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1. 发明申请

US20140073607A1 COMPOUNDS FOR USE IN THE TREATMENT OF FELINE RETROVIRAL INFECTIONS 审中-公开
标题翻译：用于治疗复发性感染的化合物
公开(公告)号：US20140073607A1
公开(公告)日：2014-03-13
申请号：US14110682
申请日：2011-05-10
申请人： Nina Justa , Katrin Hartmann , Sylvie Daminet , Mariella Debille , Joeri Auwerx , Nesya Goris , Stefaan Wera , Erwin Blomsma , Aino Billiet , Jan Swinnen , Bert Vrancx , Veerle Debeurme , Johan Neyts
发明人： Nina Justa , Katrin Hartmann , Sylvie Daminet , Mariella Debille , Joeri Auwerx , Nesya Goris , Stefaan Wera , Erwin Blomsma , Aino Billiet , Jan Swinnen , Bert Vrancx , Veerle Debeurme , Johan Neyts
IPC分类号： C07F9/6558
CPC分类号： C07F9/65583 , A61K31/662
摘要： The present invention relates to compounds and compositions for use in the treatment or prevention of retroviral infections in felines, in particular cats, and to the use of said derivatives for the manufacture of a medicament for the treatment or prevention of feline leukemia virus (FeLV) infections occurring alone or together with feline immunodeficiency virus (FIV) infections in cats.
摘要翻译：本发明涉及用于治疗或预防猫科动物，特别是猫的逆转录病毒感染的化合物和组合物，以及所述衍生物用于制备用于治疗或预防猫白血病病毒（FeLV）的药物的用途，单独感染或猫猫免疫缺陷病毒（FIV）感染发生的感染。

2. 发明授权

US09107943B2 Eye drop composition 有权
标题翻译：滴眼液组成
公开(公告)号：US09107943B2
公开(公告)日：2015-08-18
申请号：US14373322
申请日：2012-01-20
申请人： Nesya Goris , Johan Neyts , Erwin Blomsma , Stefaan Wera , Ainola Billiet , Joeri Auwerx , Veerle Debeurme , Maryline Roe , Pascal Puig
发明人： Nesya Goris , Johan Neyts , Erwin Blomsma , Stefaan Wera , Ainola Billiet , Joeri Auwerx , Veerle Debeurme , Maryline Roe , Pascal Puig
IPC分类号： A61K31/522 , A61K49/00 , A61K47/40 , A61K47/24
CPC分类号： A61K49/0004 , A61K9/0048 , A61K31/305 , A61K31/522 , A61K47/24 , A61K47/40
摘要： The present invention relates to an eye-drop composition comprising 2-amino-9-[[(1S,2R)-1,2-bis(hydroxymethyl)cyclopropyl]methyl]-1,9-dihydro-6H-Purin-6-one, and the use thereof for the diagnosis and treatment of herpetic eye infections in companion animals.
摘要翻译：本发明涉及包含2-氨基-9 - [[（1S，2R）-1,2-双（羟甲基）环丙基]甲基] -1,9-二氢-6H-嘌呤-6-酮的滴眼液组合物，一种用于诊断和治疗伴侣动物的疱疹性眼感染的用途。

3. 发明申请

US20150098904A1 EYE DROP COMPOSITION 有权
公开(公告)号：US20150098904A1
公开(公告)日：2015-04-09
申请号：US14373322
申请日：2012-01-20
申请人： Nesya Goris , Johan Neyts , Erwin Blomsma , Stefaan Wera , Ainola Billiet , Joeri Auwerx , Veerle Debeurme , Maryline Roe , Pascal Puig
发明人： Nesya Goris , Johan Neyts , Erwin Blomsma , Stefaan Wera , Ainola Billiet , Joeri Auwerx , Veerle Debeurme , Maryline Roe , Pascal Puig
IPC分类号： A61K49/00 , A61K47/40 , A61K47/24 , A61K31/522
CPC分类号： A61K49/0004 , A61K9/0048 , A61K31/305 , A61K31/522 , A61K47/24 , A61K47/40
摘要： The present invention relates to an eye-drop composition comprising 2-amino-9-[[(1S,2R)-1,2-bis(hydroxymethyl)cyclopropyl]methyl]-1,9-dihydro-6H-Purin-6-one, and the use thereof for the diagnosis and treatment of herpetic eye infections in companion animals.

