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1. 发明申请

WO2004031231A3 GENES AND POLYPEPTIDES RELATING TO PROSTATE CANCERS 审中-公开
标题翻译：与前列腺癌相关的基因和多肽
公开(公告)号：WO2004031231A3
公开(公告)日：2004-07-08
申请号：PCT/JP0312074
申请日：2003-09-22
申请人： ONCOTHERAPY SCIENCE INC , JAPAN AS REPRESENTED BY THE PR , NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKAGAWA HIDEWAKI , NAKATSURU SHUICHI
发明人： NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKAGAWA HIDEWAKI , NAKATSURU SHUICHI
IPC分类号： C07K14/47 , C12Q1/68
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/136
摘要： The present application provides novel human gene MICAL2-PV whose expression is markedly elevated in prostate cancers. Furthermore, it provides polypeptides encoded by the gene as well as polypeptides encoded by PCOTH which expression was also discovered to be elevated in prostate cancers. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of prostate cancers, as target molecules for developing drugs against the disease, and for attenuating cell growth of prostate cancer.
摘要翻译：本申请提供了新型人基因MICAL2-PV，其表达在前列腺癌中显着升高。此外，它提供由该基因编码的多肽以及由PCOTH编码的多肽，其表达也被发现在前列腺癌中升高。由该基因编码的基因和多肽可以用于例如前列腺癌的诊断中，作为用于开发针对该疾病的药物的靶分子，以及用于减轻前列腺癌的细胞生长。

2. 发明申请

WO2004031414A3 METHOD FOR DIAGNOSING PROSTATE CANCER 审中-公开
标题翻译：诊断前列腺癌的方法
公开(公告)号：WO2004031414A3
公开(公告)日：2004-07-08
申请号：PCT/JP0312073
申请日：2003-09-22
申请人： ONCOTHERAPY SCIENCE INC , JAPAN AS REPRESENTED BY THE PR , NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKAGAWA HIDEWAKI , NAKATSURU SHUICHI
发明人： NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKAGAWA HIDEWAKI , NAKATSURU SHUICHI
IPC分类号： C07K14/47 , C12Q1/68
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/136
摘要： Objective methods for detecting and diagnosing prostate cancer (PRC) or prostatic intraepithelial neoplasia (PIN) are described herein. In one embodiment, the diagnostic method involves the determining a expression level of PRC -associated gene that discriminate between PRC or PIN and nomal cell. The present invention further provides methods of screening for therapeutic agents useful in the treatment of either or both of PRC and PIN, methods of treating either or both of PRC and PIN and method of vaccinating a subject against either or both of PRC and PIN.
摘要翻译：本文描述了用于检测和诊断前列腺癌（PRC）或前列腺上皮内瘤变（PIN）的客观方法。在一个实施方案中，诊断方法涉及确定区分PRC或PIN和正常细胞的PRC相关基因的表达水平。本发明还提供筛选用于治疗PRC和PIN中的任一者或两者的治疗剂的方法，治疗PRC和PIN中的任一者或两者的方法以及针对PRC和PIN中的任一者或两者接种受试者的方法。

3. 发明申请

WO2004031413A3 METHOD FOR DIAGNOSING NON-SMALL CELL LUNG CANCERS 审中-公开
标题翻译：诊断非小细胞肺癌的方法
公开(公告)号：WO2004031413A3
公开(公告)日：2005-02-24
申请号：PCT/JP0312072
申请日：2003-09-22
申请人： ONCOTHERAPY SCIENCE INC , JAPAN AS REPRESENTED BY THE PR , NAKAMURA YUSUKE , DAIGO YATARO , NAKATSURU SHUICHI
发明人： NAKAMURA YUSUKE , DAIGO YATARO , NAKATSURU SHUICHI
IPC分类号： A61P35/00 , C12N15/113 , C12N15/12 , C12Q1/68 , A61K39/00 , C12N15/11 , G01N33/50
CPC分类号： G01N33/57423 , A61K31/7088 , C07K14/47 , C12N15/1135 , C12N2310/11 , C12N2310/14 , C12Q1/6886 , C12Q2600/136 , G01N2800/50
摘要： Disclosed are methods for detecting non-small cell lung cancer using differentially expressed genes. Furthermore, novel human genes whose expression is elevated in non-small cell lung cancer compared to no-cancerous tissues are provided. Also disclosed are methods of identifying compounds for treating and preventing non-small cell lung cancer.
摘要翻译：公开了使用差异表达基因检测非小细胞肺癌的方法。此外，提供了与非癌性组织相比在非小细胞肺癌中表达升高的新型人类基因。还公开了鉴定用于治疗和预防非小细胞肺癌的化合物的方法。

