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1. 发明申请

WO2013074705A2 MULTI-FREQUENCY LOCATING SYSTEMS AND METHODS 审中-公开
标题翻译：多频定位系统和方法
公开(公告)号：WO2013074705A2
公开(公告)日：2013-05-23
申请号：PCT/US2012/065126
申请日：2012-11-14
申请人： OLSSON, Mark , COX, David , BENCH, Stephanie M , SOUKUP, Jan , TURNER, Timothy M. , LEVIN, Ryan B. , MEREWETHER, Ray , MARTIN, Michael J.
发明人： OLSSON, Mark , COX, David , BENCH, Stephanie M , SOUKUP, Jan , TURNER, Timothy M. , LEVIN, Ryan B. , MEREWETHER, Ray , MARTIN, Michael J.
IPC分类号： G01R33/02
CPC分类号： G01V3/081 , G01R33/10
摘要： Multi-frequency buried object location system transmitters and locators are disclosed. A transmitter may generate and provide output signals to a buried object at a plu-rality of frequencies, which may be selected based on a connection type. Corresponding lo-cators may simultaneously receive a plurality of magnetic field signals emitted from the bu-ried object and generate visual and/or audible output information based at least in part on the plurality of received magnetic field signals. The visual and/or audible output may be further based on signals received from a quad-gradient antenna array.
摘要翻译：公开了多频埋地物位置系统发射机和定位器。发射机可以根据连接类型选择频率的频率，产生并提供输出信号到掩埋物体。相应的引线可以同时接收从所述对象物体发射的多个磁场信号，并且至少部分地基于所述多个接收的磁场信号产生视觉和/或听觉输出信息。视觉和/或听觉输出可以进一步基于从四梯度天线阵列接收的信号。

2. 发明申请

WO2009042435A1 PYRIDIN-2 -YL-AMINO-I, 2, 4 -THIADIAZOLE DERIVATIVES AS GLUCOKINASE ACTIVATORS FOR THE TREATMENT OF DIABETES MELLITUS 审中-公开
标题翻译：作为用于治疗糖尿病的GLUCOKINASE激活剂的吡啶-2-基氨基-1,2,4-噻二唑衍生物
公开(公告)号：WO2009042435A1
公开(公告)日：2009-04-02
申请号：PCT/US2008/076401
申请日：2008-09-15
申请人： ARRAY BIOPHARMA INC. , AICHER, Thomas Daniel , BOYD, Steven Armen , CHICARELLI, Mark Joseph , CONDROSKI, Kevin Ronald , FELL, Jay Bradford , FISCHER, John P. , GUNAWARDANA, Indrani W. , HINKLIN, Ronald Jay , SINGH, Ajay , TURNER, Timothy M. , WALLACE, Eli M.
发明人： AICHER, Thomas Daniel , BOYD, Steven Armen , CHICARELLI, Mark Joseph , CONDROSKI, Kevin Ronald , FELL, Jay Bradford , FISCHER, John P. , GUNAWARDANA, Indrani W. , HINKLIN, Ronald Jay , SINGH, Ajay , TURNER, Timothy M. , WALLACE, Eli M.
IPC分类号： C07D417/12 , C07D417/14 , A61K31/433 , A61P3/10
CPC分类号： C07D401/14 , C07D213/75 , C07D401/12 , C07D417/12 , C07D417/14
摘要： Provided are compounds of Formula (I): wherein R 2 , R 3 , R 13 , L and D 2 are as defined in the specification, which are useful in the treatment and/or prevention of diseases or disorders mediated by deficient levels of glucokinase activity or which can be treated by activating glucokinase including, but not limited to, diabetes mellitus, impaired glucose tolerance, IFG (impaired fasting glucose) and IFG (impaired fasting glycemia), as well as other diseases and disorders such as those discussed herein.
摘要翻译：提供式（I）的化合物：其中R2，R3，R13，L和D2如说明书中所定义，其可用于治疗和/或预防由缺乏葡萄糖激酶水平的活性介导的疾病或病症，或可以通过激活葡糖激酶，包括但不限于糖尿病，葡萄糖耐量降低，IFG（空腹血糖受损）和IFG（空腹血糖受损））以及其它疾病和病症如本文讨论的疾病和病症。

