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1. 发明申请

US20100221816A1 REACTION KIT 失效
标题翻译：反应套
公开(公告)号：US20100221816A1
公开(公告)日：2010-09-02
申请号：US12279840
申请日：2007-02-14
申请人： Nobuhiro Hanafusa , Koretsugu Ogata , Koji Tanimizu , Tomoichi Takahashi , Atsushi Inami , Ryuh Konoshita , Masami Maekawa , Takanori Mochizuki
发明人： Nobuhiro Hanafusa , Koretsugu Ogata , Koji Tanimizu , Tomoichi Takahashi , Atsushi Inami , Ryuh Konoshita , Masami Maekawa , Takanori Mochizuki
IPC分类号： C12M1/34 , G01N35/10 , B01L3/00 , G01N1/28 , G01N27/447
CPC分类号： B01L3/5085 , B01L3/0217 , B01L2200/04 , B01L2200/141 , B01L2200/16 , B01L2300/043 , B01L2300/044 , B01L2300/047 , B01L2300/0681 , B01L2300/123
摘要： Disclosed is a reaction kit for preventing the entry of foreign matter into a reaction plate from the outside and the pollution of a surrounding environment. The reaction kit includes: a reaction plate (2) having, on the top surface side thereof, a reaction container (4) for carrying out the reaction of a sample and a reagent container (12) containing a reagent used for the reaction of a sample and sealed with a film (14); a dispensation tip (20) arranged on the top surface side of the reaction plate (2); a cover (24) covering a space above the top surface of the reaction plate (2) and movably supporting the dispensation tip (20) so that a distal end thereof is located inside the space covered with the cover (4) and a proximal end thereof is located outside the space; and a sample container (32) for introducing a sample into the space covered with the cover (24) from the outside through a sealable opening (31) provided in a part of the cover (24).
摘要翻译：公开了一种用于防止异物从外部进入反应板并引起周围环境污染的反应试剂盒。反应试剂盒包括：反应板（2），其顶表面上具有用于进行样品和含有用于反应的试剂的试剂容器（12）的反应的反应容器（4）用薄膜（14）取样并密封; 设置在所述反作用板（2）的上表面侧的分配头（20）; 覆盖反应板（2）的顶表面上方的空间并且可移动地支撑分配尖端（20）的盖（24），使得其远端位于用盖（4）覆盖的空间内部，并且近端位于空间外面; 以及用于通过设置在所述盖（24）的一部分中的可密封开口（31）将样品从外部引入到被所述盖（24）覆盖的空间中的样本容器（32）。

2. 发明申请

US20100213067A1 REACTION KIT TREATING EQUIPMENT 失效
标题翻译：反应套件处理设备
公开(公告)号：US20100213067A1
公开(公告)日：2010-08-26
申请号：US12279830
申请日：2007-02-14
申请人： Nobuhiro Hanafusa , Koretsugu Ogata , Koji Tanimizu , Tomoichi Takahashi
发明人： Nobuhiro Hanafusa , Koretsugu Ogata , Koji Tanimizu , Tomoichi Takahashi
IPC分类号： G01N27/26 , G01N30/00 , G01N21/64 , G01N21/00 , G01N27/00
CPC分类号： G01N35/02 , G01N33/54366
摘要： Upper space on the front surface side of a reaction plate, provided with at least a reaction container causing reaction in a sample and a reagent container containing a reagent used for reaction with the sample, is covered with an airtight cover. A dispensation tip (20) for transporting liquid on the reaction plate is arranged in such a way that the distal end side is located on the inside of the covered space and the proximal portion is located on the outside. In order to handle a reaction kit (80) supported movably in the perpendicular direction and in the in-plane direction with respect to the front surface of the reaction plate, a table (82) for attaching the reaction kit (80), a drive unit (36) engaging with the proximal end of the dispensation tip (20) and driving the movement and the dispensation operation of the tip (20), a detection unit (38) for optically detecting a reaction product by receiving light generated through interaction with the reaction product on the reaction plate or the light generated from the reaction product, and a control section for controlling at least the dispensation operation by the drive unit (36) and the detection operation by the detection unit (38) are provided.
摘要翻译：反应板的前表面上的至少一个反应容器在样品中产生反应的反应容器和含有用于与样品反应的试剂的试剂容器被覆盖有气密盖。用于在反应板上输送液体的分注尖端（20）以使得远端侧位于被覆盖空间的内侧并且近端部位于外侧的方式布置。为了处理相对于反应板的前表面在垂直方向和面内方向上可移动地支撑的反应组件（80），用于安装反应组件（80）的工作台（82），驱动装置单元（36）与分注尖端（20）的近端接合并驱动尖端（20）的移动和分配操作;检测单元（38），用于通过接收通过与提供反应板上的反应产物或由反应产物产生的光，以及用于通过驱动单元（36）至少控制分配操作和由检测单元（38）进行的检测操作的控制部分。

