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1. 发明授权

US08372394B2 Compositions and methods for treating cartilage disease 有权
标题翻译：用于治疗软骨疾病的组合物和方法
公开(公告)号：US08372394B2
公开(公告)日：2013-02-12
申请号：US12311426
申请日：2008-02-21
申请人： Norimasa Iwasaki , Akio Minami , Yasuhiko Kasahara , Tatsuya Igarashi , Daisuke Kawamura , Fumiyoshi Kasahara , Chihiro Miyajima , Nobuo Ohzawa , Mariko Imai
发明人： Norimasa Iwasaki , Akio Minami , Yasuhiko Kasahara , Tatsuya Igarashi , Daisuke Kawamura , Fumiyoshi Kasahara , Chihiro Miyajima , Nobuo Ohzawa , Mariko Imai
IPC分类号： A61K35/12
CPC分类号： A61K35/28 , A61K31/734 , A61L27/20 , A61L27/3834 , A61L27/3852 , A61L2430/06 , C08L5/04
摘要： The present invention provides a composition for regenerating cartilage or treating a cartilage disease containing a monovalent metal salt of alginic acid for which the endotoxin level thereof has been lowered to an extent that does not substantially induce inflammation or fever. As a result, it is possible to provide a composition for regenerating cartilage that improves cartilage regenerative action and ease of application to a cartilage injury lesion, and a composition for treating a cartilage disease, which has the effects of protecting cartilage from mechanical irritation, inhibiting degenerative changes in cartilage caused by wear and inflammation, repairing a cartilage injury lesion, and inhibiting inflammation and pain of joint tissue.
摘要翻译：本发明提供一种用于再生软骨或治疗软骨疾病的组合物，其含有海藻酸的一价金属盐，其内毒素水平已被降低至基本上不引起炎症或发热的程度。结果，可以提供一种提高软骨再生作用的软骨再生用软化组合物和软骨损伤损伤的易用性的组合物，以及用于治疗软骨疾病的组合物，其具有保护软骨免受机械刺激，抑制由磨损和炎症引起的软骨退行性变化，修复软骨损伤病变，以及抑制关节组织的炎症和疼痛。

2. 发明授权

US08367637B2 Composition for treating arthritic disorder 有权
标题翻译：用于治疗关节炎疾病的组合物
公开(公告)号：US08367637B2
公开(公告)日：2013-02-05
申请号：US12461660
申请日：2009-08-19
申请人： Norimasa Iwasaki , Akio Minami , Yasuhiko Kasahara , Tatsuya Igarashi , Daisuke Kawamura , Nobuo Ohzawa , Mariko Imai
发明人： Norimasa Iwasaki , Akio Minami , Yasuhiko Kasahara , Tatsuya Igarashi , Daisuke Kawamura , Nobuo Ohzawa , Mariko Imai
IPC分类号： A61K31/734 , A61P19/02 , C08B37/04
CPC分类号： A61K31/715
摘要： The present invention provides compositions and methods for treating a joint disease containing as an active ingredient thereof a monovalent metal salt of alginic acid for which the endotoxin level thereof has been lowered to an extent that does not substantially induce inflammation or fever. As a result, it is possible to provide a composition for treating a joint disease which has the effects of protecting cartilage from mechanical irritation, inhibiting degenerative changes in cartilage caused by wear and inflammation, repairing cartilage injuries, suppressing inflammation and pain of joint tissue, inhibiting degeneration of synovial tissue, and inhibiting osteochondral destruction.
摘要翻译：本发明提供用于治疗关节疾病的组合物和方法，其含有作为其活性成分的海藻酸的一价金属盐，其内毒素水平已被降低至基本上不诱导炎症或发热的程度。结果，可以提供一种治疗关节疾病的组合物，其具有保护软骨免受机械刺激的作用，抑制由磨损和炎症引起的软骨的退行性变化，修复软骨损伤，抑制炎症和关节组织的疼痛，抑制滑膜组织变性，抑制骨软骨破坏。

