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1. 发明申请

WO2010100627A1 DIAGNOSIS OF NEUROPSYCHIATRIC AND BEHAVIOURAL DISORDERS 审中-公开
标题翻译：神经病学和行为障碍的诊断
公开(公告)号：WO2010100627A1
公开(公告)日：2010-09-10
申请号：PCT/IB2010/050967
申请日：2010-03-05
申请人： NOVARTIS AG , OREFICI, Graziella , BENSI, Giuliano , GRIFANTINI, Renata , MARGARIT Y ROS, Immaculada , GRANDI, Guido , BOMBACI, Mauro
发明人： OREFICI, Graziella , BENSI, Giuliano , GRIFANTINI, Renata , MARGARIT Y ROS, Immaculada , GRANDI, Guido , BOMBACI, Mauro
IPC分类号： G01N33/68
CPC分类号： G01N33/56944 , G01N33/6896 , G01N2333/315 , G01N2800/2835 , G01N2800/50
摘要： This invention provides a method of identifying GAS infection as the cause of a neuropsychiatric or behavioural disorder in a patient, or of identifying a patient at risk of developing a neuropsychiatric or behavioural disorder caused by GAS infection. This invention also provides associated protein arrays.
摘要翻译：本发明提供了鉴定GAS感染作为患者神经精神障碍或行为障碍的原因或识别患有由GAS感染引起的神经精神病或行为障碍的风险的患者的方法。本发明还提供了相关的蛋白质阵列。

2. 发明公开

EP2406637A1 DIAGNOSIS OF NEUROPSYCHIATRIC AND BEHAVIOURAL DISORDERS 审中-公开
标题翻译：诊断神经精神疾病和行为障碍
公开(公告)号：EP2406637A1
公开(公告)日：2012-01-18
申请号：EP10710652.8
申请日：2010-03-05
申请人： Novartis AG , Orefici, Graziella
发明人： OREFICI, Graziella , BENSI, Giuliano , GRIFANTINI, Renata , MARGARIT Y ROS, Immaculada , GRANDI, Guido , BOMBACI, Mauro
IPC分类号： G01N33/68
CPC分类号： G01N33/56944 , G01N33/6896 , G01N2333/315 , G01N2800/2835 , G01N2800/50
摘要： This invention provides a method of identifying GAS infection as the cause of a neuropsychiatric or behavioural disorder in a patient, or of identifying a patient at risk of developing a neuropsychiatric or behavioural disorder caused by GAS infection. This invention also provides associated protein arrays.

3. 发明申请

WO2014033193A1 STABILISED PROTEINS FOR IMMUNISING AGAINST STAPHYLOCOCCUS AUREUS 审中-公开
标题翻译：稳定的蛋白质用于免疫金黄色葡萄球菌
公开(公告)号：WO2014033193A1
公开(公告)日：2014-03-06
申请号：PCT/EP2013/067856
申请日：2013-08-29
申请人： NOVARTIS AG
发明人： BAGNOLI, Fabio , BOTTOMLEY, Matthew , GRANDI, Guido , NISSUM, Mikkel , PALLAORO, Michele , SAVINO, Silvana
IPC分类号： A61K38/16 , A61K39/085 , C07K1/113 , C07K14/315 , C07K14/31
CPC分类号： C07K14/31 , A61K39/085 , A61K2039/55505
摘要： Elimination of disulphide bond formation of cysteine-containing S.aureus antigens enhances antigen stability. The invention provides variant forms of cysteine-containing S.aureus antigen with a point mutation that replaces, deletes or modifies the cysteine residue.
摘要翻译：消除含有半胱氨酸的金黄色葡萄球菌抗原的二硫键形成增强了抗原稳定性。本发明提供了含有半胱氨酸的金黄色葡萄球菌抗原的变体形式，其具有替代，删除或修饰半胱氨酸残基的点突变。

4. 发明申请

WO2010076618A1 COMBINATION GAS VACCINES AND THERAPEUTICS 审中-公开
标题翻译：组合气体疫苗和治疗药物
公开(公告)号：WO2010076618A1
公开(公告)日：2010-07-08
申请号：PCT/IB2009/006949
申请日：2009-09-17
申请人： NOVARTIS AG , MANETTI, Andrea , CAPO, Sabrina , BENSI, Giuliano , GRANDI, Guido , MARGARIT Y ROS, Imma
发明人： MANETTI, Andrea , CAPO, Sabrina , BENSI, Giuliano , GRANDI, Guido , MARGARIT Y ROS, Imma
IPC分类号： C07K14/315 , C07K16/12 , A61K39/09 , A61P31/04
CPC分类号： C07K14/315 , A61K39/092 , A61K2039/507 , A61K2039/6037 , C07K16/1275 , Y02A50/466 , Y02A50/478 , A61K2300/00
摘要： Compositions useful for reducing the risk of, preventing, and/or treating S. pyogenes (GAS) infections which comprise combinations of GAS antigens, nucleic acid molecules encoding the antigens, or antibodies which specifically bind to the antigens.
摘要翻译：可用于降低包含GAS抗原，编码抗原的核酸分子或特异性结合抗原的抗体的化脓性链球菌（GAS）感染的风险，预防和/或治疗的风险，风险，和/或治疗的组合物。

