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1. 发明专利

JP2014169277A Wt1 peptide cancer vaccine composition for transdermal administration 有权
标题翻译： WT1胃癌用于远程管理的胃癌组合物
公开(公告)号：JP2014169277A
公开(公告)日：2014-09-18
申请号：JP2014014802
申请日：2014-01-29
申请人： Nitto Denko Corp , 日東電工株式会社 , Osaka Univ , 国立大学法人大阪大学
发明人： OKUBO KATSUYUKI , MAEDA YOSHIMI , OKAZAKI ARIMICHI , ASARI DAISUKE , SHISHIDO TAKUYA , HORI MITSUHIKO , SUGIYAMA HARUO
IPC分类号： A61K39/00 , A61K38/00 , A61K39/39 , A61P35/00 , A61P35/02 , C07K14/47
CPC分类号： A61K9/0014 , A61K38/10 , A61K39/0011 , A61K2039/54
摘要： PROBLEM TO BE SOLVED: To provide a composition for a cancer vaccine that has higher efficacy and is convenient for use.SOLUTION: The present invention provides a cancer vaccine composition for transdermal administration for cellular immunity induction, comprising (i) a WT1 peptide and/or a modified WT1 peptide; and (ii) a cellular immunity induction promoter.
摘要翻译：本发明提供一种用于细胞免疫诱导的透皮给药的癌症疫苗组合物，其包含（i）WT1肽和/ 或修饰的WT1肽; 和（ii）细胞免疫诱导启动子。

2. 发明专利

JP2014169276A Wt1 peptide cancer vaccine composition for transdermal administration 有权
标题翻译： WT1胃癌用于远程管理的胃癌组合物
公开(公告)号：JP2014169276A
公开(公告)日：2014-09-18
申请号：JP2014014800
申请日：2014-01-29
申请人： Nitto Denko Corp , 日東電工株式会社 , Osaka Univ , 国立大学法人大阪大学
发明人： OKUBO KATSUYUKI , MAEDA YOSHIMI , OKAZAKI ARIMICHI , ASARI DAISUKE , SHISHIDO TAKUYA , HORI MITSUHIKO , SUGIYAMA HARUO
IPC分类号： A61K39/00 , A61K9/08 , A61K9/107 , A61K45/00 , A61K47/12 , A61K47/20 , A61P35/00
CPC分类号： A61K9/0014 , A61K31/045 , A61K31/437 , A61K31/451 , A61K31/513 , A61K31/708 , A61K31/716 , A61K31/728 , A61K31/739 , A61K38/10 , A61K39/0011 , A61K2039/54
摘要： PROBLEM TO BE SOLVED: To provide a composition for a cancer vaccine that has higher efficacy and is convenient for use.SOLUTION: The present invention provides a cancer vaccine composition for transdermal administration for cellular immunity induction, comprising (i) a WT1 peptide and/or a modified WT1 peptide; and (ii) a pharmacologically acceptable acid as a first cellular immunity induction promoter, or a pharmacologically acceptable salt thereof.
摘要翻译：本发明提供一种用于细胞免疫诱导的透皮给药的癌症疫苗组合物，其包含（i）WT1肽和/ 或修饰的WT1肽; 和（ii）药理学上可接受的酸作为第一细胞免疫诱导启动子或其药理学上可接受的盐。

3. 发明专利

JP2013006824A Edible jelly-form composition, jelly-form preparation and method for producing jelly-form preparation 审中-公开
标题翻译：可食用形状组合物，制备和制备果胶形式的制备方法
公开(公告)号：JP2013006824A
公开(公告)日：2013-01-10
申请号：JP2012098245
申请日：2012-04-23
申请人： Nitto Denko Corp , 日東電工株式会社
发明人： ASARI DAISUKE , SHISHIDO TAKUYA , HORI MITSUHIKO , MATSUSHITA KYOHEI
IPC分类号： A61K9/06 , A61K47/10 , A61K47/36 , A61K47/42
摘要： PROBLEM TO BE SOLVED: To provide an edible jelly composition capable of favorably gelling and obtaining a jelly-form preparation by adding a drug-containing solution thereto afterward, and to provide a method for producing the jelly-form formulation.SOLUTION: The edible composition includes a gelling agent and is used for producing the jelly-form preparation by adding the drug-containing solution to be gelatinized.
摘要翻译：待解决的问题：提供一种能够通过向其中加入含药溶液而有利地胶凝和获得凝胶状制剂的食用胶冻组合物，并提供一种制备凝胶状制剂的方法。解决方案：可食用组合物包括胶凝剂，并通过加入待糊化的药物溶液来制备胶冻制剂。版权所有（C）2013，JPO＆INPIT