4. 发明申请

WO2006016525A3 GENES AND POLYPEPTIDES RELATING TO BREAST CANCERS 审中-公开
标题翻译：与乳腺癌相关的基因和多肽
公开(公告)号：WO2006016525A3
公开(公告)日：2006-07-06
申请号：PCT/JP2005014369
申请日：2005-07-29
申请人： ONCOTHERAPY SCIENCE INC , UNIV TOKYO , NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKATSURU SHUICHI
发明人： NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKATSURU SHUICHI
IPC分类号： C12Q1/68 , C07K14/47 , C12N15/12
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158
摘要： The present application provides novel human genes B1194, A2282V1, A2282V2, and A2282V3 whose expression is markedly elevated in breast cancer. These genes and polypeptides encoded thereby can be used, for example, in the diagnosis of breast cancer, and as target molecules for developing drugs against breast cancer.
摘要翻译：本申请提供了在乳腺癌中表达显着升高的新型人基因B1194，A2282V1，A2282V2和A2282V3。由此编码的这些基因和多肽可用于例如乳腺癌的诊断，以及用于开发针对乳腺癌的药物的靶分子。

5. 发明申请

WO2008018642A3 GENES AND POLYPEPTIDES RELATING TO BREAST CANCERS 审中-公开
标题翻译：与乳腺癌相关的基因和多肽
公开(公告)号：WO2008018642A3
公开(公告)日：2008-04-03
申请号：PCT/JP2007065992
申请日：2007-08-10
申请人： ONCOTHERAPY SCIENCE INC , UNIV TOKYO , NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKATSURU SHUICHI
发明人： NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKATSURU SHUICHI
IPC分类号： C07K14/43 , C12N15/12 , G01N33/00
CPC分类号： C07K16/18 , A61K31/7088 , C07K14/47 , C07K14/4748 , C12N2310/14 , C12Q1/485 , G01N33/5011 , G01N33/5035 , G01N33/57415 , G01N2333/9121 , G01N2510/00
摘要： The present application provides novel human genes A7322,
摘要翻译：本申请提供了新的人类基因A7322，

6. 发明申请

WO2007013575A3 METHOD FOR DIAGNOSING AND TREATING RENAL CELL CARCINOMA 审中-公开
标题翻译：诊断和治疗肾细胞癌的方法
公开(公告)号：WO2007013575A3
公开(公告)日：2007-10-25
申请号：PCT/JP2006314946
申请日：2006-07-21
申请人： ONCOTHERAPY SCIENCE INC , UNIV TOKYO , NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKATSURU SHUICHI
发明人： NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKATSURU SHUICHI
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： Objective methods for detecting and diagnosing renal cell carcinoma (RCC) are described herein. In one embodiment, the diagnostic method involves determining the expression level of RCC-associated gene that discriminates between RCC cells and normal cells. The present invention further provides methods of screening for therapeutic agents useful in the treatment of renal cell carcinoma, methods of treating renal cell carcinoma and method of vaccinating a subject against renal cell carcinoma.
摘要翻译：本文描述了用于检测和诊断肾细胞癌（RCC）的客观方法。在一个实施方案中，诊断方法包括确定区分RCC细胞和正常细胞的RCC相关基因的表达水平。本发明进一步提供筛选用于治疗肾细胞癌的治疗剂的方法，治疗肾细胞癌的方法以及针对肾细胞癌接种受试者的方法。

