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1. 发明申请

US20110245198A1 ENHANCED TREATMENTS TO KILL OR DEBILITATE PATHOGENIC MICROORGANISMS OF A MAMMALIAN BODY 审中-公开
标题翻译：增强杀死或治疗哺乳动物体内致病微生物的治疗方法
公开(公告)号：US20110245198A1
公开(公告)日：2011-10-06
申请号：US12727383
申请日：2010-03-19
申请人： Nikolay Nifantiev , Gerhard D. Wieland
发明人： Nikolay Nifantiev , Gerhard D. Wieland
IPC分类号： A61K31/737 , A61P31/04 , A61M37/00
CPC分类号： A61K31/715 , A61K41/0019 , A61K41/0038
摘要： Present invention relates to a composition of matter and a method that improves treatments to inactivate, kill and debilitate pathogenic microorganisms that infect on or within a mammal body, such as Helicobacter pylori. The composition of matter comprises anti-adhesive polysaccharide molecules to abolish or reduce the adhesion of H. pylori to themselves and to gastric mucin without affecting the viability of either bacteria or gastric epithelial cells. Polysaccharides isolated from seaweed are preferred anti-adhesive materials and fucoidans is a most preferred embodiment. To facilitate bacteria eradication, methods include the administration of fucoidans before, during and/or after other killing and destroying physical or chemical therapy. The inhibition or impairment of the mechanism of bacterial adhesion due to the treatment with fucoidans is aimed to diminish colonization and pathogenesis of pathogenic bacteria by making them more fragile or susceptible to killing or destroying therapies. The combined use of fucoidans with PDT is a preferred method to eradicate H. Pylori in the gastrointestinal tract.
摘要翻译：本发明涉及一种物质组合物和一种改善对哺乳动物体内如感染幽门螺杆菌或感染的致病微生物灭活，杀死和衰弱的治疗方法。物质的组成包括抗粘多糖分子以消除或减少幽门螺杆菌对其自身和胃粘蛋白的粘附，而不影响细菌或胃上皮细胞的活力。从海藻中分离的多糖是优选的抗粘剂材料，岩藻聚糖是最优选的实施方案。为了促进细菌根除，方法包括在其他杀伤和破坏物理或化学疗法之前，期间和/或之后施用岩藻多糖。由于用岩藻多糖处理引起的细菌粘附机制的抑制或损伤旨在通过使其变得更脆弱或易于杀死或破坏治疗来减少致病细菌的定植和发病。岩藻多糖与PDT的组合使用是消除胃肠道幽门螺杆菌的优选方法。

2. 发明授权

US08753807B2 Method for microbes depletion in human blood or full serum using antimicrobial photodynamic laser therapy 有权
标题翻译：使用抗微生物光动力激光治疗人血液或全血清微生物消耗的方法
公开(公告)号：US08753807B2
公开(公告)日：2014-06-17
申请号：US13375799
申请日：2010-06-02
申请人： Gerhard D. Wieland , Albrecht Volker , Karl-Heinz Völpel , Burkhard Gitter
发明人： Gerhard D. Wieland , Albrecht Volker , Karl-Heinz Völpel , Burkhard Gitter
IPC分类号： A01N1/02
CPC分类号： A61L2/0076 , A61L2202/22 , A61M1/0272 , A61M1/3683 , A61M1/3686
摘要： Treatment methods/devices are provided for attenuating/inactivating the pathogenic microbes found in biological fluids e.g. blood/blood products including human single-donor-fresh-frozen-plasma, platelet concentrate, red blood cells, blood clotting factors. An Antimicrobial Photodynamic Therapy method is used to eliminate multiple (resistant) bacteria, viral agents, fungi, parasites and other undetected or non-easily detected pathogenic microbes or particles in blood and blood products without affecting their biological properties. Resistant bacteria are difficult to be eliminated. This is especially true in the case for S. aureus and related strains, Staphylococcus epidermidis or Propionibacterium acnes, Borrelia species and other bacteria found on skin. Further embodiments eliminate undetected or non-easily detected viral agents contaminating blood/blood products responsible for spreading hepatitis, Acquired ImmunoDeficiency Syndrome and other blood borne viral diseases. Human Immunodeficiency, hepatitis B and hepatitis C viruses have emerged as major blood borne infections. Numerous parasites transmitted through bloods and derived products are also eliminated by these processes/devices.
摘要翻译：提供治疗方法/装置用于减弱/灭活生物流体中发现的致病微生物，例如血液/血液制品包括人类单供体 - 新鲜冷冻血浆，血小板浓缩物，红细胞，凝血因子。抗菌光动力治疗方法用于消除血液和血液制品中的多种（抗性）细菌，病毒剂，真菌，寄生虫和其他未检出或非易感的致病微生物或颗粒，而不影响其生物学性质。抗性细菌难以消除。在金黄色葡萄球菌和相关菌株，表皮葡萄球菌或痤疮丙酸杆菌，疏螺旋体属和皮肤上发现的其他细菌的情况下尤其如此。进一步的实施方案消除污染负责传播肝炎的血液/血液制品的未检测到的或非易于检测的病毒剂，获得性免疫缺陷综合征和其他血液传播的病毒性疾病。人类免疫缺陷病毒，乙型肝炎和丙型肝炎病毒已经成为主要的血源性感染。这些过程/装置也消除了通过血液和衍生产物传播的许多寄生虫。

