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1. 发明授权

US08754100B2 Nitrogen-containing fused heterocyclic compounds and their use as beta amyloid production inhibitors 失效
标题翻译：含氮稠合杂环化合物及其作为β-淀粉样蛋白生成抑制剂的用途
公开(公告)号：US08754100B2
公开(公告)日：2014-06-17
申请号：US13138504
申请日：2010-02-24
申请人： Noritaka Kitazawa , Daisuke Shinmyo , Koichi Ito , Nobuaki Sato , Daiju Hasegawa , Toshiyuki Uemura , Toru Watanabe
发明人： Noritaka Kitazawa , Daisuke Shinmyo , Koichi Ito , Nobuaki Sato , Daiju Hasegawa , Toshiyuki Uemura , Toru Watanabe
IPC分类号： A01N43/42 , A61K31/44 , A01N43/40 , C07D471/02 , C07D491/02 , C07D498/02 , C07D401/00
CPC分类号： C07D417/14 , C07D471/04 , C07D471/18 , C07D487/04 , C07D498/04
摘要： A compound represented by the formula [I]: or a pharmacologically acceptable salt or ester thereof, wherein Ring A represents a five-membered aromatic heterocyclic group or the like fused with a non-aromatic ring group, which may be substituted, Ring B represents a phenyl group or the like which may be substituted, X1 represents a single bond or the like, R1 and R2 each represent a C1-6 alkyl group or the like, m represents an integer of 0 to 3, and n represents an integer of 0 to 2, is effective as a therapeutic agent for a disease caused by Aβ.
摘要翻译：由式[I]表示的化合物或其药理学上可接受的盐或酯，其中环A表示与可被取代的非芳族环基稠合的五元芳族杂环基等，环B表示可以被取代的苯基等，X1表示单键等，R1和R2各自表示C1-6烷基等，m表示0〜3的整数，n表示 0〜2，作为A＆Bgr引起的疾病的治疗剂是有效的。

2. 发明授权

US09453000B2 Polycyclic compound 有权
标题翻译：多环化合物
公开(公告)号：US09453000B2
公开(公告)日：2016-09-27
申请号：US12671873
申请日：2008-08-28
申请人： Teiji Kimura , Noritaka Kitazawa , Toshihiko Kaneko , Nobuaki Sato , Koki Kawano , Koichi Ito , Mamoru Takaishi , Takeo Sasaki , Yu Yoshida , Toshiyuki Uemura , Takashi Doko , Daisuke Shinmyo , Daiju Hasegawa , Takehiko Miyagawa , Hiroaki Hagiwara
发明人： Teiji Kimura , Noritaka Kitazawa , Toshihiko Kaneko , Nobuaki Sato , Koki Kawano , Koichi Ito , Mamoru Takaishi , Takeo Sasaki , Yu Yoshida , Toshiyuki Uemura , Takashi Doko , Daisuke Shinmyo , Daiju Hasegawa , Takehiko Miyagawa , Hiroaki Hagiwara
IPC分类号： C07D471/04 , A61K31/437 , C07D487/04 , C07D498/04 , C07D403/10 , A61P25/28 , C07D403/04
CPC分类号： C07D403/10 , C07D471/04 , C07D487/04 , C07D498/04
摘要： Disclosed is a compound represented by the formula (I): or a pharmacologically acceptable salt thereof, which is effective as a therapeutic or prophylactic agent for a disease induced by Aβ, wherein Ar1 represents an imidazolyl group which may be substituted with a C1-6 alkyl group, or the like; Ar2 represents a phenyl group which may be substituted with a C1-6 alkoxy group, or the like; X1 represents a double bond, or the like; and Het represents a triazolyl group or the like which may be substituted with a C1-6 alkyl group or the like, or the like.