4. 发明专利

JP2012121873A Sheet-form preparation and method for producing the same 有权
标题翻译：表格制备及其制造方法
公开(公告)号：JP2012121873A
公开(公告)日：2012-06-28
申请号：JP2010276190
申请日：2010-12-10
申请人： Nitto Denko Corp , 日東電工株式会社
发明人： ASARI DAISUKE , SHISHIDO TAKUYA , HORI MITSUHIKO , OKAZAKI TOSHIHIKO
IPC分类号： A61K47/42 , A61K9/70 , A61K47/10 , A61K47/26 , A61K47/34 , A61K47/38
CPC分类号： A61K38/014 , A61K9/0056 , A61K9/7007 , A61K31/00 , A61K47/26 , A61K47/42
摘要： PROBLEM TO BE SOLVED: To provide a sheet-form preparation that can be easily dissolved intraorally, allows the dissolution time thereof to be easily controlled, and can stably contain a drug except an allergenic protein from cedar pollen.SOLUTION: The sheet-form preparation contains water, gelatin, and a drug except an allergenic protein from cedar pollen. Preferably, the preparation contains at least one selected from the group consisting of sugars, sugar alcohols and sugar fatty acids, and further polyethylene glycol or its derivative, crystalline cellulose and the like.
摘要翻译：待解决的问题：为了提供易于口服溶解的片状制剂，可以容易地控制其溶解时间，并且可以稳定地含有除了来自雪松花粉的过敏原蛋白质以外的药物。解决方案：片状制剂含有水，明胶和除了来自雪松花粉的过敏性蛋白质以外的药物。优选地，制剂含有选自由糖，糖醇和糖脂肪酸组成的组中的至少一种，以及其它聚乙二醇或其衍生物，结晶纤维素等。版权所有（C）2012，JPO＆INPIT

5. 发明专利

JP2011153113A Film-form preparation 有权
标题翻译：电影制作
公开(公告)号：JP2011153113A
公开(公告)日：2011-08-11
申请号：JP2010017321
申请日：2010-01-28
申请人： Nitto Denko Corp , 日東電工株式会社
发明人： ASARI DAISUKE , HORI MITSUHIKO , SHISHIDO TAKUYA
IPC分类号： A61K39/35 , A61K9/70 , A61K47/10 , A61K47/26 , A61K47/32 , A61K47/38 , A61P37/08
CPC分类号： A61K9/006 , A61K9/1623 , A61K9/7007 , A61K47/38
摘要： PROBLEM TO BE SOLVED: To provide a film-form preparation which, in desensitization therapy, enables a patient to self-administer an allergen and adjust the dose, has excellent portability, has no residual sensation, provides excellent protection against accidental swallowing, is easy for a caregiver to administer, and can greatly improve the QOL of both patients and caregivers and additionally, enables arbitrary control of the dissolution time in the mouth, particularly sublingually and has very little sticky sensation in the mouth and better feeling when touched by the fingers and to provide a method for producing the film-form preparation.
SOLUTION: The film-form preparation comprises an allergen, an edible polymer which is soluble in both water and a polar organic solvent, and one, two or more types of particles selected from the group consisting of monosaccharide to hexasaccharide sugars and sugar alcohols thereof which have an average particle size of 0.1 to 100 μm.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种薄膜形式的制剂，其在脱敏疗法中使得患者能够自我施用变应原并调节剂量，具有优异的携带性，没有残留感觉，提供极好的防止意外吞咽的保护作用护理人员很容易管理，可以大大提高患者和护理人员的生活质量，另外，可以任意控制口腔中溶出时间，特别是舌下，口感很小，触摸感更好并提供一种制备薄膜形成剂的方法。解决方案：膜形式制剂包含可溶于水和极性有机溶剂的变应原，可食用聚合物和选自单糖至六糖和糖的一种，两种或更多种颗粒醇的平均粒径为0.1〜100μm。版权所有（C）2011，JPO＆INPIT

