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1. 发明申请

WO2004091387A2 DUAL MEASUREMENT ANALYTE DETECTION SYSTEM 审中-公开
标题翻译：双测量分析仪检测系统
公开(公告)号：WO2004091387A2
公开(公告)日：2004-10-28
申请号：PCT/US2004/011432
申请日：2004-04-14
申请人： OPTISCAN BIOMEDICAL CORPORATION , BRAIG, James, R. , RULE, Peter , WITTE, Kenneth, G. , HARTSTEIN, Philip, C. , STERLING, Bernhard, B.
发明人： BRAIG, James, R. , RULE, Peter , WITTE, Kenneth, G. , HARTSTEIN, Philip, C. , STERLING, Bernhard, B.
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546
摘要： An analyte detection system (10) is configured to measure concentrations of at least first and second analytes in a single material sample supported by a sample element (120, 302, 402, 602). The measurement of a second analyte can be conditioned on a quantitative or qualitative result of the first measurement. In one embodiment, the first analyte is glucose and the second analyte is a ketone. According to such an embodiment the ketone is measured if the result of the glucose measurement exceeds a previously-specified value or falls outside of a previously-specified range.
摘要翻译：分析物检测系统（10）被配置为测量由样品元件（120,302,402,602）支撑的单个材料样品中的至少第一和第二分析物的浓度。第二分析物的测量可以对第一次测量的定量或定性结果进行调节。在一个实施方案中，第一分析物是葡萄糖，第二分析物是酮。根据这样的实施方案，如果葡萄糖测量结果超过预先规定的值或者超出预先规定的范围，则测量酮。

2. 发明申请

WO2004062500A1 CARTRIDGE LANCE 审中-公开
公开(公告)号：WO2004062500A1
公开(公告)日：2004-07-29
申请号：PCT/US2003/041610
申请日：2003-12-30
申请人： OPTISCAN BIOMEDICAL CORPORATION , RULE, Peter , BRAIG, James, R. , HARTSTEIN, Philip, C.
发明人： RULE, Peter , BRAIG, James, R. , HARTSTEIN, Philip, C.
IPC分类号： A61B5/15
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546 , A61B5/150022 , A61B5/150213 , A61B5/150221 , A61B5/150358 , A61B5/150389 , A61B5/150412 , A61B5/150442 , A61B5/150503 , A61B5/15087 , A61B5/15142 , A61B5/1519 , A61B5/157 , G01N21/71
摘要： An analyte detection system (1709) for analysis of a body fluid is provided, comprising an analysis portion and a sample collection portion which is configured to be removably coupled to the analysis portion. The analysis portion comprises a detector (250) configured to detect electromagnetic radiation and a source of electromagnetic radiation (220). The source is positioned with respect to the detector such that electromagnetic radiation emitted by the source is received by the detector. The sample collection portion comprises a housing, a lance (1741) and a sample chamber (1734). The lance is mounted within and moveable with respect to the housing. The sample chamber is configured to be positionable, upon coupling of the sample collection portion to the analysis portion, with respect to the source and detector such that at least a portion of any electromagnetic radiation emitted by the source passes through the sample chamber prior to being received by the detector.
摘要翻译：提供了一种用于分析体液的分析物检测系统（1709），包括分析部分和样品收集部分，其被配置为可移除地耦合到分析部分。分析部分包括被配置为检测电磁辐射和电磁辐射源（220）的检测器（250）。源相对于检测器定位，使得由源发射的电磁辐射由检测器接收。样品收集部分包括壳体，喷枪（1741）和样品室（1734）。喷枪相对于壳体安装并可移动。样品室被配置为在样品收集部分与分析部分相对于源和检测器耦合时可定位，使得由源发射的任何电磁辐射的至少一部分在被存在之前通过样品室由检测器接收。

3. 发明申请

WO2003013345A3 DEVICE FOR CAPTURING THERMAL SPECTRA FROM TISSUE 审中-公开
公开(公告)号：WO2003013345A3
公开(公告)日：2003-02-20
申请号：PCT/US2002/025366
申请日：2002-08-08
申请人： OPTISCAN BIOMEDICAL CORPORATION , RULE, Peter , BRAIG, James, R. , GOLDBERGER, Daniel, S. , CORTELLA, Julian, M. , SMITH, Heidi, M. , HERRERA, Roger, O. , WITTE, Kenneth, G. , HARTSTEIN, Philip, C. , AGOSTINO, Mark, D.
发明人： RULE, Peter , BRAIG, James, R. , GOLDBERGER, Daniel, S. , CORTELLA, Julian, M. , SMITH, Heidi, M. , HERRERA, Roger, O. , WITTE, Kenneth, G. , HARTSTEIN, Philip, C. , AGOSTINO, Mark, D.
IPC分类号： A61B6/00
摘要： A device and method are provided for use with a noninvasive optical measurement system, such as a thermal gradient spectrometer, for improved determination of analyte concentrations within living tissue. In one embodiment, a wearable window (100) is secured to a patient's forearm thereby isolating a measurement site on the patient's skin for determination of blood glucose levels. The wearable window (100) effectively replaces a window of the spectrometer, and thus forms an interface between the patient's skin and a thermal mass window of the spectrometer. When the spectrometer must be temporarily removed from the patient's skin, such as to allow the patient mobility, the wearable window (100) is left secured to the forearm so as to maintain a consistent measurement site on the skin. When the spectrometer is later reattached to the patient, the wearable window (100) will again form an interface between the spectrometer and the same location of skin as before.