3. 发明授权

US08333930B2 Reaction kit treating equipment 失效
标题翻译：反应试剂盒处理设备
公开(公告)号：US08333930B2
公开(公告)日：2012-12-18
申请号：US12279830
申请日：2007-02-14
申请人： Nobuhiro Hanafusa , Koretsugu Ogata , Koji Tanimizu , Tomoichi Takahashi
发明人： Nobuhiro Hanafusa , Koretsugu Ogata , Koji Tanimizu , Tomoichi Takahashi
IPC分类号： B01J8/00
CPC分类号： G01N35/02 , G01N33/54366
摘要： Upper space on the front surface side of a reaction plate, provided with at least a reaction container causing reaction in a sample and a reagent container containing a reagent used for reaction with the sample, is covered with an airtight cover. A dispensation tip (20) for transporting liquid on the reaction plate is arranged in such a way that the distal end side is located on the inside of the covered space and the proximal portion is located on the outside. In order to handle a reaction kit (80) supported movably in the perpendicular direction and in the in-plane direction with respect to the front surface of the reaction plate, a table (82) for attaching the reaction kit (80), a drive unit (36) engaging with the proximal end of the dispensation tip (20) and driving the movement and the dispensation operation of the tip (20), a detection unit (38) for optically detecting a reaction product by receiving light generated through interaction with the reaction product on the reaction plate or the light generated from the reaction product, and a control section for controlling at least the dispensation operation by the drive unit (36) and the detection operation by the detection unit (38) are provided.
摘要翻译：反应板的前表面上的至少一个反应容器在样品中产生反应的反应容器和含有用于与样品反应的试剂的试剂容器被覆盖有气密盖。用于在反应板上输送液体的分注尖端（20）以使得远端侧位于被覆盖空间的内侧并且近端部位于外侧的方式布置。为了处理相对于反应板的前表面在垂直方向和面内方向上可移动地支撑的反应组件（80），用于安装反应组件（80）的工作台（82），驱动装置单元（36）与分注尖端（20）的近端接合并驱动尖端（20）的移动和分配操作;检测单元（38），用于通过接收通过与提供反应板上的反应产物或由反应产物产生的光，以及用于通过驱动单元（36）至少控制分配操作和由检测单元（38）进行的检测操作的控制部分。

4. 发明授权

US08257966B2 Reaction kit 失效
标题翻译：反应试剂盒
公开(公告)号：US08257966B2
公开(公告)日：2012-09-04
申请号：US12279840
申请日：2007-02-14
申请人： Nobuhiro Hanafusa , Koretsugu Ogata , Koji Tanimizu , Tomoichi Takahashi , Atsushi Inami , Ryuh Konoshita , Masami Maekawa , Takanori Mochizuki
发明人： Nobuhiro Hanafusa , Koretsugu Ogata , Koji Tanimizu , Tomoichi Takahashi , Atsushi Inami , Ryuh Konoshita , Masami Maekawa , Takanori Mochizuki
IPC分类号： C12M1/34 , B01L3/00 , G01N35/10 , G01N1/28 , G01N27/447
CPC分类号： B01L3/5085 , B01L3/0217 , B01L2200/04 , B01L2200/141 , B01L2200/16 , B01L2300/043 , B01L2300/044 , B01L2300/047 , B01L2300/0681 , B01L2300/123
摘要： Disclosed is a reaction kit for preventing the entry of foreign matter into a reaction plate from the outside and the pollution of a surrounding environment. The reaction kit includes: a reaction plate (2) having, on the top surface side thereof, a reaction container (4) for carrying out the reaction of a sample and a reagent container (12) containing a reagent used for the reaction of a sample and sealed with a film (14); a dispensation tip (20) arranged on the top surface side of the reaction plate (2); a cover (24) covering a space above the top surface of the reaction plate (2) and movably supporting the dispensation tip (20) so that a distal end thereof is located inside the space covered with the cover (4) and a proximal end thereof is located outside the space; and a sample container (32) for introducing a sample into the space covered with the cover (24) from the outside through a sealable opening (31) provided in a part of the cover (24).
摘要翻译：公开了一种用于防止异物从外部进入反应板并引起周围环境污染的反应试剂盒。反应试剂盒包括：反应板（2），其顶表面上具有用于进行样品和含有用于反应的试剂的试剂容器（12）的反应的反应容器（4）用薄膜（14）取样并密封; 设置在所述反作用板（2）的上表面侧的分配头（20）; 覆盖反应板（2）的顶表面上方的空间并且可移动地支撑分配尖端（20）的盖（24），使得其远端位于用盖（4）覆盖的空间内部，并且近端位于空间外面; 以及用于通过设置在所述盖（24）的一部分中的可密封开口（31）将样品从外部引入到被所述盖（24）覆盖的空间中的样本容器（32）。

