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1. 发明申请

US20070264197A1 Method for detecting a progressive, chronic dementia disease, and corresponding peptides and detection reagents 审中-公开
标题翻译：用于检测进行性慢性痴呆疾病的方法，以及相应的肽和检测试剂
公开(公告)号：US20070264197A1
公开(公告)日：2007-11-15
申请号：US11726160
申请日：2007-03-20
申请人： Norbert Lamping , Hans-Dieter Zucht , Harmut Selle , Michael Jurgens , Gabriele Heine , Rudiger Hess
发明人： Norbert Lamping , Hans-Dieter Zucht , Harmut Selle , Michael Jurgens , Gabriele Heine , Rudiger Hess
IPC分类号： A61K38/00 , A61K31/7052 , A61K38/16 , A61K39/395 , A61K49/00 , A61P25/28 , C07H21/00 , C07K14/00 , C07K16/00 , G01N33/68
CPC分类号： C07K14/52 , A61K38/00 , G01N33/6896 , G01N2500/00 , G01N2800/2814
摘要： Novel peptides and the quantitative methods for the determination thereof in body fluids of patients suffering from progredient chronic dementia, in relation to the concentration of said peptides in a control group. The peptides derive from a protein precursor having the corresponding gene, are processed in a specific manner, and are optionally post-translationally modified, especially phosphorylised. An increase in the concentrations of these peptides or the corresponding non-processed protein indicates progredient chronic dementia. Also disclosed are methods of using the peptides for controlling the course of progredient chronic dementia and for the prognosis of progredient chronic dementia, especially for complementing or replacing mini-mental scores, and for developing therapeutic agents to combat progredient chronic dementia such as Alzheimer's disease.
摘要翻译：新型肽及其在患有慢性痴呆症的患者体液中的定量方法，与对照组中所述肽的浓度有关。衍生自具有相应基因的蛋白质前体的肽以特定方式加工，并且任选地经翻译后修饰，特别是磷酸化。这些肽或相应的未加工蛋白质的浓度的增加表示慢性痴呆。还公开了使用肽来控制慢性痴呆进展过程和慢性痴呆进展预后的方法，特别是用于补充或替代小分数，以及用于开发治疗剂以对抗慢性痴呆症如阿尔茨海默病。

2. 发明申请

US20050048584A1 Method for detecting alzheimer's disease and differentiating alzheimer's disease from other demential diseases associated peptides and use thereof 审中-公开
标题翻译：用于检测阿尔茨海默氏病和将阿尔茨海默氏病与其他痴呆疾病相关肽分化的方法及其用途
公开(公告)号：US20050048584A1
公开(公告)日：2005-03-03
申请号：US10497073
申请日：2002-11-27
申请人： Norbert Lamping , Hans-Dieter Zucht , Harmut Selle , Michael Jurgens , Gabriele Heine , Rudiger Hess
发明人： Norbert Lamping , Hans-Dieter Zucht , Harmut Selle , Michael Jurgens , Gabriele Heine , Rudiger Hess
IPC分类号： G01N33/53 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P25/28 , C07K7/06 , C07K7/08 , C07K14/47 , C12N15/09 , C12Q1/68 , G01N30/88 , G01N33/68 , G01N33/567
CPC分类号： G01N33/6896 , A61K38/00 , C07K14/472 , G01N2800/2821
摘要： The invention relates to defined peptide and the quantiative determination thereof in the body fluids of patients suffering from Alzheimer's disease in relation to the concentration thereof in a control group of patients who are healthy or suffer from other dementia diseases. The inventive peptides originate from the C3f fragment of the complement C3 protein precursor with the corresponding gene and are modified in a specific manner and are optionally post-translationally or chemically modified. Modification occurs with respect to the concentrations of said peptides in patients in a manner which is specific to each peptide when compared with the control group. A specific and significant modification of the concentration of said peptides in relation to the concentration thereof in healthy persons indicates a differentiation with respect to Alzheimer's disease. The invention also relates to the use of said peptides as a progress control, and in the development of diagnostic and therapeutic agents.
摘要翻译：本发明涉及定义的肽及其在患有阿尔茨海默病的患者的体液中与其在健康或患有其它痴呆疾病的对照组中的浓度相关的定量肽。本发明的肽源自具有相应基因的补体C3蛋白前体的C3f片段，并以特定方式进行修饰并且任选地进行翻译后或化学修饰。与对照组相比，以每种肽特异性的方式，对患者中所述肽的浓度进行修饰。所述肽相对于其在健康人中的浓度的浓度的具体和显着的改变表明相对于阿尔茨海默病的分化。本发明还涉及所述肽作为进展对照以及诊断和治疗剂的开发的用途。

