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1. 发明授权

US5041567A Antibacterial monic acid derivatives 失效
标题翻译：抗菌单酸衍生物
公开(公告)号：US5041567A
公开(公告)日：1991-08-20
申请号：US276910
申请日：1988-11-28
申请人： Norman H. Rogers , Peter J. O'Hanlon , Graham Walker , Michael J. Crimmin
发明人： Norman H. Rogers , Peter J. O'Hanlon , Graham Walker , Michael J. Crimmin
IPC分类号： A01N43/16 , A61K8/49 , A61K31/41 , A61K31/42 , A61K31/425 , A61P31/00 , A61P31/04 , A61P33/02 , C07C205/45 , C07D261/00 , C07D261/08 , C07D261/18 , C07D263/00 , C07D263/32 , C07D275/00 , C07D277/00 , C07D277/22 , C07D303/00 , C07D309/00 , C07D333/00 , C07D333/22 , C07D333/28 , C07D407/06 , C07D409/14 , C07D413/06 , C07D413/14 , C07D417/14 , C07F9/653
CPC分类号： C07D277/22 , C07C205/45 , C07C255/00 , C07C309/00 , C07C323/00 , C07D261/08 , C07D261/18 , C07D263/32 , C07D333/22 , C07D333/28 , C07D407/06 , C07D409/14 , C07D413/14 , C07D417/14 , C07F9/653
摘要： ##STR1## wherein R
1 is unsubstituted or substituted phenyl, have been prepared which have antibacterial and/or antimycoplasmal activity.

2. 发明授权

US4861788A Antibacterial 1-normon-2-yl-heterocyclic compounds 失效
标题翻译：抗菌1-正二-2-基 - 杂环化合物
公开(公告)号：US4861788A
公开(公告)日：1989-08-29
申请号：US8893
申请日：1987-01-30
申请人： Norman H. Rogers , Graham Walker , Michael J. Crimmin , Peter J. O'Hanlon
发明人： Norman H. Rogers , Graham Walker , Michael J. Crimmin , Peter J. O'Hanlon
IPC分类号： A61K31/41 , A61K31/44 , A61K31/443 , A61K31/4433 , A61P15/14 , A61P31/00 , A61P31/04 , C07D405/06 , C07D405/14 , C07D407/06 , C07D409/14 , C07D413/06 , C07D413/14 , C07F7/18
CPC分类号： C07D405/14 , C07D407/06 , C07D413/14
摘要： Compounds of formula (I): ##STR1## wherein ##STR2## is a 5-membered heterocyclic group having a 6-.pi.electron system, the five ring atoms being either(a) one carbon atom and four atoms selected from carbon and nitrogen,(b) two carbon atoms, two nitrogen atoms and one atom selected from oxygen and sulphur, or(c) four carbon atoms and one atom selected from oxygen and sulphurand R.sup.1 is a substituent on a carbon or nitrogen of ##STR3## selected from C.sub.1-20 alkyl, C.sub.2-8 alkenyl aryl, aralkyl and heterocyclyl, each of which may optionally be substituted; hydrogen and C.sub.3-7 cycloalkyl,and, where appropriate, R.sup.2 is a substituent on a carbon or nitrogen of ##STR4## and when present is the same or different to R.sup.1 and is selected from C.sub.1-20 alkyl, C.sub.2-8 alkenyl, aryl, aralkyl and heterocyclyl each of which may optionally be substituted; hydrogen and C.sub.3-7 cycloalkyl, have antibacterial and antimycoplasmal activity.
摘要翻译：式（I）的化合物：其中是具有6-pi电子系统的5元杂环基，5个环原子是（a）一个碳原子和选自碳的四个原子和氮，（b）两个碳原子，两个氮原子和一个选自氧和硫的原子，或（c）四个碳原子和一个选自氧和硫的原子，并且R1是