5. 发明申请

US20100196209A1 Method of Dispensing in Reaction Vessel and Reaction Vessel Processing Apparatus 审中-公开
标题翻译：反应容器和反应容器加工装置中的分配方法
公开(公告)号：US20100196209A1
公开(公告)日：2010-08-05
申请号：US11887507
申请日：2006-03-30
申请人： Nobuhiro Hanafusa , Koretsugu Ogata , Ryuh Konoshita , Yusuke Nakamura , Yozo Ohnishi
发明人： Nobuhiro Hanafusa , Koretsugu Ogata , Ryuh Konoshita , Yusuke Nakamura , Yozo Ohnishi
IPC分类号： G01N35/10
CPC分类号： B01L3/0262 , B01L2400/022 , B01L2400/024 , G01N35/1016 , G01N35/1095
摘要： It is intended to facilitate dispensing of a minute amount of a nonvolatile liquid. In a preferred embodiment, in dispensing of mineral oil (40) onto a reaction solution (170) that is previously dispensed to a probe arrangement part (18), a liquid droplet (40a) of the mineral oil (40) is formed on a tip end of a tip (70) of the nozzle, and the liquid droplet (40a) is transferred into the reaction well while it is in contact with the inner wall face of the reaction well or the surface of the reaction solution (170) previously dispensed to the reaction well.
摘要翻译：旨在便于分配微量的非挥发性液体。在优选的实施方案中，在将矿物油（40）分配到预先分配到探针装置部分（18）的反应溶液（170）上时，矿物油（40）的液滴（40a）形成在喷嘴的尖端（70）的尖端，并且液滴（40a）在与反应井的内壁面或反应溶液（170）的表面接触的同时被转移到反应槽中分配到反应良好。

6. 发明授权

US08293521B2 Method of dispensing nonvolatile liquid in reaction vessel and reaction vessel processing apparatus 失效
标题翻译：在反应容器和反应容器处理装置中分配非挥发性液体的方法
公开(公告)号：US08293521B2
公开(公告)日：2012-10-23
申请号：US11887357
申请日：2006-03-30
申请人： Nobuhiro Hanafusa , Koretsugu Ogata , Ryuh Konoshita , Yusuke Nakamura , Yozo Ohnishi
发明人： Nobuhiro Hanafusa , Koretsugu Ogata , Ryuh Konoshita , Yusuke Nakamura , Yozo Ohnishi
IPC分类号： C12M1/36 , C12M1/38 , C12M3/00
CPC分类号： B01L3/0268 , B01J2219/00317 , B01J2219/0036 , B01J2219/00364 , B01J2219/00702 , B01L3/502715 , B01L2200/0642 , B01L2200/0684 , B01L2200/142 , B01L2200/16 , B01L2300/044 , B01L2300/0636 , B01L2300/0825 , G01N35/1016 , G01N35/1095
摘要： It is intended to easily dispense a minute amount of nonvolatile liquid. In a preferred embodiment, in dispensing of mineral oil (nonvolatile liquid), dispensing is conducted in the condition that the amount of air contained in a tip (70) is small by aspirating a larger amount of mineral oil (40) than a single dispensing amount in the tip (70) of a nozzle (28).
摘要翻译：旨在容易地分配少量的非挥发性液体。在优选的实施方案中，在分配矿物油（非挥发性液体）时，分配是在吸收比单一分配物更多的矿物油（40）的情况下，包含在尖端（70）中的空气量较小在喷嘴（28）的尖端（70）中的量。