3. 发明申请

US20120094269A1 Novel method for microbes depletion in human blood or full serum using antimicrobial photodynamic laser therapy 有权
标题翻译：使用抗微生物光动力激光治疗人类血液或全血清微生物消耗的新方法
公开(公告)号：US20120094269A1
公开(公告)日：2012-04-19
申请号：US13375799
申请日：2010-06-02
申请人： Gerhard D. Wieland , Albrecht Volker , Karl-Heinz Völpel , Burkhard Gitter
发明人： Gerhard D. Wieland , Albrecht Volker , Karl-Heinz Völpel , Burkhard Gitter
IPC分类号： A01N1/02 , C12M1/42
CPC分类号： A61L2/0076 , A61L2202/22 , A61M1/0272 , A61M1/3683 , A61M1/3686
摘要： Treatment methods/devices are provided for attenuating/inactivating the pathogenic microbes found in biological fluids e.g. blood/blood products including human single-donor-fresh-frozen-plasma, platelet concentrate, red blood cells, blood clotting factors. An Antimicrobial Photodynamic Therapy method is used to eliminate multiple (resistant) bacteria, viral agents, fungi, parasites and other undetected or non-easily detected pathogenic microbes or particles in blood and blood products without affecting their biological properties. Resistant bacteria are difficult to be eliminated. This is especially true in the case for S. aureus and related strains, Staphylococcus epidermidis or Propionibacterium acnes, Borrelia species and other bacteria found on skin. Further embodiments eliminate undetected or non-easily detected viral agents contaminating blood/blood products responsible for spreading hepatitis, Acquired ImmunoDeficiency Syndrome and other blood borne viral diseases. Human Immunodeficiency, hepatitis B and hepatitis C viruses have emerged as major blood borne infections. Numerous parasites transmitted through bloods and derived products are also eliminated by these processes/devices.
摘要翻译：提供治疗方法/装置用于减弱/灭活生物流体中发现的致病微生物，例如血液/血液制品包括人类单供体 - 新鲜冷冻血浆，血小板浓缩物，红细胞，凝血因子。抗菌光动力治疗方法用于消除血液和血液制品中的多种（抗性）细菌，病毒剂，真菌，寄生虫和其他未检出或非易感的致病微生物或颗粒，而不影响其生物学性质。抗性细菌难以消除。在金黄色葡萄球菌和相关菌株，表皮葡萄球菌或痤疮丙酸杆菌，疏螺旋体属和皮肤上发现的其他细菌的情况下尤其如此。进一步的实施方案消除污染负责传播肝炎的血液/血液制品的未检测到的或非易于检测的病毒剂，获得性免疫缺陷综合征和其他血液传播的病毒性疾病。人类免疫缺陷病毒，乙型肝炎和丙型肝炎病毒已经成为主要的血源性感染。这些过程/装置也消除了通过血液和衍生产物传播的许多寄生虫。

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