3. 发明授权

US4812470A Antibacterial monic acid derivatives 失效
标题翻译：抗菌单酸衍生物
公开(公告)号：US4812470A
公开(公告)日：1989-03-14
申请号：US469819
申请日：1983-02-25
申请人： Norman H. Rogers , Peter J. O'Hanlon , Graham Walker , Michael J. Crimmin
发明人： Norman H. Rogers , Peter J. O'Hanlon , Graham Walker , Michael J. Crimmin
IPC分类号： A01N43/16 , A61K8/49 , A61K31/41 , A61K31/42 , A61K31/425 , A61P31/00 , A61P31/04 , A61P33/02 , C07C205/45 , C07D261/00 , C07D261/08 , C07D261/18 , C07D263/00 , C07D263/32 , C07D275/00 , C07D277/00 , C07D277/22 , C07D303/00 , C07D309/00 , C07D333/00 , C07D333/22 , C07D333/28 , C07D407/06 , C07D409/14 , C07D413/06 , C07D413/14 , C07D417/14 , C07F9/653 , A01N43/78
CPC分类号： C07D277/22 , C07C205/45 , C07C255/00 , C07C309/00 , C07C323/00 , C07D261/08 , C07D261/18 , C07D263/32 , C07D333/22 , C07D333/28 , C07D407/06 , C07D409/14 , C07D413/14 , C07D417/14 , C07F9/653
摘要： A compound of the formula (I) ##STR1## wherein R is a group ##STR2## R.sup.1 is hydrogen, phenyl, C.sub.1-20 alkyl, C.sub.2-8 alkenyl or C.sub.2-8 alkynyl each of which may optionally be substituted; or C.sub.3-7 cycloalkyl,X is a divalent group --Y--C.dbd.C--, andY is oxygen or sulphur,have antibacterial and/or antimycoplasmal activity.
摘要翻译：式（I）化合物其中R是一个基团R 1是氢，苯基，C 1-20烷基，C 2-8链烯基或C 2-8炔基，各自可任选地被取代; 或C 3-7环烷基，X是二价基团-Y-C = C-，Y是氧或硫，具有抗细菌和/或抗支原体活性。

4. 发明授权

US4362743A Antibacterial monic acid esters 失效
标题翻译：抗菌单酸酯
公开(公告)号：US4362743A
公开(公告)日：1982-12-07
申请号：US289103
申请日：1981-07-31
申请人： Norman H. Rogers , Peter J. O'Hanlon , Graham Walker
发明人： Norman H. Rogers , Peter J. O'Hanlon , Graham Walker
IPC分类号： A61K31/35 , A61K31/351 , A61P31/04 , C07D309/10 , C07D407/06 , C07D309/06
CPC分类号： C07D407/06 , C07D309/10
摘要： Compounds of formula (II): ##STR1## in which Y represents ##STR2## and R.sub.0 represents a C.sub.2-20 alkyl, C.sub.3-8 cycloalkyl, C.sub.4-20 alkenyl, arakyl, cycloalkylalkyl, heterocyclyl or heterocyclylalkyl group, which is substituted by a hydroxyiminohydrazono- or semicarbazono group, have activity against human and veterinary bacteria and mycoplasma. They may be produced by conventional methods and are used in conventional formulations.
摘要翻译：式（II）的化合物：其中Y代表<！ - SIPO - >和R 0代表C2-20烷基，C3-8环烷基，C4-20烯基，芳烷基，环烷基烷基，杂环基或芳基被羟亚氨基腙或氨基咔唑基取代的杂环基烷基具有抗人和兽医细菌和支原体的活性。它们可以通过常规方法制备并且用于常规制剂中。

