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1. 发明授权

US5859249A 2-phenyl-2-(2'-piperidinylidene)acetate derivative, process for manufacturing the same, and process for manufacturing optically active 2-phenyl-2-(2'-piperidinyl)acetate derivative by asymmetrically hydrogenating the same 失效
标题翻译： 2-苯基-2-（2'-亚哌啶基）乙酸酯衍生物，其制备方法，以及通过不对称氢化其制备光学活性2-苯基-2-（2'-哌啶基）乙酸酯衍生物的方法
公开(公告)号：US5859249A
公开(公告)日：1999-01-12
申请号：US895428
申请日：1997-07-16
申请人： Nobuo Seido , Takenobu Nishikawa , Tsukasa Sotoguchi , Yoshifumi Yuasa , Takashi Miura , Hidenori Kumobayashi
发明人： Nobuo Seido , Takenobu Nishikawa , Tsukasa Sotoguchi , Yoshifumi Yuasa , Takashi Miura , Hidenori Kumobayashi
IPC分类号： C07C229/34 , C07C271/22 , C07D211/70 , C07D211/02 , C07D211/32
CPC分类号： C07C229/34 , C07C271/22 , C07D211/70
摘要： Disclosed is a 2-phenyl-2-(2'-piperidinylidene)acetate derivative suitably used for a raw material of a 2-phenyl-2-(2'-piperidinyl)acetate derivative and a process for manufacturing the same. Also disclosed is a process for manufacturing an optically active 2-phenyl-2-(2'-piperidinyl)acetate derivative which is a major intermediate for an antidepressant. The 2-phenyl-2-(2'-piperidinylidene)acetate derivative is manufactured by cyclizing a 7-(N-substituted amino)-3-oxo-2-heptanoate derivative. The optically active 2-phenyl-2-(2'-piperidinyl)acetate derivative is manufactured by asymmetrically hydrogenating the 2-phenyl-2-(2'-piperidinylidene)acetate derivative in the presence of a complex of a Group VIII transition metal or an acid.
摘要翻译：公开了适用于2-苯基-2-（2'-哌啶基）乙酸酯衍生物的原料的2-苯基-2-（2'-亚哌啶基）乙酸酯衍生物及其制造方法。还公开了作为抗抑郁药的主要中间体的光学活性2-苯基-2-（2'-哌啶基）乙酸酯衍生物的制造方法。通过使7-（N-取代的氨基）-3-氧代-2-庚酸酯衍生物环化制备2-苯基-2-（2'-亚哌啶基）乙酸酯衍生物。光学活性的2-苯基-2-（2'-哌啶基）乙酸酯衍生物是通过在第VIII族过渡金属络合物存在下不对称氢化2-苯基-2-（2'-亚哌啶基）乙酸酯衍生物制备的，酸。

2. 发明授权

US5801271A 7-(n-substituted amino)-2-phenylheptanoic acid derivative and process for manufacturing the same 失效
标题翻译： 7-（正取代氨基）-2-苯基庚酸衍生物及其制造方法
公开(公告)号：US5801271A
公开(公告)日：1998-09-01
申请号：US895429
申请日：1997-07-16
申请人： Nobuo Seido , Takenobu Nishikawa , Tsukasa Sotoguchi , Yoshifumi Yuasa , Takashi Miura , Hidenori Kumobayashi
发明人： Nobuo Seido , Takenobu Nishikawa , Tsukasa Sotoguchi , Yoshifumi Yuasa , Takashi Miura , Hidenori Kumobayashi
IPC分类号： B01J31/02 , B01J31/22 , C07B61/00 , C07C229/34 , C07C269/06 , C07C271/18 , C07C271/22 , C07C303/28 , C07C309/73 , C07C271/06
CPC分类号： C07C271/22 , C07C229/34 , Y02P20/55
摘要： Disclosed is a 7-(N-substituted amino)-3-oxo-2-phenylheptanoate derivative, 7-(N-substituted amino)-3-hydroxy-2-phenylheptanoate derivative, and 7-(N-substituted amino)-3-benzenesulfonyloxy-2-phenylheptanoate derivative, which are quite important major intermediates for an antidepressant. The 7-(N-substituted amino)-3-oxo-2-phenylheptanoate derivative can be manufactured by condensing an enolate of phenylacetates with a 5-(N-substituted amino) pentanoate derivative.
摘要翻译：公开了7-（N-取代氨基）-3-氧代-2-苯基庚酸酯衍生物，7-（N-取代氨基）-3-羟基-2-苯基庚酸酯衍生物和7-（N-取代氨基）-3 - 苯磺酰氧基-2-苯基庚酸酯衍生物，它们是抗抑郁药的重要主要中间体。 7-（N-取代氨基）-3-氧代-2-苯基庚酸酯衍生物可以通过将苯乙酸酯的烯醇化物与5-（N-取代的氨基）戊酸酯衍生物缩合来制备。

