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1. 发明专利

JP2014139178A Imaging agent for fibrosing diseases 审中-公开
标题翻译：成像剂治疗疾病
公开(公告)号：JP2014139178A
公开(公告)日：2014-07-31
申请号：JP2014019966
申请日：2014-02-05
申请人： Nitto Denko Corp , 日東電工株式会社
发明人： NIITSU YOJIRO , YU LEI , ZHAO GANG , SANG VAN , WANG XINGHE , LIU JIAN , SANJIB KUMAR DAS , TANAKA YASUYUKI , KAJIWARA KEIKO , TAKAHASHI HIROICHI , MIYAZAKI MIYONO
IPC分类号： A61K49/00 , A61B5/055 , G01N33/48 , G01R33/28 , G01R33/32 , G01R33/48
CPC分类号： A61K49/085 , A61K49/0002 , A61K49/0041 , A61K49/0052 , A61K49/0054 , A61K49/128 , A61K51/065 , C08G69/10 , C08G69/48
摘要： PROBLEM TO BE SOLVED: To provide an agent and a method for imaging a cell and/or a part of tissue characterized by fibrosing, as well as an agent and a method for determining and/or diagnosing fibrosing diseases.SOLUTION: There is provided a polymer conjugate which can comprise a detectable label, a retinoid, and a polymer. The polymer conjugate can be used to image a part of tissue, deliver a detectable label to the part of tissue or a cell and/or diagnose a condition or a disease.
摘要翻译：要解决的问题：提供用于对特征为纤维化的细胞和/或部分组织成像的药剂和方法，以及用于确定和/或诊断纤维化疾病的药剂和方法。解决方案：提供一种聚合物缀合物，其可以包含可检测标记，类视黄醇和聚合物。聚合物缀合物可用于对组织的一部分进行成像，将可检测标记递送至组织或细胞的一部分和/或诊断疾病或疾病。

2. 发明专利

JP2002372537A Immuno-chromatograph test piece and detection method of test substance 审中-公开
标题翻译：免疫色谱试验片和检测物质检测方法
公开(公告)号：JP2002372537A
公开(公告)日：2002-12-26
申请号：JP2001181177
申请日：2001-06-15
申请人： Nitto Denko Corp , 日東電工株式会社
发明人： TANAKA YASUYUKI , MARUYAMA KOJI , SENDA SHUJI
IPC分类号： G01N33/543 , G01N33/569
摘要： PROBLEM TO BE SOLVED: To provide a test piece capable of preventing a substance blocking development of test substance or the like included in a test sample from being deposited on a water-absorbing base material, and detecting safely the test substance, and a detection method of the test substance using the test piece, concerning inspection by an immuno-chromatograph method.
SOLUTION: In this immuno-chromatograph test piece formed by arranging a test sample acceptance part on the water-absorbing base material, a dropping pad for dropping the test sample and a filter are laminated and disposed on the water-absorbing base material. This detection method of the test substance is characterized by performing immuno-chromatography by using the immuno- chromatograph test piece.
COPYRIGHT: (C)2003,JPO
摘要翻译：要解决的问题：提供一种能够防止测试样品中包含的测试物质等的物质阻塞发展的试片沉积在吸水性基材上，并且安全地检测被检物质和检测方法的试验物质，通过免疫色谱法进行检查。解决方案：在通过在吸水性基材上配置试验样品接收部而形成的免疫色谱试验片中，将吸收了试样的滴液滴和过滤器层叠并配置在吸水性基材上。该检测物质的检测方法的特征在于，使用免疫色谱试验片进行免疫色谱法。

3. 发明专利

JP2012020995A Agent for treating renal fibrosis 审中-公开
标题翻译：治疗肾脏纤维化的药剂
公开(公告)号：JP2012020995A
公开(公告)日：2012-02-02
申请号：JP2011134708
申请日：2011-06-17
申请人： Nitto Denko Corp , 日東電工株式会社
发明人： NIITSU YOJIRO , KAJIWARA KEIKO , TANAKA YASUYUKI , MIYAZAKI MIYONO
IPC分类号： A61K47/10 , A61K9/127 , A61K31/7088 , A61K45/00 , A61K47/24 , A61K48/00 , A61P13/12 , A61P43/00
CPC分类号： C12N15/113 , A61K9/127 , A61K31/07 , A61K31/7088 , A61K31/713 , A61K47/10 , A61K47/542 , A61K47/6911 , A61K47/6919 , A61K47/6921 , C12N15/111 , C12N2310/14 , C12N2320/32
摘要： PROBLEM TO BE SOLVED: To provide an agent for treating renal fibrosis.SOLUTION: The invention relates to a carrier for delivering a substance to extracellular matrix-producing cells in the kidney, the carrier containing a retinoid as the targeting agent; and the agent for treating renal fibrosis using the carrier.
摘要翻译：待解决的问题：提供治疗肾纤维化的药剂。解决方案：本发明涉及一种用于将物质递送到肾脏中的细胞外基质产生细胞的载体，所述载体含有类视黄醇作为靶向剂; 和使用载体治疗肾纤维化的药剂。版权所有（C）2012，JPO＆INPIT