5. 发明授权

US4435583A 2-Halo-substituted monic acid A useful as antibacterial compounds 失效
标题翻译： 2-卤代取代的单酸A可用作抗菌化合物
公开(公告)号：US4435583A
公开(公告)日：1984-03-06
申请号：US447516
申请日：1982-12-07
申请人： Norman H. Rogers , Michael J. Crimmin
发明人： Norman H. Rogers , Michael J. Crimmin
IPC分类号： A61K31/35 , A61P31/04 , C07D407/06 , C07D309/06
CPC分类号： C07D407/06
摘要： Compounds of formula (I): ##STR1## wherein Y is halogen,R.sup.1 is hydrogen, a salt forming radical, alkyl or aralkyl,have antibacterial and/or antimycoplasmal activity.
摘要翻译：式（I）的化合物：其中Y是卤素，R 1是氢，成盐基，烷基或芳烷基，具有抗菌和/或抗支原体活性。

6. 发明授权

US4284570A Antibacterial compounds 失效
标题翻译：抗菌化合物
公开(公告)号：US4284570A
公开(公告)日：1981-08-18
申请号：US85894
申请日：1979-10-18
申请人： Norman H. Rogers , Peter J. O'Hanlon
发明人： Norman H. Rogers , Peter J. O'Hanlon
IPC分类号： C07D309/10
CPC分类号： C07D309/10
摘要： This invention relates to antibacterial compounds and in particular to a class of esters which have antibacterial activity against certain Gram-positive and Gram-negative organisms, and also possess antimycoplasmal activity. The compounds are therefore of value in the treatment of human and veterinary infections.

7. 发明授权

US4222942A Isolation of organic acids 失效
标题翻译：有机酸的分离
公开(公告)号：US4222942A
公开(公告)日：1980-09-16
申请号：US946873
申请日：1978-09-29
申请人： Peter J. O'Hanlon , Maurice C. Woodford , Norman H. Rogers
发明人： Peter J. O'Hanlon , Maurice C. Woodford , Norman H. Rogers
IPC分类号： C07D407/06 , C12P17/16 , C07D309/06
CPC分类号： C12R1/39 , C12P17/162
摘要： A process for the purification of pseudomonic acid, particularly suitable for isolating the compound when prepared by bacterial culture, comprises making a solution in an organic solvent of the acidic components of the crude preparation substantially free of the neutral components. The polarity of the organic solvent is adjusted so that the pseudomonic acid crystallizes. This may be achieved either by adding a non-polar diluent such as n-heptane to the solution for example in methyl iso-butyl ketone; or by employing a di-C.sub.1-6 alkyl ether in which the acidic components dissolve and then crystallize out.
摘要翻译：当通过细菌培养制备时，特别适用于分离化合物的假单胞菌酸的纯化方法包括在基本上不含中性组分的粗制品的酸性组分的有机溶剂中制备溶液。调节有机溶剂的极性，使得假单胞菌酸结晶。这可以通过向例如甲基异丁基酮中的溶液中加入非极性稀释剂如正庚烷来实现; 或通过使用其中酸性组分溶解然后结晶出的二-C 1-6烷基醚。

