专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2004037796A2 1-(4-BENZYL-PIPERAZIN-1-YL)-3-PHENYL-PROPENONE DERIVATIVES 审中-公开
标题翻译： 1-（4-苄基 - 哌嗪-1-基）-3-苯基 - 丙酮酮衍生物
公开(公告)号：WO2004037796A2
公开(公告)日：2004-05-06
申请号：PCT/EP2003/011848
申请日：2003-10-24
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , BOLLBUCK, Birgit , EDER, Jörg , HENG, Richard , RÉVÉSZ, Lászlo , SCHLAPBACH, Achim , WÄLCHLI, Rudolf
发明人： BOLLBUCK, Birgit , EDER, Jörg , HENG, Richard , RÉVÉSZ, Lászlo , SCHLAPBACH, Achim , WÄLCHLI, Rudolf
IPC分类号： C07D241/00
CPC分类号： C07D295/185 , C07D207/14 , C07D207/16 , C07D207/28 , C07D211/48 , C07D211/58 , C07D215/38 , C07D233/74
摘要： A compound of formula (I), or a pharmaceutically acceptable salt or ester thereof, wherein the symbols have meaning as defined, which are antagonists of CCR-1 and which find use pharmaceutically for treatment of diseases and conditions in which CCR-1 is implicated, e.g. inflammatory diseases.
摘要翻译：式（I）的化合物或其药学上可接受的盐或酯，其中符号具有如所定义的含义，其为CCR-1的拮抗剂并且可用于药物治疗疾病和涉及CCR-1的条件，例如，炎症性疾病。

2. 发明申请

WO2007039285A1 BICYCLIC AROMATIC COMPOUNDS USEFUL AS INHIBITORS OF MITOGEN-ACTIVATED PROTEIN KINASE-ACTIVATED PROTEIN KINASE-2 审中-公开
标题翻译：作为活化蛋白激活蛋白激酶蛋白激酶-2的抑制剂的双相芳族化合物有用
公开(公告)号：WO2007039285A1
公开(公告)日：2007-04-12
申请号：PCT/EP2006/009597
申请日：2006-10-04
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , HENG, Richard , KOCH, Guido , SCHLAPBACH, Achim , VELCICKY, Juraj , WÄLCHLI, Rudolf
发明人： HENG, Richard , KOCH, Guido , SCHLAPBACH, Achim , VELCICKY, Juraj , WÄLCHLI, Rudolf
IPC分类号： C07D487/04 , C07D513/04 , A61K31/519 , A61K31/549 , A61P29/00 , A61P9/00 , A61P25/00 , A61P17/00
CPC分类号： C07D487/04 , C07D513/04
摘要： A compound of formula (I) or a pharmaceutically acceptable salt or prodrug ester thereof: wherein the groups R1-R6, A and Y are as defined in the specification, as inhibitors of (MK2 or MAPKAP kinase-2).
摘要翻译：式（I）化合物或其药学上可接受的盐或前药酯：其中R1-R6，A和Y基团如说明书中所定义，作为（MK2或MAPKAP激酶-2）的抑制剂。

3. 发明申请

WO2005103054A2 COMPOUNDS AS CCRI ANTAGONISTS 审中-公开
标题翻译：化合物作为CCRI拮抗剂
公开(公告)号：WO2005103054A2
公开(公告)日：2005-11-03
申请号：PCT/EP2005/004422
申请日：2005-04-25
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , HENG, Richard , RÉVÉSZ, Lászlo , SCHLAPBACH, Achim , WÄLCHLI, Rudolf
发明人： HENG, Richard , RÉVÉSZ, Lászlo , SCHLAPBACH, Achim , WÄLCHLI, Rudolf
IPC分类号： C07D487/08
CPC分类号： C07D451/14 , C07D451/04 , C07D487/08
摘要： A compound of formula (I), or a pharmaceutically acceptable salt or ester thereof, wherein the symbols have meaning as defined, which are antagonists of CCR-1 and which find use pharmaceutically for treatment of diseases and conditions in which CCR-1 is implicated, e.g. inflammatory diseases.
摘要翻译：式（I）化合物或其药学上可接受的盐或酯，其中符号具有如上所定义的含义，其是CCR-1的拮抗剂，其可用于治疗CCR-1涉及的疾病和病症，例如炎性疾病。

