes in vitro. The method comprises culturing chrondrocytes in the presence of a stimulating amount of an NPAR agonist.
摘要翻译：公开了一种在需要这种生长，修复或再生的受试者的部位刺激软骨生长，修复或再生的方法。该方法包括向该部位施用治疗有效量的非蛋白水解活化的凝血酶受体激动剂的步骤。还公开了一种在体外刺激软骨细胞的增殖和扩增的方法。该方法包括在刺激量的NPAR激动剂存在下培养软骨细胞。

8. 发明申请

WO2010033862A3 METHODS FOR TREATING CANCER USING NPAR AGONISTS 审中-公开
标题翻译：使用NPAR激动剂治疗癌症的方法
公开(公告)号：WO2010033862A3
公开(公告)日：2010-08-19
申请号：PCT/US2009057571
申请日：2009-09-18
申请人： UNIV TEXAS , CARNEY DARRELL H
发明人： CARNEY DARRELL H
IPC分类号： A61K38/19 , A61K38/48 , A61P35/00
CPC分类号： A61K38/4833
摘要： The present invention includes methods of treating cancer in a subject, comprising administering to the subject a therapeutically effective amount of a non-proteolytically activated thrombin receptor agonist.
摘要翻译：本发明包括治疗受试者的癌症的方法，包括向受试者施用治疗有效量的非蛋白水解活化的凝血酶受体激动剂。

9. 发明申请

WO0205836A3 STIMULATION OF BONE GROWTH WITH THROMBIN PEPTIDE DERIVATIVES 审中-公开
标题翻译：刺激骨髓增生与硫蛋白肽衍生物
公开(公告)号：WO0205836A3
公开(公告)日：2002-12-19
申请号：PCT/US0122641
申请日：2001-07-18
申请人： UNIV TEXAS , CARNEY DARRELL H , CROWTHER ROGER S , SIMMONS DAVID J , YANG JINPING , REDIN WILLIAM R
发明人： CARNEY DARRELL H , CROWTHER ROGER S , SIMMONS DAVID J , YANG JINPING , REDIN WILLIAM R
IPC分类号： A61L27/00 , A61K38/00 , A61K38/10 , A61K38/16 , A61K38/18 , A61K38/46 , A61K38/48 , A61K45/00 , A61K47/04 , A61K47/34 , A61K47/42 , A61P19/00 , C12N9/74 , C12N9/76 , A61L27/12 , A61L27/14 , A61L27/46 , A61L27/50
CPC分类号： A61K38/10 , A61K38/16 , A61K38/4833 , A61L2430/02
摘要： Disclosed is a method of stimulation bone growth at a site in a subject in need of osteoinduction. The method comprises the step of administering a therapeutically effective amount of an agonist of the non-proteolytically activated thrombin receptor to the site.
摘要翻译：公开了在需要骨诱导的受试者的部位刺激骨生长的方法。该方法包括向该部位施用治疗有效量的非蛋白水解活化的凝血酶受体激动剂的步骤。

10. 发明申请

WO2008124173A8 COMBINATION THERAPY FOR CARDIAC REVASCULARIZATION AND CARDIAC REPAIR 审中-公开
标题翻译：心脏康复和心脏修复的组合治疗
公开(公告)号：WO2008124173A8
公开(公告)日：2008-12-24
申请号：PCT/US2008004612
申请日：2008-04-10
申请人： UNIV TEXAS , OLSZEWSKA-PAZDRAK BARBARA , CARNEY DARRELL H
发明人： OLSZEWSKA-PAZDRAK BARBARA , CARNEY DARRELL H
IPC分类号： A61K38/19 , A61K38/48 , A61P9/00
CPC分类号： A61K38/18 , A61K38/19 , A61K38/4833 , A61K2300/00
摘要： An agonist of the non-proteolytically activated thrombin receptor and an angiogenic growth factor can be used in combination in methods of therapy to stimulate cardiac revascularization, to stimulate vascular endothelial cell proliferation, to stimulate vascular endothelial cell migration and to promote repair of cardiac tissue.
摘要翻译：非蛋白水解活化凝血酶受体的激动剂和血管生成生长因子可以联合用于刺激心脏血运重建，刺激血管内皮细胞增殖，刺激血管内皮细胞迁移和促进心脏组织修复的治疗方法。

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