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    • 8. 发明申请
    • NOVEL BIOMATERIALS, THEIR PREPARATION AND USE
    • 新生物材料,其制备和使用
    • WO2003089008A1
    • 2003-10-30
    • PCT/EP2003/004076
    • 2003-04-17
    • NOVARTIS AGNOVARTIS PHARMA GMBHSZENTE, LajosSZEJTLI, JozsefKIS, György, LajosSCHOCH, Christian
    • SZENTE, LajosSZEJTLI, JozsefKIS, György, LajosSCHOCH, Christian
    • A61K47/36
    • A61K9/0024A61K9/7015A61L27/20A61L27/54A61L2300/602A61L2300/802C08L5/16
    • The present invention relates to novel materials, particularly biomaterials, in form of a precipitate, comprising at least an anionic polymeric component which is as such soluble in water and an amphiphilic ammonium-type component, which precipitate is obtainable by a process including the following steps: contacting the anionic polymeric component and an cylcodextrin component in an aqueous medium, and adding to the mixture obtained in step 1 said amphiphilic ammonium-type component, wherein said components are present in amounts effective to form said precipitate, and preferably to corresponding precipitates additionally comprising said cycxlodextrin component. Both types of precipitates may optionally comprise one or more further components. The precipitates are particularly useful as controlled-release depot formulations suitable for long-lasting delivery of said further components. The further components incorporated into the precipitates can be pharmaceutical compounds, pesticides, agrochemicals, colorants, diagnostics, enzymes, foodstuffs etc.
    • 本发明涉及沉淀物形式的新型材料,特别是生物材料,其包含至少一种如此可溶于水的阴离子聚合物组分和两亲性铵型组分,所述沉淀物可通过包括以下步骤 :将水性介质中的阴离子聚合物组分和环糊精组分接触,并加入步骤1中获得的混合物中所述的两亲性铵型组分,其中所述组分以有效形成所述沉淀物的量存在,优选以相应的沉淀物 包括所述环糊精组分。 两种类型的沉淀物可任选地包含一种或多种另外的组分。 沉淀物特别适用于适用于持久递送所述其它组分的控释剂型剂型。 掺入沉淀物中的其它组分可以是药物化合物,农药,农药,着色剂,诊断,酶,食品等。