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1. 发明授权

US07906318B2 Testing microreactor, testing device and testing method 有权
标题翻译：检测微反应器，检测装置及检测方法
公开(公告)号：US07906318B2
公开(公告)日：2011-03-15
申请号：US11121096
申请日：2005-05-04
申请人： Akihisa Nakajima , Eiichi Ueda , Kusunoki Higashino , Yasuhiro Sando , Nobuhisa Ishida
发明人： Akihisa Nakajima , Eiichi Ueda , Kusunoki Higashino , Yasuhiro Sando , Nobuhisa Ishida
IPC分类号： C12M1/34
CPC分类号： B01L3/50273 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01F15/0201 , B01F15/024 , B01L3/502723 , B01L3/502738 , B01L2200/10 , B01L2200/16 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2400/0439 , B01L2400/0487 , B01L2400/0605 , B01L2400/0633 , B01L2400/0677
摘要： A micro-reactor for analyzing a sample, comprises (1) a plate-shaped chip; (2) a plurality of regent storage sections each having a chamber to store respective agents; (3) a regent mixing section to mix plural regents fed from the plurality of regent storage sections so as to produce a mixed reagent; (4) a sample receiving section having an injection port through which a sample is injected from outside; and (5) a reacting section to mix and react the mixed regent fed from the reagent mixing section and the sample fed from the sample receiving section. The plurality of regent storage sections, the regent mixing section, the sample receiving section and the reacting section are incorporated in the chip and are connected through flow paths, and the regent mixing section includes a feed-out preventing mechanism to prevent an initially-mixed regent from being fed out to the reacting section.
摘要翻译：用于分析样品的微反应器包括（1）板状芯片; （2）多个存储部分，每个存储部分具有用于存储相应代理的室; （3）注射混合部，混合从多个摄取储存部供给的多个药剂，以制备混合试剂; （4）具有从外部注入样品的注入口的样本接收部分; 和（5）反应部分，用于混合并反应从试剂混合部分供给的混合注射器和从样品接收部分供给的样品。多个摄取储存部分，摄取混合部分，样品接收部分和反应部分结合在芯片中并通过流动路径连接，并且摄像机混合部分包括防止初始混合的送出机构摄政从被送到反应部分。

2. 发明申请

US20060088451A1 Micro-reactor for biological substance inspection and biological substance inspection device 有权
标题翻译：生物物质检验微生物检测装置及生物物质检测装置
公开(公告)号：US20060088451A1
公开(公告)日：2006-04-27
申请号：US11254210
申请日：2005-10-19
申请人： Akihisa Nakajima , Eiichi Ueda , Kusunoki Higashino , Yasuhiro Sando , Nobuhisa Ishida
发明人： Akihisa Nakajima , Eiichi Ueda , Kusunoki Higashino , Yasuhiro Sando , Nobuhisa Ishida
IPC分类号： B01J19/00
CPC分类号： B01L3/50273 , B01L2200/04 , B01L2200/10 , B01L2200/16 , B01L2300/0654 , B01L2300/0816 , B01L2300/0864 , B01L2300/087 , B01L2400/0439 , B01L2400/0655 , B01L2400/086 , Y10T436/25 , Y10T436/2575
摘要： The object of the present invention is to provide a micro-reactor, equipped with a high-precision liquid feed system of simple structure, capable of high-precision analysis of at least one item. The present invention provides a micro-reactor for biological substance inspection including a sample storage section, a reagent storage section, a sample pre-processing section, a micro-pump connecting section and a branched minute flow path. And a sample pre-processed by the sample pre-processing section is fed into the minute flow path branched off into at least two parts by a micro-pump and a liquid dividing section, and on the downstream side of each of the branched minute flow paths, the sample is fed to a flow path constituting a reaction site, and then to a flow path constituting the detection site, thereby providing simultaneous measurement of a plurality of items of a sample.
摘要翻译：本发明的目的是提供一种微型反应器，其具有结构简单的高精度液体供给系统，能够对至少一个物品进行高精度分析。本发明提供了一种用于生物物质检查的微反应器，包括样品存储部分，试剂储存部分，样品预处理部分，微泵连接部分和分支的微小流路。并且由样品预处理部分预处理的样品通过微型泵和分液部分被分配到至少两部分的微小流路中，并且在每个分支微流量的下游侧将样品送入构成反应部位的流路，然后送入构成检测部位的流路，从而同时测量多个样品。