3. 发明授权

US06608214B2 Process for producing optically active &ggr;-butyrolactone 失效
标题翻译：光学活性γ-丁内酯的制备方法
公开(公告)号：US06608214B2
公开(公告)日：2003-08-19
申请号：US10199136
申请日：2002-07-19
申请人： Tsukasa Sotoguchi , Takaji Matsumoto , Motonobu Takenaka , Takashi Miura
发明人： Tsukasa Sotoguchi , Takaji Matsumoto , Motonobu Takenaka , Takashi Miura
IPC分类号： C07D30733
CPC分类号： C07D307/33 , C07B2200/07 , C07C67/31 , Y02P20/55 , C07C69/734
摘要： This invention provides a novel process for producing optically active 3-hydroxy-&ggr;-butyrolactone in a short step, which is superior economically and in efficiency and industrially suitable by using a starting material which is inexpensive and easily available and reagents easy to handle. This invention relates to a process for producing optically active 3-hydroxy-&ggr;-butyrolactone represented by formula I: wherein the symbol * means an asymmetric carbon atom, which comprises hydrogenating an optically active 4-substituted oxy-3-hydroxybutyrate represented by formula II: wherein R1 represents a C1-4 lower alkyl group, R2 represents a protective group for a hydroxyl group deprotected by hydrogenation with a heterogeneous hydrogenation catalyst, and the symbol * has the same meaning as defined above, in the presence of a heterogeneous hydrogenation catalyst and an acidic substance followed by deprotection and simultaneous ring closure thereof.
摘要翻译：本发明提供了一种在短时间内制备光学活性3-羟基-γ-丁内酯的新方法，其经济性和效率都优异，在工业上适用于便宜且易于获得的试剂和易于处理的试剂。本发明涉及一种由式I表示的光学活性3-羟基-γ-丁内酯的制备方法：其中符号*表示不对称碳原子，其包括将由式II表示的光学活性的4-取代的氧基-3-羟基丁酸：其中R1表示C1-4低级烷基，R2表示通过异相氢化催化剂氢化脱保护的羟基的保护基，符号*具有与上述相同的含义，在非均相加氢催化剂存在下和酸性物质，然后脱保护并同时闭环。

4. 发明授权

US5824822A Phospphine-phosinite compound and process for preparing 4-�(R)-1'-formylethyl!-azetidin-2-one derivatives using the same 失效
标题翻译：磷酸 - 磷酸盐化合物和使用其制备4 - [（R）-1'-甲酰乙基] - 氮杂环丁-2-酮衍生物的方法
公开(公告)号：US5824822A
公开(公告)日：1998-10-20
申请号：US677226
申请日：1996-07-09
申请人： Takao Saito , Akifumi Yoshida , Kazuhiko Matsumura , Takashi Miura , Hidenori Kumobayashi
发明人： Takao Saito , Akifumi Yoshida , Kazuhiko Matsumura , Takashi Miura , Hidenori Kumobayashi
IPC分类号： C07D205/08 , C07F9/09 , C07F9/50 , C07F9/655 , C07F9/02 , C07D205/00
CPC分类号： C07F9/65517 , C07D205/08 , C07F9/5022 , Y02P20/55
摘要： A phosphine-phosphinite compound represented by formula (I): ##STR1## wherein R.sup.1 and R.sup.2, which may be the same or different, each represent a substituted or unsubstituted phenyl group or a substituted or unsubstituted naphthyl group, and a process for preparing a 4-�(R)-1'-formylethyl!azetidin-2-one derivative using the compound (I). The compound (I), either in combination, or as a complex, with a transition metal compound, is useful as a catalyst for asymmetric hydroformylation and makes it possible to easily synthesize an important intermediate for carbapenem antibiotics or a precursor thereof at high regioselectivity and diastereo-selectivity.
摘要翻译：由式（I）表示的膦 - 磷化合物：其中R 1和R 2可以相同或不同，各自表示取代或未取代的苯基或取代或未取代的萘基，用于使用化合物（I）制备4 - [（R）-1'-甲酰乙基]氮杂环丁-2-酮衍生物。与过渡金属化合物组合或作为络合物的化合物（I）可用作不对称加氢甲酰化的催化剂，并且可以容易地以高区域选择性合成碳青霉烯类抗生素或其前体的重要中间体，非对映选择性。