7. 发明申请

WO2006085684A9 METHOD OF DIAGNOSING BLADDER CANCER 审中-公开
标题翻译：诊断膀胱癌的方法
公开(公告)号：WO2006085684A9
公开(公告)日：2006-10-19
申请号：PCT/JP2006302684
申请日：2006-02-09
申请人： ONCOTHERAPY SCIENCE INC , UNIV TOKYO , NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKATSURU SHUICHI
发明人： NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKATSURU SHUICHI
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/57407 , G01N2500/00
摘要： Objective methods for detecting and diagnosing bladder cancer (BLC) are described herein. In one embodiment, the diagnostic method involves determining the expression level of a BLC-associated gene that discriminates between BLC cells and normal cells. The present invention further provides means for predicting and preventing bladder cancer metastasis using BLC-associated genes having unique altered expression patterns in bladder cancer cells with lymph-node metastasis. Finally, the present invention provides methods of screening for therapeutic agents useful in the treatment of bladder cancer, methods of treating bladder cancer and method for vaccinating a subject against bladder cancer. In particular, the present application provides novel human genes C2093, B5860Ns and C6055s whose expression is markedly elevated in bladder cancers. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of bladder cancers, as target molecules for developing drugs against the disease, and for attenuating cell growth of bladder cancer.
摘要翻译：本文描述了用于检测和诊断膀胱癌（BLC）的客观方法。在一个实施方案中，诊断方法包括确定区分BLC细胞和正常细胞的BLC相关基因的表达水平。本发明进一步提供了使用在具有淋巴结转移的膀胱癌细胞中具有独特改变的表达模式的BLC相关基因来预测和预防膀胱癌转移的手段。最后，本发明提供了筛选可用于治疗膀胱癌的治疗剂的方法，治疗膀胱癌的方法以及针对膀胱癌接种受试者的方法。具体而言，本申请提供了在膀胱癌中表达显着升高的新型人基因C2093，B5860N和C6055。由基因编码的基因和多肽可以用于例如膀胱癌的诊断，作为开发针对该疾病的药物的靶分子，以及用于减弱膀胱癌的细胞生长。

8. 发明申请

WO2005029067A3 METHOD OF DIAGNOSING BREAST CANCER 审中-公开
标题翻译：诊断乳腺癌的方法
公开(公告)号：WO2005029067A3
公开(公告)日：2005-08-18
申请号：PCT/JP2004011741
申请日：2004-08-10
申请人： ONCOTHERAPY SCIENCE INC , UNIV TOKYO , NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKATSURU SHUICHI
发明人： NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKATSURU SHUICHI
IPC分类号： C07K14/47 , C12N9/10 , C12Q1/68 , G01N33/574 , G01N33/48
CPC分类号： C12Q1/6886 , C07K14/4702 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/57415 , G01N2500/04
摘要： Compositions and objective methods for detecting, diagnosing, and treating breast cancer (BRC) are described herein. In particular, the present invention describes three BRC-associated genes, referred to herein as A5657, B9769, and C7965, up-regulated in BRC cells as compared to normal cells. In one embodiment, the diagnostic method involves determining the expression level of a BRC-associated gene that discriminates between BRC cells and normal cells; in an alternate embodiment, the diagnostic method involves determining the expression level of a BRC-associated gene that discriminates among BRC cells, between DCIS cells and IDC cells. The present invention further provides methods of screening for therapeutic agents useful in the treatment of breast cancer, methods of treating breast cancer and methods for vaccinating a subject against breast cancer.
摘要翻译：本文描述了用于检测，诊断和治疗乳腺癌（BRC）的组合物和客观方法。特别地，本发明描述了与正常细胞相比，在BRC细胞中上调的三种BRC相关基因（本文称为A5657，B9769和C7965）。在一个实施方案中，诊断方法包括确定区分BRC细胞和正常细胞的BRC相关基因的表达水平; 在替代实施方案中，诊断方法包括确定区分BRC细胞，DCIS细胞和IDC细胞之间的BRC相关基因的表达水平。本发明进一步提供了筛选用于治疗乳腺癌的治疗剂的方法，以及用于治疗乳腺癌的方法以及接种受试者抵抗乳腺癌的方法。