6. 发明专利

JP2007091764A Percutaneous absorption type preparation 有权
标题翻译： PERCUTANEOUS吸收式制备
公开(公告)号：JP2007091764A
公开(公告)日：2007-04-12
申请号：JP2007008043
申请日：2007-01-17
申请人： Abbott Japan Co Ltd , Nitto Denko Corp , アボットジャパン株式会社 , 日東電工株式会社
发明人： NAKANO YOSHIHISA , HORI MITSUHIKO , YAMAMOTO KEIJI , OTSUKA SABURO
IPC分类号： A61K31/137 , A61K9/70 , A61K31/085 , A61K31/22 , A61P11/08
摘要： PROBLEM TO BE SOLVED: To provide a solubilizer of tulobuterol for percutaneous absorption type preparations, and to provide a method for using the solubilizer.
SOLUTION: The solubilizer of tulobuterol for percutaneous absorption type preparations comprises at least one selected from a group consisting of an ester of a 12-16C fatty acid, a monoglyceride of an 8-10C fatty acid, an ester of a 6-10C dibasic acid, a polyoxyethylene alkyl ether of 2-5 addition molar number, and a polyoxyethylene alkyl phenyl ether of 2-5 addition molar number, and the method for assisting dissolution of the tulobuterol into a paste layer comprises compounding the solubilizer in the paste layer.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：为经皮吸收型制剂提供杜洛替罗的增溶剂，并提供使用该增溶剂的方法。解毒剂：十四指醇用于经皮吸收型制剂的增溶剂包括选自12-16C脂肪酸的酯，8-10C脂肪酸的单酸甘油酯，6- 10位二元酸，2-5加成摩尔数的聚氧乙烯烷基醚和2-5的加成摩尔数的聚氧乙烯烷基苯基醚，以及辅助将楚胡特罗溶解成糊状层的方法包括将增溶剂混合在糊状物层。版权所有（C）2007，JPO＆INPIT

7. 发明专利

JP2006076994A Fentanyl-containing adhesive preparation 有权
标题翻译：含有粘合剂的制剂
公开(公告)号：JP2006076994A
公开(公告)日：2006-03-23
申请号：JP2005215405
申请日：2005-07-26
申请人： Nitto Denko Corp , 日東電工株式会社
发明人： SAEKI YUJI , NISHIMURA MASATO , MATSUOKA KENSUKE , MURAOKA TAKAMITSU , HOSAKA YOSHIFUMI , HORI MITSUHIKO , NINOMIYA KAZUHISA , AKEMI HITOSHI , KURODA HIDETOSHI
IPC分类号： A61K31/4468 , A61K9/70 , A61K47/10 , A61K47/14 , A61K47/32 , A61P25/04 , C07D211/58
CPC分类号： A61K9/7053 , A61K31/4468
摘要： PROBLEM TO BE SOLVED: To provide a fentanyl-containing percutaneously absorbable adhesive preparation, which is obtained from economic starting materials, has a constitution simpler than that of conventional ones, has sufficient skin permeability, and which enables control of skin permeability by changing the mixing ratio of two kinds of polyisobutylene compounds having different molecular weights, a tackifier and an organic liquid.
SOLUTION: The percutaneously absorbable adhesive preparation comprises a support and an adhesive layer laminated on one surface thereof, wherein the adhesive layer comprises fentanyl, two kinds of the polyisobutylene compounds having different molecular weights, the tackifier and the organic liquid compatible with the two kinds of polyisobutylene compounds and the tackifier.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：提供从经济起始材料获得的含有芬太尼的经皮吸收性粘合剂制剂，具有比常规的简单的结构，具有足够的皮肤渗透性，并且能够通过以下方式控制皮肤渗透性改变具有不同分子量的两种聚异丁烯化合物的混合比例，增粘剂和有机液体。皮肤吸收性粘合剂包括在其一个表面上层叠的支撑体和粘合剂层，其中粘合剂层包括芬太尼，两种具有不同分子量的聚异丁烯化合物，增粘剂和与两种聚异丁烯化合物和增粘剂。版权所有（C）2006，JPO＆NCIPI

