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1. 发明申请

US20090241964A1 METHODS AND DEVICES FOR PASSIVE RESIDUAL LUNG VOLUME REDUCTION AND FUNCTIONAL LUNG VOLUME EXPANSION 有权
标题翻译：被动残余肺容量减少和功能肺容量扩张的方法和装置
公开(公告)号：US20090241964A1
公开(公告)日：2009-10-01
申请号：US12407709
申请日：2009-03-19
申请人： Nikolai Aljuri , Rodney C. Perkins , Ryan Olivera , Hoang Nguyen , Sri Radhakrishnan , Niyazi Beyhan
发明人： Nikolai Aljuri , Rodney C. Perkins , Ryan Olivera , Hoang Nguyen , Sri Radhakrishnan , Niyazi Beyhan
IPC分类号： A61M16/00
CPC分类号： A61M16/0434 , A61B1/2676 , A61B5/0084 , A61B5/08 , A61B5/4836 , A61B17/12104 , A61B17/12136 , A61F2002/043 , A61M16/0003 , A61M16/0436 , A61M16/208 , A61M25/10 , A61M2016/0027 , A61M2016/003 , A61M2025/1052 , A61M2202/0208 , A61M2205/3334 , A61M2207/10 , Y10T29/49826
摘要： The volume of a hyperinflated lung compartment is reduced by sealing a distal end of the catheter in an airway feeding the lung compartment. Air passes out of the lung compartment through a passage in the catheter while the patient exhales. A one-way flow element associated with the catheter prevents air from re-entering the lung compartment as the patient inhales. Over time, the pressure of regions surrounding the lung compartment cause it to collapse as the volume of air diminishes. Residual volume reduction effectively results in functional lung volume expansion. Optionally, the lung compartment may be sealed in order to permanently prevent air from re-entering the lung compartment. The invention further discloses a catheter with a transparent occlusion element at its tip that enables examination of the lung passageway through a viewing scope.
摘要翻译：通过在进入肺隔室的气道中密封导管的远端来减少超膨胀的肺隔室的体积。当患者呼气时，空气通过导管中的通道从肺隔间通过。与导管相关联的单向流动元件防止空气在患者吸入时再次进入肺隔室。随着时间的推移，随着空气体积的减小，肺室周围的区域压力会使其崩溃。残余体积减少有效地导致功能性肺容积扩张。任选地，肺隔室可以被密封以便永久地防止空气重新进入肺隔室。本发明还公开了一种在其顶端具有透明阻塞元件的导管，其能够通过观察范围检查肺通道。

2. 发明授权

US09050094B2 Methods and devices for passive residual lung volume reduction and functional lung volume expansion 有权
标题翻译：被动残余肺容积减少和功能性肺容积扩张的方法和装置
公开(公告)号：US09050094B2
公开(公告)日：2015-06-09
申请号：US12407709
申请日：2009-03-19
申请人： Nikolai Aljuri , Rodney C. Perkins , Ryan Olivera , Hoang Nguyen , Sri Radhakrishnan , Niyazi Beyhan
发明人： Nikolai Aljuri , Rodney C. Perkins , Ryan Olivera , Hoang Nguyen , Sri Radhakrishnan , Niyazi Beyhan
IPC分类号： A61M16/00 , A61B17/12 , A61M16/04 , A61M25/10
CPC分类号： A61M16/0434 , A61B1/2676 , A61B5/0084 , A61B5/08 , A61B5/4836 , A61B17/12104 , A61B17/12136 , A61F2002/043 , A61M16/0003 , A61M16/0436 , A61M16/208 , A61M25/10 , A61M2016/0027 , A61M2016/003 , A61M2025/1052 , A61M2202/0208 , A61M2205/3334 , A61M2207/10 , Y10T29/49826
摘要： The volume of a hyperinflated lung compartment is reduced by sealing a distal end of the catheter in an airway feeding the lung compartment. Air passes out of the lung compartment through a passage in the catheter while the patient exhales. A one-way flow element associated with the catheter prevents air from re-entering the lung compartment as the patient inhales. Over time, the pressure of regions surrounding the lung compartment cause it to collapse as the volume of air diminishes. Residual volume reduction effectively results in functional lung volume expansion. Optionally, the lung compartment may be sealed in order to permanently prevent air from re-entering the lung compartment. The invention further discloses a catheter with a transparent occlusion element at its tip that enables examination of the lung passageway through a viewing scope.
摘要翻译：通过在进入肺隔室的气道中密封导管的远端来减少超膨胀的肺隔室的体积。当患者呼气时，空气通过导管中的通道从肺隔间通过。与导管相关联的单向流动元件防止空气在患者吸入时再次进入肺隔室。随着时间的推移，随着空气体积的减小，肺室周围的区域压力会使其崩溃。残余体积减少有效地导致功能性肺容积扩张。任选地，肺隔室可以被密封以便永久地防止空气重新进入肺隔室。本发明还公开了一种在其顶端具有透明阻塞元件的导管，其能够通过观察范围检查肺通道。