3. 发明申请

US20100048506A1 Composition for treating arthritic disorder 有权
标题翻译：用于治疗关节炎疾病的组合物
公开(公告)号：US20100048506A1
公开(公告)日：2010-02-25
申请号：US12461660
申请日：2009-08-19
申请人： Norimasa Iwasaki , Akio Minami , Yasuhiko Kasahara , Tatsuya Igarashi , Daisuke Kawamura , Nobuo Ohzawa , Mariko Imai
发明人： Norimasa Iwasaki , Akio Minami , Yasuhiko Kasahara , Tatsuya Igarashi , Daisuke Kawamura , Nobuo Ohzawa , Mariko Imai
IPC分类号： A61K31/715 , A61P19/02
CPC分类号： A61K31/715
摘要： The present invention provides compositions and methods for treating a joint disease containing as an active ingredient thereof a monovalent metal salt of alginic acid for which the endotoxin level thereof has been lowered to an extent that does not substantially induce inflammation or fever. As a result, it is possible to provide a composition for treating a joint disease which has the effects of protecting cartilage from mechanical irritation, inhibiting degenerative changes in cartilage caused by wear and inflammation, repairing cartilage injuries, suppressing inflammation and pain of joint tissue, inhibiting degeneration of synovial tissue, and inhibiting osteochondral destruction.
摘要翻译：本发明提供用于治疗关节疾病的组合物和方法，其含有作为其活性成分的海藻酸的一价金属盐，其内毒素水平已被降低至基本上不引起炎症或发热的程度。结果，可以提供一种治疗关节疾病的组合物，其具有保护软骨免受机械刺激的作用，抑制由磨损和炎症引起的软骨的退行性变化，修复软骨损伤，抑制炎症和关节组织的疼痛，抑制滑膜组织变性，抑制骨软骨破坏。

4. 发明申请

US20100015102A1 Composition for treatment of cartilage disease 有权
标题翻译：用于治疗软骨疾病的组合物
公开(公告)号：US20100015102A1
公开(公告)日：2010-01-21
申请号：US12311426
申请日：2008-02-21
申请人： Norimasa Iwasaki , Akio Minami , Yasuhiko Kasahara , Tatsuya Igarashi , Daisuke Kawamura , Fumiyoshi Kasahara , Chihiro Miyajima , Nobuo Ohzawa , Mariko Imai
发明人： Norimasa Iwasaki , Akio Minami , Yasuhiko Kasahara , Tatsuya Igarashi , Daisuke Kawamura , Fumiyoshi Kasahara , Chihiro Miyajima , Nobuo Ohzawa , Mariko Imai
IPC分类号： A61K35/12 , A61K31/715 , A61P19/04
CPC分类号： A61K35/28 , A61K31/734 , A61L27/20 , A61L27/3834 , A61L27/3852 , A61L2430/06 , C08L5/04
摘要： The present invention provides a composition for regenerating cartilage or treating a cartilage disease containing a monovalent metal salt of alginic acid for which the endotoxin level thereof has been lowered to an extent that does not substantially induce inflammation or fever. As a result, it is possible to provide a composition for regenerating cartilage that improves cartilage regenerative action and ease of application to a cartilage injury lesion, and a composition for treating a cartilage disease, which has the effects of protecting cartilage from mechanical irritation, inhibiting degenerative changes in cartilage caused by wear and inflammation, repairing a cartilage injury lesion, and inhibiting inflammation and pain of joint tissue.
摘要翻译：本发明提供一种用于再生软骨或治疗软骨疾病的组合物，其含有海藻酸的一价金属盐，其内毒素水平已被降低至基本上不引起炎症或发热的程度。结果，可以提供一种提高软骨再生作用的软骨再生用软化组合物和软骨损伤损伤的易用性的组合物，以及用于治疗软骨疾病的组合物，其具有保护软骨免受机械刺激，抑制由磨损和炎症引起的软骨退行性变化，修复软骨损伤病变，以及抑制关节组织的炎症和疼痛。

