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    • 3. 发明申请
    • VARIOUS GENES IMPLICATED IN PREMATURE CANITIES
    • 各种各样的基因都在预期的范围内
    • WO2005068650A2
    • 2005-07-28
    • PCT/EP2005000549
    • 2005-01-07
    • OREALDE LACHARRIERE OLIVIERBLOUIN JEAN-LOUISDELOCHE CLAIREANTONARAKIS STYLIANOS
    • DE LACHARRIERE OLIVIERBLOUIN JEAN-LOUISDELOCHE CLAIREANTONARAKIS STYLIANOS
    • A61K8/60A61K48/00A61Q5/00A61Q5/10C12Q1/68A61K7/06
    • A61Q5/10A61K8/606C12Q1/6883C12Q2600/156C12Q2600/172
    • Use of at least one polynucleotide fragment comprising at least 18 consecutive nucleotides the sequence of which corresponds to all or part of the region of the human chromosome 1 included between the markers D1S2797 and D1S2868, or between the marker D1S2842 and the telomer q, or to that of the region of the human chromosome 2 included between the markers D2S149 and D2S392, or of the region of the human chromosome 2 included between the markers D2S347 and D2S142, or of the region of the human chromosome 3 included between the markers D3S3567 and D3S1277, or between the markers D3S1285 and D3S3653, or of the region of the human chromosome 4 included between the markers D4S1501 and D4S408, or of the region of the human chromosome 6 included between the markers D6S308 and D6S1581, or of the region of the human chromosome 7 included between the markers D7S657 and D7S530, or between the markers D7S1824 and D7S615, or of the region of the human chromosome 9 included between the markers D9S1677 and D9S1682, or of the region of the human chromosome 10 included between the markers D10S591 and D10S547, or of the region of the human chromosome 12 included between the markers D12S310 and D12S85, or between the markers D12S99 and D12S364, or of the region of the human chromosome 15 included between the markers D15S1040 and D15S641, or between the markers D15S978 and D15S153, or of the region of the human chromosome 16 included between the markers D16S503 and D16S516, or between the markers D16S3030 and D16S50, or of the region of the human chromosome 18 included between the markers D18S464 and D18S1102, or of the region of the human chromosome 19 included between the markers D19S216 and D19S221, or of the region of the human chromosome 20 included between the markers D20S107 and D20S100, use of agents capable of modifying the function associated with one of these regions, use of expression products of one of these regions and use of agents capable of modifying the function of these expression products for cosmetic, therapeutic or diagnostic purposes.
    • 使用至少一个包含至少18个连续核苷酸的多核苷酸片段,其序列对应于包括在标记D1S2797和D1S2868之间或标记D1S2842与调节物q之间的人染色体1的全部或部分区域,或至少 标记D2S149和D2S392之间的人染色体2的区域或包含在标记D2S347和D2S142之间的人类染色体2的区域或包含在标记D3S3567和D3S1277之间的人类染色体3区域 或标记D3S1285和D3S3653之间或包含在标记D4S1501和D4S408之间的人类染色体4区域或包含在标记D6S308和D6S1581之间的人类染色体6的区域之间或人类区域 标记D7S657和D7S530之间或标记D7S1824和D7S615之间的染色体7或包含在标记D9S1之间的人染色体9区域 677和D9S1682,或包含在标记D10S591和D10S547之间的人类染色体10的区域,或包含在标记D12S310和D12S85之间或标记D12S99和D12S364之间或者标记D12S99和D12S364之间的区域 标记D15S1040和D15S641之间或标记D15S978和D15S153之间的人染色体15或包含在标记D16S503和D16S516之间的标记D16S3030和D16S516之间的区域或标记D16S3030和D16S50之间的区域 包括在标记D18S464和D18S1102之间的人类染色体18或包含在标记D19S216和D19S221之间的人类染色体19的区域或包含在标记D20S107和D20S100之间的人染色体20区域的使用的试剂 能够修改与这些区域之一相关联的功能,使用这些区域之一的表达产物和使用能够修饰t的功能的试剂 用于化妆品,治疗或诊断目的的表达产品。
    • 6. 发明专利
    • Use of human polynucleotides for treatment, prevention and diagnosis of pigmentation disorders, especially premature whitening of hair, derived from chromosomes 9 or 6
    • FR2842104A1
    • 2004-01-16
    • FR0208696
    • 2002-07-10
    • OREAL
    • DE LACHARRIERE OLIVIERBLOUIN JEAN LOUISDELOCHE CLAIREANTONARAKIS STYLIANOS
    • A61K8/60A61K48/00A61P17/00A61Q5/06A61Q5/10C12Q1/68A61K7/48A61K7/075A61K31/7084A61K31/7088
    • Cosmetic or therapeutic use, in the field of pigmentation, of at least one polynucleotide fragment (I), of 30-5000 nucleotides (nt) and containing at least 18 consecutive nt that correspond to all or part of specific genes present on human chromosomes 9 or 6. Cosmetic or therapeutic use, in the field of pigmentation, of at least one polynucleotide fragment (I), of 30-5000 nucleotides (nt) and containing at least 18 consecutive nt that correspond to all or part of specific genes present on human chromosomes 9 or 6. The specified genes are: (a) for chromosome 9: FREQ, NT-030046.18, NT-030046.17, GTF3C5, CEL, CELL, FS, ABO, BARLH1, DDX31, GTF3C4 and Q96MA6; and (b) for chromosome 6: HLAG, NT-007592.446, .506, .507 or .508, HSPA1B, G8, NEU1, NG22, BAT8, HLA-DMB or -DMA,BRD2, HLA-DQA1 or -DQA2, NT-007592.588, .459 or .457, GRM4, RNF23 or FLJ22638. Independent claims are also included for the following: (1) diagnosing a predisposition to premature canitis (whitening of the hair) by identifying the alleles of the specified genes; (2) use of at least one of the SNP (single-nucleotide poymorphism) markers 418620, rs302919, 913705, 931886, 429269, 2526008, 2734988, 2734967, 1419664, 2517502, rs733539, rs494620, 154973, 206779, 60071 or rs763028 for determining genes implicated in pigmentation of the skin and other external parts of the body; (3) similar use and method of a combination of at least one (I) derived from chromosome 9 and at least one derived from chromosome 6; (4) kit containing at least two (I); and (5) similar method and use using a combination of at least one (I) derived from DDX31 or GTF3C4 and at least one fragment derived from the following genes (present on chromosomes 3, 5 or 11) KIAA1042, CCK, CACNA1D, ARHGEF3, AL133097, KLHL3, HNRPA0, CDC25C, EGR1, C5orf3, 6 or 7, LOC51308, ETF1, HSPA9B, PCDHA1 to 13, CSF1R, RPL7, PDGFRB, TCOF1, AL133039, CD74, RPS14, NDST1, G3BP, GLRA1, MFAP3, GALNT10, FLJ11715, GUCY1A2, CUL5, ACAT1, NPAT, ATM, AF035326, AF035327, AF035328, BC029536, FLJ20535, DED2, ENS303941, IGSF4, LOC51092, BC010946, TAGLN, PCSK7 or ENS300650. ACTIVITY : Dermatological. No details of tests for dermatological activity are given. MECHANISM OF ACTION : Modulating gene expression or activity of encoded products.