4. 发明公开

EP1558594A2 1-(4-BENZYL-PIPERAZIN-1-YL)-3-PHENYL-PROPENONE DERIVATIVES 审中-公开
标题翻译： 1-（4-苄基 - 哌嗪-1-基）-3-苯基 - 丙酮酮衍生物
公开(公告)号：EP1558594A2
公开(公告)日：2005-08-03
申请号：EP03809328.2
申请日：2003-10-24
申请人： Novartis AG , Novartis Pharma GmbH
发明人： BOLLBUCK, Birgit , EDER, Jörg , HENG, Richard , RéVéSZ, Lászlo , SCHLAPBACH, Achim , WÄLCHLI, Rudolf
IPC分类号： C07D295/18 , C07D233/74 , A61K31/496 , C07D207/14 , C07D211/48 , C07D207/16 , C07D207/28 , C07D215/38 , C07D211/58 , A61P29/00
CPC分类号： C07D295/185 , C07D207/14 , C07D207/16 , C07D207/28 , C07D211/48 , C07D211/58 , C07D215/38 , C07D233/74
摘要： A compound of formula (I), or a pharmaceutically acceptable salt or ester thereof, wherein the symbols have meaning as defined, which are antagonists of CCR-1 and which find use pharmaceutically for treatment of diseases and conditions in which CCR-1 is implicated, e.g. inflammatory diseases.
摘要翻译：式（I）化合物或其药学上可接受的盐或酯，其中符号具有如定义的含义，它们是CCR-1的拮抗剂并且可用于药物治疗涉及CCR-1的疾病和病症，例如炎性疾病。

5. 发明公开

EP1794164A2 BRIDGED PIPERAZINE AND PIPERIDINE DERIVATIVES AS CCR1 ANTAGONISTS 审中-公开
标题翻译：桥联哌啶AS CCR1拮抗剂
公开(公告)号：EP1794164A2
公开(公告)日：2007-06-13
申请号：EP05737794.7
申请日：2005-04-25
申请人： Novartis AG , NOVARTIS-PHARMA GMBH
发明人： HENG, Richard , RÉVÉSZ, Lászlo , SCHLAPBACH, Achim , WÄLCHLI, Rudolf
IPC分类号： C07D487/08 , C07D498/08 , A61K31/4995 , A61P37/00
CPC分类号： C07D451/14 , C07D451/04 , C07D487/08
摘要： A compound of formula (I), or a pharmaceutically acceptable salt or ester thereof, wherein the symbols have meaning as defined, which are antagonists of CCR-1 and which find use pharmaceutically for treatment of diseases and conditions in which CCR-1 is implicated, e.g. inflammatory diseases.

6. 发明授权

EP1165085B1 PHTHALAZINE DERIVATIVES FOR TREATING INFLAMMATORY DISEASES 有权
标题翻译：酞炎症性疾病的治疗
公开(公告)号：EP1165085B1
公开(公告)日：2006-06-14
申请号：EP00920604.6
申请日：2000-03-28
申请人： Novartis AG , Novartis Pharma GmbH
发明人： BOLD, Guido , DAWSON KING, Janet , FREI, Jörg , HENG, Richard , MANLEY, Paul, William , WIETFELD, Bernhard , WOOD, Jeanette, Marjorie
IPC分类号： A61K31/50 , C07D401/06 , C07D401/12 , C07D401/14 , C07D471/04 , A61P29/00 , A61P19/02
CPC分类号： C07D401/06 , A61K31/501 , A61K31/502 , C07D401/14
摘要： The invention relates to the treatment of an inflammatory disease, and/or pain with an inhibitor of VEGF receptor tyrosine kinase of formula (I), wherein r is 0 to 2, n is 0 to 3, R1 and R2 a) are independently in each case lower alkyl; b) together form a bridge of subformula (I*), wherein the bond is achieved via the two terminal C atoms and m is 0 to 4, or c) together form a bridge of subformula (I**), wherein one or two of the ring members T1, T2, T3 and T4 are nitrogen and the others are in each case CH, and the bond is achieved via atoms T1 and T4; G is -C(=O)-, CHF-, -CF2-, lower alkylene, C2-C6alkenylene, lower alkylene or C3-C6alkenylene substituted by acyloxy or hydroxy, -CH2-O-, -CH2-S-, -CH2-NH-, -CH2-O-CH2-, -CH2-S-CH2-, -CH2-NH-CH2-, oxa (-O-), thia (-S-), imino (-NH-), -CH2-O-CH2-, -CH2-S-CH2- or -CH2-NH-CH2-; A, B, D, E and T are independently N or CH subject to the proviso that at least one and not more than three of these radicals are N; Q is lower alkyl, lower alkoxy or halogen; Ra and Ra' are each independently H or lower alkyl; X is imino, oxa, or thia; Y is hydrogen, aryl, heteroaryl, or unsubstituted or substituted cycloalkyl; and Z is mono- or disubstituted amino, halogen, alkyl, substituted alkyl, hydroxy, etherified or esterified hydroxy, nitro, cyano, carboxy, esterified carboxy, alkanoyl, carbamoyl, N-mono-or N, N-disubstituted carbamoyl, amidino, guanidino, mercapto, sulfo, phenylthio, phenyl lower alkylthio, alkylphenylthio, phenylsulfinyl, phenyl-lower alkylsulfinyl, alkylphenylsulfinyl, phenylsulfonyl, phenyl-lower alkylsulfonyl, alkylphenylsulfonyl, or (alternatively or, in a broader aspect of the invention, in addition) selected from the group consisting of ureido, halo-lower alkylthio, halo-lower alkansulfonyl, pyrazolyl, lower-alkyl pyrazolyl and C2-C7alkenyl; wherein - if more than 1 radical Z (m ≥ 2) is present - the substituents Z are selected independently from each other; and wherein the bonds characterized in subformula (I) by a wavy line are either single or double bonds; or an N-oxide of said compound, wherein 1 or more N atoms carry an oxygen atom; or a pharmaceutically acceptable salt thereof.