3. 发明授权

US07666538B2 Fuel cell device 失效
标题翻译：燃料电池装置
公开(公告)号：US07666538B2
公开(公告)日：2010-02-23
申请号：US11005747
申请日：2004-12-07
申请人： Nobuhisa Ishida , Yasuhiro Sando , Kusunoki Higashino
发明人： Nobuhisa Ishida , Yasuhiro Sando , Kusunoki Higashino
IPC分类号： H01M2/00
CPC分类号： H01M8/1009 , H01M8/04156 , H01M8/04194 , H01M8/04291 , H01M8/1011 , Y02E60/523
摘要： A fuel cell device has a small and compact structure as a whole. The fuel cell device employs a fuel cell (e.g., direct methanol fuel cell of an MEA structure) using liquid fuel. Diluted liquid fuel is prepared by diluting the liquid fuel (methanol-contained liquid in the case of DMFC) with dilution liquid, and is supplied to the fuel cell. A first pump unit stacked on the fuel cell supplies the diluted liquid fuel to the fuel cell while diluting the liquid fuel by mixing the liquid fuel and the dilution liquid together. A second pump unit stacked on the fuel cell collects liquid (water usable as dilution liquid in DMFC) produced by an electrochemical reaction in the fuel cell.
摘要翻译：燃料电池装置整体上具有小而紧凑的结构。燃料电池装置采用液体燃料的燃料电池（例如MEA结构的直接甲醇燃料电池）。通过稀释液体燃料（在DMFC的情况下含有甲醇的液体）稀释液体来制备稀释的液体燃料，并将其供应到燃料电池。堆叠在燃料电池上的第一泵单元将稀释的液体燃料供应到燃料电池，同时通过将液体燃料和稀释液混合在一起来稀释液体燃料。堆叠在燃料电池上的第二泵单元收集通过燃料电池中的电化学反应产生的液体（可用作DMFC中的稀释液体的水）。

4. 发明申请

US20060088929A1 Micro-reactor for gene inspection 审中-公开
标题翻译：用于基因检查的微反应器
公开(公告)号：US20060088929A1
公开(公告)日：2006-04-27
申请号：US11253417
申请日：2005-10-19
申请人： Akihisa Nakajima , Eiichi Ueda , Kusunoki Higashino , Yasuhiro Sando , Nobuhisa Ishida
发明人： Akihisa Nakajima , Eiichi Ueda , Kusunoki Higashino , Yasuhiro Sando , Nobuhisa Ishida
IPC分类号： C12M1/34
CPC分类号： B01L3/50273 , B01L3/502753 , B01L2200/027 , B01L2200/10 , B01L2200/16 , B01L2300/0816 , B01L2300/087 , B01L2400/0439 , B01L2400/0605 , F04B43/046 , G01N35/1095 , G01N2035/1034
摘要： The invention provides gene-inspecting micro-reactor for detecting a bacterial cell wherein flexibility and high sensitivity are secured, low cost by a disposable type is realized, highly accurate detection is possible in a simple structure, and preliminary processing suitable for amplification reaction can be done for specimen efficiently and rapidly. After lysing a bacterial cell in the specimen by bacteriolysis reagent stored in bacteriolysis reagent storage section 3, and after adsorbing bacterial genes on carriers filled in carrier filling section 4, there is conducted preliminary processing for washing and detecting bacterial genes. Further, there are provided a control means that switches the direction of liquid-feeding for a liquid containing bacterial genes fed to carrier filling section 4, a check valve, amplified reagent storage section 7 and a cooling means such as Pertier element that cools reagent mixing section.
摘要翻译：本发明提供用于检测细菌细胞的基因检测微反应器，其中确保了灵活性和高灵敏度，实现了一次性型的低成本，在简单的结构中可以进行高精度的检测，并且适用于扩增反应的预处理可以是为样品高效快速地完成。在溶菌试剂储存部3中储存的溶菌试剂溶解试样中的细菌细胞后，在载体填充部4的载体上吸附细菌基因后，进行洗涤和检测细菌基因的初步处理。此外，提供了一种控制装置，其切换供给载体填充部分4的细菌基因的液体的供液方向，止回阀，扩增试剂储存部分7和冷却试剂混合物的Pertier元件的冷却装置部分。