4. 发明专利

JP2004187534A Method for evaluating physiological activity of microorganism or cell and kit therefor 审中-公开
公开(公告)号：JP2004187534A
公开(公告)日：2004-07-08
申请号：JP2002357288
申请日：2002-12-09
申请人： Nitto Denko Corp , 日東電工株式会社
发明人： TANAKA YASUYUKI , MARUYAMA KOJI , SAIGA TAKESHI
IPC分类号： G01N33/48 , C12Q1/02
摘要： PROBLEM TO BE SOLVED: To provide a method for evaluating the physiological activity of a microorganism or a cell, by which the microorganism, and the like, are monitored in real time and the physiological states of the microorganism and the cell, especially the life and death of the cell is accurately discriminated.
SOLUTION: The method for evaluating the physiological activity of the microorganism or the cell comprises a process for collecting the microorganism or the cell by adhesion or transfer with an adhesive sheet, a process for dyeing the microorganism or the cell with a solution containing carboxyfluorescein diacetate and a process for cleaning the dyed microorganism or cell with a cleaning liquid. The kit for evaluating the physiological activity of the microorganism or the cell comprises the cleaning liquid having

5. 发明专利

JP2013126975A Intestinal fibrosis treatment agent 有权
标题翻译： INTESTINAL FIBROSIS TREATMENT AGENT
公开(公告)号：JP2013126975A
公开(公告)日：2013-06-27
申请号：JP2012252167
申请日：2012-11-16
申请人： Nitto Denko Corp , 日東電工株式会社
发明人： AYABE TOKIYOSHI , NAKAMURA KIMINORI , AJINOMI KENJIRO , TANAKA YASUYUKI
IPC分类号： A61K47/10 , A61K9/127 , A61K31/713 , A61K45/00 , A61P43/00 , C12N5/071 , C12Q1/02 , G01N33/15 , G01N33/50
CPC分类号： C12N15/113 , A61K9/1271 , A61K9/1272 , A61K31/07 , A61K38/00 , A61K47/10 , A61K47/54 , A61K47/6911 , C12N5/0679 , C12N15/111 , C12N2310/14 , C12N2320/32 , C12N2501/07 , C12N2503/02 , G01N33/5044 , G01N33/6893 , G01N2500/00 , G01N2800/065
摘要： PROBLEM TO BE SOLVED: To provide an intestinal fibrosis treatment agent.SOLUTION: The invention pertains to a material delivery carrier for extracellular matrix-producing cells in the intestines comprising a retinoid as a targeting agent, as well as to an intestinal fibrosis treatment agent using the carrier.
摘要翻译：待解决的问题：提供肠纤维化处理剂。解决方案：本发明涉及包含类视黄醇作为靶向剂的肠中细胞外基质产生细胞的物质递送载体，以及使用该载体的肠纤维化处理剂。版权所有（C）2013，JPO＆INPIT

6. 发明专利

JP2003304880A Method for detecting target nucleic acid 审中-公开
标题翻译：检测目标核酸的方法
公开(公告)号：JP2003304880A
公开(公告)日：2003-10-28
申请号：JP2002115307
申请日：2002-04-17
申请人： Nitto Denko Corp , 日東電工株式会社
发明人： TANAKA YASUYUKI , OKADA KEISAKU , ASAI RIYOUKO
IPC分类号： C12N15/09 , C12Q1/68
CPC分类号： Y02A50/451
摘要： PROBLEM TO BE SOLVED: To provide a method for detecting a target nucleic acid, capable of rapidly and simply detecting presence of the target nucleic acid in a sample to be examined, compared with a conventional hybridization method and to provide a test piece for detection of the target nucleic acid suitable therefor and a kit for detection of the target nucleic acid. SOLUTION: The method for detecting the target nucleic acid by using a detection probe and a capturing probe which bind to the target nucleic acid, but have no binding property to each other comprises (a) a step for mixing a labeled complex having the detection probe and a signal reporter with a sample to be examined, (b) a step for introducing the mixture obtained by the step (a) onto a water-absorbing substrate having a stationary phase obtained by immobilizing the capturing probe through bond of a ligand to a ligand- binding compound, (c) a step for developing the mixture on the water-absorbing substrate under stringent conditions and (d) a step for detecting a signal from the signal reporter in the stationary phase. The test piece for detection of the target nucleic acid is composed of the water-absorbing substrate. The kit for detection of the target nucleic acid comprises the labeled complex and the test piece. COPYRIGHT: (C)2004,JPO
摘要翻译：待解决的问题：提供一种检测目标核酸的方法，其能够快速且简单地检测待检样品中目标核酸的存在，与传统的杂交方法相比，并提供试验片用于检测适合其的靶核酸和用于检测靶核酸的试剂盒。解决方案：通过使用与靶核酸结合但不具有彼此结合性的检测探针和捕获探针来检测靶核酸的方法包括（a）混合具有检测探针和具有要检查的样品的信号报告物，（b）将通过步骤（a）获得的混合物引入到通过固定捕获探针而获得的具有固定相的吸水性基材的步骤配体与配体结合化合物，（c）在严格条件下在吸水性基材上显影混合物的步骤和（d）在固定相中检测来自信号报告基团的信号的步骤。用于检测靶核酸的试验片由吸水性基材构成。用于检测靶核酸的试剂盒包括标记的复合物和试验片。版权所有（C）2004，JPO