8. 发明专利

JP2003300873A Plaster and method for producing the same 审中-公开
标题翻译：塑料及其制造方法
公开(公告)号：JP2003300873A
公开(公告)日：2003-10-21
申请号：JP2002110609
申请日：2002-04-12
申请人： Meiji Milk Prod Co Ltd , Nitto Denko Corp , 日東電工株式会社 , 明治乳業株式会社
发明人： HORI MITSUHIKO , YAMAMOTO KEIJI , MATSUOKA KENSUKE , NAKANO YOSHIHISA , AJINOMI KENJIRO , YAMADA MASASHI , OTSUKA MASARU , SUZUKI YASUNORI , KAWASHIMA AKIHIRO
IPC分类号： A61K9/70 , A61K31/137 , A61K47/10 , A61K47/14 , A61P9/02
CPC分类号： A61K9/7061 , A61K31/137
摘要： PROBLEM TO BE SOLVED: To provide a plaster which can improve the transdermal absorption of 2-amino-1-(2',5'-dimethoxyphenyl)ethanol (DMAE) or its pharmacologically acceptable salt and does not cause a trouble such as the stay or overflow of an adhesive.
SOLUTION: The plaster is obtained by laminating (A) a non-crosslinked adhesive layer containing the DMAE or its pharmacologically acceptable salt to one side of a support and then laminating (B) a crosslinked adhesive layer to (A) the non-crosslinked adhesive layer.
COPYRIGHT: (C)2004,JPO
摘要翻译：待解决的问题：提供可以改善2-氨基-1-（2'，5'-二甲氧基苯基）乙醇（DMAE）或其药理学上可接受的盐的透皮吸收的石膏，并且不会引起诸如作为粘合剂的停留或溢出。解决方案：通过将（A）含有DMAE或其药理学上可接受的盐的非交联粘合剂层层压到载体的一侧，然后将（B）交联粘合剂层层压（A）交联粘合剂层。版权所有（C）2004，JPO

9. 发明专利

JP2003300868A Plaster and method for producing the same 有权
标题翻译：塑料及其制造方法
公开(公告)号：JP2003300868A
公开(公告)日：2003-10-21
申请号：JP2002110612
申请日：2002-04-12
申请人： Nitto Denko Corp , 日東電工株式会社
发明人： HORI MITSUHIKO , YAMAMOTO KEIJI , MATSUOKA KENSUKE , NAKANO YOSHIHISA
IPC分类号： A61K9/70
CPC分类号： A61K9/7061 , Y10T442/2738 , Y10T442/674
摘要： PROBLEM TO BE SOLVED: To provide a plaster which can improve the transdermal absorption of a medicine and does not cause a trouble such as the stay or overflow of an adhesive. SOLUTION: The plaster is obtained by laminating (A) a non-crosslinked adhesive layer containing the medicine to one side of a support and then laminating (B) a crosslinked adhesive layer to (A) the non-crosslinked adhesive layer. COPYRIGHT: (C)2004,JPO

10. 发明专利

JP2017114898A ワクチン組成物审中-公开
公开(公告)号：JP2017114898A
公开(公告)日：2017-06-29
申请号：JP2017033269
申请日：2017-02-24
申请人：日東電工株式会社 , Nitto Denko Corp
发明人： FUKASAKA MASAHIRO , OKAZAKI ARIMICHI , ASARI DAISUKE , HORI MITSUHIKO , AKIRA SHIZUO , TAKEUCHI OSAMU
IPC分类号： A61K39/39 , A61K39/145 , A61P31/16
CPC分类号： A61K39/145 , A61K39/12 , A61K39/39 , A61K2039/5252 , A61K2039/541 , A61K2039/542 , A61K2039/55561 , A61K2039/55572 , A61K2039/575 , C12N7/00 , C12N2710/00034 , C12N2760/16034 , C12N2760/16134
摘要：【課題】感染症の予防又は治療剤として有用で、効果的に全身性免疫応答及び粘膜免疫応答を誘導させることのできる舌下投与可能なワクチン組成物を提供する。【解決手段】ヒト又は動物の口腔内に投与されるワクチン組成物であって、少なくとも一種類の感染症由来抗原と、トール様受容体2/6(TLR2/6)アゴニスト又はその塩とを含むことを特徴とするワクチン組成物。【選択図】なし

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