3. 发明申请

WO2008091770A1 2-AMINOPYRIDINE DERIVATIVES AS GLUCOKINASE ACTIVATORS 审中-公开
标题翻译： 2-氨基吡啶衍生物作为GLUCOKINASE激活剂
公开(公告)号：WO2008091770A1
公开(公告)日：2008-07-31
申请号：PCT/US2008/051194
申请日：2008-01-16
申请人： ARRAY BIOPHARMA INC. , AICHER, Thomas Daniel , BOYD, Steven Armen , CHICARELLI, Mark Joseph , CONDROSKI, Kevin Ronald , GARREY, Rustam Ferdinand , HINKLIN, Ronald Jay , SINGH, Ajay , TURNER, Timothy M.
发明人： AICHER, Thomas Daniel , BOYD, Steven Armen , CHICARELLI, Mark Joseph , CONDROSKI, Kevin Ronald , GARREY, Rustam Ferdinand , HINKLIN, Ronald Jay , SINGH, Ajay , TURNER, Timothy M.
IPC分类号： C07D417/14 , C07D495/04 , A61K31/4439
CPC分类号： C07D495/04 , C07D417/14
摘要： Provided are compounds having the Formula (I) or salts thereof, wherein: L is O, S, SO, SO 2 , CHOH, C(O), or CH 2 ; D 2 is CR 12 or N; R 2 is aryl, heteroaryl, saturated or partially unsaturated cycloalkyl, or saturated or partially unsaturated heterocyclyl (optionally substituted with oxo), wherein said aryl, heteroaryl, cycloalkyl and heterocyclyl are monocyclic or bicyclic and are further optionally substituted with one or more groups independently selected from C 1 -C 6 alkyl, F, Cl, Br, I, CF 3 , CN, OR 6 , C(=O)R 6 , C(=O)OR 6 , O(CH 2 ) n C(=O)OR 6 , C(=O)NR 6 R 7 , NO 2 and (1-6C alkyl)OR 6 ; R 3 is H, Br, OR 6 , SR 6 , C(O)OR 6 , C(O)NR 6 R 7 , C(O)R 6 , heteroaryl, or C 1 -C 6 alkyl substituted with one or more groups independently selected from V n -aryl, V n -OR 6 , V n - C(=O)OR 6 and V n -NR 6 R 7 ; R 11 is H or Cl; and R 13 is N-(1 -6C alkanoyl)piperidin-4-yl; that are useful in the treatment and/or prevention of diseases mediated by deficient levels of glucokinase activity, such as diabetes mellitus. Also provided are methods of treating or preventing diseases and disorders characterized by underactivity of glucokinase or which can be treated by activating glucokinase.
摘要翻译：提供具有式（I）或其盐的化合物，其中：L是O，S，SO，SO 2，CHOH，C（O）或CH 2 ; D 是CR 12或N; R 2是芳基，杂芳基，饱和或部分不饱和的环烷基或饱和或部分不饱和的杂环基（任选被氧代取代），其中所述芳基，杂芳基，环烷基和杂环基是单环或双环的，被一个或多个独立地选自C 1 -C 6烷基，F，Cl，Br，I，CF 3 N，CN， C（= O）R 6，C（= O）OR 6，O（CH 2）2， C（= O）OR 6，C（= O）NR 6 R 7，NO 2和（1-6C烷基）OR 6; R 3是H，Br，OR 6，SR 6，C（O）OR 6，C（O） O）NR 6 R 7，C（O）R 6，杂芳基或C 1 -C 6烷基，被一个或多个独立地选自以下的基团取代的亚烷基烷基：V n - 芳基，V n -OR 6，V C（= O）OR 6和V 6和-NR 6 R 7， SUP>; R 11是H或Cl; 和R 13是N-（1-6C烷酰基）哌啶-4-基; 其可用于治疗和/或预防由缺乏水平的葡糖激酶活性（例如糖尿病）介导的疾病。还提供了治疗或预防以葡萄糖激酶不足活性为特征的疾病和病症的方法，或者可以通过激活葡糖激酶治疗。

4. 发明申请

WO2013066869A1 PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS 审中-公开
标题翻译：作为GPR119调节剂的哌啶取代的LACTAMS
公开(公告)号：WO2013066869A1
公开(公告)日：2013-05-10
申请号：PCT/US2012/062576
申请日：2012-10-30
申请人： ARRAY BIOPHARMA INC. , AICHER, Thomas Daniel , BENSCIK, Josef Roland , BOYD, Steven Armen , CONDROSKI, Kevin Ronald , FELL, Jay Bradford , FISCHER, John Peter , HINKLIN, Ronald Jay , PRATT, Scott , SINGH, Ajay , TURNER, Timothy M.
发明人： AICHER, Thomas Daniel , BENSCIK, Josef Roland , BOYD, Steven Armen , CONDROSKI, Kevin Ronald , FELL, Jay Bradford , FISCHER, John Peter , HINKLIN, Ronald Jay , PRATT, Scott , SINGH, Ajay , TURNER, Timothy M.
IPC分类号： C07D413/14 , C07D417/14 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/433 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/12 , A61P9/00 , A61P25/28 , A61P25/18
CPC分类号： C07D417/14 , C07D413/14
摘要： Compounds of Formula (I) and pharmaceutically acceptable salts thereof in which X 1 , X 2 , X 3 , L, R 3 , R 4 , R 5 , R 7 and n have the meanings given in the specification, are modulators of GPR119 and are useful in the treatment or prevention of diseases such as such as, but not limited to, type 2 diabetes, diabetic complications, symptoms of diabetes, metabolic syndrome, obesity, dyslipidemia, and related conditions.
摘要翻译：其中X1，X2，X3，L，R3，R4，R5，R7和n具有本说明书中给出的含义的式（I）化合物及其药学上可接受的盐是GPR119的调节剂，可用于治疗或预防的疾病，例如但不限于2型糖尿病，糖尿病并发症，糖尿病症状，代谢综合征，肥胖症，血脂异常和相关病症。

