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1. 发明申请

US20080161326A1 Novel Sulfone Amide Amide Derivatives 失效
标题翻译：新型磺酰胺酰胺衍生物
公开(公告)号：US20080161326A1
公开(公告)日：2008-07-03
申请号：US10589693
申请日：2005-02-15
申请人： Norikazu Otake , Yoshio Ogino , Akio Kanatani
发明人： Norikazu Otake , Yoshio Ogino , Akio Kanatani
IPC分类号： A61K31/52 , C07D235/04 , A61K31/4184 , A61P3/04 , A61P3/10 , C07D473/00
CPC分类号： C07D471/04 , C07D235/14 , C07D473/00 , C07D487/04
摘要： The present invention relates to compounds of the general formula (I): wherein A, B, C and D each independently are a methine group or a nitrogen atom, said methine group optionally having a substituent(s) with at least one of them meaning the methine group; E means a group represented by the following formulae (E1): R1 means a lower alkyl group or an aryl group optionally having a substituent(s) or means a lower alkylene group linked to arbitrary, linkable position(s) of E, and others. The compounds of the present invention are useful as an agent for the treatment of a variety of diseases related to NPY.
摘要翻译：本发明涉及通式（I）的化合物：其中A，B，C和D各自独立地为次甲基或氮原子，所述次甲基任选具有取代基，其中至少一个为含义次甲基; E表示由下式（E1）表示的基团：R 1表示低级烷基或任选具有取代基的芳基，或指与任意可连接位置连接的低级亚烷基（E）等。本发明的化合物可用作治疗与NPY有关的各种疾病的药剂。

2. 发明申请

US20060205750A1 Novel benzimidazole derivatives 失效
公开(公告)号：US20060205750A1
公开(公告)日：2006-09-14
申请号：US11431274
申请日：2006-05-10
申请人： Norikazu Otake , Minoru Moriya , Yoshio Ogino , Kenji Matsuda , Yoshikazu Nagae , Akio Kanatani , Takehiro Fukami
发明人： Norikazu Otake , Minoru Moriya , Yoshio Ogino , Kenji Matsuda , Yoshikazu Nagae , Akio Kanatani , Takehiro Fukami
IPC分类号： A61K31/4747 , A61K31/4184 , C07D487/10
CPC分类号： C07D473/30 , C07D405/04 , C07D471/04 , C07D471/10 , C07D473/00 , C07D491/04
摘要： The present invention relates to a compound of the formula (I): (wherein A, B, C and D are independently nitrogen or optionally substituted methine; E is nitrogen, methine or hydroxy substituted methine; n is 0 or 1; T, U, V and W are independently nitrogen or optionally substituted methine; X is —N(SO2R4)—, —N(COR5)— or —CO—; Y is —C(R6)(R7)—, —O— or —N(R8)—, provided that the compound (I) when E is nitrogen, n is 0, X is —CO—, and Y is —O— is excluded) and the like, which are useful as an agent for the treatment of various diseases related to NPY, for example cardiovascular disorders such as angina, acute or congestive heart failure, myocardial infarction, hypertension, nephropathy, electrolyte abnormality, vasospasm, arteriosclerosis, etc., central nervous system disorders such as bulimia, depression, anxiety, seizure, epilepsy, dementia, pain, alcoholism, drug withdrawal, circadian rhythm disorders, schizophrenia, memory impairment, sleep disorders, cognitive impairment, etc., metabolic diseases such as obesity, diabetes, hormone abnormality, hypercholesterolemia, hyperlipidemia, gout, fatty liver, etc., genital or reproductive disorders such as infertility, preterm labor, sexual dysfunction, etc., gastro-intestinal disorders, respiratory disorder, inflammatory diseases or glaucoma, and the like, also for example, atherosclerosis, hypogonadism, hyperandrogenism, polycystic ovary syndrome (Pickwickian syndrome), hirsutism, gastro-intestinal motility disorder, obesity-related gastro-esophageal reflux, obesity hypoventilation, sleep apnea, inflammation, systemic inflammation of the vasculature, osteoarthritis, insulin resistance, bronchoconstriction, alcohol preference, metabolic syndrome, Alzheimer's disease, cardiac hypertrophy, left ventricular hypertrophy, hypertriglyceridemia, low HDL cholesterol, cardiovascular disorders such as coronary heart disease (CHD), cerebrovascular disease, stroke, peripheral vascular disease, sudden death, gallbladder diseases, cancer (breast, endometrial, colon), breathlessness, hyperuricemia, impaired fertility, low back pain, or increased anesthetic risk, and the like.