5. 发明申请

US20140213524A1 COMPOSITION FOR REGENERATION OF CARTILAGE 审中-公开
标题翻译：用于再生植物的组合物
公开(公告)号：US20140213524A1
公开(公告)日：2014-07-31
申请号：US14239663
申请日：2012-08-22
申请人： Norimasa Iwasaki , Atsushi Sukegawa , Akio Minami , Nobuo Ohzawa
发明人： Norimasa Iwasaki , Atsushi Sukegawa , Akio Minami , Nobuo Ohzawa
IPC分类号： A61K38/19 , A61K31/734
CPC分类号： A61K38/195 , A61K31/734 , A61L27/20 , A61L27/54 , A61L2300/252 , A61L2300/414 , A61L2430/06 , C08L5/04
摘要： A novel composition for regenerating a cartilage has been demanded, which can achieve a good effect of regenerating a hyaline cartilage that is a nearly normal cartilage without requiring the use of any transplanted cell. The present invention provides a composition for regenerating a cartilage, wherein (a) a monovalent metal salt of low endotoxin alginic acid and (b) SDF-1 are used in combination.
摘要翻译：已经需要用于再生软骨的新型组合物，其可以实现再生几乎正常软骨的透明软骨的良好效果，而不需要使用任何移植的细胞。本发明提供一种用于再生软骨的组合物，其中（a）低内毒素海藻酸的一价金属盐和（b）SDF-1的组合使用。

6. 发明申请

US20060134158A1 Chitosan/acidic biopolymer hybrid fiber and culture base for animal cells 审中-公开
标题翻译：壳聚糖/酸性生物聚合物混合纤维和动物细胞培养基
公开(公告)号：US20060134158A1
公开(公告)日：2006-06-22
申请号：US10519541
申请日：2003-06-26
申请人： Tokifumi Majima , Norimasa Iwasaki , Tadanao Funakoshi , Akio Minami , Shin-ichiro Nishimura , Seiichi Tokura , Kazuo Harada , Sachiko Nonaka , Nobuhiki Maekawa
发明人： Tokifumi Majima , Norimasa Iwasaki , Tadanao Funakoshi , Akio Minami , Shin-ichiro Nishimura , Seiichi Tokura , Kazuo Harada , Sachiko Nonaka , Nobuhiki Maekawa
IPC分类号： C12N5/08 , B32B27/04 , A61F13/00
CPC分类号： A61L27/3817 , A61K35/12 , A61L27/20 , A61L27/3804 , A61L27/3843 , A61L27/3895 , A61L27/48 , A61L27/58 , C12N5/0068 , C12N5/0655 , C12N2533/72 , C12N2533/74 , D01F8/16 , Y10T442/2566 , C08L5/08
摘要： It is intended to provide a three-dimensional scaffolds appropriate for culturing animal cells such as chondrocytes and fibroblasts. These three-dimensional scaffolds which comprise a chitosan/acidic biopolymers hybrid fibers composed of chitosan or its salts in the inside of the fiber and complexes of chitosan with biodegradable acidic biopolymers coating the fiber surface, are made of fibers capable of retaining their shapes after allowing to stand Dulbecco's modified Eagle's medium (DMEM) containing 10% of FBS (fetal bovine serum) at room temperature for 2 weeks.
摘要翻译：旨在提供适合于培养动物细胞如软骨细胞和成纤维细胞的三维支架。这些三维支架由纤维内部由壳聚糖或其盐形成的壳聚糖/酸性生物聚合物混合纤维和壳聚糖与可生物降解的酸性生物聚合物复合物包覆纤维表面组成，由能够在允许后保留其形状的纤维制成在室温下放置含有10％FBS（胎牛血清）的Dulbecco改良的Eagle培养基（DMEM）2周。

