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1. 发明申请

WO2012139081A3 METHODS FOR TREATING CONDITIONS ASSOCIATED WITH MASP-2 DEPENDENT COMPLEMENT ACTIVATION 审中-公开
标题翻译：用于处理与MASP-2相关的补充激活相关条件的方法
公开(公告)号：WO2012139081A3
公开(公告)日：2012-11-29
申请号：PCT/US2012032650
申请日：2012-04-06
申请人： UNIV LEICESTER , OMEROS CORP , DEMOPULOS GREGORY A , DUDLER TOM , SCHWAEBLE HANS-WILHELM
发明人： DEMOPULOS GREGORY A , DUDLER TOM , SCHWAEBLE HANS-WILHELM
IPC分类号： A61K39/395 , C12N15/11
CPC分类号： C07K16/40 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/71 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a living subject. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to Inhibit MASP-2-dependent complement activation. In some embodiments, the MASP-2 inhibitory agent inhibits cellular injury associated with MASP-2-rnediated alternative complement pathway activation, while leaving the classical (Clq -dependent) pathway component of the immune system Intact. In another aspect, the invention provides compositions for inhibiting the effects of lectin-dependent complement activation, comprising a therapeutically effective amount of a MASP-2 inhibitory agent and a pharmaceutically acceptable carrier.
摘要翻译：一方面，本发明提供抑制活体受试者中MASP-2依赖性补体活化的作用的方法。所述方法包括向有需要的受试者施用一定量的有效抑制MASP-2依赖性补体活化的MASP-2抑制剂的步骤。在一些实施方案中，MASP-2抑制剂抑制与MASP-2相关的替代补体途径活化相关的细胞损伤，同时保留免疫系统的经典（Clq依赖性）途径成分完整。在另一方面，本发明提供了用于抑制凝集素依赖性补体活化的作用的组合物，其包含治疗有效量的MASP-2抑制剂和药学上可接受的载体。

2. 发明申请

WO2013192240A3 COMPOSITIONS AND METHODS OF INHIBITING MASP-1 AND/OR MASP-2 AND/OR MASP-3 FOR THE TREATMENT OF VARIOUS DISEASES AND DISORDERS 审中-公开
标题翻译：抑制MASP-1和/或MASP-2和/或MASP-3用于治疗各种疾病和疾病的组合物和方法
公开(公告)号：WO2013192240A3
公开(公告)日：2014-07-03
申请号：PCT/US2013046432
申请日：2013-06-18
申请人： OMEROS CORP , UNIV LEICESTER
发明人： SCHWAEBLE HANS-WILHELM , DEMOPULOS GREGORY A , DUDLER THOMAS , GRAY PATRICK
IPC分类号： A61K39/00
CPC分类号： C07K16/40 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/18 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： In one aspect, the invention provides methods and compositions for inhibiting MASP-3 -dependent complement activation in a subject suffering from or at risk for developing, a disease or disorder selected from the group consisting of paroxysmal nocturnal hemoglobinuria, age-related macular degeneration, arthritis, disseminated intravascular coagulation, thrombotic microangiopathy, asthma, dense deposit disease, pauci-immune necrotizing crescentic glomerulonephritis, traumatic brain injury, aspiration pneumonia, endophthalmitis, neuromyelitis optica and Behcet's disease by administering to the subject a composition comprising an amount of a MASP-3 inhibitory agent in an amount effective to inhibit MASP-3 -dependent complement activation. In some embodiments, the subject is administered a MASP-2 inhibitory agent and a MASP-1 inhibitory agent, a MASP-2 inhibitory agent and a MASP-3 inhibitory agent administered, a MASP-3 inhibitory agent and a MASP-1 inhibitory agent, or a MASP-1 inhibitory agent, a MASP-2 inhibitory agent and a MASP-3 inhibitory agent.
摘要翻译：一方面，本发明提供了在患有或处于发展中的疾病或病症的受试者中抑制MASP-3依赖性补体活化的方法和组合物，所述疾病或病症选自阵发性夜间血红蛋白尿，年龄相关性黄斑变性，关节炎，弥漫性血管内凝血，血栓性微血管病变，哮喘，致密沉积病，波氏免疫坏死性新月体性肾小球肾炎，创伤性脑损伤，吸入性肺炎，眼内炎，眼科神经性眼炎和白塞病，通过向受试者施用包含一定量的MASP- 3抑制剂以有效抑制MASP-3依赖性补体活化的量。在一些实施方案中，给予受试者MASP-2抑制剂和MASP-1抑制剂，MASP-2抑制剂，MASP-2抑制剂和MASP-3抑制剂，MASP-3抑制剂和MASP-1抑制剂，或MASP-1抑制剂，MASP-2抑制剂和MASP-3抑制剂。

