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1. 发明专利

AU2010256880B2 Identification of small molecules recognized by antibodies in subjects with neurodegenerative diseases 未知
公开(公告)号：AU2010256880B2
公开(公告)日：2015-01-22
申请号：AU2010256880
申请日：2010-06-01
申请人： OPKO HEALTH INC , UNIV TEXAS
发明人： MOOLA REDDY , GERMAN DWIGHT , CONNELL STEVEN , WILSON ROSEMARY , WILSON JOHNNIE , KODADEK THOMAS
IPC分类号： G01N33/564 , C07K1/04 , C07K7/06 , G01N33/68
摘要： The present invention provides for the identification of individuals having neurodegenerative diseases (ND). Peptoids recognized by Parkinson's Disease- and Alzheimer's Disease-specific antibodies are identified, allowing one to diagnose or predict ND in subjects.

2. 发明专利

CA2764153A1 IDENTIFICATION OF SMALL MOLECULES RECOGNIZED BY ANTIBODIES IN SUBJECTS WITH NEURODEGENERATIVE DISEASES 未知
公开(公告)号：CA2764153A1
公开(公告)日：2010-12-09
申请号：CA2764153
申请日：2010-06-01
申请人： UNIV TEXAS , OPKO HEALTH INC
发明人： MOOLA REDDY , GERMAN DWIGHT , CONNELL STEVEN , WILSON ROSEMARY , WILSON JOHNNIE , KODADEK THOMAS
IPC分类号： G01N33/564 , C07K1/04 , C07K7/06 , G01N33/68
摘要： The present invention provides for the identification of individuals having neurodegenerative diseases (ND). Peptoids recognized by Parkinson's Disease- and Alzheimer's Disease-specific antibodies are identified, allowing one to diagnose or predict ND in subjects.

3. 发明专利

BRPI1013012A2 identificação de pequenas moléculas reconhecidas por anticorpos em indivíduos com doenças neurodegenerativas 未知
公开(公告)号：BRPI1013012A2
公开(公告)日：2016-10-18
申请号：BRPI1013012
申请日：2010-06-01
申请人： OPKO HEALTH INC , UNIV TEXAS
发明人： GERMAN DWIGHT , WILSON JOHNNIE , MOOLA REDDY , WILSON ROSEMARY , CONNELL STEVEN , KODADEK THOMAS
IPC分类号： C07K7/06 , C07K1/04 , G01N33/564 , G01N33/68

4. 发明专利

CA2763685A1 PEPTOID LIGANDS FOR ISOLATION AND TREATMENT OF AUTOIMMUNE T-CELLS 未知
公开(公告)号：CA2763685A1
公开(公告)日：2010-12-02
申请号：CA2763685
申请日：2010-05-28
申请人： UNIV TEXAS , OPKO HEALTH INC
发明人： GOCKE ANNE R , UDUGAMASOORIYA D GOMIKA , KODADEK THOMAS
IPC分类号： G01N33/50 , A61K47/48 , C07K7/00
摘要： The present invention provides for the identification of autoreactive T cell populations from individuals having autoimmune diseases, such as multiple sclerosis and EAE. Peptoids recognized by autoreactive T cells can be used to identify various types of autoimmune disease, and can also be used to target therapies against such populations.

5. 发明专利

CA2764153C IDENTIFICATION OF SMALL MOLECULES RECOGNIZED BY ANTIBODIES IN SUBJECTS WITH NEURODEGENERATIVE DISEASES 未知
公开(公告)号：CA2764153C
公开(公告)日：2021-07-27
申请号：CA2764153
申请日：2010-06-01
申请人： UNIV TEXAS , OPKO HEALTH INC
发明人： MOOLA REDDY , GERMAN DWIGHT , CONNELL STEVEN , WILSON ROSEMARY , WILSON JOHNNIE , KODADEK THOMAS
IPC分类号： C07K7/06 , C07K1/04 , G01N33/564
摘要： The present invention provides for the identification of individuals having neurodegenerative diseases (ND). Peptoids recognized by Parkinson's Disease- and Alzheimer's Disease-specific antibodies are identified, allowing one to diagnose or predict ND in subjects.