4. 发明申请

US20100137240A1 USE OF NUCLEOSIDE DERIVATIVES AS ANTI-KOI HERPES VIRUS IN FISH 审中-公开
标题翻译：核苷酸衍生物作为抗病毒药物在鱼类中的使用
公开(公告)号：US20100137240A1
公开(公告)日：2010-06-03
申请号：US12600110
申请日：2008-05-16
申请人： Berenice Costes , Johan Neyts , Alain Vanderplasschen
发明人： Berenice Costes , Johan Neyts , Alain Vanderplasschen
IPC分类号： A61K31/7052 , C07H19/04 , C07H19/10 , C07H19/20 , A61P31/12
CPC分类号： A61K31/7076
摘要： The present invention relates to the use of N-phosphonylmethoxyethyl nucleoside analogs for manufacturing a medicament for the treatment or prevention of Koi Herpes virus infections in fish, especially in carps.
摘要翻译：本发明涉及N-膦酰基甲氧基乙基核苷类似物用于制备用于治疗或预防鱼，特别是鲤鱼中的锦鲤疱疹病毒感染的药物的用途。

5. 发明申请

US20140121187A1 1,3-DI-OXO-INDENE DERIVATIVE, PHARMACEUTICALLY ACCEPTABLE SALT OR OPTICAL ISOMER THEREOF, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS AN ANTIVIRAL, ACTIVE INGREDIENT 有权
标题翻译： 1,3-DI-OXO-INDENE衍生物，药学上可接受的盐或光学异构体，其制备方法和含有作为抗病毒活性成分的药物组合物
公开(公告)号：US20140121187A1
公开(公告)日：2014-05-01
申请号：US14126479
申请日：2012-06-18
申请人： Young Sik Jung , Chong Kgo Lee , Ihl Young Choi , Hae Soo Kim , Pil Ho Kim , Soo Bong Han , Johan Neyts , Hendrik Jan Thibaut
发明人： Young Sik Jung , Chong Kgo Lee , Ihl Young Choi , Hae Soo Kim , Pil Ho Kim , Soo Bong Han , Johan Neyts , Hendrik Jan Thibaut
IPC分类号： C07C269/00 , C07C69/12 , C07C69/63 , C07C45/00 , C07C49/747 , C07C69/22 , C07C69/78 , C07C67/00 , C07C69/736 , C07C205/45
CPC分类号： A61K31/122 , A61K31/435 , C07C45/00 , C07C49/747 , C07C49/753 , C07C49/755 , C07C67/00 , C07C67/08 , C07C69/12 , C07C69/16 , C07C69/18 , C07C69/22 , C07C69/28 , C07C69/54 , C07C69/618 , C07C69/63 , C07C69/736 , C07C69/738 , C07C69/78 , C07C205/45 , C07C225/20 , C07C225/22 , C07C231/02 , C07C233/32 , C07C233/33 , C07C233/41 , C07C233/43 , C07C233/61 , C07C233/76 , C07C247/14 , C07C269/00 , C07C271/12 , C07C271/24 , C07C271/44 , C07C271/64 , C07C275/26 , C07C275/64 , C07C323/22 , C07C2601/02 , C07C2602/08 , C07D213/65 , C07D215/20 , C07D221/04
摘要： Disclosed are 1,3-Dioxoindene derivatives, pharmaceutically acceptable salts thereof or enantiomers, a preparation method thereof, and a pharmaceutical composition for the prevention or treatment of viral diseases, comprising the same as an active ingredient. The 1,3-Dioxoindene derivatives have excellent inhibitory activity against picornaviruses including coxsackie-, entero-, echo-, Polio-, and rhinoviruses, as well as exhibiting low cytotoxicity, so that they can be useful as an active ingredient of a pharmaceutical composition for the prevention or treatment of viral diseases including poliomyelitis, paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-and-mouth disease, vesicular disease, hepatitis A, myositis, myocarditis, pancreatitis, diabetes, epidemic myalgia, encephalitis, flu, herpangina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinusitis or otitis media.
摘要翻译：公开了1,3-二氧代茚衍生物，其药学上可接受的盐或对映异构体，其制备方法和用于预防或治疗病毒性疾病的药物组合物，其包含其作为活性成分。 1,3-二氧代茚衍生物对包括柯萨奇，肠，回波，脊髓灰质炎和鼻病毒在内的小核糖核酸病毒具有优异的抑制活性，并且具有低的细胞毒性，因此它们可用作药物组合物的活性成分用于预防或治疗包括脊髓灰质炎，麻痹，急性出血性结膜炎，病毒性脑膜炎，手足口病，囊泡病，甲型肝炎，肌炎，心肌炎，胰腺炎，糖尿病，流行性肌痛，脑炎，流感，麻疹，口蹄疫，哮喘，慢性阻塞性肺病，肺炎，鼻窦炎或中耳炎。

