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1. 发明公开

EP1841740A1 3,4,(5)-SUBSTITUTED TETRAHVDROPYRIDINES 审中-公开
标题翻译： 3.4，（5） - 取代的四氢吡啶
公开(公告)号：EP1841740A1
公开(公告)日：2007-10-10
申请号：EP06700380.6
申请日：2006-01-12
申请人： Novartis AG , NOVARTIS-PHARMA GMBH
发明人： IRIE, Osamu Novartis Pharma K.K , NIHONYANAGI, Atsuko, Novartis Pharma K.K. , TOYAO, Atsushi, Novartis Pharma K.K. , KANAZAWA, Takanori, Novartis Pharma K.K. , MASUYA, Keiichi
IPC分类号： C07D211/78 , C07D401/12 , C07D401/10 , C07D409/12 , A61K31/4545 , A61P9/00
CPC分类号： C07D401/12 , C07D211/78 , C07D401/10 , C07D409/12
摘要： Organic Compounds 3,4(,5)-substituted tetrahydropyridine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,4(,5)- substituted tetrahydropyridine compound, and/or a method of treatment comprising administering a 3,4(,5)-substituted tetrahydropyridine compound, a method for the manufacture of a 3,4(,5)- substituted tetrahydropyridine compound, and novel intermediates and partial steps for its synthesis. The 3,4(,5)- substituted tetrahydropyridine compounds have the formula I wherein the substituents and symbols are as described in the specification.

2. 发明公开

EP1858849A1 ORGANIC COMPOUNDS 审中-公开
标题翻译：有机化合物
公开(公告)号：EP1858849A1
公开(公告)日：2007-11-28
申请号：EP06707453.4
申请日：2006-03-07
申请人： Novartis AG , NOVARTIS-PHARMA GMBH
发明人： MASUYA, Keiichi , YOKOKAWA, Fumiaki, Novartis Pharma K.K. , IRIE, Osamu, Novartis Pharma K.K. , NIHONYANAGI, Atsuko, Novartis Pharma K.K. , TOYAO, Atsushi, Novartis Pharma K.K. , EHARA, Takeru, Novartis Pharma K.K. , KONISHI, Kazuhide, Novartis Pharma K.K. , KANAZAWA, Takanori, Novartis Pharma K.K. , SUZUKI, Masaki, Novartis Pharma K.K.
IPC分类号： C07D211/60 , C07D401/12 , C07D413/12 , A61K31/4545 , A61P9/00
CPC分类号： C07D401/12 , C07D211/60 , C07D413/12
摘要： 3,4,5-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (= disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,4,5-substituted piperidine compound, and/or a method of treatment comprising administering a 3,4,5-substituted piperidine compound, a method for the manufacture of a 3,4,5-substituted piperidine compound, and novel intermediates and partial steps for its synthesis. The compounds are of the formula (I), wherein the substitutents are as defined in the specification.
摘要翻译： 3,4,5-取代的哌啶化合物，这些化合物用于诊断和治疗温血动物，特别是用于治疗取决于肾素活性的疾病（=病症）; 该类化合物在制备用于治疗取决于肾素活性的疾病的药物制剂中的用途; 使用该类化合物治疗取决于肾素活性的疾病; 包含3,4,5-取代哌啶化合物的药物制剂，和/或包括给予3,4,5-取代哌啶化合物的治疗方法，制备3,4,5-取代哌啶化合物的方法，以及新的中间体和其合成的部分步骤。化合物是式（I）的化合物，其中取代基如说明书中所定义。

3. 发明公开

EP1915366A2 PIPERAZINE DERIVATIVE RENIN INHIBITORS 审中-公开
标题翻译：哌嗪衍生物肾素抑制剂
公开(公告)号：EP1915366A2
公开(公告)日：2008-04-30
申请号：EP06753947.8
申请日：2006-05-29
申请人： Novartis AG
发明人： NIHONYANAGI, Atsuko, Novartis Pharma K.K. , TOYAO, Atsushi, Novartis Pharma K.K. , IWAKI, Yuki, Novartis Pharma K.k. , MASUYA, Keiichi
IPC分类号： C07D403/12 , A61K31/496 , C07D417/14
CPC分类号： C07D417/14 , C07D403/12
摘要： The invention relates to substituted 3,4- or higher substituted piperazine compounds, the use thereof for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (= disorder) that depends on activity of renin; pharmaceutical formulations or products comprising said compounds, and/or a method of treatment comprising administering said compounds, a method for the manufacture of said compounds, as well as novel intermediates, starting materials and/or partial steps for their synthesis. The compounds are especially of the formula (I), wherein R1, R2, R11, C, E and D are as defined in the specification.
摘要翻译：本发明涉及取代的3,4-或更高取代的哌嗪化合物，其用于制备用于治疗取决于肾素活性的疾病的药物制剂的用途; 使用该类化合物治疗取决于肾素活性的疾病; 这些化合物用于诊断和治疗温血动物，特别是用于治疗取决于肾素活性的疾病（=病症）; 包含所述化合物的药物制剂或产品，和/或包括施用所述化合物的治疗方法，制备所述化合物的方法以及新的中间体，原料和/或其合成的部分步骤。该化合物尤其是式（I）的化合物，其中R 1，R 2，R 11，C，E和D如说明书中所定义。

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