4. 发明申请

WO2004062493A1 WEARABLE DEVICE FOR MEASURING ANALYTE CONCENTRATION 审中-公开
标题翻译：用于测量分析仪浓度的可测装置
公开(公告)号：WO2004062493A1
公开(公告)日：2004-07-29
申请号：PCT/US2003/041579
申请日：2003-12-30
申请人： OPTISCAN BIOMEDICAL CORPORATION , RULE, Peter , BRAIG, James, R. , HERRERA, Roger, O. , WITTE, Kenneth, G. , MUNROW, Michael, A. , HARTSTEIN, Philip, C.
发明人： RULE, Peter , BRAIG, James, R. , HERRERA, Roger, O. , WITTE, Kenneth, G. , MUNROW, Michael, A. , HARTSTEIN, Philip, C.
IPC分类号： A61B5/00
CPC分类号： A61B5/14546 , A61B5/0059 , A61B5/14532 , A61B5/1455
摘要： An analyte detection system includes a first wearable module, a detector, and a processor. The first wearable module has an optical input through which electromagnetic radiation may enter said first wearable module. The first wearable module is configured to be worn on and engage a living wearer’s body such that electromagnetic radiation omitted by the body of the wearer can enter the first wearable module via the optical input. The detector is in optical communication with the optical input. The processor is in communication with the detector. The processor is configured to estimate the concentration of an analyte in the wearer’s tissue based on the emitted electromagnetic radiation.
摘要翻译：分析物检测系统包括第一耐磨模块，检测器和处理器。第一可佩戴模块具有光学输入，电磁辐射可通过该输入进入所述第一可穿戴模块。第一可穿戴模块被配置为佩戴在活体佩戴者的身体上并使其接合，使得佩戴者的身体省略的电磁辐射可经由光学输入进入第一佩戴模块。检测器与光学输入端光学通信。处理器与检测器通信。处理器被配置为基于发射的电磁辐射来估计穿着者组织中的分析物的浓度。

5. 发明申请

WO2003030731A3 METHOD AND APPARATUS FOR IMPROVING CLINICAL ACCURACY OF ANALYTE MEASUREMENTS 审中-公开
公开(公告)号：WO2003030731A3
公开(公告)日：2003-04-17
申请号：PCT/US2002/032281
申请日：2002-10-09
申请人： OPTISCAN BIOMEDICAL CORPORATION , BRAIG, James, R. , RULE, Peter , HARTSTEIN, Philip, C. , SMITH, Heidi, M.
发明人： BRAIG, James, R. , RULE, Peter , HARTSTEIN, Philip, C. , SMITH, Heidi, M.
IPC分类号： A61B5/00
摘要： Herein is described a system that includes a processing circuit for identifying possible zone D errors among estimated blood glucose concentration values. The system converts estimated blood glucose concentration values which are identified as possible zone D errors into adjusted blood glucose concentration values which are lower in blood glucose concentration magnitude than their corresponding estimated blood glucose concentration values, thereby decreasing the occurrence of zone D errors. Herein is also disclosed a method for improving the clinical accuracy of an analyte concentration measurement. One method includes a first act of computing an estimated analyte concentration having an associated first error that is clinically significant and a second act of processing the estimated analyte concentration to generate an adjusted analyte concentration having a second error that is clinically insignificant.