6. 发明授权

US08658616B2 Nucleoside aryl phosphoramidates and their use as anti-viral agents for the treatment of hepatitis C virus 失效
标题翻译：核苷芳基氨基磷酸酯及其作为抗病毒药物用于治疗丙型肝炎病毒的用途
公开(公告)号：US08658616B2
公开(公告)日：2014-02-25
申请号：US12516253
申请日：2007-11-23
申请人： Christopher McGuigan , Plinio Perrone , Johan Neyts
发明人： Christopher McGuigan , Plinio Perrone , Johan Neyts
IPC分类号： A61K31/70 , A01N43/04 , C07H19/167 , C07H19/173
CPC分类号： C07H19/20
摘要： Compounds having the general formula (I): are provided which have enhanced inhibitory potency and are thus useful in methods of prophylaxis or treatment of a viral infection such as hepatitis C virus. The compounds are phosphoramidate derivatives of nucleoside compounds derived from bases such as adenine and guanine. The glycoside moiety of the nucleoside compound can be substituted at the ss-2′ position with methyl and the phosphoramidate group can be 1-naphthyl linked by —O— to the P atom. These compounds can be administered as pharmaceutical compositions, and methods for their preparation are also provided.
摘要翻译：提供具有通式（I）的化合物，其具有增强的抑制效力，因此可用于预防或治疗病毒感染如丙型肝炎病毒的方法。这些化合物是衍生自诸如腺嘌呤和鸟嘌呤的碱的核苷化合物的氨基磷酸衍生物。核苷化合物的糖苷部分可以在β-2'位被甲基取代，氨基磷酸酯基可以通过-O-连接到P原子上的1-萘基。这些化合物可以作为药物组合物施用，并且还提供了它们的制备方法。

7. 发明申请

US20120022073A1 COMPOUND FOR THE TREATMENT OF ENTEROVIRUSES 有权
标题翻译：化合物治疗肠胃炎
公开(公告)号：US20120022073A1
公开(公告)日：2012-01-26
申请号：US13168263
申请日：2011-06-24
申请人： Johan Neyts , Armando De Palma , Hendrik Jan Thibaut , Pieter Leyssen , Simon Tucker
发明人： Johan Neyts , Armando De Palma , Hendrik Jan Thibaut , Pieter Leyssen , Simon Tucker
IPC分类号： A61K31/501 , A61P31/14 , A61P31/12
CPC分类号： A61K31/501 , A61K31/4184 , A61K31/422 , A61K31/506 , A61K45/06 , A61K2300/00 , Y02A50/465
摘要： The present invention relates to the treatment, alleviation, prevention or reduction in the incidence of symptoms, diseases or conditions resulting from or associated with enteroviruses, more particularly the enteroviral infections they cause.
摘要翻译：本发明涉及治疗，缓解，预防或减少由肠道病毒引起或与肠病毒相关的症状，疾病或病症的发生，特别是其引起的肠道病毒感染。

8. 发明授权

US07790730B2 Imidazo[4,5-d]pyrimidines, their uses and methods of preparation 有权
标题翻译：咪唑并[4,5-d]嘧啶，其用途和制备方法
公开(公告)号：US07790730B2
公开(公告)日：2010-09-07
申请号：US11190751
申请日：2005-07-26
申请人： Choung U. Kim , Johan Neyts , David A. Oare , Gerhard Puerstinger
发明人： Choung U. Kim , Johan Neyts , David A. Oare , Gerhard Puerstinger
IPC分类号： C07D473/02 , A61P31/14 , A61K31/52 , C07D471/04 , A61K31/4745 , C07D261/08
CPC分类号： C07D471/04 , C07D473/00 , C07D473/30
摘要： The present invention relates to pharmaceutical compositions for the treatment or prevention of viral infections comprising as an active principle at least one compound having the general formula (A): wherein U is N or C; X is selected from C1-C10 alkylene, C2-10 alkenylene or C2-10 alkynylene, where each may include one or more intrachain heteroatoms selected from O, S, or NR11, provided any such heteroatom is not adjacent to the N in the ring; R3 is selected from aryl, aryloxy, arylthio, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl-N(R10)—, or heterocycle, where each said substituent is optionally substituted with at least one R17, provided that for cycloalkenyl the double bond is not adjacent to a nitrogen; and the other substituents are described in the specification. The invention also relates to processes for the preparation of compounds according to the invention having above mentioned general formula, their pharmaceutically acceptable formulations and their use as a medicine or to treat or prevent viral infections.
摘要翻译：本发明涉及用于治疗或预防病毒感染的药物组合物，其包含至少一种具有通式（A）的化合物作为活性成分：其中U为N或C; X选自C1-C10亚烷基，C2-10亚烯基或C2-10亚炔基，其中每个可以包括一个或多个选自O，S或NR 11的链内杂原子，条件是任何这样的杂原子不与环中的N相邻 ; R 3选自芳基，芳氧基，芳硫基，环烷基，环烯基，环炔基，芳基-N（R 10） - 或杂环，其中每个所述取代基任选被至少一个R 17取代，条件是对于环烯基，双键不相邻到氮气并且其它取代基在说明书中描述。本发明还涉及制备具有上述通式的本发明化合物及其药学上可接受的制剂及其作为药物的用途或用于治疗或预防病毒感染的化合物的方法。