3. 发明申请

US20070031908A1 Method for detecting a progressive, chronic dementia disease, and corresponding peptides and detection reagents 审中-公开
标题翻译：用于检测进行性慢性痴呆疾病的方法，以及相应的肽和检测试剂
公开(公告)号：US20070031908A1
公开(公告)日：2007-02-08
申请号：US10549141
申请日：2004-03-18
申请人： Norbert Lamping , Hans Zucht , Hartmut Selle , Michael Jurgens , Gabriele Heine , Rudiger Hess , Markus Kellmann , Jens Lamerz , Thomas Mohring
发明人： Norbert Lamping , Hans Zucht , Hartmut Selle , Michael Jurgens , Gabriele Heine , Rudiger Hess , Markus Kellmann , Jens Lamerz , Thomas Mohring
IPC分类号： G01N33/543
CPC分类号： C07K14/4711 , G01N33/6896 , G01N33/9406 , G01N2800/2821
摘要： The invention relates to a method for detecting progressive, chronic dementia diseases or a predisposition to such diseases or method for the prognosis of such diseases. For this purpose, the concentration of particular peptides in body fluids or other samples from the patient is measured in a method which can be carried out in a laboratory. The invention further relates to peptides which have been found for determining the presence and/or the grade of the progressive, chronic dementia disease. The invention additionally relates to detection reagents such as antibodies and nucleic acids and the like for detecting said peptides or the corresponding nucleic acids. The invention further relates to pharmaceutical products which comprise the peptides according to the present invention, antibodies directed to said peptides, nucleic acids corresponding to said peptides, peptide antagonists, or peptide agonists for the therapy, diagnosis, prognosis or prophylaxis of neurological diseases, in particular of Alzheimer's disease. The invention further relates to methods for stratifying patients or participants in clinical studies.
摘要翻译：本发明涉及一种用于检测进行性慢性痴呆疾病或倾向于这些疾病或这种疾病预后的方法。为此目的，以可以在实验室中进行的方法测量体液或来自患者的其它样品中特定肽的浓度。本发明还涉及已经发现用于确定进行性慢性痴呆疾病的存在和/或等级的肽。本发明还涉及用于检测所述肽或相应核酸的检测试剂，例如抗体和核酸等。本发明还涉及包含根据本发明的肽的药物产品，针对所述肽的抗体，对应于所述肽的核酸，肽拮抗剂或肽激动剂，用于治疗，诊断，预后或预防神经疾病，特别是阿尔茨海默病。本发明还涉及用于分层临床研究中的患者或参与者的方法。

4. 发明申请

US20080118929A1 Tif1-Beta Peptides and Nucleic Acids for Diagnosis and Therapy of Cancer and Colorectal Cancerous Disorders 审中-公开
标题翻译： Tif1-β肽和核酸用于癌症和结肠直肠癌的诊断和治疗
公开(公告)号：US20080118929A1
公开(公告)日：2008-05-22
申请号：US11883133
申请日：2006-01-24
申请人： Harald Tammen , Rudiger Hess , Karl Schorn , Rudolf Reiter , Susanne Neitz , Norbert Lamping
发明人： Harald Tammen , Rudiger Hess , Karl Schorn , Rudolf Reiter , Susanne Neitz , Norbert Lamping
IPC分类号： G01N33/574 , C07K14/00 , C07K16/18 , C12N15/11 , C12N15/00 , C12N5/06 , C12Q1/68
CPC分类号： G01N33/57419
摘要： Many disorders, especially neoplastic disorders such as cancer and polyps, are the result of hyperproliferative cells or of cells with differentiation disorders. For these types of disorders early detection is of pivotal importance and reliable and early biomarkers for common types of cancers such as colorectal cancer are still not available. Thus, there is a need for new markers and for methods for identifying such new markers. The invention provides peptides and proteins and derivatives thereof originating from transcription intermediary factor-1 beta (TIF1-beta) suitable as markers and therapeutics for disorders such as cancer, preferably colorectal cancerous or related disorders such as polyps.
摘要翻译：许多疾病，特别是肿瘤性疾病如癌症和息肉，是过度增殖细胞或具有分化障碍的细胞的结果。对于这些类型的疾病，早期检测是至关重要的，并且常见类型的癌症如结肠直肠癌的可靠和早期生物标志物仍然不可用。因此，需要新的标记和用于鉴定这种新标记的方法。本发明提供源自转录中介因子-1β（TIF1-β）的肽和蛋白质及其衍生物，其适用于诸如癌症，优选结肠直肠癌或相关疾病如息肉的疾病的标记物和治疗剂。