6. 发明申请

WO2003005894A1 STANDARD FOR NON-INVASIVE OPTICAL MEASUREMENT SYSTEMS 审中-公开
标题翻译：无入射光学测量系统的标准
公开(公告)号：WO2003005894A1
公开(公告)日：2003-01-23
申请号：PCT/US2002/021888
申请日：2002-07-09
申请人： OPTISCAN BIOMEDICAL CORPORATION , BRAIG, James, R. , CORTELLA, Julian, M. , MUNROW, Mike , WITTE, Kenneth, G. , SMITH, Heidi, M. , HARTSTEIN, Philip, C. , HERRERA, Roger, O. , RULE, Peter
发明人： BRAIG, James, R. , CORTELLA, Julian, M. , MUNROW, Mike , WITTE, Kenneth, G. , SMITH, Heidi, M. , HARTSTEIN, Philip, C. , HERRERA, Roger, O. , RULE, Peter
IPC分类号： A61B5/00
CPC分类号： A61B5/1495 , A61B5/14532 , A61B5/1455 , A61B2560/0233
摘要： In accordance with one embodiment there is provided a method of providing a known spectrum to a noninvasive optical detection system of the type having a window for receiving infrared energy. The method comprises affixing a standard to the window. The standard comprises a body formed from a material having known and stable spectral properties. The method further comprises placing at least a portion of the body directly against the window, and operating the optical detection system to detect an emission spectrum of the body. In accordance with another embodiment an infrared spectrometer comprises a window for receiving infrared energy. The window has an exposed surface. The infrared spectrometer further comprises a standard comprising a body formed of a material having known and stable spectral properties. At least part of the body is removably disposed directly against the exposed surface of the window.
摘要翻译：根据一个实施例，提供了一种向具有用于接收红外能量的窗口的类型的无创光学检测系统提供已知光谱的方法。该方法包括将标准附加到窗口。该标准包括由具有已知且稳定的光谱性质的材料形成的主体。该方法还包括将身体的至少一部分直接放置在窗户上，并且操作光学检测系统以检测身体的发射光谱。根据另一实施例，红外光谱仪包括用于接收红外能量的窗口。窗户有一个暴露的表面。红外光谱仪还包括标准，其包括由具有已知且稳定的光谱性质的材料形成的主体。身体的至少一部分可拆卸地直接设置在窗户的暴露表面上。

7. 发明申请

WO2004092715A1 SAMPLE ELEMENT FOR USE IN MATERIAL ANALYSIS 审中-公开
标题翻译：用于材料分析的样品元素
公开(公告)号：WO2004092715A1
公开(公告)日：2004-10-28
申请号：PCT/US2004/011693
申请日：2004-04-15
申请人： OPTISCAN BIOMEDICAL CORPORATION , BRAIG, James, R. , LI, Ken, I. , STERLING, Bernhard, B. , RULE, Peter , HARTSTEIN, Philip, C.
发明人： BRAIG, James, R. , LI, Ken, I. , STERLING, Bernhard, B. , RULE, Peter , HARTSTEIN, Philip, C.
IPC分类号： G01N21/86
CPC分类号： G01N21/8483 , G01N21/03 , G01N21/0303 , G01N21/3577 , G01N2021/0346
摘要： A system and method are provided for determining a concentration of an analyte in a material sample. The method includes providing a sample element with a sample chamber at least partially defined by at least one window formed from a material having greater than about 1% wavelength-domain variation in absorbtivity of electromagnetic radiation incident thereon. The methot further includes employing the sample element with an analyte detection system which determines the concentration of the analyte with clinically acceptable accuracy.
摘要翻译：提供了用于确定材料样品中分析物浓度的系统和方法。所述方法包括提供样品室，所述样品室至少部分地由至少一个窗口形成，所述至少一个窗口由从其入射的电磁辐射的吸收率具有大于约1％的波长域的变化的材料形成。甲基还包括使用样品元件分析物检测系统，其以临床可接受的精度确定分析物的浓度。

8. 发明申请

WO2004016171A1 DEVICE AND METHOD FOR IN VITRO DETERMINATION OF ANALYTE CONCENTRATIONS WITHIN BODY FLUIDS 审中-公开
标题翻译：用于体内测定体内分析物浓度的装置和方法
公开(公告)号：WO2004016171A1
公开(公告)日：2004-02-26
申请号：PCT/US2003/025352
申请日：2003-08-12
申请人： OPTISCAN BIOMEDICAL CORPORATION , BRAIG, James, R. , RULE, Peter , HARTSTEIN, Philip, C.
发明人： BRAIG, James, R. , RULE, Peter , HARTSTEIN, Philip, C.
IPC分类号： A61B5/15
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/150022 , A61B5/150061 , A61B5/150213 , A61B5/150274 , A61B5/150358 , A61B5/150412 , A61B5/150458 , A61B5/150755 , A61B5/15087 , A61B5/151 , A61B5/15136 , A61B5/1514 , A61B5/157 , A61B2562/0295 , G01N21/35
摘要： A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.
摘要翻译：能够在患者附近部署的无试剂全血分析物检测系统具有能够发射包括光谱带的辐射束的源。全血系统还具有光束的光路中的检测器。全血系统还具有容纳源和检测器的壳体。全血系统还具有位于束的光路中的样品元件。样品元件具有不消除光谱带中的辐射束的透射率的样品池和样品池壁。