3. 发明申请

WO2007117996A3 METHODS FOR TREATING CONDITIONS ASSOCIATED WITH MASP-2 DEPENDENT COMPLEMENT ACTIVATION 审中-公开
标题翻译：用于处理与MASP-2相关的补充激活相关条件的方法
公开(公告)号：WO2007117996A3
公开(公告)日：2007-12-21
申请号：PCT/US2007065274
申请日：2007-03-27
申请人： UNIV LEICESTER , OMEROS CORP , SCHWAEBLE HANS-WILHELM , STOVER CORDULA MARGARET , TEDFORD CLARK E , PARENT JAMES B , FUJITA TEIZO
发明人： SCHWAEBLE HANS-WILHELM , STOVER CORDULA MARGARET , TEDFORD CLARK E , PARENT JAMES B , FUJITA TEIZO
IPC分类号： A61K39/395 , C07K16/40
CPC分类号： C07K16/40 , A01K67/0276 , A01K2207/15 , A01K2217/00 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0375 , A61K39/395 , A61K49/0008 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/71 , C07K2317/76 , C07K2317/92 , C12N9/6408 , C12N9/6424 , C12Y304/21104 , Y10S514/912
摘要： In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a living subject. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation. In some embodiments, the MASP-2 inhibitory agent inhibits cellular injury associated with MASP-2-mediated alternative complement pathway activation, while leaving the classical (Clq-dependent) pathway component of the immune system intact. In another aspect, the invention provides compositions for inhibiting the effects of lectin-dependent complement activation, comprising a therapeutically effective amount of a MASP-2 inhibitory agent and a pharmaceutically acceptable carrier.
摘要翻译：一方面，本发明提供抑制活体受试者中MASP-2依赖性补体活化的作用的方法。所述方法包括向有需要的受试者施用一定量的有效抑制MASP-2依赖性补体活化的MASP-2抑制剂的步骤。在一些实施方案中，MASP-2抑制剂抑制与MASP-2介导的替代补体途径活化相关的细胞损伤，同时保持免疫系统的经典（Clq依赖性）通路组分完整。在另一方面，本发明提供了用于抑制凝集素依赖性补体活化的作用的组合物，其包含治疗有效量的MASP-2抑制剂和药学上可接受的载体。

4. 发明申请

WO2013180834A3 COMPOSITIONS AND METHODS OF INHIBITING MASP-1, MASP-2 AND/OR MASP-3 FOR TREATMENT OF PAROXYSMAL NOCTURNAL HEMOGLOBINURIA 审中-公开
标题翻译：抑制MASP-1，MASP-2和/或MASP-3的组合物和方法用于治疗复发性肺动脉高压
公开(公告)号：WO2013180834A3
公开(公告)日：2014-04-03
申请号：PCT/US2013035488
申请日：2013-04-05
申请人： OMEROS CORP , UNIV LEICESTER
发明人： SCHWAEBLE HANS-WILHELM , DEMOPULOS GREGORY A
IPC分类号： A61K39/00
CPC分类号： C07K16/40 , A61K39/3955 , A61K2039/505 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/54 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： Provided are methods and compositions for inhibiting MASP-3-dependent complement activation in a subject suffering from paroxysmal nocturnal hemoglobinuria by administering to the subject a composition comprising an amount of a MASP-3 inhibitory agent in an amount effective to inhibit MAS P-3-depencien! complement activation. Also provided are methods and compositions for increasing the survival of red blood cells in a subject suffering from paroxysmal nocturnal hemoglobinuria by administering to the subject a composition comprising an amount of at least one of a MASP-1 inhibitory agent and/or a MAS P-3 inhibitory agent effective to increase the survival of red blood cells. The subject may be administered a MASP-2 inhibitory agent and a MASP-1 inhibitory agent, a MASP-2 inhibitory agent and a MASP-3 inhibitory agent, administered, a MASP-3 inhibitory agent and a MASP-1 inhibitory agent, or a MASP-1 inhibitory agent, a MASP-2 inhibitory agent and a MASP-3 inhibitory agent.
摘要翻译：本发明提供了通过向受试者施用含有一定量的MASP-3抑制剂的组合物来抑制MASP-3依赖性补体活化的方法和组合物，所述组合物含有有效抑制MAS P-3- depencien！补体激活。还提供了通过向受试者施用包含一定量的MASP-1抑制剂和/或MASP-1抑制剂中的至少一种的组合物来增加患有阵发性夜间血红蛋白尿患者的红细胞的存活的方法和组合物， 3抑制剂有效增加红细胞的存活。受试者可以施用MASP-2抑制剂和MASP-1抑制剂，MASP-2抑制剂和MASP-3抑制剂，MASP-3抑制剂和MASP-1抑制剂，或 MASP-1抑制剂，MASP-2抑制剂和MASP-3抑制剂。

