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1. 发明申请

WO0177294A3 HPV-SPECIFIC SHORT-MERS 审中-公开
标题翻译： HPV特异性短型
公开(公告)号：WO0177294A3
公开(公告)日：2002-04-04
申请号：PCT/US0140501
申请日：2001-04-11
申请人： ORIGENIX TECHNOLOGIES INC , IYER RADHAKRISHNAN , JIN YI , ZHOU WENQIANG , ROLAND ARLENE
发明人： IYER RADHAKRISHNAN , JIN YI , ZHOU WENQIANG , ROLAND ARLENE
IPC分类号： C12N15/09 , A61K31/7125 , A61K38/00 , A61K48/00 , A61P15/00 , A61P17/12 , A61P31/20 , A61P35/00 , C07K14/025 , A61K31/70 , C07H21/00
CPC分类号： C07K14/005 , A61K38/00 , C12N2710/20022
摘要： The invention provides oligonucleotides capable of inhibiting human papillomavirus (HPV) replication. More specifically, the invention provides oligonucleotides complementary to the translational start site of the HPV E1 open reading frame which inhibit HPV replication through interaction with a nucleic acid or a protein target. Oligonucleotides of the invention contain at least 4 deoxyribonucleotides and/or ribonucleotides and may include a variety of modifications to the internucleotide linkages or the mononucleotides. Furthermore, the invention provides pharmaceutical compositions and methods for treating disorders or diseases associated with HPV infection.
摘要翻译：本发明提供能够抑制人乳头状瘤病毒（HPV）复制的寡核苷酸。更具体地，本发明提供与HPV E1开放阅读框的翻译起始位点互补的寡核苷酸，其通过与核酸或蛋白质靶标的相互作用抑制HPV复制。本发明的寡核苷酸含有至少4个脱氧核糖核苷酸和/或核糖核苷酸，并且可以包括对核苷酸间键或单核苷酸的多种修饰。此外，本发明提供了用于治疗与HPV感染相关的疾病或疾病的药物组合物和方法。

2. 发明专利

CA2838875A1 CAMPTOTHECIN DERIVATIVE, METHOD FOR PREPARING SAME, PHARMACEUTICAL COMPOSITION AND USE THEREOF 未知
公开(公告)号：CA2838875A1
公开(公告)日：2013-01-03
申请号：CA2838875
申请日：2012-05-22
申请人： ZHOU WENQIANG
发明人： ZHOU WENQIANG
IPC分类号： C07F9/6561 , A61K31/675 , A61P35/00 , C07D491/22
摘要： The present invention relates to a camptothecin derivative having a structure as represented by Formula (II), in which Xn+ is selected among H+, K+, Na+, Li+, Mg2+, Ca2+, Zn2+, Fe3+, and ammonium, while R1, R2, R3, and R4 individually represent a hydrogen, a nitro group, a nitrile group, a halogen, a carboxyl group, an optionally substituted amino group, a substituted silicon group, a monocyclic aryloxy group, an optionally substituted C1-C6 alkoxy group, an optionally substituted C1-C6 alkylcarbonyl group, an optionally substituted C1-C6 alkyl group, or an optionally substituted C1-C6 cycloalkyl group; alternatively, R1 and R2 are connected via one to three other atoms to form a heterocyclic ring; and in another embodiment, R3 and R4 form a cyclic compound via -O-(CH2)n-O-, in which n = 1 or 2. The compound is provided with great aqueous solubility, compound stability, and great efficacy in treatment of cancer. [Formula (II)]

3. 发明专利

CA2838875C CAMPTOTHECIN DERIVATIVE, METHOD FOR PREPARING SAME, PHARMACEUTICAL COMPOSITION AND USE THEREOF 未知
公开(公告)号：CA2838875C
公开(公告)日：2016-06-21
申请号：CA2838875
申请日：2012-05-22
申请人： ZHOU WENQIANG
发明人： ZHOU WENQIANG
IPC分类号： C07F9/6561 , A61K31/675 , A61P35/00 , C07D491/22
摘要： The present invention relates to a camptothecin derivative having a structure as represented by Formula (II), in which X n+ is selected from H+, K+, Na+, Li+, Mg2+, Ca2+, Zn2+, Fe3+, and ammonium ion, while R1, R2, R3, and R4 independently represent a hydrogen, a hydroxyl group, a nitro group, a cyano group, a halogen, a carboxyl group, an optionally substituted amino group, a silicon-containing group, a monocyclic aryloxy group, an optionally substituted C1-C6 alkoxy group, an optionally substituted C1-C6 alkylcarbonyl group, an optionally substituted C1-C6 alkyl group, or an optionally substituted C3-C6 cycloalkyl group; alternatively, R1 and R2 are connected via one to three other atoms to form a heterocyclic ring; and in another embodiment, R3 and R4 are oxygen atoms and connected via -O-(CH2)n-O-, forming a ring, in which n = l or 2. The compound has great water-solubility, chemical stability, and great efficacy in treatment on cancer. (See formula II)

4. 发明专利

AU2012276175B2 Camptothecin derivative, method for preparing same, pharmaceutical composition and use thereof 未知
公开(公告)号：AU2012276175B2
公开(公告)日：2016-08-11
申请号：AU2012276175
申请日：2012-05-22
申请人： ZHOU WENQIANG
发明人： ZHOU WENQIANG , DENG JING
IPC分类号： C07F9/6561 , A61K31/675 , A61P35/00 , C07D491/22
摘要： The present invention relates to a camptothecin derivative having a structure as represented by Formula (II), in which X