7. 发明授权

US06382134B1 Fish rearing system 失效
标题翻译：养鱼系统
公开(公告)号：US06382134B1
公开(公告)日：2002-05-07
申请号：US09048336
申请日：1998-03-26
申请人： Daniel Edward Gruenberg , Shinji Morimura , Shinichiroh Kawaguchi , Akio Minami
发明人： Daniel Edward Gruenberg , Shinji Morimura , Shinichiroh Kawaguchi , Akio Minami
IPC分类号： A01K6100
CPC分类号： A01K63/04
摘要： A fish rearing system having a water circulation system comprising: a trapping section including a particle trap 2 for capturing residual feed and fish feces contained in the water, a sediment trap 6 for accumulating a sediment in a rearing tank and separating the sediment from the water, a residual feed detecting sensor 5 interposed in a pipe 4 communicating with the particle trap 2 and the sediment trap 6, and a micro-screen filter 7; a denitrification device 12 for denitrifying a nitrogen compound dissolved and contained in the water; a bubble surfacing device 11 for generating bubbles by supplying air and/or ozone and removing surface active substances contained in the water by capturing the bubbles; an ultraviolet disinfection device 13 for disinfecting the circulating rearing water; an ammonium treatment section consisting of a immersion treatment device 15 and a non-immersion treatment device 14 and having a function of decomposing ammonium contained in the water; and an aeration device 21 for dissolving oxygen into the water; wherein the denitrification device 12 is disposed at the upstream of the bubble surfacing device 11 and includes a bypass pipe 10. Thus, the fish rearing system capable of performing water quality control at a low cost can be obtained by a rational combination of devices.
摘要翻译：一种具有水循环系统的鱼饲养系统，包括：捕集部分，包括用于捕获残留饲料的颗粒捕获器2和包含在水中的鱼粪;沉淀池6，用于在饲养槽中积聚沉淀物并将沉淀物与水分离插入与颗粒捕集器2和沉淀物捕集器6连通的管4中的残留进料检测传感器5和微滤器7; 用于使溶解并包含在水中的氮化合物脱氮的脱氮装置12; 用于通过供应空气和/或臭氧并通过捕获气泡去除包含在水中的表面活性物质来产生气泡的气泡表面装置11; 用于对循环饲养水进行消毒的紫外消毒装置13; 由浸渍处理装置15和非浸渍处理装置14构成的具有分解水分中的铵的功能的铵处理部，以及用于将氧气溶解到水中的曝气装置21; 其中脱氮装置12设置在气泡堆积装置11的上游，并且包括旁通管10.因此，能够以低成本执行水质控制的鱼饲养系统可以通过装置的合理组合来获得。

8. 发明授权

US6139088A Automobile door 失效
标题翻译：汽车门
公开(公告)号：US6139088A
公开(公告)日：2000-10-31
申请号：US759418
申请日：1996-12-05
申请人： Shinichi Okamoto , Keizo Nishitani , Yoshihito Aoki , Akio Minami , Mitsunobu Kato
发明人： Shinichi Okamoto , Keizo Nishitani , Yoshihito Aoki , Akio Minami , Mitsunobu Kato
IPC分类号： B60R16/02 , B60J5/04 , B60R13/02 , B60R13/08 , B62D65/00
CPC分类号： B60J5/0416 , B60J5/0463 , B60R13/0243 , B60R13/0892 , B60R2013/0287 , E05Y2201/43
摘要： An automobile door that is significantly easy to fabricate, enhanced in ease of assembling door components, and reduced in the number of parts to be mounted. The door comprises an outer panel and an inner panel. The inner panel is composed of a main panel made of metal and a resin-molded sub panel formed integrally with the main panel. The inner panel is formed with a mount on which door functional parts to be mounted on the door are mounted. The inner panel is also formed integrally with electrically connecting means for connecting these door functional parts with each other.
摘要翻译：汽车门很容易制造，增强了组装门组件的便利性，减少了要安装的零件数量。门包括外板和内板。内板由金属制的主面板和与主面板一体形成的树脂模制副面板构成。内板形成有安装有安装在门上的门功能部件的安装件。内板也与用于将这些门功能部件相互连接的电连接装置一体地形成。