5. 发明申请

WO2009101403A1 HYBRID POLYPEPTIDES COMPRISING GBS-80 AND SPB1 PROTEINS OF STREPTOCOCCUS 审中-公开
标题翻译：包含GBS-80和SPB1蛋白质的杂交多肽
公开(公告)号：WO2009101403A1
公开(公告)日：2009-08-20
申请号：PCT/GB2009/000384
申请日：2009-02-11
申请人： NOVARTIS AG , MARGARIT Y ROS, Immaculada , GRANDI, Guido , TELFORD, John, L. , MAIONE, Domenico
发明人： MARGARIT Y ROS, Immaculada , GRANDI, Guido , TELFORD, John, L. , MAIONE, Domenico
IPC分类号： C07K19/00 , C07K14/315 , C12N15/62 , A61K39/09
CPC分类号： A61K39/092 , A61K2039/55505 , A61K2039/55561 , A61K2039/55566 , C07K14/315
摘要： GBS antigens GBS-80 and Spb1 are expressed in a single polypeptide chain, preferably with Spb1 upstream of GBS-80. Thus the invention provides a polypeptide comprising an amino acid sequence NH 2 -W-X-L-Y-Z-CO 2 H, wherein: X is a Spb1 sequence; L is an optional linker; Y is a GBS-80 sequence; W is an optional N-terminal sequence; and Z is an optional C-terminal sequence.
摘要翻译： GBS抗原GBS-80和Spb1在单个多肽链中表达，优选用GBS-80上游的Spb1表达。因此，本发明提供了包含氨基酸序列NH 2 -W-X-L-Y-Z-CO 2 H的多肽，其中：X是Spb1序列; L是可选的接头; Y是GBS-80序列; W是可选的N-末端序列; Z是可选的C-末端序列。

6. 发明申请

WO2014033192A1 STABILISED PROTEINS FOR IMMUNISING AGAINST STAPHYLOCOCCUS AUREUS 审中-公开
标题翻译：用于免疫斑马鱼的稳定蛋白
公开(公告)号：WO2014033192A1
公开(公告)日：2014-03-06
申请号：PCT/EP2013/067855
申请日：2013-08-29
申请人： NOVARTIS AG
发明人： BAGNOLI, Fabio , BUFALI, Simone , CIANETTI, Simona , COSLOVI, Anna , GRANDI, Guido , NISSUM, Mikkel , PALLAORO, Michele , SAVINO, Silvana , SOTGIU, Michele
IPC分类号： A61K38/16 , A61K39/085 , C07K1/113 , C07K14/315
CPC分类号： A61K39/085 , A61K39/39 , A61K2039/55511 , A61K2039/70 , C07K14/3156
摘要： Elimination of disulphide bond formation ofcysteine-containing S.aureus antigens enhances antigen stability. The invention provides a composition comprising variant forms of cysteine-containing S.aureus antigen with a point mutation that replaces, deletes or modifies the cysteine residue.
摘要翻译：消除含有半胱氨酸的金黄色葡萄球菌抗原的二硫键形成增强了抗原的稳定性。本发明提供包含替代，删除或修饰半胱氨酸残基的点突变的含半胱氨酸的金黄色葡萄球菌抗原的变体形式的组合物。

7. 发明申请

WO2013030783A1 IMMUNOGENIC PROTEINS AND COMPOSITIONS 审中-公开
标题翻译：免疫原性蛋白质和组合物
公开(公告)号：WO2013030783A1
公开(公告)日：2013-03-07
申请号：PCT/IB2012/054464
申请日：2012-08-30
申请人： NOVARTIS AG , MAIONE, Domenico , RINAUDO, Cira Daniela , GRANDI, Guido
发明人： MAIONE, Domenico , RINAUDO, Cira Daniela , GRANDI, Guido
IPC分类号： C07K14/315 , A61K39/09
CPC分类号： C07K14/315 , A61K39/092
摘要： The invention provides proteins and compositions for the treatment and prevention of Streptococcus agalactiae (Group B streptococcus; GBS).
摘要翻译：本发明提供了用于治疗和预防无乳链球菌（B族链球菌; GBS）的蛋白质和组合物。