6. 发明专利

BRPI1014995A2 ligantes peptídeos para o isolamento e tratamento de células t autoimunes 未知
公开(公告)号：BRPI1014995A2
公开(公告)日：2016-04-26
申请号：BRPI1014995
申请日：2010-05-28
申请人： OPKO HEALTH INC , UNIV TEXAS
发明人： GOCKE ANNE R , UDUGAMASOORIYA D GOMIKA , KODADEK THOMAS
IPC分类号： A61K47/48 , C07K7/00 , G01N33/50

7. 发明专利

AU2010253797B2 Peptoid ligands for isolation and treatment of autoimmune T-cells 未知
公开(公告)号：AU2010253797B2
公开(公告)日：2015-03-12
申请号：AU2010253797
申请日：2010-05-28
申请人： OPKO HEALTH INC , UNIV TEXAS
发明人： GOCKE ANNE R , UDUGAMASOORIYA D GOMIKA , KODADEK THOMAS
IPC分类号： G01N33/50 , A61K47/48 , C07K7/00
摘要： The present invention provides for the identification of autoreactive T cell populations from individuals having autoimmune diseases, such as multiple sclerosis and EAE. Peptoids recognized by autoreactive T cells can be used to identify various types of autoimmune disease, and can also be used to target therapies against such populations.

8. 发明专利

HK1169709A1 IDENTIFICATION OF SMALL MOLECULES RECOGNIZED BY ANTIBODIES IN SUBJECTS WITH NEURODEGENERATIVE DISEASES 未知
公开(公告)号：HK1169709A1
公开(公告)日：2013-02-01
申请号：HK12110345
申请日：2012-10-18
申请人： UNIV TEXAS , OPKO HEALTH INC
发明人： MOOLA REDDY , GERMAN DWIGHT , CONNELL STEVEN , WILSON ROSEMARY , WILSON JOHNNIE , KODADEK THOMAS
IPC分类号： G01N20060101 , C07K20060101
摘要： The present invention provides for the identification of individuals having neurodegenerative diseases (ND). Peptoids recognized by Parkinson's Disease- and Alzheimer's Disease-specific antibodies are identified, allowing one to diagnose or predict ND in subjects.

9. 发明专利

CO6450654A2 IDENTIFICACIÓN DE MOLÉCULAS PEQUEÑAS RECONOCIDAS POR ANTICUERPOS EN SUJETOS CON ENFERMEDADES NEURODEGENERATIVAS 未知
公开(公告)号：CO6450654A2
公开(公告)日：2012-05-31
申请号：CO11141472
申请日：2011-10-21
申请人： REGENST OF THE UNIVERSITY OF TEXAS SYSTEM BOARD OF , OPKO HEALTH INC
发明人： MOOLA REDDY , GERMAN DWIGHT , CONNELL STEVEN , WILSON ROSEMARY , WILSON JOHNNIE , KODADEK THOMAS
IPC分类号： G01N33/564
摘要： La presente invención se proporciona para la identificación de individuos que tienen enfermedades neurodegenerativas (ND). Los peptoides reconocidos por anticuerpos específicos de la enfermedad de Parkinson- y Enfermedad de Alzheimer se identifican, permitiendo diagnosticar o predecir ND en sujetos.

10. 发明申请

WO2006124644A3 PROTEIN AND ANTIBODY PROFILING USING SMALL MOLECULE MICROARRAYS 审中-公开
标题翻译：使用小分子微阵列的蛋白质和抗体分析
公开(公告)号：WO2006124644A3
公开(公告)日：2007-03-15
申请号：PCT/US2006018507
申请日：2006-05-12
申请人： UNIV TEXAS , KODADEK THOMAS
发明人： KODADEK THOMAS
IPC分类号： G01N33/68
CPC分类号： G01N33/6854 , G01N33/54366 , G01N33/6803 , G01N33/6842 , G01N33/6845
摘要： Aspects of the present invention describe methodology by which arrays of synthetic molecules can be created and employed for various types of proteomics profiling experiments. The most important of these from a clinical standpoint are the visualization of antibody and T cell binding patterns, which could be employed as a tool for monitoring the state of the immune system of a patient. This may be a generally useful tool for the diagnosis of many types of disease states. Similar techniques are employed to detect the post-translational modification of specific proteins, a tool for the visualization of induction of signal transduction pathways in cells and tissues treated with drugs. Finally, aspects of the invention teach a method for the creation of simpler arrays with .less than 100 features that are, nonetheless, effective for protein profiling experiments.
摘要翻译：本发明的方面描述了可以产生合成分子阵列并用于各种类型的蛋白质组学分析实验的方法。从临床观点来看，其中最重要的是抗体和T细胞结合模式的可视化，其可以用作监测患者免疫系统状态的工具。这可能是诊断许多类型疾病状态的一般有用的工具。采用相似的技术来检测特异性蛋白质的翻译后修饰，用于在用药物处理的细胞和组织中信号转导途径诱导的可视化工具。最后，本发明的方面教导了一种用于创建简单阵列的方法，该方法具有100个以上特征，但对于蛋白质分析实验是有效的。

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