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1. 发明申请

WO2007142711A3 METHODS FOR DIAGNOSING AND TREATING CANCER 审中-公开
标题翻译：癌症诊断与治疗方法
公开(公告)号：WO2007142711A3
公开(公告)日：2008-12-18
申请号：PCT/US2007005443
申请日：2006-10-31
申请人： ONCOMED PHARM INC , GURNEY AUSTIN , LEWICKI JOHN , SATYAL SANJEEV , HOEY TIMOTHY
发明人： GURNEY AUSTIN , LEWICKI JOHN , SATYAL SANJEEV , HOEY TIMOTHY
IPC分类号： C07K1/00
CPC分类号： C07K16/30 , A61K45/06 , A61K2039/505 , C07K16/2896 , C07K16/468 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76
摘要： The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis, characterization, prognosis and treatment of cancer and specifically targeting cancer stem cells. The present invention provides a soluble FZD receptor comprising an extracellular domain of a human FZD receptor that inhibits growth of tumor cells. The present invention still further provides a soluble receptor comprising a Fri domain of a human FZD receptor that binds a ligand of a human FZD receptor and said soluble receptor is capable of inhibiting tumor growth. The present invention still further provides a method of treating cancer comprising administering a soluble FZD receptor comprising for example, either an extracellular domain of a human FZD receptor or a Fri domain of a human FZD receptor, in an amount effective to inhibit tumor growth.
摘要翻译：本发明涉及用于表征，诊断和治疗癌症的组合物和方法。特别地，本发明提供了用于癌症的诊断，表征，预后和治疗以及特异性靶向癌症干细胞的方法和方法。本发明提供了包含抑制肿瘤细胞生长的人FZD受体的细胞外结构域的可溶性FZD受体。本发明还提供一种包含结合人FZD受体的配体的人FZD受体的Fri结构域的可溶性受体，并且所述可溶性受体能够抑制肿瘤生长。本发明还提供一种治疗癌症的方法，其包括以有效抑制肿瘤生长的量施用包含例如人FZD受体的细胞外结构域或人FZD受体的Fri结构域的可溶性FZD受体。

2. 发明公开

EP2066694A4 COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING CANCER 失效
标题翻译：癌症的治疗和诊断的组合物和方法
公开(公告)号：EP2066694A4
公开(公告)日：2010-05-05
申请号：EP07838966
申请日：2007-09-28
申请人： ONCOMED PHARM INC
发明人： GURNEY AUSTIN , HOEY TIMOTHY , SATYAL SANJEEV , AXELROD FUMIKO
IPC分类号： C07K16/00 , C07H21/04 , C12N15/00 , C12P21/08
CPC分类号： A61K39/39558 , A61K31/4745 , A61K31/513 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61N5/10 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3046 , C07K16/3069 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , A61K2300/00

3. 发明申请

WO2008100563A3 COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING CANCER 审中-公开
标题翻译：诊断和治疗癌症的组合物和方法
公开(公告)号：WO2008100563A3
公开(公告)日：2008-12-18
申请号：PCT/US2008001948
申请日：2008-02-14
申请人： ONCOMED PHARM INC , GURNEY AUSTIN , AXELROD FUMIKO
发明人： GURNEY AUSTIN , AXELROD FUMIKO
IPC分类号： A61K39/395
CPC分类号： C07K16/28 , A61K2039/505 , C07K2317/24 , C07K2317/92
摘要： Humanized antibodies that specifically binds to a non-ligand binding region of human Notch 1 are described. Also described are methods of treating cancer, the methods comprising administering a therapeutically effective amount of a humanized anti-Notch 1 antibody.
摘要翻译：描述了特异性结合人刻缺蛋白1的非配体结合区的人源化抗体。还描述了治疗癌症的方法，所述方法包括施用治疗有效量的人源化抗刻缺蛋白1抗体。

4. 发明申请

WO2008070090A3 COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING CANCER 审中-公开
标题翻译：诊断和治疗癌症的组合物和方法
公开(公告)号：WO2008070090A3
公开(公告)日：2008-11-20
申请号：PCT/US2007024858
申请日：2007-12-05
申请人： ONCOMED PHARM INC , LEWICKI JOHN , GURNEY AUSTIN , SATYAL SANJEEV
发明人： LEWICKI JOHN , GURNEY AUSTIN , SATYAL SANJEEV
IPC分类号： A61K39/395 , C12N5/06 , C12N5/16 , G01N33/53
CPC分类号： C07K16/28 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/2851 , C07K2317/73 , C07K2317/732 , C07K2317/734 , A61K2300/00
摘要： An isolated antibody that specifically binds to an extracellular domain of human DDR2 and has a therapeutic effect on a solid tumor is described. Also described is a method of treating cancer, the method comprising administering to a patient having a solid tumor an antibody of the present disclosure in a therapeutically effective amount.
摘要翻译：描述了特异性结合人DDR2的细胞外结构域并对实体瘤具有治疗效果的分离的抗体。还描述了一种治疗癌症的方法，该方法包括以治疗有效量向患有实体瘤的患者施用本公开的抗体。