9. 发明申请

US20070128625A1 Drug-resistant mutants of hepatitis C virus 审中-公开
标题翻译：丙型肝炎病毒的耐药性突变体
公开(公告)号：US20070128625A1
公开(公告)日：2007-06-07
申请号：US11491756
申请日：2006-07-24
申请人： Nina Boddeker , Johan Neyts , I-Hung Shih , Inge Vliegen , Weidong Zhong
发明人： Nina Boddeker , Johan Neyts , I-Hung Shih , Inge Vliegen , Weidong Zhong
IPC分类号： C12Q1/70 , C12Q1/68
CPC分类号： C12Q1/707 , C12N7/00 , C12N2770/24211 , C12N2770/24222 , C12Q2600/156
摘要： The present invention provides nucleotides, peptides, HCV mutants, and cell lines containing mutations associated with drug resistance. In addition, the present invention provides methods for screening for therapeutic compounds capable of inhibiting HCV as well as methods for inhibiting HCV, e.g., by targeting specific binding sites associated with HCV drug resistance.
摘要翻译：本发明提供核苷酸，肽，HCV突变体和含有与耐药相关的突变的细胞系。此外，本发明提供了筛选能够抑制HCV的治疗化合物以及抑制HCV的方法的方法，例如通过靶向与HCV耐药性相关的特异性结合位点。

10. 发明授权

US09464067B2 Indanone derivatives, pharmaceutically acceptable salts or optical isomers thereof, preparation method for same, and pharmaceutical compositions containing same as active ingredient for preventing or treating viral diseases 有权
标题翻译：茚酮衍生物，其药学上可接受的盐或旋光异构体，其制备方法和含有作为预防或治疗病毒性疾病的活性成分的药物组合物
公开(公告)号：US09464067B2
公开(公告)日：2016-10-11
申请号：US14126485
申请日：2012-06-18
申请人： Young Sik Jung , Chong Kgo Lee , Hae Soo Kim , Hee Chun Jeong , Pil Ho Kim , Soo Bong Han , Jin Soo Shin , Johan Neyts , Hendrik Jan Thibaut
发明人： Young Sik Jung , Chong Kgo Lee , Hae Soo Kim , Hee Chun Jeong , Pil Ho Kim , Soo Bong Han , Jin Soo Shin , Johan Neyts , Hendrik Jan Thibaut
IPC分类号： C07D307/93 , C07D209/94 , C07D405/04 , C07D405/12 , C07D407/12 , C07D409/12 , C07D417/12 , C07D471/04 , C07D487/04
CPC分类号： C07D307/93 , C07C233/32 , C07D209/94 , C07D405/04 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/048 , C07F9/65517
摘要： Disclosed are indanone derivatives, pharmaceutically acceptable salts thereof or enantiomers, a preparation method thereof, and a pharmaceutical composition for the prevention or treatment of viral diseases, comprising the same as an active ingredient. The indanone derivatives have excellent inhibitory activity against picornaviruses including coxsackie-, entero-, echo-, Polio-, and rhinoviruses, as well as exhibiting low cytotoxicity, so that they can be useful as an active ingredient of a pharmaceutical composition for the prevention or treatment of viral diseases including poliomyelitis, paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-and-mouth disease, vesicular disease, hepatitis A, myositis, myocarditis, pancreatitis, diabetes, epidemic myalgia, encephalitis, cold, herpangina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinusitis or otitis media.
摘要翻译：公开了茚酮衍生物，其药学上可接受的盐或对映体，其制备方法和用于预防或治疗病毒性疾病的药物组合物，其包含其作为活性成分。茚酮衍生物对包括柯萨奇，肠反应，脊髓灰质炎和鼻病毒的小核糖核酸病毒具有优异的抑制活性，并且具有低的细胞毒性，因此它们可用作药物组合物的活性成分，用于预防或治疗包括脊髓灰质炎，麻痹，急性出血性结膜炎，病毒性脑膜炎，手足口病，囊泡病，甲型肝炎，肌炎，心肌炎，胰腺炎，糖尿病，流行性肌痛，脑炎，感冒，呼吸窘迫综合征，口腔疾病，哮喘，慢性阻塞性肺病，肺炎，鼻窦炎或中耳炎。

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