3. 发明申请

US20090062529A1 MULTI-CYCLIC COMPOUNDS 有权
标题翻译：多环化合物
公开(公告)号：US20090062529A1
公开(公告)日：2009-03-05
申请号：US12200731
申请日：2008-08-28
申请人： Teiji KIMURA , Noritaka Kitazawa , Toshihiko Kaneko , Nobuaki Sato , Koki Kawano , Koichi Ito , Mamoru Takaishi , Takeo Sasaki , Yu Yoshida , Toshiyuki Uemura , Takashi Doko , Daisuke Shinmyo , Daiju Hasegawa , Takehiko Miyagawa , Hiroaki Hagiwara
发明人： Teiji KIMURA , Noritaka Kitazawa , Toshihiko Kaneko , Nobuaki Sato , Koki Kawano , Koichi Ito , Mamoru Takaishi , Takeo Sasaki , Yu Yoshida , Toshiyuki Uemura , Takashi Doko , Daisuke Shinmyo , Daiju Hasegawa , Takehiko Miyagawa , Hiroaki Hagiwara
IPC分类号： C07D487/04 , C07D498/04
CPC分类号： C07D403/10 , C07D401/14 , C07D403/14 , C07D409/14
摘要： A compound represented by the formula (I): or a pharmacologically acceptable salt thereof, wherein Ar1 represents an imidazolyl group or the like which may be substituted with a C1-6 alkyl group, Ar2 represents a phenyl group or the like which may be substituted with a C1-6 alkoxy group, X1 represents a double bond or the like and Het represents a triazolyl group or the like which may be substituted with a C1-6 alkyl group or the like, is effective as a therapeutic or prophylactic agent for a disease caused by Aβ.
摘要翻译：由式（I）表示的化合物或其药理学上可接受的盐，其中Ar 1表示可被C 1-6烷基取代的咪唑基等，Ar 2表示可被取代的苯基等具有C 1-6烷氧基，X 1表示双键等，Het表示可以被C 1-6烷基等取代的三唑基等，作为治疗或预防药物是有效的由Abeta引起的疾病

4. 发明授权

US07935815B2 Imidazoyl pyridine compounds and salts thereof 有权
标题翻译：咪唑酰吡啶化合物及其盐
公开(公告)号：US07935815B2
公开(公告)日：2011-05-03
申请号：US12200731
申请日：2008-08-28
申请人： Teiji Kimura , Noritaka Kitazawa , Toshihiko Kaneko , Nobuaki Sato , Koki Kawano , Koichi Ito , Mamoru Takaishi , Takeo Sasaki , Yu Yoshida , Toshiyuki Uemura , Takashi Doko , Daisuke Shinmyo , Daiju Hasegawa , Takehiko Miyagawa , Hiroaki Hagiwara
发明人： Teiji Kimura , Noritaka Kitazawa , Toshihiko Kaneko , Nobuaki Sato , Koki Kawano , Koichi Ito , Mamoru Takaishi , Takeo Sasaki , Yu Yoshida , Toshiyuki Uemura , Takashi Doko , Daisuke Shinmyo , Daiju Hasegawa , Takehiko Miyagawa , Hiroaki Hagiwara
IPC分类号： C07D491/00 , C07D513/00 , C07D515/00 , C07D265/36 , C07D498/02 , C07D487/00 , C07D513/02 , C07D515/02 , C07D401/00
CPC分类号： C07D403/10 , C07D401/14 , C07D403/14 , C07D409/14
摘要： A compound represented by the formula (I): or a pharmacologically acceptable salt thereof, wherein Ar1 represents an imidazolyl group or the like which may be substituted with a C1-6 alkyl group, Ar2 represents a phenyl group or the like which may be substituted with a C1-6 alkoxy group, X1 represents a double bond or the like and Het represents a triazolyl group or the like which may be substituted with a C1-6 alkyl group or the like, is effective as a therapeutic or prophylactic agent for a disease caused by Aβ.
摘要翻译：由式（I）表示的化合物或其药理学上可接受的盐，其中Ar 1表示可被C 1-6烷基取代的咪唑基等，Ar 2表示可被取代的苯基等具有C 1-6烷氧基，X 1表示双键等，Het表示可以被C 1-6烷基等取代的三唑基等，作为治疗或预防药物是有效的 A＆BGR引起的疾病

5. 发明申请

US20120053171A1 Nitrogen-Containing Fused Heterocyclic Compounds and Their use as Beta Amyloid Production Inhibitors 失效
标题翻译：含氮混合杂环化合物及其作为β淀粉样蛋白生产抑制剂的用途
公开(公告)号：US20120053171A1
公开(公告)日：2012-03-01
申请号：US13138504
申请日：2010-02-24
申请人： Noritaka Kitazawa , Daisuke Shinmyo , Koichio Ito , Nobuaki Sato , Daiju Hasegawa , Toshiyuki Uemura , Toru Watanabe
发明人： Noritaka Kitazawa , Daisuke Shinmyo , Koichio Ito , Nobuaki Sato , Daiju Hasegawa , Toshiyuki Uemura , Toru Watanabe
IPC分类号： A61K31/55 , A61K31/4985 , A61K31/496 , A61K31/4375 , C07D487/04 , A61K31/4439 , C07D498/04 , A61P25/28 , C07D471/04 , A61P25/00 , A61K31/5365 , A61K31/437
CPC分类号： C07D417/14 , C07D471/04 , C07D471/18 , C07D487/04 , C07D498/04
摘要： A compound represented by the formula [I]: or a pharmacologically acceptable salt or ester thereof, wherein Ring A represents a five-membered aromatic heterocyclic group or the like fused with a non-aromatic ring group, which may be substituted, Ring B represents a phenyl group or the like which may be substituted, X1 represents a single bond or the like, R1 and R2 each represent a C1-6 alkyl group or the like, m represents an integer of 0 to 3, and n represents an integer of 0 to 2, is effective as a therapeutic agent for a disease caused by Aβ.
摘要翻译：由式[I]表示的化合物或其药理学上可接受的盐或酯，其中环A表示与可被取代的非芳族环基稠合的五元芳族杂环基等，环B表示可以被取代的苯基等，X1表示单键等，R1和R2各自表示C1-6烷基等，m表示0〜3的整数，n表示 0〜2，作为A＆Bgr引起的疾病的治疗剂是有效的。