5. 发明申请

WO2012037393A1 PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS 审中-公开
标题翻译：作为GPR119调节剂的哌啶取代的LACTAMS
公开(公告)号：WO2012037393A1
公开(公告)日：2012-03-22
申请号：PCT/US2011/051821
申请日：2011-09-15
申请人： ARRAY BIOPHARMA INC. , AICHER, Thomas Daniel , BENCSIK, Josef R. , BOYD, Steven Armen , CONDROSKI, Kevin Ronald , FELL, Jay Bradford , FISCHER, John P. , HINKLIN, Ronald Jay , PRATT, Scott Alan , SINGH, Ajay , TURNER, Timothy M.
发明人： AICHER, Thomas Daniel , BENCSIK, Josef R. , BOYD, Steven Armen , CONDROSKI, Kevin Ronald , FELL, Jay Bradford , FISCHER, John P. , HINKLIN, Ronald Jay , PRATT, Scott Alan , SINGH, Ajay , TURNER, Timothy M.
IPC分类号： A61K31/4468 , A61K31/454 , A61P3/04 , C07D413/14
CPC分类号： C07D413/14 , A61K31/4468 , A61K31/454 , C07D211/76 , C07D401/04 , C07D401/14
摘要： Compounds of Formula (I) and pharmaceutically acceptable salts thereof in which X 1 , X 2 , L, R 3 , R 4 , R 5 , R 7 and n have the meanings given in the specification, are modulators of GPR119 and are useful in the treatment or prevention of diseases such as such as, but not limited to, type 2 diabetes, diabetic complications, symptoms of diabetes, metabolic syndrome, obesity, dyslipidemia, and related conditions.
摘要翻译：其中X1，X2，L，R3，R4，R5，R7和n具有本说明书中给出的含义的式（I）化合物及其药学上可接受的盐是GPR119的调节剂，可用于治疗或预防疾病例如但不限于2型糖尿病，糖尿病并发症，糖尿病症状，代谢综合征，肥胖症，血脂异常和相关病症。

6. 发明申请

WO2011146335A1 PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS 审中-公开
标题翻译：作为GPR119调节剂的哌啶取代的LACTAMS
公开(公告)号：WO2011146335A1
公开(公告)日：2011-11-24
申请号：PCT/US2011/036443
申请日：2011-05-13
申请人： ARRAY BIOPHARMA INC. , AICHER, Thomas Daniel , BENCSIK, Josef Roland , BOYD, Steven Armen , CONDROSKI, Kevin Ronald , FELL, Jay Bradford , FISCHER, John P. , HINKLIN, Ronald Jay , PRATT, Scott Alan , SINGH, Ajay , TURNER, Timothy M.
发明人： AICHER, Thomas Daniel , BENCSIK, Josef Roland , CONDROSKI, Kevin Ronald , FELL, Jay Bradford , FISCHER, John P. , HINKLIN, Ronald Jay , PRATT, Scott Alan , SINGH, Ajay , TURNER, Timothy M.
IPC分类号： C07D401/14 , A61K31/4545 , A61P3/10
CPC分类号： C07D413/14 , C07D401/14 , C07D405/14
摘要： Compounds of Formula (I): and pharmaceutically acceptable salts thereof in which X 1 , X 2 , L, R 3 , R 4 , R 5 , R 6 , R 6a , R 7 , R 9 , R 9a , and n have the meanings given in the specification, are modulators of GPR119 and are useful in the treatment or prevention of diseases such as such as, but not limited to, type 2 diabetes, diabetic complications, symptoms of diabetes, metabolic syndrome, obesity, dyslipidemia, and related conditions.
摘要翻译：其中X1，X2，L，R3，R4，R5，R6，R6a，R7，R9，R9a和n具有本说明书中给出的含义的式（I）化合物及其药学上可接受的盐是GPR119的调节剂并且可用于治疗或预防诸如但不限于2型糖尿病，糖尿病并发症，糖尿病症状，代谢综合征，肥胖症，血脂异常和相关病症等疾病。

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