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1. 发明申请

WO2004050704A8 THERAPEUTIC AND DIAGNOSTIC AGENTS 审中-公开
标题翻译：治疗与诊断代理
公开(公告)号：WO2004050704A8
公开(公告)日：2005-12-08
申请号：PCT/AU0301586
申请日：2003-11-28
申请人： ORDER SISTERS OF MERCY QUEENSL , CLARK GEORGINA JANE , HART DEREK NIGEL JOHN
发明人： CLARK GEORGINA JANE , HART DEREK NIGEL JOHN
IPC分类号： A61K38/00 , A61K38/17 , C07H21/04 , C07K14/705 , C07K16/28 , C07K16/30 , C12N15/63 , C12Q1/06 , G01N33/574 , G01N33/68
CPC分类号： C07K14/70503 , A61K38/00 , C07K16/3061 , G01N33/57484 , G01N33/6893 , G01N2800/22
摘要： The present invention relates generally to therapeutic and diagnostic agents. More particularly, the present invention provides molecules having structural features characteristic of immunoregulatory signalling (IRS) molecules and which are expressed by cells of haematopoietic lineages such as, in particular, leukocytes. The molecules of the present invention find broad application inter alia as diagnostic markers for cells, targets for cell therapy and as validated drug targets in order to modulate the immune response and to treat, prevent and diagnose a range of diseases conditions including cancer, genetic disease, inflammatory conditions and conditions associated with aberrant haematopoietic cell function or activity. The present invention extends to binding partners of the instant molecules such as, for example, antibodies, ligands, adaptor and other signalling associated molecules, agonists and antagonists and to methods of screening for same.
摘要翻译：本发明一般涉及治疗和诊断剂。更具体地，本发明提供具有免疫调节信号（IRS）分子特征的结构特征的分子，并且由造血谱系细胞，特别是白细胞表达。本发明的分子尤其可广泛应用于细胞的诊断标志物，细胞治疗的靶标和经验证的药物靶标，以调节免疫反应并治疗，预防和诊断一系列疾病状况，包括癌症，遗传病，炎性病症和与异常造血细胞功能或活性相关的病症。本发明延伸到本发明分子的结合配偶体，例如抗体，配体，衔接子和其它信号传导相关分子，激动剂和拮抗剂以及其筛选方法。

2. 发明专利

NZ533348A Method of supporting the viability, proliferation and/or differentiation of mammalian dendritic cells comprising culturing dendritic cells and/or precursors thereof in the presence of mononuclear immune cells 未知
公开(公告)号：NZ533348A
公开(公告)日：2008-04-30
申请号：NZ53334802
申请日：2002-11-26
申请人： ORDER SISTERS OF MERCY QUEENSL
发明人： HART DEREK NIGEL JOHN , HO CHRISTOPHER SIAW KANG , RAMIREZ JOSE ALEJANDRO LOPEZ
IPC分类号： A61K35/12 , C12N5/02 , C12N5/0784 , C12N5/06 , C12N5/08
摘要： A method of supporting the viability, proliferation and/or differentiation of mammalian dendritic cells wherein the method comprises culturing dendritic cells and/or precursors thereof in the presence of an effective number of mononuclear immune cells. Furthermore the culture is not supplemented with exogenous cytokine and the method is carried out for a time and under conditions sufficient of the mononuclear immune cells to support the dendritic cells and/or precursors thereof.

3. 发明专利

NZ505932A Human cmrf-35-h9 receptor which binds IgM 未知
公开(公告)号：NZ505932A
公开(公告)日：2003-12-19
申请号：NZ50593299
申请日：1999-01-14
申请人： ORDER SISTERS OF MERCY QUEENSL
发明人： HART DEREK NIGEL JOHN
IPC分类号： A61K38/17 , C07K14/735
摘要： An immunoglobulin receptor isolated from human dendritic cells and other cells, designated CMRF-35-H9, which binds IgM and which has an amino acid sequence as laid out in the specification. Also covered is the use of said receptor in the preparation of a medicament for modulating immune response in a patient.