6. 发明申请

US20110065696A1 IMIDAZOYL PYRIDINE COMPOUNDS AND SALTS THEREOF 审中-公开
标题翻译：咪唑啉吡啶化合物及其盐
公开(公告)号：US20110065696A1
公开(公告)日：2011-03-17
申请号：US12950670
申请日：2010-11-19
申请人： Teiji KIMURA , Noritaka Kitazawa , Toshihiko Kaneko , Nobuaki Sato , Koki Kawano , Koichi Ito , Mamoru Takaishi , Takeo Sasaki , Yu Yoshida , Toshiyuki Uemura , Takashi Doko , Daisuke Shinmyo , Daiju Hasegawa , Takehiko Miyagawa , Hiroaki Hagiwara
发明人： Teiji KIMURA , Noritaka Kitazawa , Toshihiko Kaneko , Nobuaki Sato , Koki Kawano , Koichi Ito , Mamoru Takaishi , Takeo Sasaki , Yu Yoshida , Toshiyuki Uemura , Takashi Doko , Daisuke Shinmyo , Daiju Hasegawa , Takehiko Miyagawa , Hiroaki Hagiwara
IPC分类号： A61K31/437 , C07D471/04 , C07D487/04 , C07D498/04 , A61K31/519 , A61K31/4439 , A61K31/5383 , A61P25/00 , A61P25/28
CPC分类号： C07D403/10 , C07D401/14 , C07D403/14 , C07D409/14
摘要： A compound represented by the formula (I): or a pharmacologically acceptable salt thereof, wherein Ar1 represents an imidazolyl group or the like which may be substituted with a C1-6 alkyl group, Ar2 represents a phenyl group or the like which may be substituted with a C1-6 alkoxy group, X1 represents a double bond or the like and Het represents a triazolyl group or the like which may be substituted with a C1-6 alkyl group or the like, is effective as a therapeutic or prophylactic agent for a disease caused by Aβ.
摘要翻译：由式（I）表示的化合物或其药理学上可接受的盐，其中Ar 1表示可被C 1-6烷基取代的咪唑基等，Ar 2表示可被取代的苯基等具有C 1-6烷氧基，X 1表示双键等，Het表示可以被C 1-6烷基等取代的三唑基等，作为治疗或预防药物是有效的 A＆BGR引起的疾病

7. 发明申请

US20110009619A1 POLYCYCLIC COMPOUND 有权
标题翻译：多环化合物
公开(公告)号：US20110009619A1
公开(公告)日：2011-01-13
申请号：US12671873
申请日：2008-08-28
申请人： Teiji Kimura , Noritaka Kitazawa , Toshihiko Kaneko , Nobuaki Sato , Koki Kawano , Koichi Ito , Mamoru Takaishi , Takeo Sasaki , Yu Yoshida , Toshiyuki Uemura , Takashi Doko , Daisuke Shinmyo , Daiju Hasegawa , Takehiko Miyagawa , Hiroaki Hagiwara
发明人： Teiji Kimura , Noritaka Kitazawa , Toshihiko Kaneko , Nobuaki Sato , Koki Kawano , Koichi Ito , Mamoru Takaishi , Takeo Sasaki , Yu Yoshida , Toshiyuki Uemura , Takashi Doko , Daisuke Shinmyo , Daiju Hasegawa , Takehiko Miyagawa , Hiroaki Hagiwara
IPC分类号： C07D487/04 , C07D471/04 , C07D498/04
CPC分类号： C07D403/10 , C07D471/04 , C07D487/04 , C07D498/04
摘要： Disclosed is a compound represented by the formula (I): or a pharmacologically acceptable salt thereof, which is effective as a therapeutic or prophylactic agent for a disease induced by Aβ, wherein Ar1 represents an imidazolyl group which may be substituted with a C1-6 alkyl group, or the like; Ar2 represents a phenyl group which may be substituted with a C1-6 alkoxy group, or the like; X1 represents a double bond, or the like; and Het represents a triazolyl group or the like which may be substituted with a C1-6 alkyl group or the like, or the like.
摘要翻译：公开了由式（I）表示的化合物或其药理学上可接受的盐，其作为由A＆bgr诱导的疾病的治疗或预防剂是有效的，其中Ar1表示可被C1- 6烷基等; Ar 2表示可被C 1-6烷氧基取代的苯基等; X1表示双键等; Het表示可以被C 1-6烷基等取代的三唑基等。