5. 发明授权

US06323174B1 Diene compound and process for producing the same 失效
标题翻译：二烯化合物及其制备方法
公开(公告)号：US06323174B1
公开(公告)日：2001-11-27
申请号：US09571549
申请日：2000-05-16
申请人： Mitsuhiko Fujiwhara , Takenobu Nishikawa , Yoji Hori , Toshimitsu Hagiwara , Hisao Iwai , Takashi Miura
发明人： Mitsuhiko Fujiwhara , Takenobu Nishikawa , Yoji Hori , Toshimitsu Hagiwara , Hisao Iwai , Takashi Miura
IPC分类号： A61K746
CPC分类号： C11B9/0019 , C07C2/04 , C07C45/54 , C07C47/21 , C07C67/293 , C07C2531/22 , C11B9/0007 , C07C11/12 , C07C69/007 , C07C69/145 , C07C69/16 , C07C69/24
摘要： The invention provides a chain diene compound with desirable regioselectivity, in the presence of a specific ruthenium compound. This chain diene compound is a promising raw material for terpene. It has a structure represented by the general formula (I): wherein R1 represents H, a C1-C6 alkyl group which may be substituted or a C2-C6 alkenyl group which may be substituted, R2 represents a phenyl group which may have a C1-C4 alkyl group or a C1-C12 acyloxy group which may have a phenyl group or a naphthyl group, or a benzyl group or R2 is a hydroxy group which reversibly forms an aldehyde group through shifting of the position of the double bond adjacent to said hydroxy group. The chain diene compound is produced by reacting 2-substituted-1,3-butadienes with terminal olefins in the presence of a ruthenium compound in a hydrophilic solvent. Further, the above method provides an inexpensive process for preparing a mild fragrant component and a perfume composition, such as 4-methyl-5-hexen-1-al and 4-vinyl-8-methyl-7-nonenal.
摘要翻译：在特定的钌化合物的存在下，本发明提供具有理想的区域选择性的链二烯化合物。该链二烯化合物是萜烯的有希望的原料。它具有由通式（I）表示的结构：其中R1表示H，可被取代的C1-C6烷基或可被取代的C2-C6烯基，R2表示可具有C1 -C4烷基或可以具有苯基或萘基的C1-C12酰氧基或苄基，或R2是通过使所述双键邻近的所述双键移位而可逆地形成醛基的羟基羟基。链二烯化合物通过在亲水性溶剂中在钌化合物的存在下使2-取代-1,3-丁二烯与末端烯烃反应制备。此外，上述方法提供了用于制备温和香料组分和香料组合物的廉价方法，例如4-甲基-5-己烯-1-醇和4-乙烯基-8-甲基-7-壬烯醛。