4. 发明专利

AU750770B2 Human CMRF-35-H9 receptor which binds IgM 未知
公开(公告)号：AU750770B2
公开(公告)日：2002-07-25
申请号：AU2078699
申请日：1999-01-14
申请人： ORDER SISTERS OF MERCY QUEENSL
发明人： HART DEREK NIGEL JOHN
IPC分类号： C12N15/09 , A61K38/00 , A61P37/06 , A61P43/00 , C07K14/705 , C07K14/735 , C12N5/02 , C12P21/02 , A61K38/17

5. 发明专利

CA2508632A1 DEC-205 (LY 75) / DCL-1 INTERGENIC SPLICE VARIANTS ASSOCIATED WITH HODKIN'S DISEASE, AND USES THEREOF 未知
公开(公告)号：CA2508632A1
公开(公告)日：2004-06-24
申请号：CA2508632
申请日：2003-12-05
申请人： ORDER SISTERS OF MERCY QUEENSL
发明人： KATO MASATO , HART DEREK NIGEL JOHN
IPC分类号： A61P35/00 , C07K14/705 , C12N15/12
摘要： The inventors have identified intergenically spliced DEC-205/DCL-1 mRNAs, which encode the intact DEC-205 ectodomain together with an additional carbohdrate recognition domain, a transmembrane domain and a cytoplasmic domain derived from DCL-1. These DEC-205/DCL-1 intergenic splice variants we re identified on Reed-Sternberg cells and thus have application in the therapy and investigation of Hodgkin~s disease.

6. 发明专利

CA2507709A1 THERAPEUTIC AND DIAGNOSTIC AGENTS 未知
公开(公告)号：CA2507709A1
公开(公告)日：2004-06-17
申请号：CA2507709
申请日：2003-11-28
申请人： ORDER SISTERS OF MERCY QUEENSL
发明人： CLARK GEORGINA JANE , HART DEREK NIGEL JOHN
IPC分类号： A61K38/00 , A61K38/17 , C07H21/04 , C07K14/705 , C07K16/28 , C07K16/30 , C12N15/63 , C12Q1/06 , G01N33/574 , G01N33/68
摘要： The present invention relates generally to therapeutic and diagnostic agents . More particularly, the present invention provides molecules having structura l features characteristic of immunoregulatory signalling (IRS) molecules and which are expressed by cells of haematopoietic lineages such as, in particular, leukocytes. The molecules of the present invention find broad application inter alia as diagnostic markers for cells, targets for cell therapy and as validated drug targets in order to modulate the immune respon se and to treat, prevent and diagnose a range of diseases conditions including cancer, genetic disease, inflammatory conditions and conditions associated with aberrant haematopoietic cell function or activity. The present inventio n extends to binding partners of the instant molecules such as, for example, antibodies, ligands, adaptor and other signalling associated molecules, agonists and antagonists and to methods of screening for same.

7. 发明专利

AU2002351887A1 GENOMIC SEQUENCES ENCODING DENDRITIC CELL EXPRESSED S-ADENOSYL HOMOCYSTEINE HYDROLASE LIKE MOLECULES 未知
公开(公告)号：AU2002351887A1
公开(公告)日：2003-07-15
申请号：AU2002351887
申请日：2002-12-24
申请人： ORDER SISTERS OF MERCY QUEENSL
发明人： KATO MASATO , ANGEL NICOLA ZOE , COOPER BENJAMINE JAY , HART DEREK NIGEL JOHN
IPC分类号： A01K67/027 , A61K38/00 , C12N9/14 , C12N15/55 , C12Q1/02 , C12Q1/34 , G01N33/50 , G01N33/68
摘要： The present invention discloses the genomic structure and sequence of DCAL. It also provides methods for producing a genetically modified non-human animal model having altered DCAL gene function as well as methods for using this model in the study of the immune system, and particularly DC function, and in screening for biologically active agents that modulate DCAL function. The present invention also discloses the use of such modulatory agents in methods for modulating immune responses, and in compositions for treating and/or preventing DCAL-related conditions. Also disclosed is the use of the genetically modified non-human animal model of the invention in the study of brain physiology and more particularly neuronal cell function.