8. 发明申请

WO2011121576A2 IMMUNOGENIC PROTEINS AND COMPOSITIONS 审中-公开
标题翻译：免疫原性蛋白质和组成
公开(公告)号：WO2011121576A2
公开(公告)日：2011-10-06
申请号：PCT/IB2011/051415
申请日：2011-04-01
申请人： NOVARTIS AG , GRANDI, Guido , MAIONE, Domenico , RINUADO, Daniela
发明人： GRANDI, Guido , MAIONE, Domenico , RINUADO, Daniela
IPC分类号： A61K39/00
CPC分类号： A61K39/092 , A61K2039/55 , A61K2039/57 , A61K2039/575 , C07K14/315 , C07K16/1275 , C07K2317/734 , C07K2319/40
摘要： The invention provides proteins and compositions for the treatment and prevention of Streptococcus agalactiae (Group B streptococcus; GBS).
摘要翻译：本发明提供用于治疗和预防无乳链球菌（B族链球菌; GBS）的蛋白质和组合物。

9. 发明申请

WO2009027768A2 IMMUNOGENIC COMPOSITIONS FOR GRAM POSITIVE BACTERIA 审中-公开
标题翻译： GRAM积极细菌的免疫组化
公开(公告)号：WO2009027768A2
公开(公告)日：2009-03-05
申请号：PCT/IB2007/004695
申请日：2007-07-26
申请人： NOVARTIS AG , GRANDI, Guido , TELFORD, John , MORA, Marirosa , GALEOTTI, Cesira , RINAUDO, Daniela , MANETTI, Andrea, Guido, Oreste
发明人： GRANDI, Guido , TELFORD, John , MORA, Marirosa , GALEOTTI, Cesira , RINAUDO, Daniela , MANETTI, Andrea, Guido, Oreste
IPC分类号： A61K39/00
CPC分类号： A61K39/092 , A61K2039/523 , A61K2039/543 , A61K2039/55505 , A61K2039/55566 , C07K14/3156
摘要： The invention relates to the identification of a new adhesion islands within the genomes of several Gram positive Streptococcus serotypes and isolates. Adhesion island polypeptides of the invention may be used in immunogenic compositions for prophylactic or therapeutic immunization against GAS, GBS, and S pneumococcal infections.
摘要翻译：本发明涉及在几种革兰氏阳性链球菌血清型和分离物的基因组内鉴定新的粘附岛。本发明的粘附岛多肽可用于针对GAS，GBS和S型肺炎球菌感染的预防性或治疗性免疫的免疫原性组合物中。

10. 发明申请

WO2008020335A2 IMMUNOGENIC COMPOSITIONS FOR STREPTOCOCCUS AGALACTIAE 审中-公开
标题翻译：用于结核分枝杆菌的免疫组化
公开(公告)号：WO2008020335A2
公开(公告)日：2008-02-21
申请号：PCT/IB2007/003693
申请日：2007-06-11
申请人： NOVARTIS AG , MAIONE, Domenico , NORAIS, Nathalie , GRANDI, Guido
发明人： MAIONE, Domenico , NORAIS, Nathalie , GRANDI, Guido
CPC分类号： A61K39/092 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K14/315 , G01N33/56944 , G01N2469/20
摘要： The invention relates to immunogenic polypeptides derived from epitopes in a Streptococcus agalactiae ("GBS") protein GBS 80 and their use as prophylactic, diagnostic and therapeutic compositions. The invention also provides nucleic acids encoding the immunogenic polypeptides. Also provided are vectors useful for making such immunogenic polypeptides and host cells transformed with such vectors. In particular, the invention relates to a group immunogenic polypeptides derived from GBS 80. The compositions may include one or more of the immunogenic polypeptides either alone or with other antigenic components. For example, the immunogenic polypeptides may be combined with other GBS antigens to provide therapeutic compositions with broader range. In addition, the immunogenic polypeptides may also include flanking portions of the GBS 80 protein.
摘要翻译：本发明涉及源自无乳链球菌（GBS）蛋白GBS 80中的表位的免疫原性多肽及其作为预防，诊断和治疗组合物的用途。本发明还提供编码免疫原性多肽的核酸。还提供了可用于制备这种免疫原性多肽的载体和用这些载体转化的宿主细胞。特别地，本发明涉及衍生自GBS80的组免疫原性多肽。组合物可以单独或与其它抗原成分一起包括一种或多种免疫原性多肽。例如，免疫原性多肽可以与其他GBS抗原组合以提供更宽范围的治疗组合物。此外，免疫原性多肽还可以包括GBS 80蛋白的侧翼部分。

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