7. 发明申请

WO2008034600A1 PYRROLE DERIVATIVES USEFUL FOR THE TREATMENT OF CYTOKINE-MEDIATED DISEASES 审中-公开
标题翻译：用于治疗细胞因子介导性疾病的微量元素衍生物
公开(公告)号：WO2008034600A1
公开(公告)日：2008-03-27
申请号：PCT/EP2007/008153
申请日：2007-09-19
申请人： NOVARTIS AG , HENG, Richard , KOCH, Guido , SCHLAPBACH, Achim , SEILER, Max, Peter
发明人： HENG, Richard , KOCH, Guido , SCHLAPBACH, Achim , SEILER, Max, Peter
IPC分类号： C07D405/14 , C07D403/04 , C07D401/14 , C07D401/04 , A61K31/506 , A61K31/444 , A61K31/4439 , A61P37/00
CPC分类号： C07D405/14 , C07D401/04 , C07D401/14 , C07D403/04
摘要： A compound of Formula (I) or a pharmaceutically acceptable salt or prodrug ester thereof, wherein the groups R1-R6 and A are as defined in the specification.
摘要翻译：式（I）的化合物或其药学上可接受的盐或前药酯，其中基团R 1 -R 6和A如说明书中所定义。

8. 发明申请

WO2022137082A1 PYRROLO[3,2-B]PYRIDINE DERIVATIVES USEFUL IN TREATING CONDITIONS ASSOCIATED WITH CGAS 审中-公开
公开(公告)号：WO2022137082A1
公开(公告)日：2022-06-30
申请号：PCT/IB2021/062026
申请日：2021-12-20
申请人： NOVARTIS AG
发明人： CARCACHE, David , GRUBER, Florian , GUERINI, Danilo , GUNZENHAUSER, Martin , HENG, Richard , PERRUCCIO, Francesca , SIMIC, Oliver , SPANKA, Carsten
IPC分类号： C07D471/04 , A61P37/00 , A61K31/437
摘要： The present disclosure relates to a compound of Formula (I): (I), or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, or tautomer thereof, wherein Ring A, and R1 through R4 are as defined herein, and methods of making and using the same.

9. 发明申请

WO2022137085A1 INDOLE DERIVATIVES USEFUL IN TREATING CONDITIONS ASSOCIATED WITH CGAS 审中-公开
公开(公告)号：WO2022137085A1
公开(公告)日：2022-06-30
申请号：PCT/IB2021/062029
申请日：2021-12-20
申请人： NOVARTIS AG
发明人： CARCACHE, David , GRUBER, Florian , GUERINI, Danilo , GUNZENHAUSER, Martin , HENG, Richard , PERRUCCIO, Francesca , SIMIC, Oliver , SPANKA, Carsten
IPC分类号： C07D403/14 , A61P37/00 , C07D401/14 , C07D413/14 , C07D491/107 , A61K31/4196
摘要： The present disclosure relates to a compound of Formula (I): (I), or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, or tautomer thereof, wherein R1 through R8 are as defined herein, and methods of making and using the same.

10. 发明申请

WO2013008095A1 NOVEL PYRROLO PYRIMIDINE DERIVATIVES 审中-公开
标题翻译：新型吡咯啉吡啶衍生物
公开(公告)号：WO2013008095A1
公开(公告)日：2013-01-17
申请号：PCT/IB2012/001699
申请日：2012-07-07
申请人： NOVARTIS AG , HENG, Richard , HOEGENAUER, Elizabeth, Kate , KOCH, Guido , PULZ, Robert, Alexander , VULPETTI, Anna , WAELCHLI, Rudolf
发明人： HENG, Richard , HOEGENAUER, Elizabeth, Kate , KOCH, Guido , PULZ, Robert, Alexander , VULPETTI, Anna , WAELCHLI, Rudolf
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00 , A61P29/00
CPC分类号： A61K31/519 , C07D487/04
摘要： The present invention describes new pyrrolo pyrimidine derivatives and pharmaceutically acceptable salts thereof which appear to interact with Bruton's tyrosine kinase (Btk). Accordingly, the novel pyrrolo pyrimidines may be effective in the treatment of autoimmune disorders, inflammatory diseases, allergic diseases, airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD), transplant rejection, cancers e.g. of hematopoietic origin or solid tumors.
摘要翻译：本发明描述了与布鲁顿酪氨酸激酶（Btk）相互作用的新的吡咯并嘧啶衍生物及其药学上可接受的盐。因此，新的吡咯并嘧啶可能有效治疗自身免疫疾病，炎性疾病，过敏性疾病，气道疾病如哮喘和慢性阻塞性肺疾病（COPD），移植排斥反应，癌症。的造血起源或实体瘤。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式