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1. 发明申请

WO2003018043A1 COMPOSITIONS AND METHODS FOR TREATING SUBJECTS WITH HYPERGLYCEMIA 审中-公开
标题翻译：用高效液相色谱法处理物质的组合物和方法
公开(公告)号：WO2003018043A1
公开(公告)日：2003-03-06
申请号：PCT/US2002/027996
申请日：2002-09-03
申请人： OHIO UNIVERSITY , CHEN, Xiaozhuo , LIU, Fang , LI, Yungsheng , LI, Jing
发明人： CHEN, Xiaozhuo , LIU, Fang , LI, Yungsheng , LI, Jing
IPC分类号： A61K35/78
CPC分类号： C07H13/08 , A61K36/185
摘要： A partially purified plant extract for treating subjects who are hyperglycemic is provided. The partially-purified plant extract comprises a plurality of water soluble compounds having a molecular weight greater than 800 and less than 1500 grams/mole. One of the compounds in the partially-purified plant extract is the hydrolysable gallotannin known as penta-O-galloyl-D-glucose. The partially-purified plant extract is substantially free of triterpenoids, including corosolic acid and high molecular weight ellagitannins, i.e., ellagitannins having a molecular weight of greater than 1500 grams/mole. In a highly preferred embodiment, the partially purified plant extract is derived from the tropical plant Lagerstroemia Speciosa. L , which is also known as banaba. The present invention also relates to a method of using the present partially-purified extract to treat subjects who are hyperglycemic.
摘要翻译：提供了用于治疗高血糖患者的部分纯化的植物提取物。部分纯化的植物提取物包含分子量大于800且小于1500克/摩尔的多种水溶性化合物。部分纯化的植物提取物中的一种化合物是称为五-O-酰基-D-葡萄糖的可水解的gal单宁。部分纯化的植物提取物基本上不含三萜类化合物，包括科罗索酸和高分子量鞣花素，即分子量大于1500克/摩尔的鞣花素。在非常优选的实施方案中，部分纯化的植物提取物衍生自热带植物紫薇。 L，也被称为banaba。本发明还涉及使用本发明部分纯化的提取物来治疗高血糖患者的方法。

2. 发明公开

EP1427429A1 COMPOSITIONS AND METHODS FOR TREATING SUBJECTS WITH HYPERGLYCEMIA 审中-公开
标题翻译：组合物和方法对于高血糖患者的治疗
公开(公告)号：EP1427429A1
公开(公告)日：2004-06-16
申请号：EP02796457.6
申请日：2002-09-03
申请人： Ohio University
发明人： CHEN, Xiaozhuo , LIU, Fang , LI, Yungsheng , LI, Jing
IPC分类号： A61K35/78
CPC分类号： C07H13/08 , A61K36/185
摘要： A partially purified plant extract for treating subjects who are hyperglycemic is provided. The partially-purified plant extract comprises a plurality of water soluble compounds having a molecular weight greater than 800 and less than 1500 grams/mole. One of the compounds in the partially-purified plant extract is the hydrolysable gallotannin known as penta-O-galloyl-D-glucose. The partially-purified plant extract is substantially free of triterpenoids, including corosolic acid and high molecular weight ellagitannins, i.e., ellagitannins having a molecular weight of greater than 1500 grams/mole. In a highly preferred embodiment, the partially purified plant extract is derived from the tropical plant Lagerstroemia Speciosa. L, which is also known as banaba. The present invention also relates to a method of using the present partially-purified extract to treat subjects who are hyperglycemic.

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