5. 发明申请

WO2005123128A3 METHODS FOR TREATING CONDITIONS ASSOCIATED WITH MASP-2 DEPENDENT COMPLEMENT ACTIVATION 审中-公开
标题翻译：用于处理与MASP-2相关的补充激活相关条件的方法
公开(公告)号：WO2005123128A3
公开(公告)日：2007-01-25
申请号：PCT/US2005020647
申请日：2005-06-09
申请人： OMEROS CORP , UNIV LEICESTER , SCHWAEBLE HANS-WILHELM , STOVER CORDULA M , TEDFORD CLARK E , PARENT JAMES B , FUJITA TEIZO
发明人： SCHWAEBLE HANS-WILHELM , STOVER CORDULA M , TEDFORD CLARK E , PARENT JAMES B , FUJITA TEIZO
IPC分类号： A61K39/395 , A61K31/00 , A61K38/02 , A61P9/00 , A61P21/00 , A61P37/00 , C07K16/40
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A61K2039/505 , C07K16/40 , C07K2317/24 , C07K2317/55 , C12N9/6424
摘要： In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a living subject. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation. In some embodiments, the MASP-2 inhibitory agent inhibits cellular injury associated with MASP-2-mediated alternative complement pathway activation, while leaving the classical (C l q-dependent) pathway component of the immune system intact. In another aspect, the invention provides compositions for inhibiting the effects of lectin-dependent complement activation, comprising a therapeutically effective amount of a MASp-2 inhibitory agent and a pharmaceutically acceptable carrier.
摘要翻译：一方面，本发明提供抑制活体受试者中MASP-2依赖性补体活化的作用的方法。所述方法包括向有需要的受试者施用一定量的有效抑制MASP-2依赖性补体活化的MASP-2抑制剂的步骤。在一些实施方案中，MASP-2抑制剂抑制与MASP-2介导的替代补体途径活化相关的细胞损伤，同时保留免疫系统的经典（C 1 q-依赖）途径组分。另一方面，本发明提供了用于抑制凝集素依赖性补体活化作用的组合物，其包含治疗有效量的MASP-2抑制剂和药学上可接受的载体。

6. 发明授权

EP2386316B1 Methods for treating conditions associated with MASP-2 dependent complement activation 有权转让
公开(公告)号：EP2386316B1
公开(公告)日：2018-02-28
申请号：EP10183216
申请日：2005-06-09
申请人： OMEROS CORP , UNIV LEICESTER
发明人： SCHWAEBLE HANS-WILHELM , STOVER CORDULA M , TEDFORD CLARK E , PARENT JAMES B , FUJITA TEIZO
IPC分类号： A61K39/395 , A61K31/00 , A61K38/02 , A61P9/00 , A61P21/00 , A61P37/00 , C07K16/40
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A61K2039/505 , C07K16/40 , C07K2317/24 , C07K2317/55 , C12N9/6424
摘要： In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a living subject. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation. In some embodiments, the MASP-2 inhibitory agent inhibits cellular injury associated with MASP-2-mediated alternative complement pathway activation, while leaving the classical (C I q-dependent) pathway component of the immune system intact. In another aspect, the invention provides compositions for inhibiting the effects of lectin-dependent complement activation, comprising a therapeutically effective amount of a MASp-2 inhibitory agent and a pharmaceutically acceptable carrier.

7. 发明公开

EP2694108A4 METHODS FOR TREATING CONDITIONS ASSOCIATED WITH MASP-2 DEPENDENT COMPLEMENT ACTIVATION 有权
标题翻译：方法苦难均与MASP-2的补体依赖性连接处理
公开(公告)号：EP2694108A4
公开(公告)日：2014-10-01
申请号：EP12767899
申请日：2012-04-06
申请人： UNIV LEICESTER , OMEROS CORP
发明人： DEMOPULOS GREGORY A , DUDLER TOM , SCHWAEBLE HANS-WILHELM
IPC分类号： A61K39/395 , C07K16/40 , C12N15/11
CPC分类号： C07K16/40 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/71 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a living subject. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation. In some embodiments, the MASP-2 inhibitory agent inhibits cellular injury associated with MASP-2-mediated alternative complement pathway activation, while leaving the classical (C1q-dependent) pathway component of the immune system intact. In another aspect, the invention provides compositions for inhibiting the effects of lectin-dependent complement activation, comprising a therapeutically effective amount of a MASP-2 inhibitory agent and a pharmaceutically acceptable carrier.