7. 发明申请

US20100221704A1 Method of Dispensing Nonvolatile Liquid in Reaction Vessel and Reaction Vessel Processing Apparatus 失效
标题翻译：在反应容器和反应容器加工装置中分配非挥发性液体的方法
公开(公告)号：US20100221704A1
公开(公告)日：2010-09-02
申请号：US11887357
申请日：2006-03-30
申请人： Nobuhiro Hanafusa , Koretsugu Ogata , Ryuh Konoshita , Yusuke Nakamura , Yozo Ohnishi
发明人： Nobuhiro Hanafusa , Koretsugu Ogata , Ryuh Konoshita , Yusuke Nakamura , Yozo Ohnishi
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： B01L3/0268 , B01J2219/00317 , B01J2219/0036 , B01J2219/00364 , B01J2219/00702 , B01L3/502715 , B01L2200/0642 , B01L2200/0684 , B01L2200/142 , B01L2200/16 , B01L2300/044 , B01L2300/0636 , B01L2300/0825 , G01N35/1016 , G01N35/1095
摘要： It is intended to easily dispense a minute amount of nonvolatile liquid. In a preferred embodiment, in dispensing of mineral oil (nonvolatile liquid), dispensing is conducted in the condition that the amount of air contained in a tip (70) is small by aspirating a larger amount of mineral oil (40) than a single dispensing amount in the tip (70) of a nozzle (28).
摘要翻译：旨在容易地分配少量的非挥发性液体。在优选的实施方案中，在分配矿物油（非挥发性液体）时，分配是在吸收比单一分配物更多的矿物油（40）的情况下，包含在尖端（70）中的空气量较小在喷嘴（28）的尖端（70）中的量。

8. 发明申请

US20090011947A1 Detection Chip and Method for Detecting Substance Using Same 审中-公开
标题翻译：检测芯片及其检测方法
公开(公告)号：US20090011947A1
公开(公告)日：2009-01-08
申请号：US11886458
申请日：2006-03-17
申请人： Tomoyuki Ozawa , Hiroyuki Kuroki , Nobuhiro Hanafusa , Koretsugu Ogata
发明人： Tomoyuki Ozawa , Hiroyuki Kuroki , Nobuhiro Hanafusa , Koretsugu Ogata
IPC分类号： C40B30/04 , C40B60/12
CPC分类号： B01L3/5085 , B01L2200/0684 , B01L2300/0819 , B01L2300/0858 , G01N21/03 , G01N21/253 , G01N21/6428 , G01N21/6452 , G01N2021/0325 , G01N2021/0357 , G01N2021/0382
摘要： A detection chip comprises a substrate and a well-shaped reaction portion formed in the substrate, in which the well-shaped reaction portion comprises a bottom portion having a planar shape and a side portion the width between which is widen from the bottom portion toward an opening portion.
摘要翻译：检测芯片包括基板和形成在基板中的良好形状的反应部分，其中，良好形状的反应部分包括具有平面形状的底部部分和侧部分，其宽度从底部部分朝向开口部分。