6. 发明授权

US06239324B1 Diene compound and process for producing the same 失效
标题翻译：二烯化合物及其制备方法
公开(公告)号：US06239324B1
公开(公告)日：2001-05-29
申请号：US09383920
申请日：1999-08-26
申请人： Mitsuhiko Fujiwhara , Takenobu Nishikawa , Yoji Hori , Toshimitsu Hagiwara , Hisao Iwai , Takashi Miura
发明人： Mitsuhiko Fujiwhara , Takenobu Nishikawa , Yoji Hori , Toshimitsu Hagiwara , Hisao Iwai , Takashi Miura
IPC分类号： C07C202
CPC分类号： C11B9/0019 , C07C2/04 , C07C45/54 , C07C47/21 , C07C67/293 , C07C2531/22 , C11B9/0007 , C07C11/12 , C07C69/007 , C07C69/145 , C07C69/16 , C07C69/24
摘要： The invention provides a chain diene compound with desirable regioselectivity, in the presence of a specific ruthenium compound. This chain diene compound is a promising raw material for terpene. It has a structure represented by the general formula (IX): wherein R1 represents H, a C1-C6 alkyl group which may be substituted or a C2-C6 alkenyl group which may be substituted, R2 represents a phenyl group which may have a C1-C4 alkyl group or a C1-C12 acyloxy group which may have a phenyl group or a naphthyl group, or a benzyl group or R2 is a hydroxy group which reversibly forms an aldehyde group through shifting of the position of the double bond adjacent to said hydroxy group. The chain diene compound is produced by reacting 2-substituted-1,3-butadienes with terminal olefins in the presence of a ruthenium compound in a hydrophilic solvent. Further, the above method provides an inexpensive process for preparing a mild fragrant component and a perfume composition, such as 4-methyl-5-hexen-1-al and 4-vinyl-8-methyl-7-nonenal.
摘要翻译：在特定的钌化合物的存在下，本发明提供具有理想的区域选择性的链二烯化合物。该链二烯化合物是萜烯的有希望的原料。其具有由通式（IX）表示的结构：其中R 1表示H，可被取代的C 1 -C 6烷基或可被取代的C 2 -C 6烯基，R 2表示可具有C 1 -C4烷基或可以具有苯基或萘基的C1-C12酰氧基或苄基，或R2是通过使所述双键邻近的所述双键的位置的移动可逆地形成醛基的羟基羟基。链二烯化合物通过在亲水性溶剂中在钌化合物的存在下使2-取代-1,3-丁二烯与末端烯烃反应制备。此外，上述方法提供了用于制备温和香料组分和香料组合物的廉价方法，例如4-甲基-5-己烯-1-醇和4-乙烯基-8-甲基-7-壬烯醛。

7. 发明授权

US08312162B2 Information processing apparatus and information processing method 失效
标题翻译：信息处理装置和信息处理方法
公开(公告)号：US08312162B2
公开(公告)日：2012-11-13
申请号：US12869153
申请日：2010-08-26
申请人： Tsuyoshi Honma , Akihiko Kinoshita , Hiroyuki Chiba , Takashi Miura
发明人： Tsuyoshi Honma , Akihiko Kinoshita , Hiroyuki Chiba , Takashi Miura
IPC分类号： G06F15/16
CPC分类号： H04L29/08729 , H04L67/2819 , H04N21/42661 , H04N21/44004 , H04N21/44209 , H04N21/458 , H04N21/8456
摘要： There is provided an information processing apparatus including a communication unit which communicates with a distribution server that contains content data for streaming delivery, a buffer unit which temporarily stores stream data obtained from the distribution server, a storage unit which stores an inserting content, a reproduction unit which reproduces the content inserted by the storage unit, and a control unit which measures a bandwidth of the network, determines whether it is possible to reproduce until the end of a next chapter defined by a chapter point set in the content based on a buffer volume of the buffer unit and the bandwidth, and when determined it is impossible, switches the content to be produced by the reproduction unit to the inserting content.
摘要翻译：提供了一种信息处理设备，包括：通信单元，其与包含用于流传送的内容数据的分发服务器进行通信;临时存储从分发服务器获得的流数据的缓冲单元，存储插入内容的存储单元，再现由存储单元插入的内容的单元和测量网络带宽的控制单元，确定是否可以再现直到由基于缓冲器的内容中设置的章节点定义的下一章节的结尾缓冲单元的体积和带宽，并且当确定不可能时，将由再现单元产生的内容切换到插入内容。

8. 发明授权

US08007174B2 Bag-like container with spout 有权
标题翻译：袋状容器带喷口
公开(公告)号：US08007174B2
公开(公告)日：2011-08-30
申请号：US11793519
申请日：2005-06-06
申请人： Madoka Yamaguchi , Masahiro Akioka , Mutsushi Hirano , Kenji Yoshihiro , Takashi Miura
发明人： Madoka Yamaguchi , Masahiro Akioka , Mutsushi Hirano , Kenji Yoshihiro , Takashi Miura
IPC分类号： B65D33/10 , B65D33/00 , B65D33/16 , B65D30/16
CPC分类号： A61J1/2093 , A61J1/10 , B65D33/2525 , B65D33/2533 , B65D75/008 , B65D75/566 , B65D75/5805 , B65D75/5883 , B65D2575/565 , Y10S383/906
摘要： A bag-like container with a spout in which a plastic linear fastener is interposed in an upper part of the container so that when water content or the like is to be supplied after contents of a liquid food container or the like have been administered to a subject, opening and closing the linear fastener enables the water content or the like to be supplied in an uncomplicated manner without the use of a separate member such as a spout that is an open part for pouring food, water, or the like into the container.
摘要翻译：具有喷口的袋状容器，其中塑料线性紧固件插入容器的上部，使得当向液体食品容器等的内容物施用水分或类似物之后，主体，打开和关闭线性紧固件使得能够以不复杂的方式供应含水量，而不需要使用诸如作为将食品，水等倾入容器的开放部分的喷嘴的单独构件。

