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1. 发明申请

WO2021005604A1 LONG-ACTING IGF-1 OR IGF-1 VARIANTS AND METHODS OF PRODUCING SAME 审中-公开
公开(公告)号：WO2021005604A1
公开(公告)日：2021-01-14
申请号：PCT/IL2020/050769
申请日：2020-07-09
申请人： OPKO BIOLOGICS LTD.
发明人： HERSHKOVITZ, Oren , ISRAELI-YAGEV, Lital , BAR-ILAN, Ahuva , MOSCHCOVICH, Laura , GOLAN, Moran
IPC分类号： C07K14/65 , A61K38/00 , C12N15/85
摘要： Compositions which include polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotropin attached to the carboxy terminus or amino terminus of an insulin-like growth factor 1 (IGF-1) or IGF-1 variant. Polynucleotides encoding the same are disclosed. Pharmaceutical compositions and pharmaceutical formulations comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.

2. 发明申请

WO2018011799A1 LONG-ACTING COAGULATION FACTOR VII AND METHODS OF PRODUCING SAME 审中-公开
标题翻译：长效凝固因子VII及其制备方法
公开(公告)号：WO2018011799A1
公开(公告)日：2018-01-18
申请号：PCT/IL2017/050784
申请日：2017-07-11
申请人： OPKO BIOLOGICS LTD.
发明人： HERSHKOVITZ, Oren , MOSCHCOVICH, Laura
IPC分类号： C07K14/59 , C07K14/61
摘要： Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotropin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions and pharmaceutical formulations comprising the polypeptides and polynucleotides of the disclosure and methods of using and producing same are also disclosed.
摘要翻译：公开了包含至少一个连接到羧基末端而不连接到凝固因子的氨基末端的绒毛膜促性腺激素的羧基末端肽（CTP）和编码它的多核苷酸的多肽。还公开了包含本公开的多肽和多核苷酸的药物组合物和药物制剂以及使用和生产它们的方法。

3. 发明申请

WO2022197963A1 LONG-ACTING GROWTH HORMONE COMPOSITIONS 审中-公开
公开(公告)号：WO2022197963A1
公开(公告)日：2022-09-22
申请号：PCT/US2022/020807
申请日：2022-03-17
申请人： PFIZER INC. , OPKO BIOLOGICS LTD.
发明人： ALI, Fawziya Karim , ATKINSON, Andrew, Samuel , HERSHKOVITZ, Oren , MCCORMAC, Paul, Brendan , MOSCHCOVICH, Laura , NEIDHARDT, Edith, Anna , SEK, David, Christopher
IPC分类号： A61K38/27 , C07K14/61 , C07K19/00 , C12N15/09 , C12N15/18
摘要： The subject matter described herein is directed to pharmaceutical compositions comprising a long-acting recombinant human growth hormone, and their use in growth-related disorders, methods of making, dosage forms, and uses thereof. In another aspect, disclosed herein are methods of treating growth-related disorders by administering the pharmaceutical compositions.

4. 发明申请

WO2016092549A1 METHODS OF PRODUCING LONG ACTING CTP-MODIFIED GROWTH HORMONE POLYPEPTIDES 审中-公开
标题翻译：生产长效CTP改性生长激素多肽的方法
公开(公告)号：WO2016092549A1
公开(公告)日：2016-06-16
申请号：PCT/IL2015/051196
申请日：2015-12-10
申请人： OPKO BIOLOGICS LTD.
发明人： HERSHKOVITZ, Oren , MOSCHCOVICH, Laura
IPC分类号： C07K14/61 , C07K14/59
CPC分类号： C07K14/59 , A61K38/00 , C07K14/505 , C07K14/555 , C07K14/575 , C07K14/61 , C07K2319/00 , C07K2319/31 , C12N9/6437 , C12N9/644 , C12N15/85 , C12Y304/21021 , C12Y304/21022
摘要： Disclosed herein is a method for manufacturing a recombinant human growth hormone (h GH) modified by a CTP extension in a mammalian cells culture system.
摘要翻译：本文公开了一种用于制造在哺乳动物细胞培养系统中通过CTP延伸修饰的重组人生长激素（h GH）的方法。

5. 发明申请

WO2019211842A1 LONG-ACTING HUMAN GROWTH HORMONE-ANTAGONISTS AND METHODS OF PRODUCING THE SAME 审中-公开
公开(公告)号：WO2019211842A1
公开(公告)日：2019-11-07
申请号：PCT/IL2019/050479
申请日：2019-04-30
申请人： OPKO BIOLOGICS LTD.
发明人： HERSHKOVITZ, Oren , BAR-ILAN, Ahuva , MOSCHCOVICH, Laura , ISRAELI YAGEV, Lital
IPC分类号： A61K38/27 , C07K14/61 , C12N15/09
摘要： Compositions which include human growth hormone (hGH) antagonist variants, polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotropin attached to the carboxy terminus of a human growth hormone (hGH) antagonist and at least one CTP attached to the amino terminus of a hGH antagonist, hGHA variants linked to one or more polyethylene glycol polymers (PEG) via reversible or non-reversible linkers. Polynucleotides encoding the same are disclosed. Pharmaceutical compositions and pharmaceutical formulations comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.

