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1. 发明授权

US07517676B2 Human cyclooxygenase-3 enzyme and uses thereof 有权
标题翻译：人环加氧酶-3酶及其用途
公开(公告)号：US07517676B2
公开(公告)日：2009-04-14
申请号：US11651705
申请日：2007-01-10
申请人： Ning Qin , Ellen E. Codd , Christopher Flores , Sui-Po Zhang
发明人： Ning Qin , Ellen E. Codd , Christopher Flores , Sui-Po Zhang
IPC分类号： C12P21/06 , C12N9/02 , C12N15/00 , C12N5/02 , C07H21/04
CPC分类号： C12N9/0083 , A61K38/00
摘要： The present invention provides nucleic acid and polypeptide sequences describing a neve isozyme of the cyclooxygenase enzyme, herein named as human cyclooxygenase 3. The isolated nucleic acid or polypeptide molecule of the invention can be used in detection assays, gene therapy, and screening assays.
摘要翻译：本发明提供描述环氧合酶的神经同工酶的核酸和多肽序列，本文命名为人环加氧酶3.本发明的分离的核酸或多肽分子可用于检测测定，基因治疗和筛选测定。

2. 发明申请

US20070166789A1 Human cyclooxygenase-3 enzyme and uses thereof 有权
标题翻译：人环加氧酶-3酶及其用途
公开(公告)号：US20070166789A1
公开(公告)日：2007-07-19
申请号：US11651705
申请日：2007-01-10
申请人： Ning Qin , Ellen Codd , Christopher Flores , Sui-Po Zhang
发明人： Ning Qin , Ellen Codd , Christopher Flores , Sui-Po Zhang
IPC分类号： C12P21/06 , C12N9/02 , C07H21/04
CPC分类号： C12N9/0083 , A61K38/00
摘要： The present invention provides nucleic acid and polypeptide sequences describing a novel isozyme of the cyclooxygenase enzyme, herein named as human cyclooxygenase-3. The isolated nucleic acid or polypeptide molecule of the invention can be used in detection assays, gene therapy, and screening assays.
摘要翻译：本发明提供描述环氧合酶的新型同工酶的核酸和多肽序列，这里命名为人环加氧酶-3。本发明的分离的核酸或多肽分子可用于检测测定，基因治疗和筛选测定。

3. 发明授权

US07049084B2 Neuroblastoma cell lines expressing the α2δ subunit of calcium channels and methods therefore 失效
公开(公告)号：US07049084B2
公开(公告)日：2006-05-23
申请号：US09870338
申请日：2001-05-30
申请人： Sui-Po Zhang , Susan K. Yagel , Ellen E. Codd
发明人： Sui-Po Zhang , Susan K. Yagel , Ellen E. Codd
IPC分类号： G01N33/574 , G01N33/53
CPC分类号： G01N33/6872 , C12N5/0693 , C12N2503/02 , C12N2510/04 , G01N2500/10
摘要： The present invention provides methods for identifying test substances that bind to the α2δ subunit of a calcium channel.

4. 发明授权

US07927820B2 Assay systems and methods for detecting molecules that interact with membrane channels 有权
标题翻译：用于检测与膜通道相互作用的分子的测定系统和方法
公开(公告)号：US07927820B2
公开(公告)日：2011-04-19
申请号：US10894836
申请日：2004-07-20
申请人： Sui-Po Zhang , Ellen E. Codd
发明人： Sui-Po Zhang , Ellen E. Codd
IPC分类号： G01N33/53
CPC分类号： G01N33/542 , G01N33/6872 , G01N2500/10
摘要： The invention provides an assay system for detecting a molecule that interacts with a membrane channel, the assay system including cell membranes including one or more membrane channels; support bodies including scintillant and a coupling agent that associates with the cell membrane; a ligand that is selected to bind the membrane channel, the ligand including a scintillant-activating label. According to the invention, association of the support bodies with the cell membrane and binding of the ligand to the membrane channel results in emission from the scintillant of the support bodies, and, in the presence of a test molecule that interacts with the membrane channel, the emission from the scintillant of the support bodies changes. Methods of identifying a molecule that interacts with a cell membrane channel are also described.
摘要翻译：本发明提供了一种用于检测与膜通道相互作用的分子的测定系统，该测定系统包括包含一个或多个膜通道的细胞膜; 支持体，包括闪烁体和与细胞膜缔合的偶联剂; 被选择以结合膜通道的配体，该配体包括闪烁体激活标记。根据本发明，支持体与细胞膜的结合和配体与膜通道的结合导致来自支持体的闪烁体的发射，并且在与膜通道相互作用的测试分子的存在下，来自支撑体的闪烁体的发射变化。还描述了鉴定与细胞膜通道相互作用的分子的方法。

5. 发明授权

US06780650B2 Ligand binding assays for vanilloid receptors 有权
标题翻译：香草素受体的配体结合测定
公开(公告)号：US06780650B2
公开(公告)日：2004-08-24
申请号：US09975650
申请日：2001-10-11
申请人： Sui-Po Zhang , Ellen E. Codd
发明人： Sui-Po Zhang , Ellen E. Codd
IPC分类号： G01N30566
CPC分类号： G01N33/566 , G01N33/5306 , G01N2333/705 , G01N2500/04
摘要： The present invention describes an assay in which pH alters RTX affinity to VR1 receptors. The RTX affinity was increased with increasing pH from 4.1 to 8.6. Both the RTX affinity and apparent number of RTX binding sites were decreased with increasing pH from 8.6 to 10.6. The high pH may be causing the cell membranes to denature. These pH conditions (pH 8.0 to pH 9.0) provide a high signal to noise ratio, give a more robust assay and require use of less experimental materials.
摘要翻译：本发明描述了其中pH改变对VR1受体的RTX亲和力的测定。随着pH值从4.1增加到8.6，RTX亲和力增加。 RTX亲和力和RTX结合位点的表观数都随着pH值从8.6降低到10.6而降低。高pH可能导致细胞膜变性。这些pH条件（pH8.0至pH9.0）提供高的信噪比，给出更强的测定，并且需要使用较少的实验材料。

