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1. 发明申请

WO2018209169A1 PEPTIDES AND METHODS FOR TREATING NEURODEGENERATIVE DISORDERS 审中-公开
公开(公告)号：WO2018209169A1
公开(公告)日：2018-11-15
申请号：PCT/US2018/032200
申请日：2018-05-11
申请人： OHIO STATE INNOVATION FOUNDATION
发明人： SHEN, Yingjie , GU, Yuanzheng , XU, Kui
IPC分类号： C07K7/08 , C07K7/04
CPC分类号： C07K14/4711 , A61K38/1716 , A61K2039/505 , C07K16/18 , C07K2317/34 , C12N9/16 , G01N33/6896 , G01N2333/4709
摘要： Disclosed herein are compositions and methods for treating and preventing neurodegenerative diseases, such as Alzheimer's disease. In some embodiments, the composition comprises a peptide that disrupts the binding between PTPs and APP, preventing β-amyloidogenic processing of APP without affecting other major substrates of b- and γ-secretases. Alternatively, in some embodiments, an antibody or a fragment of an antibody against PTPs or APP may be used to disrupt the binding between PTPs and APP. In some embodiments, the composition comprises compounds or enzymes, which restore perineuronal balance of PTPs ligands CS and HS, thereby preventing abnormally increased β-amyloidogenic processing of APP. Compositions and methods disclosed herein can be used in combination to treat and prevent neurodegenerative diseases.

2. 发明申请

WO2017197253A2 PEPTIDES AND METHODS FOR TREATING NEURODEGENERATIVE DISORDERS 审中-公开
标题翻译：肽和治疗神经退行性疾病的方法
公开(公告)号：WO2017197253A2
公开(公告)日：2017-11-16
申请号：PCT/US2017/032387
申请日：2017-05-12
申请人： OHIO STATE INNOVATION FOUNDATION
发明人： SHEN, Yingjie , GU, Yuanzheng , XU, Kui
IPC分类号： A61K39/395 , C07K16/28
摘要： Disclosed herein are compositions and methods for treating and preventing neurodegenerative diseases, such as Alzheimer's disease. In some embodiments, the composition comprises a peptide that disrupts the binding between PTPσ and APP, preventing β-amyloidogenic processing of APP without affecting other major substrates of β- and ϒ-secretases. Alternatively, in some embodiments, an antibody or a fragment of an antibody against PTPσ or APP may be used to disrupt the binding between PTPσ and APP. In some embodiments, the composition comprises compounds or enzymes, which restore perineuronal balance of PTPσ ligands CS and HS, thereby preventing abnormally increased β-amyloidogenic processing of APP. Compositions and methods disclosed herein can be used in combination to treat and prevent neurodegenerative diseases.
摘要翻译：本文公开了用于治疗和预防神经变性疾病例如阿尔茨海默氏病的组合物和方法。在一些实施方案中，组合物包含破坏PTPσ和APP之间的结合的肽，防止APP的β-淀粉样蛋白加工处理而不影响β-和γ-分泌酶的其他主要底物。或者，在一些实施方案中，抗PTPσ或APP的抗体或抗体片段可用于破坏PTPσ和APP之间的结合。在一些实施方案中，组合物包含化合物或酶，其恢复PTPσ配体CS和HS的神经元平衡，从而防止APP的异常增加的β-淀粉样变性加工。本文公开的组合物和方法可以联合使用以治疗和预防神经变性疾病。

3. 发明申请

WO2017197253A3 PEPTIDES AND METHODS FOR TREATING NEURODEGENERATIVE DISORDERS 审中-公开
公开(公告)号：WO2017197253A3
公开(公告)日：2017-11-16
申请号：PCT/US2017/032387
申请日：2017-05-12
申请人： OHIO STATE INNOVATION FOUNDATION
发明人： SHEN, Yingjie , GU, Yuanzheng , XU, Kui
IPC分类号： A61K38/17 , A61K39/395 , A61P25/28
摘要： Disclosed herein are compositions and methods for treating and preventing neurodegenerative diseases, such as Alzheimer's disease. In some embodiments, the composition comprises a peptide that disrupts the binding between PTPσ and APP, preventing β-amyloidogenic processing of APP without affecting other major substrates of β- and ϒ-secretases. Alternatively, in some embodiments, an antibody or a fragment of an antibody against PTPσ or APP may be used to disrupt the binding between PTPσ and APP. In some embodiments, the composition comprises compounds or enzymes, which restore perineuronal balance of PTPσ ligands CS and HS, thereby preventing abnormally increased β-amyloidogenic processing of APP. Compositions and methods disclosed herein can be used in combination to treat and prevent neurodegenerative diseases.

4. 发明公开

EP3454885A2 PEPTIDES AND METHODS FOR TREATING NEURODEGENERATIVE DISORDERS 审中-实审
公开(公告)号：EP3454885A2
公开(公告)日：2019-03-20
申请号：EP17796930.0
申请日：2017-05-12
申请人： Ohio State Innovation Foundation
发明人： SHEN, Yingjie , GU, Yuanzheng , XU, Kui
IPC分类号： A61K38/17 , A61K39/395 , A61P25/28

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