8. 发明专利

CA2464606A1 METHOD OF MODULATING THE IMMUNOACTIVITY OF AN IMMUNOCOMPETENT GRAFT BY PROGENIPOIETIN 未知
公开(公告)号：CA2464606A1
公开(公告)日：2003-05-01
申请号：CA2464606
申请日：2002-10-24
申请人： ORDER SISTERS OF MERCY QUEENSL
发明人： HART DEREK NIGEL JOHN , HILL GEOFFREY ROGER , MACDONALD KELLI PATRICIA ANNE
IPC分类号： A61L27/00 , A61K35/14 , A61K35/26 , A61K35/28 , A61K38/00 , A61K38/17 , A61K38/19 , A61P37/06 , A61K38/18 , A61K38/45
摘要： The present invention relates generally to a method of modulating the immunoactivity of a population of immune cells and, more particularly to a method of down-regulating the immunoactivity of an immunocompetent graft. Th e method of the present invention is useful, inter alia, in the treatment and/ or prophylaxis of conditions characterised by aberrant, unwanted or otherwise inappropriate graft immunoactivity such as, but not limited to, the prophylaxis treatment of graft versus host disease in allogeneic stem cell graft recipients.

9. 发明专利

AU1844501A Dendritic cell-specific antibodies 未知
公开(公告)号：AU1844501A
公开(公告)日：2001-06-12
申请号：AU1844501
申请日：2000-12-01
申请人： ORDER SISTERS OF MERCY QUEENSL
发明人： HART DEREK NIGEL JOHN , VUCKOVIC SLAVICA
IPC分类号： C07K16/28 , C07K14/47 , G01N33/577 , C12N5/20 , C12N5/08 , A61K39/00
摘要： The present invention relates generally to immuno-interactive agents which are capable of interacting with an epitope on a molecule in or on dendritic cells (DC). More particularly, the present invention provides immunological reagents such as but not limited to immunoglobulin agents which are capable of interacting with an epitope on a molecule present on or within a subset of DC. Generally, the DC are a subset of DC which have been subjected to differentiation stimulus. The resulting differentiated, activated subset of DC produce a molecule comprising an immunologically detectable epitope which is not detectable in non-differentiated DC. The present invention further relates to cell lines which produce the instant immuno-interactive molecules and to a method for identifying and purifying the above-mentioned subset of DC from a biological sample such as blood using the instant immuno-interactive molecules. The present invention further provides for modulators of the interaction between the instant immuno-interactive molecules and an epitope to which they bind. These modulators are useful in controlling an immune response. The present invention further provides an antigenic molecule or part thereof or cell preparation comprising same which is capable of interacting with the subject immuno-interactive agents. The present invention is further directed to the use of the subject immuno-interactive molecules and/or modulators thereof in the manufacture of medicaments for use in immunomodulation and immunotherapy. An immuno-interactive molecule includes an antibody, fragments thereof and recombinant synthetic or hybrid forms of antibodies.

10. 发明专利

NZ335545A Monoclonal dendritic cell (DC)-specific antibodies that binds to DC activated antigen CMRF-56 未知
公开(公告)号：NZ335545A
公开(公告)日：2001-01-26
申请号：NZ33554597
申请日：1997-10-09
申请人： ORDER SISTERS OF MERCY QUEENSL
发明人： HART DEREK NIGEL JOHN
IPC分类号： A61K39/395 , C07K16/28 , G01N33/577
摘要： A monoclonal antibody or binding fragments thereof which specifically bind to dendritic cells activation antigen CMRF-56. Disclosed is a hybridoma cell line CMRF-56 which secretes mAb CMRF-56. The secreted mAb CMRF-56 binds specifically to an epitope on activated human dendritic cell but does not bind to activation antigens CMRF-44 and CD83. The process provides a method for identifying and purifying dendritic cells from blood using such antibodies.

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