5. 发明申请

US20050272144A1 Micro-reactor for improving efficiency of liquid mixing and reaction 审中-公开
标题翻译：用于提高液体混合和反应效率的微反应器
公开(公告)号：US20050272144A1
公开(公告)日：2005-12-08
申请号：US11142986
申请日：2005-06-02
申请人： Yasuhiro Sando , Eiichi Ueda , Akihisa Nakajima , Kusunoki Higashino , Nobuhisa Ishida
发明人： Yasuhiro Sando , Eiichi Ueda , Akihisa Nakajima , Kusunoki Higashino , Nobuhisa Ishida
IPC分类号： B01F5/04 , B01F5/06 , B01F5/10 , B01F11/00 , B01F13/00 , B01F15/02 , B01L3/00 , C12M1/00 , C12M1/34 , F04B43/04
CPC分类号： B01L3/50273 , B01F5/0475 , B01F5/0478 , B01F5/0646 , B01F5/0647 , B01F5/102 , B01F11/0071 , B01F13/0059 , B01F15/0203 , B01F15/024 , B01J19/0093 , B01J2219/00862 , B01J2219/00889 , B01J2219/00891 , B01L3/502738 , B01L3/502746 , B01L2300/0816 , B01L2300/0861 , B01L2300/0867 , B01L2400/0439 , B01L2400/0633 , B01L2400/0638 , F04B43/046
摘要： A micro-reactor is provided with a flow jointing section to joint flows of at least two kinds of liquids including a reacting reagent by feeding the two kinds of liquids with a micro pump; a mixing flow path connected to a downstream end of the flow jointing section so as to diffuse and mix the liquids; and a reaction advancing section to advance the reaction among the mixed liquids.
摘要翻译：微反应器具有流动接合部分，通过用微型泵将两种液体供给至少两种包括反应试剂的液体的流动; 混合流路连接到流动接合部分的下游端，以便使液体扩散和混合; 以及促进混合液体中的反应的反应进行部。

6. 发明授权

US07374332B2 Method, device and system for mixing liquids 失效
标题翻译：混合液体的方法，装置和系统
公开(公告)号：US07374332B2
公开(公告)日：2008-05-20
申请号：US10970324
申请日：2004-10-21
申请人： Kusunoki Higashino , Yasuhiro Sando , Nobuhisa Ishida
发明人： Kusunoki Higashino , Yasuhiro Sando , Nobuhisa Ishida
IPC分类号： B01F3/08
CPC分类号： B01F13/0062 , B01F13/0071 , Y10T137/87571
摘要： A method and a device are provided which can mix two liquids faster at a precise mixing ratio. The method for mixing at least two liquids transported in respective channels includes transporting, of the two liquids, a liquid having a low mixing rate intermittently in one of the channels, and transporting, of the two liquids, a liquid having a high mixing rate so as to join the liquid having a low mixing rate from both sides of the channel for the liquid having a low mixing rate.
摘要翻译：提供了一种可以以精确混合比较快地混合两种液体的方法和装置。用于混合在各个通道中输送的至少两种液体的方法包括在一个通道中间歇地输送两种液体中具有低混合速率的液体，并且输送具有高混合速率的液体的两种液体为了将具有低混合速率的液体的通道两侧的低混合速率的液体加入。