8. 发明授权

US06648954B2 Water-based pigment dispersion, use thereof and process for the production thereof 失效
标题翻译：水性颜料分散体及其制造方法及其制造方法
公开(公告)号：US06648954B2
公开(公告)日：2003-11-18
申请号：US09797827
申请日：2001-03-05
申请人： Toshiyuki Uemura , Jun Kaneda , Eriko Suzuki , Takashi Negishi , Seiji Aida
发明人： Toshiyuki Uemura , Jun Kaneda , Eriko Suzuki , Takashi Negishi , Seiji Aida
IPC分类号： C09D1100
CPC分类号： C09D11/322 , C09B67/0034
摘要： A water-based pigment dispersion comprising 100 parts by weight of a pigment, 3 to 30 parts by weight of a sulfonic acid group-containing pigment derivative and water, wherein the sulfonic acid group-containing pigment derivative has only one sulfonic acid group in a molecule of a pigment of which the type is the same as the type of the pigment to be dispersed, the sulfonic acid group forms at least one salt selected from the group consisting of ammonia salt, an organic amine salt and a salt in which at least 15% of the sulfonic acid group is liberated and the rest is a salt with monovalent metal, the content of metal ion having a valence of at least 2 in a solid matter of the above water-based pigment dispersion is 500 ppm or less, and the above pigment is dispersed in water according to electrostatic repulsion due to the sulfonic acid group-containing pigment derivative adsorbed on the particle surface of the pigment, an inkjet recording liquid containing the same and process for the production thereof.
摘要翻译：一种水性颜料分散体，其包含100重量份的颜料，3〜30重量份的含磺酸基的颜料衍生物和水，其中所述含磺酸基的颜料衍生物在颜料的分子类型与待分散的颜料的类型相同，磺酸基形成至少一种选自氨盐，有机胺盐和盐的盐，其中至少磺酸基的15％被释放，其余的是与一价金属的盐，在上述水性颜料分散体的固体物质中，化合价至少为2的金属离子的含量为500ppm以下，由于吸附在颜料的颗粒表面上的含有磺酸基的颜料衍生物，含有该颜料的喷墨记录液，由于静电排斥，上述颜料分散在水中，生产。

9. 发明授权

US07958438B2 CAN system 有权
公开(公告)号：US07958438B2
公开(公告)日：2011-06-07
申请号：US12076980
申请日：2008-03-26
申请人： Toshiyuki Uemura , Yasuyuki Inoue
发明人： Toshiyuki Uemura , Yasuyuki Inoue
IPC分类号： G08C25/00
CPC分类号： G06F11/2215 , H04L1/24
摘要： Provided is a CAN system that can generate an error signal without requiring hardware for generating an error signal to be connected to a bus. A protocol processing part within a CAN controller incorporates error data into receive data or send data, based on error data information stored in a register.

10. 发明申请

US20080183835A1 CAN system 有权
标题翻译： CAN系统
公开(公告)号：US20080183835A1
公开(公告)日：2008-07-31
申请号：US12076980
申请日：2008-03-26
申请人： Toshiyuki Uemura , Yasuyuki Inoue
发明人： Toshiyuki Uemura , Yasuyuki Inoue
IPC分类号： G06F15/16
CPC分类号： G06F11/2215 , H04L1/24
摘要： Provided is a CAN system that can generate an error signal without requiring hardware for generating an error signal to be connected to a bus. A protocol processing part within a CAN controller incorporates error data into receive data or send data, based on error data information stored in a register.
摘要翻译：提供了一种CAN系统，其可以产生误差信号，而不需要用于产生要连接到总线的错误信号的硬件。 CAN控制器中的协议处理部分根据存储在寄存器中的错误数据信息，将错误数据合并到接收数据或发送数据。

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