9. 发明申请

WO2007013360A2 PANCREATIC CANCER RELATED GENE CST6 AND GABRP 审中-公开
标题翻译：胰腺癌相关基因CST6和GABRP
公开(公告)号：WO2007013360A2
公开(公告)日：2007-02-01
申请号：PCT/JP2006314444
申请日：2006-07-14
申请人： ONCOTHERAPY SCIENCE INC , UNIV TOKYO , NAKAMURA YUSUKE , NAKAGAWA HIDEWAKI , NAKATSURU SHUICHI
发明人： NAKAMURA YUSUKE , NAKAGAWA HIDEWAKI , NAKATSURU SHUICHI
IPC分类号： C12N15/113 , C12Q1/68 , G01N33/574
CPC分类号： G01N33/57438 , A61K38/00 , C07K14/705 , C07K14/70571 , C12N15/1135 , C12Q1/6886 , C12Q2600/136 , G01N2500/00
摘要： Objective methods of detecting and diagnosing pancreatic cancer (PDAC) are described herein. In one embodiment, the diagnostic method involves determining the expression level of CST6 or GABRP that discriminates between PDAC cells and normal cells. Finally, the present invention provides methods of screening for therapeutic agents useful in the treatment of pancreatic cancer, methods of treating pancreatic cancer and method of vaccinating a subject against pancreatic cancer.
摘要翻译：本文描述了检测和诊断胰腺癌（PDAC）的客观方法。在一个实施方案中，诊断方法涉及确定区分PDAC细胞和正常细胞的CST6或GABRP的表达水平。最后，本发明提供了筛选用于治疗胰腺癌的治疗剂，胰腺癌治疗方法和接种受试者免受胰腺癌的方法。

10. 发明申请

WO2008020596A3 TREATING OR PREVENTING CANCERS OVER-EXPRESSING REG4 OR KIAA0101 审中-公开
标题翻译：治疗或预防过度表达REG4或KIAA0101的癌症
公开(公告)号：WO2008020596A3
公开(公告)日：2008-06-12
申请号：PCT/JP2007065873
申请日：2007-08-08
申请人： ONCOTHERAPY SCIENCE INC , NAKAMURA YUSUKE , NAKAGAWA HIDEWAKI , NAKATSURU SHUICHI
发明人： NAKAMURA YUSUKE , NAKAGAWA HIDEWAKI , NAKATSURU SHUICHI
IPC分类号： A61K31/7088 , A61K38/00 , A61K39/395 , A61P35/00 , C07K14/475 , C07K16/32 , C12N15/113 , C12Q1/68 , G01N33/53
CPC分类号： C12N15/1135 , A61K38/00 , C07K14/47 , C07K16/18 , C07K2317/56 , C07K2317/565 , C12N2310/111 , C12N2310/14 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158
摘要： The invention features a method for inhibiting growth of a cancer cell by contacting the cell with a composition of an siRNA that inhibits expression of REG4 or KIAA0101. Methods of treating cancer are also within the invention. The invention also features products, including nucleic acid sequences and vectors as well as to compositions comprising them, useful in the provided methods. The invention also provides a method for inhibiting of tumor cell, for example pancreatic cancer cell, prostatic cancer cell, breast cancer cell, and bladder cancer cell, particularly pancreatic ductal adenocarcinoma (PDAC) by inhibiting REG4 gene. The present invention also relates to methods of treating or preventing PDAC in a subject comprising the step of administering to said subject a pharmaceutically effective amount of an antibody or fragment thereof that binds to a protein encoded by REG4. The present invention also relates to methods of diagnosing chemo-radiation therapeutic resistance of a cancer. The present invention also provides therapeutic agents or methods for treating cancer using the polypeptides. The polypeptides of the present invention are composed of an amino acid sequence which comprises polypeptide which comprises QKGIGEFF/SEQ ID NO: 21. The polypeptides of the present invention can be introduced into cancer cells by modifying the polypeptides with transfection agents such as poly-arginine.
摘要翻译：本发明的特征在于通过使细胞与抑制REG4或KIAA0101表达的siRNA的组合物接触来抑制癌细胞生长的方法。治疗癌症的方法也在本发明之内。本发明的特征还在于提供的方法中有用的产品，包括核酸序列和载体以及包含它们的组合物。本发明还提供了通过抑制REG4基因抑制肿瘤细胞，例如胰腺癌细胞，前列腺癌细胞，乳腺癌细胞和膀胱癌细胞，特别是胰腺导管腺癌（PDAC）的方法。本发明还涉及在受试者中治疗或预防PDAC的方法，其包括向所述受试者施用药学有效量的与由REG4编码的蛋白质结合的抗体或其片段的步骤。本发明还涉及诊断癌症的化学放射治疗抗性的方法。本发明还提供了使用所述多肽治疗癌症的治疗剂或方法。本发明的多肽由包含包含QKGIGEFF / SEQ ID NO：21的多肽的氨基酸序列组成。可以通过用转染剂如聚精氨酸修饰多肽将本发明的多肽引入癌细胞。

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