5. 发明专利

ZA201309559B COMPTOTHECIN DERIVATIVE, METHOD FOR PREPARING SAME, PHARMACEUTICAL COMPOSITION AND USE THEREOF 未知
公开(公告)号：ZA201309559B
公开(公告)日：2014-08-27
申请号：ZA201309559
申请日：2013-12-18
申请人： ZHOU WENQIANG
发明人： ZHOU WENQIANG , DENG JING
IPC分类号： A61K20060101 , A61P20060101 , C07D20060101 , C07F20060101

6. 发明专利

AU2012276175A1 Camptothecin derivative, method for preparing same, pharmaceutical composition and use thereof 未知
公开(公告)号：AU2012276175A1
公开(公告)日：2014-01-09
申请号：AU2012276175
申请日：2012-05-22
申请人： ZHOU WENQIANG
发明人： ZHOU WENQIANG , DENG JING
IPC分类号： C07F9/6561 , A61K31/675 , A61P35/00 , C07D491/22
摘要： The present invention relates to a camptothecin derivative having a structure as represented by Formula (II), in which X

7. 发明专利

EA021814B1 ПРОИЗВОДНОЕ КАМПТОТЕЦИНА, СПОСОБ ЕГО ПОЛУЧЕНИЯ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И ЕЕ ПРИМЕНЕНИЕ 未知
公开(公告)号：EA021814B1
公开(公告)日：2015-09-30
申请号：EA201370251
申请日：2012-05-22
申请人： ZHOU WENQIANG
发明人： ZHOU WENQIANG , DENG JING
IPC分类号： C07F9/6561 , A61K31/675 , A61P35/00 , C07D491/22
摘要： Изобретениеотноситсяк производномукамптотецина, котороеимееттакуюструктуру, какпредставленоформулой (II), вкоторой Xвыбраниз H, K, Na, Li, Mg, Ca, Zn, Feиионааммония, где R, R, Rи Rнезависимопредставляютсобойводород, гидроксильнуюгруппу, нитрогруппу, цианогруппу, галоген, карбоксильнуюгруппу, необязательнозамещеннуюаминогруппу, кремнийсодержащуюгруппу, моноциклическуюарилоксигруппу, необязательнозамещенную C-C-алкоксигруппу, необязательнозамещенную C-C-алкилкарбонильнуюгруппу, необязательнозамещенную C-C-алкильнуюгруппуилинеобязательнозамещенную C-C-циклоалкильнуюгруппу; вкачествеальтернативы Rи Rсоединеныпосредством 1-3 другихатомовс образованиемгетероциклическогокольца; вдругомвариантеосуществления Rи Rпредставляютсобойатомыкислородаи соединеныпосредством -O-(CH)-O-, образуякольцо, вкотором n=1 или 2. Соединениеобладаетвысокойводорастворимостью, химическойстабильностьюи высокойактивностьюприлечениирака.

8. 发明专利

AU2393902A Synthesis and antiviral evaluation of nucleic acid based (NAB) libraries 未知
公开(公告)号：AU2393902A
公开(公告)日：2002-02-05
申请号：AU2393902
申请日：2001-07-13
申请人： ORIGENIX TECHNOLOGIES INC
发明人： IYER RADHAKRISHNAN P , ZHOU WENQIANG , JIN YI , ROLAND ARLENE , LYAKU JAPHET
IPC分类号： A61K31/7052 , A61P31/12 , C07B61/00 , C07H19/06 , C07H19/16 , C07H21/00 , C12Q20060101

9. 发明专利

AU5760401A Hpv-specific short-mers 未知
公开(公告)号：AU5760401A
公开(公告)日：2001-10-23
申请号：AU5760401
申请日：2001-04-11
申请人： ORIGENIX TECHNOLOGIES INC
发明人： IYER RADHAKRISHNAN , JIN YI , ZHOU WENQIANG , ROLAND ARLENE
IPC分类号： C12N15/09 , A61K31/7125 , A61K38/00 , A61K48/00 , A61P15/00 , A61P17/12 , A61P31/20 , A61P35/00 , C07K14/025

10. 发明专利

CA2406485A1 HPV-SPECIFIC SHORT-MERS 未知
公开(公告)号：CA2406485A1
公开(公告)日：2001-10-18
申请号：CA2406485
申请日：2001-04-11
申请人： ORIGENIX TECHNOLOGIES INC
发明人： IYER RADHAKRISHNAN , ZHOU WENQIANG , ROLAND ARLENE , JIN YI
IPC分类号： C12N15/09 , A61K31/7125 , A61K38/00 , A61K48/00 , A61P15/00 , A61P17/12 , A61P31/20 , A61P35/00 , C07K14/025 , A61K31/70 , C07H21/00
摘要： The invention provides oligonucleotides capable of inhibiting human papillomavirus (HPV) replication. More specifically, the invention provides oligonucleotides complementary to the translational start site of the HPV E1 open reading frame which inhibit HPV replication through interaction with a nucleic acid or a protein target. Oligonucleotides of the invention contain at least 4 deoxyribonucleotides and/or ribonucleotides and may include a variet y of modifications to the internucleotide linkages or the mononucleotides. Furthermore, the invention provides pharmaceutical compositions and methods for treating disorders or diseases associated with HPV infection.

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