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    • 4. 发明申请
    • INTRA BODY CAPSULE MOTION SENSING AND POSITION DETERMINATION SYSTEMS AND METHODS
    • 内部身体运动感觉和位置确定系统和方法
    • US20140031642A1
    • 2014-01-30
    • US13882503
    • 2011-10-31
    • Yoav KimchyAnton PlotkinRonen LifshitzOleg Obodovsky
    • Yoav KimchyAnton PlotkinRonen LifshitzOleg Obodovsky
    • A61B6/12
    • A61B6/12A61B5/061A61B5/062A61B5/067A61B5/073A61B5/6882A61B5/7207A61B6/06A61B6/107A61B6/4057A61B6/4258A61B6/481A61B6/483A61B6/50A61B6/547A61B6/56
    • A system for detecting clinically-relevant features of a gastrointestinal (GI) tract of a subject. The system comprises an external magnetic field generator adapted to be affixed to a patient for generating at predetermined time intervals a magnetic field with respect to the subject. The magnetic field has a predetermined polarity and flux density, thereby establishing a patient coordinate system based upon the magnetic field. The system includes a capsule adapted to be swallowed by a subject. The system further includes at least one radiation source emitting X-ray or gamma radiation and at least one radiation detector. The radiation detector is configured to detect in a first energy window collimated X-ray fluorescence radiation from the X-ray contrast agent composition excited by the emitted radiation, and to detect a second energy window Compton-backscattered radiation from the X-ray contrast agent and the wall of the GI tract produced in response to the emitted radiation. The system includes a magnetic field detector configured to generate a first output responsive to a detected polarity and detected levels of flux density during exposure to the externally generated magnetic field. A processor generates a second output based upon relative changes in the first output, the first output varying as a function of relative changes in physical location or angular orientation of the capsule associated with movement of the capsule within the GI tract. A control unit configured to selectively enable or disable X-ray or gamma ray emissions from the capsule produced by the at least one radiation source based upon the second output, such that the GI tract is selectively irradiated upon detected movement of the capsule.
    • 用于检测受试者的胃肠(GI)道的临床相关特征的系统。 该系统包括适于固定在患者身上的外部磁场发生器,用于以预定的时间间隔产生相对于被摄体的磁场。 磁场具有预定的极性和通量密度,从而基于磁场建立患者坐标系。 该系统包括适于被受试者吞咽的胶囊。 该系统还包括发射X射线或γ射线的至少一个辐射源和至少一个辐射探测器。 辐射检测器被配置为在第一能量窗口中检测来自由所发射的辐射激发的X射线造影剂组合物的准直X射线荧光辐射,并且检测来自X射线造影剂的第二能量窗康普顿背散射辐射 以及响应于所发射的辐射产生的胃肠道的壁。 该系统包括磁场检测器,其被配置为响应于检测到的极性而产生第一输出,并且在暴露于外部产生的磁场期间检测到磁通密度的水平。 处理器基于第一输出中的相对变化产生第二输出,第一输出作为与胶囊在GI道内的运动相关联的胶囊的物理位置或角度定向的相对变化的函数而变化。 控制单元,被配置为基于所述第二输出,选择性地启用或禁用由所述至少一个辐射源产生的所述胶囊的X射线或γ射线发射,使得根据检测到的所述胶囊的运动选择性地照射所述GI道。