3. 发明申请

US20100048600A1 NOVEL BENZIMIDAZOLE DERIVATIVES 失效
公开(公告)号：US20100048600A1
公开(公告)日：2010-02-25
申请号：US12605503
申请日：2009-10-26
申请人： NORIKAZU OTAKE , Minoru Moriya , Yoshio Ogino , Kenji Matsuda , Yoshikazu Nagae , Akio Kanatani , Takehiro Fukami
发明人： NORIKAZU OTAKE , Minoru Moriya , Yoshio Ogino , Kenji Matsuda , Yoshikazu Nagae , Akio Kanatani , Takehiro Fukami
IPC分类号： A61K31/438 , C07D401/04 , C07D401/14 , A61P3/10
CPC分类号： C07D473/30 , C07D405/04 , C07D471/04 , C07D471/10 , C07D473/00 , C07D491/04
摘要： The present invention relates to a compound of the formula (I): (wherein A, B, C and D are independently nitrogen or optionally substituted methine; E is nitrogen, methine or hydroxy substituted methine; n is 0 or 1; T, U, V and W are independently nitrogen or optionally substituted methine; X is —N(SO2R4)—, —N(COR5)— or —CO—; Y is —C(R6)(R7)—, —O— or —N(R8)—, provided that the compound (I) when E is nitrogen, n is 0, X is —CO—, and Y is —O— is excluded) and the like, which are useful as an agent for the treatment of various diseases related to NPY, for example cardiovascular disorders such as angina, acute or congestive heart failure, myocardial infarction, hypertension, nephropathy, electrolyte abnormality, vasospasm, arteriosclerosis, etc., central nervous system disorders such as bulimia, depression, anxiety, seizure, epilepsy, dementia, pain, alcoholism, drug withdrawal, circadian rhythm disorders, schizophrenia, memory impairment, sleep disorders, cognitive impairment, etc., metabolic diseases such as obesity, diabetes, hormone abnormality, hypercholesterolemia, hyperlipidemia, gout, fatty liver, etc., genital or reproductive disorders such as infertility, preterm labor, sexual dysfunction, etc., gastro-intestinal disorders, respiratory disorder, inflammatory diseases or glaucoma, and the like, also for example, atherosclerosis, hypogonadism, hyperandrogenism, polycystic ovary syndrome (Pickwickian syndrome), hirsutism, gastro-intestinal motility disorder, obesity-related gastro-esophageal reflux, obesity hypoventilation, sleep apnea, inflammation, systemic inflammation of the vasculature, osteoarthritis, insulin resistance, bronchoconstriction, alcohol preference, metabolic syndrome, Alzheimer's disease, cardiac hypertrophy, left ventricular hypertrophy, hypertriglyceridemia, low HDL cholesterol, cardiovascular disorders such as coronary heart disease (CHD), cerebrovascular disease, stroke, peripheral vascular disease, sudden death, gallbladder diseases, cancer (breast, endometrial, colon), breathlessness, hyperuricemia, impaired fertility, low back pain, or increased anesthetic risk, and the like.

4. 发明授权

US07803807B2 Benzimidazole derivatives 失效
标题翻译：苯并咪唑衍生物
公开(公告)号：US07803807B2
公开(公告)日：2010-09-28
申请号：US12605503
申请日：2009-10-26
申请人： Norikazu Otake , Minoru Moriya , Yoshio Ogino , Kenji Matsuda , Yoshikazu Nagae , Akio Kanatani , Takehiro Fukami
发明人： Norikazu Otake , Minoru Moriya , Yoshio Ogino , Kenji Matsuda , Yoshikazu Nagae , Akio Kanatani , Takehiro Fukami
IPC分类号： A61K31/438 , C07D401/14 , A61P3/10
CPC分类号： C07D473/30 , C07D405/04 , C07D471/04 , C07D471/10 , C07D473/00 , C07D491/04
摘要： The present invention relates to compounds of Formula (I) wherein A, B and C are independently methine, said methine being optionally substituted; D is nitrogen; T, U, V and W are independently methine or nitrogen, said methine being optionally substituted and least two of T, U, V and W are said methine groups; X is —N(SO2R4)—, N(COR5)— or —CO—; Y is C(R6)(R7)—, —O— or —N(R8) and a pharmaceutically acceptable salt, ester or N-oxide derivative thereof.
摘要翻译：本发明涉及式（I）的化合物，其中A，B和C独立地为次甲基，所述次甲基任选被取代; D是氮; T，U，V和W独立地是次甲基或氮，所述次甲基任选被取代，T，U，V和W中的至少两个是所述次甲基; X是-N（SO 2 R 4） - ，N（COR 5） - 或-CO-; Y是C（R6）（R7） - ， - O-或-N（R8）及其药学上可接受的盐，酯或N-氧化物衍生物。