9. 发明申请

US20110003286A1 REACTOR PLATE AND REACTION PROCESSING METHOD 有权
标题翻译：反应板和反应处理方法
公开(公告)号：US20110003286A1
公开(公告)日：2011-01-06
申请号：US12525947
申请日：2007-11-19
申请人： Nobuhiro Hanafusa , Koretsugu Ogata , Takahiro Nishimoto , Masaki Kanai
发明人： Nobuhiro Hanafusa , Koretsugu Ogata , Takahiro Nishimoto , Masaki Kanai
IPC分类号： C12Q1/68 , C12M1/00 , C12M1/34
CPC分类号： B01L3/502723 , B01L3/5025 , B01L3/502738 , B01L3/50853 , B01L2200/0684 , B01L2200/141 , B01L2300/046 , B01L2300/0816 , B01L2300/0829 , B01L2300/0864 , B01L2400/0622 , B01L2400/0644 , G01N35/1097
摘要： Disclosed herein is a reactor plate which prevents the entry of foreign matter from the outside and the pollution of a surrounding environment. A reactor plate (1) includes a reaction well (5), a reaction well channel connected to the reaction well (5), and reaction well air vent channels (19) and (21) connected to the reaction well (5). The reaction well channel has a main channel (13), a metering channel (15) branched off the main channel (13), and an injection channel (17) of which one end is connected to the metering channel (15) and the other end is connected to the reaction well (5). The main channel (13) and the reaction well air vent channel (21) can be hermetically sealed. The injection channel (17) is formed narrower than the metering channel (15) not so as to allow the passage of a liquid at a liquid introduction pressure applied to introduce the liquid into the main channel (13) and the metering channel (15) and at a purge pressure applied to purge the liquid from the main channel (13) but so as to allow the passage of the liquid at a pressure higher than the liquid introduction pressure and the purge pressure.
摘要翻译：本文公开了一种反应器板，其防止异物从外部进入并且污染周围环境。反应器板（1）包括反应井（5），连接到反应井（5）的反应井通道和连接到反应井（5）的反应井排气通道（19）和（21）。反应井通道具有主通道（13），从主通道（13）分支的计量通道（15）和注入通道（17），其一端连接到计量通道（15），另一端连接到计量通道末端连接到反应槽（5）。主通道（13）和反应孔排气通道（21）可以密封。注射通道（17）形成得比计量通道（15）窄，使得能够以施加液体引入压力的液体通过以将液体引入主通道（13）和计量通道（15）并且施加吹扫压力以从主通道（13）吹扫液体，但是允许液体在比液体引入压力和吹扫压力高的压力下通过。

10. 发明授权

US09550184B2 Reactor plate and reaction processing method 有权
标题翻译：反应板和反应处理方法
公开(公告)号：US09550184B2
公开(公告)日：2017-01-24
申请号：US12525947
申请日：2007-11-19
申请人： Nobuhiro Hanafusa , Koretsugu Ogata , Takahiro Nishimoto , Masaki Kanai
发明人： Nobuhiro Hanafusa , Koretsugu Ogata , Takahiro Nishimoto , Masaki Kanai
IPC分类号： C12M1/00 , B01L3/00 , G01N35/10
CPC分类号： B01L3/502723 , B01L3/5025 , B01L3/502738 , B01L3/50853 , B01L2200/0684 , B01L2200/141 , B01L2300/046 , B01L2300/0816 , B01L2300/0829 , B01L2300/0864 , B01L2400/0622 , B01L2400/0644 , G01N35/1097
摘要： Disclosed herein is a reactor plate which prevents the entry of foreign matter from the outside and the pollution of a surrounding environment. A reactor plate (1) includes a reaction well (5), a reaction well channel connected to the reaction well (5), and reaction well air vent channels (19) and (21) connected to the reaction well (5). The reaction well channel has a main channel (13), a metering channel (15) branched off the main channel (13), and an injection channel (17) of which one end is connected to the metering channel (15) and the other end is connected to the reaction well (5). The main channel (13) and the reaction well air vent channel (21) can be hermetically sealed. The injection channel (17) is formed narrower than the metering channel (15) not so as to allow the passage of a liquid at a liquid introduction pressure applied to introduce the liquid into the main channel (13) and the metering channel (15) and at a purge pressure applied to purge the liquid from the main channel (13) but so as to allow the passage of the liquid at a pressure higher than the liquid introduction pressure and the purge pressure.
摘要翻译：本文公开了一种反应器板，其防止异物从外部进入并且污染周围环境。反应器板（1）包括反应井（5），连接到反应井（5）的反应井通道和连接到反应井（5）的反应井排气通道（19）和（21）。反应井通道具有主通道（13），从主通道（13）分支的计量通道（15）和注入通道（17），其一端连接到计量通道（15），另一端连接到计量通道末端连接到反应槽（5）。主通道（13）和反应孔排气通道（21）可以密封。注射通道（17）形成得比计量通道（15）窄，使得能够以施加液体引入压力的液体通过以将液体引入主通道（13）和计量通道（15）并且施加吹扫压力以从主通道（13）吹扫液体，但是允许液体在比液体引入压力和吹扫压力高的压力下通过。

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