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1. 发明申请

WO0000242A3 DRUG DISPENSER 审中-公开
标题翻译：药物分配器
公开(公告)号：WO0000242A3
公开(公告)日：2000-02-24
申请号：PCT/US9914680
申请日：1999-06-29
申请人： ORBON CORP , RICHEAL RODGER J , CHEN JEFFREY Y , SENATORI MARK D , MCKINNON RAY , LOONG LIM WAI
发明人： RICHEAL RODGER J , CHEN JEFFREY Y , SENATORI MARK D , MCKINNON RAY , LOONG-LIM WAI
IPC分类号： A61F9/00 , A61J1/00 , A61J1/20 , A61M37/00
CPC分类号： A61F9/0008 , A61J1/2027 , A61J1/2041 , A61J1/2093
摘要： This invention is a drug dispenser (10) for administering a drug solution (50) ophthalmically comprising a cylindrical member (20) having an open proximal end (32), a distal end (28) having a hole (26), and a connecting passage (36) formed in a sidewall thereof. A plunger (34) receivable in the proximal end (32) of the cylindrical member (20) wherein the member (20) is axially slidable on the plunger (34) between a non-mix, and a mix position. The dispenser (10) further comprises a piston (40) slidably disposed within the cylindrical member (20) in sealing engagement therewith. The distal end (42) of the piston (40) is located proximally of the passage (36), and forms a drug chamber (44) with the distal end (28) of the member (20) for storing a drug (22) when the member (20) is in its non-mix position. The proximal end (46) of the piston (40) is distally spaced from the plunger (34) to form a diluent chamber (48) therebetween for storing a diluent when the cylindrical member (20) is in its non-mix position. When the cylindrical member (20) is moved to its mix position the drug chamber (44), and diluent chamber (48) are in fluid communication.
摘要翻译：本发明是一种用于给药液体（50）的药物分配器（10），其中眼药液包括具有开口近端（32）的圆柱形构件（20），具有孔（26）的远端（28）通道（36）形成在其侧壁中。柱塞（34）可接收在圆柱形构件（20）的近端（32）中，其中构件（20）可在非混合位置和混合位置之间在柱塞（34）上轴向滑动。分配器（10）还包括可滑动地设置在与其密封接合的圆柱形构件（20）内的活塞（40）。活塞（40）的远端（42）位于通道（36）的近侧，并与构件（20）的远端（28）形成用于储存药物（22）的药物室（44）当构件（20）处于其非混合位置时。活塞（40）的近端（46）与柱塞（34）向远侧间隔开，以在其间形成稀释剂室（48），用于当圆柱形构件（20）处于非混合位置时储存稀释剂。当圆柱形构件（20）移动到其混合位置时，药物室（44）和稀释剂室（48）处于流体连通状态。

2. 发明专利

AU1307399A Stabilized, dry pharmaceutical compositions for drug delivery and methods of preparing same 未知
公开(公告)号：AU1307399A
公开(公告)日：1999-05-31
申请号：AU1307399
申请日：1998-11-04
申请人： ORBON CORP
发明人： RICHEAL RODGER J , HEMMES PAUL R , CHIOU GEORGE C Y
IPC分类号： A61K9/00 , A61K9/16 , A61K38/00 , A61K38/04 , A61K38/095 , A61K38/22 , A61K38/26 , A61K38/27 , A61K38/28 , A61K38/43
摘要： Dry, stabilized pharmaceutical spheres comprising a precisely measured amount of the pharmaceutical and a filler material that facilitates the immediate dissolution of the pharmaceutical upon contact with a solution are provided as well as methods for preparing same.

3. 发明专利

AU4726299A Drug dispenser 未知
公开(公告)号：AU4726299A
公开(公告)日：2000-01-17
申请号：AU4726299
申请日：1999-06-29
申请人： ORBON CORP
发明人： RICHEAL RODGER J , CHEN JEFFREY Y , SENATORI MARK D , MCKINNON RAY , LOONG-LIM WAI
IPC分类号： A61F9/00 , A61J1/00 , A61J1/20
摘要： A drug dispenser for administering a drug solution ophthalmically. The dispenser comprises a cylindrical member having an open proximal end, a distal end having a hole for dispensing the drug solution, and a connecting passage formed in a sidewall thereof. A plunger is receivable in the proximal end of the cylindrical member and the member is axially slidable on the plunger between a non-mix position and a mix position. The dispenser further comprises a piston having a distal end and a proximal end and slidably disposed within the cylindrical member in sealing engagement therewith. The distal end of the piston is located proximally of the passage and forms a drug chamber with the distal end of the member for storing a drug when the member is in its non-mix position. The proximal end of the piston is distally spaced from the plunger to form a diluent chamber therebetween for storing a diluent when the cylindrical member is in its non-mix position. When the cylindrical member is moved to its mix position the drug chamber and diluent chamber are in fluid communication and the diluent is free to flow through the passage to mix with the drug to form the drug solution.

4. 发明公开

EP1091783A4 DRUG DISPENSER 审中-公开
标题翻译：药物递送装置
公开(公告)号：EP1091783A4
公开(公告)日：2002-08-21
申请号：EP99930813
申请日：1999-06-29
申请人： ORBON CORP
发明人： RICHEAL RODGER J , CHEN JEFFREY Y , SENATORI MARK D , MCKINNON RAY , LOONG-LIM WAI
IPC分类号： A61F9/00 , A61J1/00 , A61J1/20 , A61M37/00
CPC分类号： A61F9/0008 , A61J1/2027 , A61J1/2041 , A61J1/2093
摘要： A drug dispenser for administering a drug solution ophthalmically. The dispenser comprises a cylindrical member having an open proximal end, a distal end having a hole for dispensing the drug solution, and a connecting passage formed in a sidewall thereof. A plunger is receivable in the proximal end of the cylindrical member and the member is axially slidable on the plunger between a non-mix position and a mix position. The dispenser further comprises a piston having a distal end and a proximal end and slidably disposed within the cylindrical member in sealing engagement therewith. The distal end of the piston is located proximally of the passage and forms a drug chamber with the distal end of the member for storing a drug when the member is in its non-mix position. The proximal end of the piston is distally spaced from the plunger to form a diluent chamber therebetween for storing a diluent when the cylindrical member is in its non-mix position. When the cylindrical member is moved to its mix position the drug chamber and diluent chamber are in fluid communication and the diluent is free to flow through the passage to mix with the drug to form the drug solution.

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