5. 发明申请

WO2007145840A3 COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING CANCER 审中-公开
标题翻译：用于诊断和治疗癌症的组合物和方法
公开(公告)号：WO2007145840A3
公开(公告)日：2008-10-02
申请号：PCT/US2007012837
申请日：2007-05-31
申请人： ONCOMED PHARM INC , LEWICKI JOHN , GURNEY AUSTIN , HOEY TIMOTHY , YEN WAN-CHING JY , SATYAL SANJEEV
发明人： LEWICKI JOHN , GURNEY AUSTIN , HOEY TIMOTHY , YEN WAN-CHING JY , SATYAL SANJEEV
IPC分类号： A61K39/395 , A61K38/00 , G01N33/574
CPC分类号： C07K16/30 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61N5/10 , C07K16/18 , C07K16/28 , C07K16/3015 , C07K16/3046 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis, characterization, prognosis and treatment of cancer and specifically targeting cancer stem cells. The present invention provides an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human NOTCH receptor and inhibits growth of tumor cells. The present invention further provides a method of treating cancer, the method comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human NOTCH receptor protein and inhibits growth of tumor cells.
摘要翻译：本发明涉及用于表征，诊断和治疗癌症的组合物和方法。特别地，本发明提供了用于癌症的诊断，表征，预后和治疗以及特异性靶向癌症干细胞的方法和方法。本发明提供了特异性结合人类NOTCH受体的细胞外结构域的非配体结合区并抑制肿瘤细胞生长的抗体。本发明还提供了一种治疗癌症的方法，所述方法包括施用治疗有效量的特异性结合人NOTCH受体蛋白的细胞外结构域的非配体结合区的抗体并抑制肿瘤细胞的生长。

6. 发明申请

WO2008091641A3 COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING CANCER 审中-公开
标题翻译：诊断和治疗癌症的组合物和方法
公开(公告)号：WO2008091641A3
公开(公告)日：2008-12-04
申请号：PCT/US2008000884
申请日：2008-01-24
申请人： ONCOMED PHARM INC , GURNEY AUSTIN , SATO AARON , FITCH-BRUHNS MAUREEN
发明人： GURNEY AUSTIN , SATO AARON , FITCH-BRUHNS MAUREEN
IPC分类号： C07K16/00
CPC分类号： C07K16/2863 , A61K31/337 , A61K39/39533 , A61K39/3955 , A61K39/39558 , A61K2039/505 , C07K16/28 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C12N5/12 , Y10S530/809 , A61K2300/00
摘要： Isolated antibodies that specifically binds to an extracellular conserved ligand binding region of a human Notch receptor and inhibits growth of a tumor are described. Also described are methods of treating cancer, the method comprising administering an anti-Notch antibody in an amount effective to inhibit tumor growth.
摘要翻译：描述了特异性结合人Notch受体的细胞外保守配体结合区并抑制肿瘤生长的分离抗体。还描述了治疗癌症的方法，所述方法包括以有效抑制肿瘤生长的量施用抗Notch抗体。

7. 发明申请

WO2016033284A4 COMBINATION THERAPY FOR TREATMENT OF CANCER 审中-公开
标题翻译：用于治疗癌症的组合治疗
公开(公告)号：WO2016033284A4
公开(公告)日：2016-04-28
申请号：PCT/US2015047102
申请日：2015-08-27
申请人： ONCOMED PHARM INC
发明人： GURNEY AUSTIN , YEN WAN-CHING
IPC分类号： A61K38/17 , A61K31/337 , A61K39/395 , A61P35/00
CPC分类号： C07K16/30 , A61K31/337 , A61K31/475 , A61K38/177 , A61K39/395 , A61K2039/505 , A61K2039/545 , C07K16/2863 , C07K2317/56 , C07K2317/565 , C07K2317/73 , A61K2300/00
摘要： The present invention provides methods comprising combination therapy for treating cancer. Wnt pathway inhibitors in combination with mitotic inhibitors administered in a staggered or sequential dosing manner for the treatment of cancer and other diseases.
摘要翻译：本发明提供了用于治疗癌症的组合疗法的方法。 Wnt通路抑制剂与有丝分裂抑制剂联合，以交错或连续给药方式给药，用于治疗癌症和其他疾病。