5. 发明授权

US4749830A Contact pieces for vacuum switchgear, and method for the manufacture thereof 失效
标题翻译：真空开关柜的接触件及其制造方法
公开(公告)号：US4749830A
公开(公告)日：1988-06-07
申请号：US8799
申请日：1987-01-30
申请人： Horst Kippenberg , Reiner Muller , Hannelore Schnodt , Irmo Paulus , Rudiger Hess
发明人： Horst Kippenberg , Reiner Muller , Hannelore Schnodt , Irmo Paulus , Rudiger Hess
IPC分类号： H01H1/04 , H01H1/02 , H01H11/04 , H01H33/66
CPC分类号： H01H1/0203
摘要： Contact pieces for vacuum switchgear comprise a base material with additives of readily vaporizable components to produce a sufficiently conductive switch path in the switch-off process. It is desired to have an overvoltage-free switching behavior for the vacuum switchgear. The additives are concentrated in a firmly adhering layer covering the switching surface of the contact piece. Such contact pieces can be manufactured in particular by direct fusing of the additives on the surface, by fusing a separate application of the additives in powder form, in granulate form or as foil or sheet on the surface or alternatively by vapor deposition of the additives on the switching surface of a given contact piece body of base material. Advantageously, a CuCr contact piece base material is used.
摘要翻译：用于真空开关装置的接触件包括具有容易蒸发的部件的添加剂的基底材料，以在断开过程中产生足够导电的开关路径。希望对真空开关装置具有无过压开关行为。添加剂集中在覆盖接触片的切换面的牢固粘附层上。这样的接触片可以特别地通过在表面上直接熔融添加剂来制造，通过将粉末形式的添加剂以颗粒形式或作为表面上的箔片或片材分开施用，或者通过将添加剂气相沉积在基材的给定接触片体的切换面。有利地，使用CuCr接触片基材。

6. 发明授权

US4321439A Electrical contact construction for air-blast circuit breakers 失效
标题翻译：气动断路器的电气接触结构
公开(公告)号：US4321439A
公开(公告)日：1982-03-23
申请号：US90122
申请日：1979-11-01
申请人： Rudiger Hess , Heiner Marin
发明人： Rudiger Hess , Heiner Marin
IPC分类号： H01H33/88 , H01H33/18 , H01H33/70 , H01H33/91
CPC分类号： H01H33/91 , H01H33/7053
摘要： An electrical contact construction for air-blast circuit breakers, particularly blast-piston or "puffer" type breakers, which subject the arc drawn during current interruption to a compressed-gas blast as well as a magnetic-force effect which lengthens the arc. To increase the interruption capacity of such breakers, and particularly to improve arc behavior during the interruption process, a tubular member is disposed within the interior spaces of the tubular contacts of such a breaker in which the switching gases flow. The member has an inner surface which is conically shaped and is matched to the contour of openings provided in nozzle members disposed at the end faces of the tubular contacts to improve gas flow.
摘要翻译：用于气动断路器的电接触结构，特别是鼓风活塞或“波纹”型断路器，其在电流中断期间将电弧吸收到压缩气体爆炸以及延长电弧的磁力作用。为了增加这种断路器的中断能力，特别是为了改善中断过程中的电弧行为，管状构件设置在开关气体流过的这种断路器的管状触点的内部空间内。该构件具有圆锥形的内表面，并且与设置在管状触点的端面处的喷嘴构件中的开口轮廓相匹配，以改善气体流动。

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