7. 发明申请

US20060094004A1 Micro-reactor, biological material inspection device, and microanalysis system 审中-公开
标题翻译：微反应器，生物材料检测装置和微量分析系统
公开(公告)号：US20060094004A1
公开(公告)日：2006-05-04
申请号：US11255664
申请日：2005-10-21
申请人： Akihisa Nakajima , Eiichi Ueda , Kusunoki Higashino , Yasuhiro Sando , Nobuhisa Ishida , Youichi Aoki
发明人： Akihisa Nakajima , Eiichi Ueda , Kusunoki Higashino , Yasuhiro Sando , Nobuhisa Ishida , Youichi Aoki
IPC分类号： C12Q1/70
CPC分类号： B01L3/502738 , B01F5/0647 , B01F13/0059 , B01L3/50273 , B01L3/502761 , B01L7/52 , B01L2200/04 , B01L2200/10 , B01L2200/141 , B01L2300/0654 , B01L2300/0864 , B01L2300/0867 , B01L2300/0883 , B01L2300/0887 , B01L2300/12 , B01L2300/161 , B01L2300/1861 , B01L2400/0415 , B01L2400/0487 , B01L2400/0616 , B01L2400/0638 , B01L2400/0655 , B01L2400/082
摘要： A micro reactor for inspecting a biological material, comprising: a first substrate on which a minute flow path is formed; a second substrate laminated on the first substrate so as to cover the minute flow path; a detection section provided on the minute flow path formed between the first and second substrates so as to inspect a liquid mixture of a sample and a reagent; (4) an opening section formed at a region on the second substrate corresponding to the detection section so as to irradiate inspection light to the liquid mixture arriving the detection; and (5) a transparent member to cover the opening section.
摘要翻译：一种用于检查生物材料的微反应器，包括：形成有微小流路的第一基板; 层叠在所述第一基板上以覆盖所述微小流路的第二基板; 检测部，设置在形成在第一和第二基板之间的微小流路上，以检查样品和试剂的液体混合物; （4）形成在与所述检测部对应的所述第二基板上的区域的开口部，以将检查光照射到到达所述检测的所述液体混合物; 和（5）透明构件以覆盖开口部分。

8. 发明申请

US20050250200A1 Testing microreactor, testing device and testing method 有权
标题翻译：检测微反应器，检测装置及检测方法
公开(公告)号：US20050250200A1
公开(公告)日：2005-11-10
申请号：US11121096
申请日：2005-05-04
申请人： Akihisa Nakajima , Eiichi Ueda , Kusunoki Higashino , Yasuhiro Sando , Nobuhisa Ishida
发明人： Akihisa Nakajima , Eiichi Ueda , Kusunoki Higashino , Yasuhiro Sando , Nobuhisa Ishida
IPC分类号： B01F5/06 , B01F13/00 , B01F15/02 , B01L3/00 , C12M1/00 , C12M1/34 , C12N15/09 , C12Q1/68 , G01N33/53 , G01N37/00
CPC分类号： B01L3/50273 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01F15/0201 , B01F15/024 , B01L3/502723 , B01L3/502738 , B01L2200/10 , B01L2200/16 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2400/0439 , B01L2400/0487 , B01L2400/0605 , B01L2400/0633 , B01L2400/0677
摘要： A micro-reactor for analyzing a sample, comprises (1) a plate-shaped chip; (2) a plurality of regent storage sections each having a chamber to store respective agents; (3) a regent mixing section to mix plural regents fed from the plurality of regent storage sections so as to produce a mixed reagent; (4) a sample receiving section having an injection port through which a sample is injected from outside; and (5) a reacting section to mix and react the mixed regent fed from the reagent mixing section and the sample fed from the sample receiving section. The plurality of regent storage sections, the regent mixing section, the sample receiving section and the reacting section are incorporated in the chip and are connected through flow paths, and the regent mixing section includes a feed-out preventing mechanism to prevent an initially-mixed regent from being fed out to the reacting section.
摘要翻译：用于分析样品的微反应器包括（1）板状芯片; （2）多个存储部分，每个存储部分具有用于存储相应代理的室; （3）注射混合部，混合从多个摄取储存部供给的多个药剂，以制备混合试剂; （4）具有从外部注入样品的注入口的样本接收部分; 和（5）反应部分，用于混合并反应从试剂混合部分供给的混合的试剂和从样品接收部分供给的样品。多个摄取储存部分，摄取混合部分，样品接收部分和反应部分结合在芯片中并且通过流动路径连接，并且注射混合部分包括防止初始混合的防止出料机构摄政从被送到反应部分。