6. 发明申请

WO2016092550A2 METHODS OF PRODUCING LONG ACTING CTP-MODIFIED POLYPEPTIDES 审中-公开
标题翻译：生产长效CTP改性多糖的方法
公开(公告)号：WO2016092550A2
公开(公告)日：2016-06-16
申请号：PCT/IL2015/051197
申请日：2015-12-10
申请人： OPKO BIOLOGICS LTD.
发明人： HERSHKOVITZ, Oren , MOSCHCOVICH, Laura
IPC分类号： A61K38/22
CPC分类号： C07K14/59 , A61K38/00 , C07K14/505 , C07K14/555 , C07K14/575 , C07K14/61 , C07K2319/00 , C07K2319/31 , C12N9/6437 , C12N9/644 , C12N15/85 , C12Y304/21021 , C12Y304/21022
摘要： Disclosed herein is a method for manufacturing a recombinant polypeptide of interest modified by a CTP extension in a mammalian cells culture system.
摘要翻译：本文公开了一种用于在哺乳动物细胞培养系统中制备由CTP延伸修饰的目标重组多肽的方法。

7. 发明公开

EP4212546A1 METHODS OF PRODUCING LONG ACTING CTP-MODIFIED POLYPEPTIDES 审中-实审
公开(公告)号：EP4212546A1
公开(公告)日：2023-07-19
申请号：EP22209083.9
申请日：2015-12-10
申请人： OPKO Biologics Ltd.
发明人： HERSHKOVITZ, Oren , MOSCHCOVICH, Laura
IPC分类号： C07K14/61 , C07K14/59 , A61K38/00 , C12N9/64
摘要： A method of manufacturing a highly glycosylated human chorionic gonadotropin carboxy terminal peptide (CTP)-modified polypeptide that is glycosylated at between 13 and 18 O-linked glycosylation sites, the method comprising stably transfecting a predetermined number of cells with an expression vector comprising a coding portion encoding the CTP-modified polypeptide, wherein the polypeptide is a coagulation Factor VII (FVII) or an activated coagulation Factor VII (FVIIa), wherein the CTP-modified polypeptide consists of three CTP units attached to the carboxy terminus of the FVII or the FVIIa, and the transfected cells express and secrete the CTP-modified polypeptide; obtaining cell clones that overexpress the CTP-modified polypeptide; expanding the clones in solution to a predetermined scale and the clones are obtained from a working cell bank (WCB) or master cell bank (MCB) that optimally expresses and secretes the CTP-modified polypeptide; harvesting the solution containing the clones; filtering the solution containing the clones to obtain a clarified harvest solution; and purifying the clarified harvest solution to obtain a purified protein solution of the CTP-modified polypeptide, wherein at least 70% of the purified CTP-modified polypeptide is the highly glycosylated form.

8. 发明公开

EP3924369A1 LONG-ACTING GLP-2 ANALOGS 审中-公开
公开(公告)号：EP3924369A1
公开(公告)日：2021-12-22
申请号：EP20712056.9
申请日：2020-02-11
申请人： OPKO Biologics Ltd.
发明人： HERSHKOVITZ, Oren , BAR-ILAN, Ahuva , LEV, Vered , MOSCHCOVICH, Laura , RIVKIN, Amit
IPC分类号： C07K14/605 , A61K47/60 , A61P3/04

9. 发明公开

EP3481855A1 LONG-ACTING COAGULATION FACTOR VII AND METHODS OF PRODUCING SAME 有权转让
公开(公告)号：EP3481855A1
公开(公告)日：2019-05-15
申请号：EP17754492.1
申请日：2017-07-11
申请人： OPKO Biologics Ltd.
发明人： HERSHKOVITZ, Oren , MOSCHCOVICH, Laura
IPC分类号： C07K14/59 , C07K14/61

10. 发明公开

EP3240564A2 METHODS OF PRODUCING LONG ACTING CTP-MODIFIED POLYPEPTIDES 审中-公开
标题翻译：生产长效CTP修饰多肽的方法
公开(公告)号：EP3240564A2
公开(公告)日：2017-11-08
申请号：EP15867141.2
申请日：2015-12-10
申请人： Opko Biologics Ltd.
发明人： HERSHKOVITZ, Oren , MOSCHCOVICH, Laura
IPC分类号： A61K38/22
CPC分类号： C07K14/59 , A61K38/00 , C07K14/505 , C07K14/555 , C07K14/575 , C07K14/61 , C07K2319/00 , C07K2319/31 , C12N9/6437 , C12N9/644 , C12N15/85 , C12Y304/21021 , C12Y304/21022
摘要： Disclosed herein is a method for manufacturing a recombinant human growth hormone (h GH) modified by a CTP extension in a mammalian cells culture system.

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