9. 发明申请

WO2006017662A1 SAMPLE ELEMENT WITH BARRIER MATERIAL AND VACUUM 审中-公开
标题翻译：带有障碍物材料和真空的样品元件
公开(公告)号：WO2006017662A1
公开(公告)日：2006-02-16
申请号：PCT/US2005/027744
申请日：2005-08-03
申请人： OPTISCAN BIOMEDICAL CORPORATION , BRAIG, James, R. , RULE, Peter , HARTSTEIN, Philip, C. , SMITH, Heidi, S.
发明人： BRAIG, James, R. , RULE, Peter , HARTSTEIN, Philip, C. , SMITH, Heidi, S.
IPC分类号： A61B5/15
CPC分类号： A61B5/14546 , A61B5/14532 , A61B5/150022 , A61B5/150099 , A61B5/150213 , A61B5/150221 , A61B5/150274 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/15117 , A61B5/15125 , A61B5/15136 , A61B5/1514 , A61B2562/0295
摘要： Disclosed is a sample element for holding a volume of bodily fluid drawn from the skin of a patient at a withdrawal site. The sample element comprises a housing defining a sample chamber therein, and a barrier. The sample element also comprises a vacuum source. The barrier has a first side configured to contact the skin of the patient at the withdrawal site, and a second side in fluid communication with the sample chamber. The barrier is configured to be pierced by a lance to permit the bodily fluid to pass from the first side to the second side. Additionally, the vacuum source can be actuated to draw the bodily fluid through the barrier and into the sample chamber. Also disclosed is a method of drawing a bodily fluid form the skin of a patient at a withdrawal site. The method comprises placing a first side of a barrier against the skin of the patient at the withdrawal site. The method further comprises forming a first opening through the barrier and a second opening in the skin of the patient at the withdrawal site. The first and second openings are in fluid communication. The method further comprises applying suction at the first opening of the barrier to draw a bodily fluid from the patient.
摘要翻译：公开了一种用于保持在抽出部位从患者皮肤抽取的体液体积的样本元件。样品元件包括在其中限定样品室的壳体和屏障。样品元件还包括真空源。障碍物具有构造成在抽出部位与患者的皮肤接触的第一侧和与样品室流体连通的第二侧。障碍物被构造成被喷枪刺穿以允许体液从第一侧通过到第二侧。此外，可以致动真空源以将体液通过屏障并进入样品室。还公开了一种在抽出部位从患者皮肤上吸取体液的方法。该方法包括将屏障的第一侧放置在患者的皮肤处于撤出部位。所述方法还包括通过所述屏障形成第一开口，并在所述拔出部位形成患者皮肤中的第二开口。第一和第二开口处于流体连通状态。该方法还包括在屏障的第一开口处施加抽吸以从患者抽取体液。

10. 发明申请

WO2004092743A1 SAMPLE ELEMENT QUALIFICATION 审中-公开
标题翻译：样品元素认证
公开(公告)号：WO2004092743A1
公开(公告)日：2004-10-28
申请号：PCT/US2004/011412
申请日：2004-04-14
申请人： OPTISCAN BIOMEDICAL CORPORATION , BRAIG, James, R. , LI, Ken, I. , WITTE, Kenneth, G. , RULE, Peter , HARTSTEIN, Philip, C.
发明人： BRAIG, James, R. , LI, Ken, I. , WITTE, Kenneth, G. , RULE, Peter , HARTSTEIN, Philip, C.
IPC分类号： G01N35/00
CPC分类号： G01N35/00732 , G01N21/03 , G01N21/5907 , G01N21/8483 , G01N2035/00752 , G01N2035/00762 , G01N2035/00772 , G01N2035/00782
摘要： A sample element (1305) includes first and second substantially parallel faces separated by an intermediate member. The parallel faces and the intermediate member at least partially define a sample chamber (1310) configured to hold a volume of fluid. The sample element further includes an optical path extending through the parallel faces and the intermediate member, such that electromagnetic radiation can propagate through the sample chamber. The sample element further includes an identifying compound disposed within or on at least one of the parallel faces. The identifying compound has at least one indexed optical absorbance feature, such that spectral analysis of electromagnetic radiation propagated through the sample chamber yields the indexed optical absorbance feature. Detection of the indexed optical absorbance feature in electromagnetic radiation propagated through the sample chamber indicates to an analyte detection system whether the sample element is configured for use with the analyte detection system.
摘要翻译：样品元件（1305）包括由中间构件分开的第一和第二基本上平行的面。平行面和中间构件至少部分地限定了构造成容纳一定体积的流体的样品室（1310）。样本元件还包括延伸穿过平行面和中间构件的光路，使得电磁辐射可以传播通过样品室。样本元件还包括设置在至少一个平行面内或之中的识别化合物。识别化合物具有至少一个索引的光吸收特征，使得通过样品室传播的电磁辐射的光谱分析产生索引的光吸收特征。通过样品室传播的电磁辐射中的指示光吸收特征的检测表明分析物检测系统是否将样品元件配置为与分析物检测系统一起使用。

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