8. 发明申请

WO2016025797A4 RSPO1 BINDING AGENTS AND USES THEREOF 审中-公开
标题翻译： RSPO1绑定代理及其用途
公开(公告)号：WO2016025797A4
公开(公告)日：2016-03-31
申请号：PCT/US2015045210
申请日：2015-08-14
申请人： ONCOMED PHARM INC
发明人： GURNEY AUSTIN
IPC分类号： A61K39/395 , A61P35/00 , C07K16/28
CPC分类号： C07K16/18 , A61K39/39558 , A61K45/06 , A61K2039/507 , C07K2317/24 , C07K2317/31 , C07K2317/565 , C07K2317/567 , C07K2317/92 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158
摘要： The present invention relates to RSPO-binding agents, particularly antibodies that specifically bind human RSPOl. Also described are methods of treating cancer and other diseases, comprising administering a therapeutically effect amount of an agent or antibody of the present invention to a patient in need thereof.
摘要翻译：本发明涉及RSPO结合剂，特别是与人RSP01特异性结合的抗体。还描述了治疗癌症和其他疾病的方法，其包括将治疗有效量的本发明的药剂或抗体给予有需要的患者。

9. 发明申请

WO2009005809A3 COMPOSITIONS AND METHODS FOR TREATING AND DIAGNOSING CANCER 审中-公开
标题翻译：用于治疗和诊断癌症的组合物和方法
公开(公告)号：WO2009005809A3
公开(公告)日：2009-04-02
申请号：PCT/US2008008210
申请日：2008-07-02
申请人： ONCOMED PHARM INC , GURNEY AUSTIN
发明人： GURNEY AUSTIN
IPC分类号： A61K39/395 , A61P35/00 , C07K14/475 , C07K14/705 , C07K16/28 , C12N15/12
CPC分类号： A61K39/39558 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/723 , C07K16/18 , C07K16/28 , C07K16/30 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/76 , C07K2319/30
摘要： The present invention relates to compositions and methods for characterizing, diagnosing and treating cancer. In particular, the present invention identifies LGR5 as a protein over-expressed in solid tumor stem cell. The present invention further identifies an interaction between RSPO1 and LGR5 as an alternative pathway for the activation of beta-catenin signaling. In certain embodiments, the present invention provides biomolecules that disrupt functional signaling via a LGR protein, including, in certain embodiments, molecules that inhibit the interaction between one or more RSPO proteins and one or more LGR proteins, such as LGR5. In certain embodiments, the present invention provides methods of treating cancer comprising disrupting functional LGR signaling and inhibiting growth of a solid tumor comprising solid tumor stem cells.
摘要翻译：本发明涉及用于表征，诊断和治疗癌症的组合物和方法。特别地，本发明将LGR5鉴定为在实体瘤干细胞中过表达的蛋白质。本发明进一步鉴定了RSPO1和LGR5之间的相互作用，作为β-连环蛋白信号传导活化的替代途径。在某些实施方案中，本发明提供了通过LGR蛋白破坏功能性信号传导的生物分子，包括在某些实施方案中抑制一种或多种RSPO蛋白与一种或多种LGR蛋白如LGR5之间相互作用的分子。在某些实施方案中，本发明提供了治疗癌症的方法，包括破坏功能性LGR信号并抑制包含固体肿瘤干细胞的实体瘤的生长。

10. 发明公开

EP2032166A4 COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING CANCER 有权
标题翻译： ZUSAMMENSETZUNGEN UND VERFAHREN ZUR DIAGNOSTIZIERUNG UND BEHANDLUNG VON KREBS
公开(公告)号：EP2032166A4
公开(公告)日：2009-09-09
申请号：EP07777332
申请日：2007-05-31
申请人： ONCOMED PHARM INC
发明人： LEWICKI JOHN , GURNEY AUSTIN , HOEY TIMOTHY , YEN WAN-CHING , SATYAL SANJEEV
IPC分类号： A61K39/395 , A61K38/00 , G01N33/574
CPC分类号： C07K16/30 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61N5/10 , C07K16/18 , C07K16/28 , C07K16/3015 , C07K16/3046 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis, characterization, prognosis and treatment of cancer and specifically targeting cancer stem cells. The present invention provides an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human NOTCH receptor and inhibits growth of tumor cells. The present invention further provides a method of treating cancer, the method comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human NOTCH receptor protein and inhibits growth of tumor cells.
摘要翻译：本发明涉及用于表征，诊断和治疗癌症的组合物和方法。特别地，本发明提供了用于癌症的诊断，表征，预后和治疗以及特异性靶向癌症干细胞的方法和方法。本发明提供了特异性结合人NOTCH受体的细胞外结构域的非配体结合区并抑制肿瘤细胞生长的抗体。本发明还提供了一种治疗癌症的方法，所述方法包括施用治疗有效量的特异性结合人NOTCH受体蛋白的细胞外结构域的非配体结合区的抗体并抑制肿瘤细胞的生长。

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