5. 发明授权

US07691860B2 Sulfonamide derivatives 失效
标题翻译：磺酰胺衍生物
公开(公告)号：US07691860B2
公开(公告)日：2010-04-06
申请号：US10589693
申请日：2005-02-15
申请人： Norikazu Otake , Yoshio Ogino , Akio Kanatani
发明人： Norikazu Otake , Yoshio Ogino , Akio Kanatani
IPC分类号： A61K31/497 , A61K31/52 , A61K31/437 , A61K31/445 , A61K31/4184 , C07D257/04 , C07D235/04 , C07D471/04 , C07D473/00 , C07D401/00
CPC分类号： C07D471/04 , C07D235/14 , C07D473/00 , C07D487/04
摘要： The present invention relates to compounds of the general formula (I): wherein A, B, C and D each independently are a methine group or a nitrogen atom, said methine group optionally having a substituent(s) with at least one of them meaning the methine group; E means a group represented by the following formulae (E1): R1 means a lower alkyl group or an aryl group optionally having a substituent(s) or means a lower alkylene group linked to arbitrary, linkable position(s) of E, and others. The compounds of the present invention are useful as an agent for the treatment of a variety of diseases related to NPY.
摘要翻译：本发明涉及通式（I）的化合物：其中A，B，C和D各自独立地为次甲基或氮原子，所述次甲基任选具有取代基，其中至少一个为含义次甲基; E表示由下式（E1）表示的基团：R 1表示低级烷基或任选具有取代基的芳基或表示与E的任意可连接位置连接的低级亚烷基等。本发明的化合物可用作治疗与NPY有关的各种疾病的药剂。

6. 发明授权

US07687514B2 Benzimidazole derivatives 失效
标题翻译：苯并咪唑衍生物
公开(公告)号：US07687514B2
公开(公告)日：2010-03-30
申请号：US11431274
申请日：2006-05-10
申请人： Norikazu Otake , Minoru Moriya , Yoshio Ogino , Kenji Matsuda , Yoshikazu Nagae , Akio Kanatani , Takehiro Fukami
发明人： Norikazu Otake , Minoru Moriya , Yoshio Ogino , Kenji Matsuda , Yoshikazu Nagae , Akio Kanatani , Takehiro Fukami
IPC分类号： A61K31/4747 , C07D221/20
CPC分类号： C07D473/30 , C07D405/04 , C07D471/04 , C07D471/10 , C07D473/00 , C07D491/04
摘要： The present invention relates to a compound of the formula (I): (wherein A, B, C and D are independently nitrogen or optionally substituted methine; E is nitrogen, methine or hydroxy substituted methine; n is 0 or 1; T, U, V and W are independently nitrogen or optionally substituted methine; X is —N(SO2R4)—, —N(COR5)— or —CO—; Y is —C(R6)(R7)—, —O— or —N(R8)—, provided that the compound (I) when E is nitrogen, n is 0, X is —CO—, and Y is —O— is excluded) and the like, which are useful as an agent for the treatment of various diseases related to NPY.
摘要翻译：本发明涉及式（I）化合物：其中A，B，C和D独立地为氮或任选取代的次甲基; E为氮，次甲基或羟基取代的次甲基; n为0或1; T，U ，V和W独立地为氮或任选取代的次甲基; X为-N（SO2R4） - ， - N（COR5） - 或-CO-; Y为-C（R6）（R7） - ， - O-或-N （R8） - ，条件是当E为氮时的化合物（I），n为0，X为-CO-，Y为-O-时除外）等，其可用作治疗与NPY相关的各种疾病。

7. 发明授权

US07105526B2 Benzimidazole derivatives 失效
标题翻译：苯并咪唑衍生物
公开(公告)号：US07105526B2
公开(公告)日：2006-09-12
申请号：US10463390
申请日：2003-06-18
申请人： Norikazu Otake , Minoru Moriya , Yoshio Ogino , Kenji Matsuda , Yoshikazu Nagae , Akio Kanatani , Takehiro Fukami
发明人： Norikazu Otake , Minoru Moriya , Yoshio Ogino , Kenji Matsuda , Yoshikazu Nagae , Akio Kanatani , Takehiro Fukami
IPC分类号： A61K31/52 , C07D239/70
CPC分类号： C07D473/30 , C07D405/04 , C07D471/04 , C07D471/10 , C07D473/00 , C07D491/04
摘要： The present invention relates to novel benzimidazole derivatives which are useful as neuropeptide Y receptor antagonists.
摘要翻译：本发明涉及可用作神经肽Y受体拮抗剂的新型苯并咪唑衍生物。