8. 发明授权

US4312867A Antibacterial compounds, processes for their preparation and compositions containing them 失效
标题翻译：抗菌化合物，其制备方法和含有它们的组合物
公开(公告)号：US4312867A
公开(公告)日：1982-01-26
申请号：US190461
申请日：1980-09-24
申请人： Norman H. Rogers , Peter J. O'Hanlon
发明人： Norman H. Rogers , Peter J. O'Hanlon
IPC分类号： A61K31/35 , A61K31/351 , A61P31/04 , C07D309/10 , A61K27/00 , C07D309/06
CPC分类号： C07D309/10
摘要： Compounds of formula (II): ##STR1## Z represents a divalent radical derived from a C.sub.1-20 alkane, C.sub.3-8 cycloalkane, C.sub.2-20 alkene, arene, aralkane, cycloalkylalkane, heterocycle, or heterocylylalkane; and R.sup.x and R.sup.y are the same or different and each represent (a) hydrogen, or (b) C.sub.1-20 alkyl, C.sub.2-8 alkenyl, either of which may be optionally substituted with C.sub.3-7 cycloalkyl, halogen, carboxy, C.sub.1-6 alkoxycarbonyl, carbamyl, aryl, heterocyclyl, hydroxy, C.sub.1-6 alkanoyloxy, amino, mono- or di-(C.sub.1-6) alkylamino; or (c) C.sub.3-7 cycloalkyl optionally substituted with C.sub.1-6 alkyl; or (d) aryl; or (e) heterocyclyl; or (f) R.sup.x and R.sup.y together with the nitrogen atom to which they are attached represent a C.sub.5-7 heterocyclic ring, are useful as antibacterial and antimycoplasma agents.
摘要翻译：式（II）化合物：Z表示衍生自C 1-20烷烃，C 3-8环烷烃，C 2-20烯烃，芳烃，芳烷烃，环烷基烷烃，杂环或杂环烷基烷烃; 并且R x和R y相同或不同，各自表示（a）氢或（b）C 1-20烷基，C 2-8链烯基，其中任一个可以任选地被C 3-7环烷基，卤素，羧基，烷氧基羰基，氨基甲酰基，芳基，杂环基，羟基，C 1-6烷酰氧基，氨基，单 - 或二 - （C 1-6）烷基氨基; 或（c）任选被C 1-6烷基取代的C 3-7环烷基; 或（d）芳基; 或（e）杂环基; 或（f）Rx和Ry与它们所连接的氮原子一起代表C5-7杂环，可用作抗细菌和抗支原体药物。

9. 发明授权

US4248887A Antibacterial compounds, processes for their preparation and compositions containing them 失效
标题翻译：抗菌化合物，其制备方法和含有它们的组合物
公开(公告)号：US4248887A
公开(公告)日：1981-02-03
申请号：US21712
申请日：1979-03-19
申请人： Norman H. Rogers , Peter J. O'Hanlon
发明人： Norman H. Rogers , Peter J. O'Hanlon
IPC分类号： C07D309/10 , C07D309/06 , A61K31/35
CPC分类号： C07D309/10
摘要： This invention relates to antibacterial compounds and in particular to a class of esters which have antibacterial activity against certain Gram-positive and Gram-negative organisms, and also possess anti-mycoplasmal activity. The compounds are therefore of value in the treatment of human and veterinary infections.
摘要翻译：本发明涉及抗细菌化合物，特别涉及一类对某些革兰氏阳性和革兰氏阴性生物体具有抗菌活性，并具有抗支原体活性的酯类。因此，这些化合物在人和兽医感染的治疗中是有价值的。

10. 发明授权

US4389410A Esters of monic acid A useful as antibacterial and antimycoplasmal agents 失效
标题翻译：单酸A的酯可用作抗细菌和抗支原体药物
公开(公告)号：US4389410A
公开(公告)日：1983-06-21
申请号：US285612
申请日：1981-07-21
申请人： Peter J. O'Hanlon , Norman H. Rogers
发明人： Peter J. O'Hanlon , Norman H. Rogers
IPC分类号： A61K31/35 , A61K31/351 , A61P31/04 , C07D309/10 , C07D407/06 , C07D309/06
CPC分类号： C07D407/06 , C07D309/10
摘要： Compounds of formula (II): ##STR1## wherein R is C.sub.1-20 alkyl; C.sub.3-8 cycloalkyl; C.sub.3-20 alkenyl; aralkyl; cycloalkylalkyl; heterocyclyl or heterocyclylalkyl; each being substituted with formyl; ##STR2## have activity against human and veterinary bacteria and mycoplasma. They may be produced by conventional methods and are used in conventional formulations.
摘要翻译：式（II）的化合物：其中R是C 1-20烷基; C3-8环烷基; C3-20烯基; 芳烷基环烷基烷基; 杂环基或杂环基烷基; 各自被甲酰基取代; + TR 具有针对人类和兽医细菌和支原体的活性。它们可以通过常规方法制备并且用于常规制剂中。

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