6. 发明授权

US06838249B2 Neuroblastoma cell lines expressing the α2δ subunit of calcium channels and methods therefore 失效
标题翻译：表达钙通道的α2delta亚基的神经母细胞瘤细胞系和方法因此
公开(公告)号：US06838249B2
公开(公告)日：2005-01-04
申请号：US10401895
申请日：2003-03-28
申请人： Sui-Po Zhang , Susan K. Yagel , Ellen E. Codd
发明人： Sui-Po Zhang , Susan K. Yagel , Ellen E. Codd
IPC分类号： G01N33/50 , A61K31/197 , A61K45/00 , A61P25/00 , A61P25/08 , C12N5/09 , C12Q1/02 , G01N33/15 , G01N33/68 , G01N33/574 , G01N33/53
CPC分类号： G01N33/6872 , C12N5/0693 , C12N2503/02 , C12N2510/04 , G01N2500/10
摘要： The present invention provides methods for identifying test substances that bind to the α2δ subunit of a calcium channel.

7. 发明授权

US08426401B2 Azetidinyl diamides as monoacylglycerol lipase inhibitors 有权
公开(公告)号：US08426401B2
公开(公告)日：2013-04-23
申请号：US12765018
申请日：2010-04-22
申请人： Haiyan Bian , Kristen Chevalier , Jose Clemente , Pete Connolly , Chris Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark McDonnell , Philip Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
发明人： Haiyan Bian , Kristen Chevalier , Jose Clemente , Pete Connolly , Chris Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark McDonnell , Philip Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
IPC分类号： A61K31/496 , C07D417/12 , C07D417/14
CPC分类号： C07D403/10 , C07D205/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Y, Z, R1, and s are defined herein.

8. 发明授权

US08362001B2 Azetidinyl diamides as monoacylglycerol lipase inhibitors 有权
公开(公告)号：US08362001B2
公开(公告)日：2013-01-29
申请号：US12765487
申请日：2010-04-22
申请人： Haiyan Bian , Kristen Chevalier , Jose Clemente , Pete Connolly , Chris Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark McDonnell , Philip Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
发明人： Haiyan Bian , Kristen Chevalier , Jose Clemente , Pete Connolly , Chris Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark McDonnell , Philip Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
IPC分类号： A61K31/496 , A61K31/506 , A61K31/517 , C07D295/192 , C07D401/14 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/10 , C07D409/06 , C07D413/06 , C07D417/06
CPC分类号： C07D403/10 , C07D205/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Y, Z, R1, and s are defined herein.

9. 发明申请

US20050019958A1 Ligand binding assays for vanilloid receptors 审中-公开
标题翻译：香草素受体的配体结合测定
公开(公告)号：US20050019958A1
公开(公告)日：2005-01-27
申请号：US10922683
申请日：2004-08-19
申请人： Sui-Po Zhang , Ellen Codd
发明人： Sui-Po Zhang , Ellen Codd
IPC分类号： G01N33/543 , G01N33/53 , G01N33/566 , G01N33/536
CPC分类号： G01N33/566 , G01N33/5306 , G01N2333/705 , G01N2500/04
摘要： The present invention describes an assay in which pH alters RTX affinity to VR1 receptors. The RTX affinity was increased with increasing pH from 4.1 to 8.6. Both the RTX affinity and apparent number of RTX binding sites were decreased with increasing pH from 8.6 to 10.6. The high pH may be causing the cell membranes to denature. These pH conditions (pH 8.0 to pH 9.0) provide a high signal to noise ratio, give a more robust assay and require use of less experimental materials.
摘要翻译：本发明描述了其中pH改变对VR1受体的RTX亲和力的测定。随着pH值从4.1增加到8.6，RTX亲和力增加。 RTX亲和力和RTX结合位点的表观数都随着pH值从8.6降低到10.6而降低。高pH可能导致细胞膜变性。这些pH条件（pH 8.0至pH 9.0）提供高信噪比，给出更强的测定，并且需要使用较少的实验材料。

10. 发明授权

US08362000B2 Azetidinyl diamides as monoacylglycerol lipase inhibitors 有权
公开(公告)号：US08362000B2
公开(公告)日：2013-01-29
申请号：US12765420
申请日：2010-04-22
申请人： Haiyan Bian , Kristen Chevalier , Jose Clemente , Pete Connolly , Chris Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark McDonnell , Philip Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
发明人： Haiyan Bian , Kristen Chevalier , Jose Clemente , Pete Connolly , Chris Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark McDonnell , Philip Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
IPC分类号： A61K31/496 , A61K31/5377 , C07D205/04 , C07D401/12 , C07D403/04 , C07D409/06 , C07D413/12
CPC分类号： C07D403/10 , C07D205/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Y, Z, R1, and s are defined herein.

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