9. 发明申请

US20110078324A1 INFORMATION PROCESSING APPARATUS AND INFORMATION PROCESSING METHOD 失效
标题翻译：信息处理设备和信息处理方法
公开(公告)号：US20110078324A1
公开(公告)日：2011-03-31
申请号：US12869153
申请日：2010-08-26
申请人： Tsuyoshi HONMA , Akihiko Kinoshita , Hiroyuki Chiba , Takashi Miura
发明人： Tsuyoshi HONMA , Akihiko Kinoshita , Hiroyuki Chiba , Takashi Miura
IPC分类号： G06F15/16
CPC分类号： H04L29/08729 , H04L67/2819 , H04N21/42661 , H04N21/44004 , H04N21/44209 , H04N21/458 , H04N21/8456
摘要： There is provided an information processing apparatus including a communication unit which communicates with a distribution server that contains content data for streaming delivery, a buffer unit which temporarily stores stream data obtained from the distribution server, a storage unit which stores an inserting content, a reproduction unit which reproduces the content inserted by the storage unit, and a control unit which measures a bandwidth of the network, determines whether it is possible to reproduce until the end of a next chapter defined by a chapter point set in the content based on a buffer volume of the buffer unit and the bandwidth, and when determined it is impossible, switches the content to be produced by the reproduction unit to the inserting content.
摘要翻译：提供了一种信息处理设备，包括：通信单元，其与包含用于流传送的内容数据的分发服务器进行通信;临时存储从分发服务器获得的流数据的缓冲单元，存储插入内容的存储单元，再现由存储单元插入的内容的单元和测量网络带宽的控制单元，确定是否可以再现直到由基于缓冲器的内容中设置的章节点定义的下一章节的结尾缓冲单元的体积和带宽，并且当确定不可能时，将由再现单元产生的内容切换到插入内容。

10. 发明授权

US07673265B2 Simulation apparatus and control method of simulation 失效
标题翻译：仿真设备及其仿真控制方法
公开(公告)号：US07673265B2
公开(公告)日：2010-03-02
申请号：US11851058
申请日：2007-09-06
申请人： Takashi Akiba , Takashi Miura
发明人： Takashi Akiba , Takashi Miura
IPC分类号： G06F17/50 , G06F9/455
CPC分类号： G06F17/5022
摘要： A simulation apparatus, including a first simulator assigning an operating cycle number, a second simulator assigning an operating cycle number, and a control portion for synchronously controlling the first simulator and the second simulator, the control portion causing communication between the first simulator and the second simulator so as to control control-information and synchronous-information of the first simulator and the second simulator, the control-information controlling operations of the first simulator and the second simulator, wherein the control portion sets up the operating cycle numbers of the first simulator and the second simulator at a first cycle value when a synchronous condition of the synchronous-information is established, the control portion sets up at least one of the operating cycle numbers of the first simulator and the second simulator at a second cycle value being larger than the first cycle value when the synchronous condition of the synchronous-information is not established.
摘要翻译：一种模拟装置，包括分配操作周期数的第一模拟器，分配操作周期数的第二模拟器和用于同步控制第一模拟器和第二模拟器的控制部分，所述控制部分引起第一模拟器与第二模拟器之间的通信模拟器，以便控制第一模拟器和第二模拟器的控制信息和同步信息，第一模拟器和第二模拟器的控制信息控制操作，其中控制部分设置第一模拟器的操作周期数并且当所述同步信息的同步状态被建立时，所述第二模拟器处于第一周期值，所述控制部分以第二周期值设定所述第一模拟器和所述第二模拟器的操作周期数中的至少一个，同步信息的同步状态时的第一个周期值没有建立。

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