9. 发明申请

US20050282054A1 Fuel cell device 失效
标题翻译：燃料电池装置
公开(公告)号：US20050282054A1
公开(公告)日：2005-12-22
申请号：US11005747
申请日：2004-12-07
申请人： Nobuhisa Ishida , Yasuhiro Sando , Kusunoki Higashino
发明人： Nobuhisa Ishida , Yasuhiro Sando , Kusunoki Higashino
IPC分类号： H01M8/04 , H01M8/10
CPC分类号： H01M8/1009 , H01M8/04156 , H01M8/04194 , H01M8/04291 , H01M8/1011 , Y02E60/523
摘要： A fuel cell device has a small and compact structure as a whole. The fuel cell device employs a fuel cell (e.g., direct methanol fuel cell of an MEA structure) using liquid fuel. Diluted liquid fuel is prepared by diluting the liquid fuel (methanol-contained liquid in the case of DMFC) with dilution liquid, and is supplied to the fuel cell. A first pump unit stacked on the fuel cell supplies the diluted liquid fuel to the fuel cell while diluting the liquid fuel by mixing the liquid fuel and the dilution liquid together. A second pump unit stacked on the fuel cell collects liquid (water usable as dilution liquid in DMFC) produced by an electrochemical reaction in the fuel cell.
摘要翻译：燃料电池装置整体上具有小而紧凑的结构。燃料电池装置采用液体燃料的燃料电池（例如MEA结构的直接甲醇燃料电池）。通过稀释液体燃料（在DMFC的情况下含有甲醇的液体）稀释液体来制备稀释的液体燃料，并将其供应到燃料电池。堆叠在燃料电池上的第一泵单元将稀释的液体燃料供应到燃料电池，同时通过将液体燃料和稀释液混合在一起来稀释液体燃料。堆叠在燃料电池上的第二泵单元收集通过燃料电池中的电化学反应产生的液体（可用作DMFC中的稀释液体的水）。

10. 发明申请

US20050092681A1 Method, device and system for mixing liquids 失效
标题翻译：混合液体的方法，装置和系统
公开(公告)号：US20050092681A1
公开(公告)日：2005-05-05
申请号：US10970324
申请日：2004-10-21
申请人： Kusunoki Higashino , Yasuhiro Sando , Nobuhisa Ishida
发明人： Kusunoki Higashino , Yasuhiro Sando , Nobuhisa Ishida
IPC分类号： G01N37/00 , B01F3/08 , B01F5/00 , B01F13/00 , B01F15/02 , B01D11/00
CPC分类号： B01F13/0062 , B01F13/0071 , Y10T137/87571
摘要： A method and a device are provided which can mix two liquids faster at a precise mixing ratio. The method for mixing at least two liquids transported in respective channels includes transporting, of the two liquids, a liquid having a low mixing rate intermittently in one of the channels, and transporting, of the two liquids, a liquid having a high mixing rate so as to join the liquid having a low mixing rate from both sides of the channel for the liquid having a low mixing rate.
摘要翻译：提供了一种可以以精确混合比较快地混合两种液体的方法和装置。用于混合在各个通道中输送的至少两种液体的方法包括在一个通道中间歇地输送两种液体中具有低混合速率的液体，并且输送具有高混合速率的液体的两种液体为了将具有低混合速率的液体的通道两侧的低混合速率的液体加入。

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