8. 发明申请

US20060111380A1 Novel azole derivatives 失效
标题翻译：新型唑衍生物
公开(公告)号：US20060111380A1
公开(公告)日：2006-05-25
申请号：US10536360
申请日：2003-11-25
申请人： Norikazu Otake , Yuji Haga , Makoto Jitsuoka , Akio Kanatani
发明人： Norikazu Otake , Yuji Haga , Makoto Jitsuoka , Akio Kanatani
IPC分类号： A61K31/4747 , C07D471/10
CPC分类号： C07D491/10
摘要： The present invention relates to a compound of the formula (I): wherein Az is a group comprising a monocyclic azole or a bicyclic aromatic ring of the same or different fused azoles; T, U, V and W are independently methine or nitrogen, said methine being optionally substituted by a substituent, and at least two of T, U, V and W are said methine groups; and X is nitrogen or methine. The compounds of the present invention are useful as agents for the treatment of various kinds of diseases related to NPY, for example, cardiovascular disorders, nervous system disorders, genitative diseases, metabolic diseases, genital or reproductive disorders, gastrointestinal disorders, respiratory disorders, inflammatory diseases or glaucoma, and the like.
摘要翻译：本发明涉及式（I）化合物：其中Az是包含相同或不同稠合唑的单环唑或双环芳环的基团; T，U，V和W独立为次甲基或氮，所述次甲基任选被取代基取代，T，U，V和W中的至少两个为所述次甲基; X是氮或次甲基。本发明的化合物可用作治疗与NPY相关的各种疾病的药剂，例如心血管疾病，神经系统疾病，基因疾病，代谢疾病，生殖器或生殖障碍，胃肠道疾病，呼吸系统疾病，炎症性疾病疾病或青光眼等。

9. 发明授权

US07589096B2 Azole derivatives 失效
标题翻译：唑衍生物
公开(公告)号：US07589096B2
公开(公告)日：2009-09-15
申请号：US12071808
申请日：2008-02-26
申请人： Norikazu Otake , Yuji Haga , Makoto Jitsuoka , Akio Kanatani
发明人： Norikazu Otake , Yuji Haga , Makoto Jitsuoka , Akio Kanatani
IPC分类号： A61K31/438 , A61K31/506 , A61K31/4545 , C07D233/96 , C07D401/14 , C07D401/02
CPC分类号： C07D491/10
摘要： The present invention relates to a compound of the formula (I): wherein Az is a group comprising a monocyclic azole or a bicyclic aromatic ring of the same or different fused azoles; T, U, V and W are independently methine or nitrogen, wherein a methine may be optionally substituted by a substituent, and at least two of T, U, V and W are methine groups; and X is nitrogen or methine. The compounds of the present invention are useful as agents for the treatment of various kinds of diseases related to NPY, for example, cardiovascular disorders, nervous system disorders, genitative diseases, metabolic diseases, genital or reproductive disorders, gastro-intestinal disorders, respiratory disorders, inflammatory diseases or glaucoma, and the like.
摘要翻译：本发明涉及式（I）化合物：其中Az是包含相同或不同稠合唑的单环唑或双环芳环的基团; T，U，V和W独立地是次甲基或氮，其中次甲基可以任选地被取代基取代，并且T，U，V和W中的至少两个是次甲基; X是氮或次甲基。本发明的化合物可用作治疗与NPY相关的各种疾病的药剂，例如心血管疾病，神经系统疾病，基因疾病，代谢疾病，生殖器或生殖障碍，胃肠道疾病，呼吸障碍，炎症性疾病或青光眼等。

10. 发明申请

US20080188507A1 Novel azole derivatives 失效
标题翻译：新型唑衍生物
公开(公告)号：US20080188507A1
公开(公告)日：2008-08-07
申请号：US12071808
申请日：2008-02-26
申请人： Norikazu Otake , Yuji Haga , Makoto Jitsuoka , Akio Kanatani
发明人： Norikazu Otake , Yuji Haga , Makoto Jitsuoka , Akio Kanatani
IPC分类号： A61K31/4747 , C07D491/14
CPC分类号： C07D491/10
摘要： The present invention relates to a compound of the formula (I): wherein Az is a group comprising a monocyclic azole or a bicyclic aromatic ring of the same or different fused azoles; T, U, V and W are independently methine or nitrogen, said methine being optionally substituted by a substituent, and at least two of T, U, V and W are said methine groups; and X is nitrogen or methine.The compounds of the present invention are useful as agents for the treatment of various kinds of diseases related to NPY, for example, cardiovascular disorders, nervous system disorders, genitative diseases, metabolic diseases, genital or reproductive disorders, gastro-intestinal disorders, respiratory disorders, inflammatory diseases or glaucoma, and the like.
摘要翻译：本发明涉及式（I）化合物：其中Az是包含相同或不同稠合唑的单环唑或双环芳环的基团; T，U，V和W独立为次甲基或氮，所述次甲基任选被取代基取代，T，U，V和W中的至少两个为所述次甲基; X是氮或次甲基。本发明的化合物可用作治疗与NPY相关的各种疾病的药剂，例如心血管疾病，神经系统疾病，基因疾病，代谢疾病，生殖器或生殖障碍，胃肠道疾病，呼吸障碍，炎症性疾病或青光眼等。

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