7. 发明专利

DE69912321D1 未知
公开(公告)号：DE69912321D1
公开(公告)日：2003-11-27
申请号：DE69912321
申请日：1999-06-22
申请人： NITTO DENKO CORP
发明人： SHIBATA KAZUHIKO , TANAKA YASUYUKI
IPC分类号： C09J7/02 , C09J107/02
摘要： A rubber-based pressure-sensitive adhesive which (i) contains as the main rubber component a natural rubber comprising, as the main component, fine particles having a particle diameter of 1 mu m or smaller contained in a raw natural rubber latex, (ii) contains as the main rubber component a linear natural rubber polymer contained in a raw natural rubber latex, (iii) contains as the main rubber component a natural rubber having a weight-average molecular weight of from 100,000 to 1,000,000 contained in a raw natural rubber latex, (iv) contains as the main rubber component a natural rubber having a rupture strength of 0.5 MPa or lower in terms of green strength contained in a raw natural rubber latex, or (v) contains as the main rubber component a natural rubber contained in the serum obtained by centrifuging a raw natural rubber latex has excellent pressure-sensitive adhesive properties, does not substantially necessitate a mastication step, and can be easily produced with a small amount of energy in a short time.

8. 发明专利

DE69606495T2 未知
公开(公告)号：DE69606495T2
公开(公告)日：2000-06-21
申请号：DE69606495
申请日：1996-11-08
申请人： SUMITOMO RUBBER IND , KAO CORP , NITTO DENKO CORP
发明人： TANAKA YASUYUKI , SAKAKI TOSHIAKI , KAWASAKI ATSUKO , HAYASHI MASAHARU , KANAMARU EIJI , SHIBATA KAZUHIKO
IPC分类号： C08C1/04 , C08C19/08 , C08F8/50
摘要： Described is a process for the production of depolymerized natural rubber, which makes it possible to obtain, at high reaction efficiency, of depolymerized natural rubber in the liquid form and having a narrow molecular weight distribution; and also a process for the production of depolymerized natural rubber which is free from odor or coloring peculiar to natural rubber and is also free from the danger of immediate allergy derived from protein. The process according to the present invention comprises adding a carbonyl compound to a natural rubber latex, and then subjecting the resulting natural rubber to air oxidation in the presence of a radical forming agent or adding a carbonyl compound to the latex of deproteinized natural rubber and then subjecting the deproteinized natural rubber to air oxidation optionally in the presence of a radical forming agent.

9. 发明专利

AU6318396A Graft natural rubber pressure-sensitive adhesive and pressure-sensitive adhesive tape using it 未知
公开(公告)号：AU6318396A
公开(公告)日：1997-02-10
申请号：AU6318396
申请日：1996-07-03
申请人： KAO CORP , SUMITOMO RUBBER IND , NITTO DENKO CORP
发明人： TANAKA YASUYUKI , SHIBATA KAZUHIKO , HAYASHI MASAHARU , NAKADE SHINICHI , KANAMARU EIJI
IPC分类号： C08F253/00 , C08L51/04 , C09J7/02 , C09J151/00 , C09J151/04

10. 发明专利

DE69912321T2 未知
公开(公告)号：DE69912321T2
公开(公告)日：2004-05-13
申请号：DE69912321
申请日：1999-06-22
申请人： NITTO DENKO CORP
发明人： SHIBATA KAZUHIKO , TANAKA YASUYUKI
IPC分类号： C09J7/02 , C09J107/02
摘要： A rubber-based pressure-sensitive adhesive which (i) contains as the main rubber component a natural rubber comprising, as the main component, fine particles having a particle diameter of 1 mu m or smaller contained in a raw natural rubber latex, (ii) contains as the main rubber component a linear natural rubber polymer contained in a raw natural rubber latex, (iii) contains as the main rubber component a natural rubber having a weight-average molecular weight of from 100,000 to 1,000,000 contained in a raw natural rubber latex, (iv) contains as the main rubber component a natural rubber having a rupture strength of 0.5 MPa or lower in terms of green strength contained in a raw natural rubber latex, or (v) contains as the main rubber component a natural rubber contained in the serum obtained by centrifuging a raw natural rubber latex has excellent pressure-sensitive adhesive properties, does not substantially necessitate a mastication step, and can be easily produced with a small amount of energy in a short time.

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