9. 发明授权

US5846091A Circuit and its connecting structure assembly in motorcar door 失效
标题翻译：电动车门及其连接结构组件
公开(公告)号：US5846091A
公开(公告)日：1998-12-08
申请号：US826420
申请日：1997-03-27
申请人： Masataka Nishijima , Keizo Nishitani , Akio Minami
发明人： Masataka Nishijima , Keizo Nishitani , Akio Minami
IPC分类号： B60J5/00 , B60R16/02 , H01B7/00 , H01R13/66 , H01R13/70 , H01R13/74 , H01R27/00 , H01R33/00
CPC分类号： B60R16/0215 , H01R13/6658 , H01R13/70 , H01R27/00 , H01H2207/022 , H01H2221/09 , H01H2231/026 , H01H2239/014
摘要： A circuit and its connecting structure assembly provided in a motorcar door includes an inner unit being able to joint to a door panel, and an arm rest unit attached on the inner unit. The inner unit has an inner panel provided with a circuit, a plurality of auxiliary components connected to the circuit, and an integrated connector section. The arm rest unit includes a connector portion corresponding to the integrated connector section, a control circuit board connected to the connector portion and to a switch section for the auxiliary components, a circuit provided in the arm rest body and connected to the control circuit board, and an optional switch connected to the circuit. In the optional switches connected to the circuit provided in the arm rest unit, software replacement of the control circuit board can change the functions of the optional switches.
摘要翻译：设置在汽车门中的电路及其连接结构组件包括能够连接到门板的内部单元和附接在内部单元上的扶手单元。内部单元具有设置有电路的内部面板，连接到电路的多个辅助部件和集成连接器部分。扶手单元包括对应于集成连接器部分的连接器部分，连接到连接器部分的控制电路板和用于辅助部件的开关部分，设置在扶手本体中并连接到控制电路板的电路，以及连接到电路的可选开关。在连接到扶手单元中提供的电路的可选开关中，控制电路板的软件更换可以改变可选开关的功能。

10. 发明申请

US20100297682A1 METHOD OF DIAGNOSTIC RHEUMATOID ARTHRITIS BY SUGAR CHAIN ANALYSIS 审中-公开
标题翻译：通过糖链分析诊断性RHEUMATOID ARTHRITIS的方法
公开(公告)号：US20100297682A1
公开(公告)日：2010-11-25
申请号：US12864079
申请日：2009-01-28
申请人： Shin-Ichiro Nishimura , Akio Minami , Jun-ichi Furukawa , Yasuro Shinohara
发明人： Shin-Ichiro Nishimura , Akio Minami , Jun-ichi Furukawa , Yasuro Shinohara
IPC分类号： C12Q1/34 , C08B37/00
CPC分类号： G01N33/6893 , G01N2400/00 , G01N2800/102
摘要： Provided is a novel method of diagnosing rheumatoid arthritis. Based on the quantitative expression profile of sugar chain expression amount in the serum (whole serum, HAP or LAP), the relevancy thereof to rheumatoid arthritis is analyzed. As a result, a sugar chain and a glycoprotein showing a change depending on the onset of rheumatoid arthritis are found out and thus a serum sugar chain and a glycoprotein usable as a novel biomarker are provided.
摘要翻译：提供了一种诊断类风湿性关节炎的新方法。基于血清（全血清，HAP或LAP）中糖链表达量的定量表达谱，分析其与类风湿性关节炎的相关性。结果，发现根据类风湿性关节炎的发作显示变化的糖链和糖蛋白，从而提供可用作新型生物标志物的血清糖链和糖蛋白。

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