8. 发明公开

EP2488203A4 METHODS FOR TREATING DISSEMINATED INTRAVASCULAR COAGULATION BY INHIBITING MASP-2 DEPENDENT COMPLEMENT ACTIVATION 有权转让
标题翻译：一种用于治疗传播性血管内凝血BY抑制MASP-2依赖的补
公开(公告)号：EP2488203A4
公开(公告)日：2013-08-14
申请号：EP10824223
申请日：2010-10-15
申请人： OMEROS CORP , UNIV LEICESTER
发明人： SCHWAEBLE HANS-WILHELM , DUDLER THOMAS A , TEDFORD CLARK E , PARENT JAMES B , DEMOPULOS GREGORY A
IPC分类号： C07K16/40
CPC分类号： C07K16/40 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/76 , C07K2317/92 , C12Y304/21104

9. 发明公开

EP2833907A4 COMPOSITIONS AND METHODS OF INHIBTING MASP-1 AND/OR MASP-3 FOR THE TREATMENT OF PAROXYSMAL NOCTURNAL HEMOGLOBINURIA 有权转让
标题翻译：组合物和用于抑制方法MASP-1和/或MASP-3用于治疗阵发性夜间血红蛋白尿
公开(公告)号：EP2833907A4
公开(公告)日：2016-03-16
申请号：EP13798222
申请日：2013-04-05
申请人： OMEROS CORP , UNIV LEICESTER
发明人： SCHWAEBLE HANS-WILHELM , DEMOPULOS GREGORY A
IPC分类号： A61K39/00 , C07K16/40
CPC分类号： C07K16/40 , A61K39/3955 , A61K2039/505 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/54 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： In one aspect, the invention provides methods and compositions for inhibiting MASP-3-dependent complement activation in a subject suffering from paroxysmal nocturnal hemoglobinuria by administering to the subject a composition comprising an amount of a MASP-3 inhibitory agent in an amount effective to inhibit MASP-3-dependent complement activation. In another aspect, the invention provides methods and compositions for increasing the survival of red blood cells in a subject suffering from paroxysmal nocturnal hemoglobinuria by administering to the subject a composition comprising an amount of at least one of a MASP-1 inhibitory agent and/or a MASP-3 inhibitory agent effective to increase the survival of red blood cells. In some embodiments, the subject is administered a MASP-2 inhibitory agent and a MASP-1 inhibitory agent, a MASP-2 inhibitory agent and a MASP-3 inhibitory agent administered, a MASP-3 inhibitory agent and a MASP-1 inhibitory agent, or a MASP-1 inhibitory agent, a MASP-2 inhibitory agent and a MASP-3 inhibitory agent.
摘要翻译：在一个方面，本发明提供方法和组合物用于抑制在从阵发性睡眠性血红蛋白尿症的受试者MASP-3依赖性补体活化通过给予受试者的组合物，其包括MASP-3抑制剂的量的有效抑制量 MASP-3依赖性补体活化。在另一个方面，本发明提供了通过给受试者施用一种组合物，其包括MASP-1抑制剂中的至少一个和/或量的增加红血细胞在从阵发性睡眠性血红蛋白尿症的受治疗者的存活的方法和组合物一个有效MASP-3抑制剂，以增加红血细胞的存活。在一些实施方案中，受试者施用MASP-2抑制剂和MASP-1抑制剂，MASP-2抑制剂和施用MASP-3抑制剂，MASP-3抑制剂和MASP-1抑制剂或MASP-1抑制剂，MASP-2抑制剂和MASP-3抑制剂。

10. 发明公开

EP2007425A4 METHODS FOR TREATING CONDITIONS ASSOCIATED WITH MASP-2 DEPENDENT COMPLEMENT ACTIVATION 有权转让
标题翻译：方法苦难均与MASP-2的补体依赖性连接处理
公开(公告)号：EP2007425A4
公开(公告)日：2010-07-07
申请号：EP07759500
申请日：2007-03-27
申请人： UNIV LEICESTER , OMEROS CORP
发明人： SCHWAEBLE HANS-WILHELM , STOVER CORDULA MARGARET , TEDFORD CLARK E , PARENT JAMES B , FUJITA TEIZO
IPC分类号： A61K39/395 , A01K67/027 , C07K14/47 , C07K16/40
CPC分类号： C07K16/40 , A01K67/0276 , A01K2207/15 , A01K2217/00 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0375 , A61K39/395 , A61K49/0008 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/71 , C07K2317/76 , C07K2317/92 , C12N9/6408 , C12N9/6424 , C12Y304/21104 , Y10S514/912

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