3. 发明授权

US08496006B2 Methods and devices for passive residual lung volume reduction and functional lung volume expansion 有权
标题翻译：被动残余肺容积减少和功能性肺容积扩张的方法和装置
公开(公告)号：US08496006B2
公开(公告)日：2013-07-30
申请号：US12820547
申请日：2010-06-22
申请人： Nikolai Aljuri , Rodney C. Perkins , Niyazi Beyhan
发明人： Nikolai Aljuri , Rodney C. Perkins , Niyazi Beyhan
IPC分类号： A61M16/04 , A61M16/20 , A61M39/22 , A61B5/08
CPC分类号： A61B17/12104 , A61B5/055 , A61B5/08 , A61B5/0813 , A61B5/085 , A61B5/6853 , A61B6/03 , A61B6/032 , A61B17/1204 , A61B17/12136 , A61B2017/00022 , A61M16/0434 , A61M16/208 , A61M25/10 , A61M2016/0027 , A61M2016/003 , A61M2025/1052 , A61M2205/3303 , A61M2205/3334 , A61M2205/3344 , A61M2210/1035 , A61M2230/46
摘要： The volume of a hyperinflated lung compartment is reduced by sealing a distal end of the catheter in an airway feeding the lung compartment. Air passes out of the lung compartment through a passage in the catheter while the patient exhales. A one-way flow element associated with the catheter prevents air from re-entering the lung compartment as the patient inhales. Over time, the pressure of regions surrounding the lung compartment cause it to collapse as the volume of air diminishes. Residual volume reduction effectively results in functional lung volume expansion. Optionally, the lung compartment may be sealed in order to permanently prevent air from re-entering the lung compartment.
摘要翻译：通过在进入肺隔室的气道中密封导管的远端来减少超膨胀的肺隔室的体积。当患者呼气时，空气通过导管中的通道从肺隔间通过。与导管相关联的单向流动元件防止空气在患者吸入时再次进入肺隔室。随着时间的推移，随着空气体积的减小，肺室周围的区域压力会使其崩溃。残余体积减少有效地导致功能性肺容积扩张。任选地，肺隔室可以被密封以便永久地防止空气重新进入肺隔室。

4. 发明申请

US20110152678A1 METHODS AND DEVICES FOR PASSIVE RESIDUAL LUNG VOLUME REDUCTION AND FUNCTIONAL LUNG VOLUME EXPANSION 有权
标题翻译：被动残余肺容量减少和功能肺容量扩张的方法和装置
公开(公告)号：US20110152678A1
公开(公告)日：2011-06-23
申请号：US12820547
申请日：2010-06-22
申请人： Nikolai Aljuri , Rodney C. Perkins , Niyazi Beyhan
发明人： Nikolai Aljuri , Rodney C. Perkins , Niyazi Beyhan
IPC分类号： A61M16/00 , A61B6/03
CPC分类号： A61B17/12104 , A61B5/055 , A61B5/08 , A61B5/0813 , A61B5/085 , A61B5/6853 , A61B6/03 , A61B6/032 , A61B17/1204 , A61B17/12136 , A61B2017/00022 , A61M16/0434 , A61M16/208 , A61M25/10 , A61M2016/0027 , A61M2016/003 , A61M2025/1052 , A61M2205/3303 , A61M2205/3334 , A61M2205/3344 , A61M2210/1035 , A61M2230/46
摘要： The volume of a hyperinflated lung compartment is reduced by sealing a distal end of the catheter in an airway feeding the lung compartment. Air passes out of the lung compartment through a passage in the catheter while the patient exhales. A one-way flow element associated with the catheter prevents air from re-entering the lung compartment as the patient inhales. Over time, the pressure of regions surrounding the lung compartment cause it to collapse as the volume of air diminishes. Residual volume reduction effectively results in functional lung volume expansion. Optionally, the lung compartment may be sealed in order to permanently prevent air from re-entering the lung compartment.
摘要翻译：通过在进入肺隔室的气道中密封导管的远端来减少超膨胀的肺隔室的体积。当患者呼气时，空气通过导管中的通道从肺隔间通过。与导管相关联的单向流动元件防止空气在患者吸入时再次进入肺隔室。随着时间的推移，随着空气体积的减小，肺室周围的区域压力会使其崩溃。残余体积减少有效地导致功能性肺容积扩张。任选地，肺隔室可以被密封以便永久地防止空气重新进入肺隔室。

5. 发明申请

US20100158795A1 METHODS AND SYSTEMS FOR ASSESSING LUNG FUNCTION AND DELIVERING THERAPEUTIC AGENTS 审中-公开
标题翻译：用于评估肺功能和递送治疗药物的方法和系统
公开(公告)号：US20100158795A1
公开(公告)日：2010-06-24
申请号：US12474169
申请日：2009-05-28
申请人： Nikolai Aljuri , Niyazi Beyhan
发明人： Nikolai Aljuri , Niyazi Beyhan
IPC分类号： A61K33/00 , A61K51/00 , A61B5/08
CPC分类号： A61B5/0833 , A61B5/14542 , A61B5/4839 , A61M16/04 , A61M2016/0413 , A61M2025/1052 , A61M2210/1039
摘要： Methods and systems for isolating, assessing and treating lung compartments are disclosed. One or more lung compartments are accessed through an isolation catheter, oxygen rich gas is delivered to the compartments, and blood oxygen or exhaled carbon dioxide are monitored to assess lung compartment function. Diseased lung compartments may be treated using therapeutic agents delivered to the diseased compartments through the isolation catheter. Therapeutic agents include carbon monoxide, radioactive agents, chemotherapeutic agents or angiogenesis inhibitors and angiocidal agents.
摘要翻译：公开了用于分离，评估和治疗肺隔室的方法和系统。通过隔离导管接近一个或多个肺隔间，将富氧气体输送到隔室，并监测血氧或呼出的二氧化碳以评估肺隔室功能。可以使用通过隔离导管递送到患病隔室的治疗剂来治疗疾病的肺隔室。治疗剂包括一氧化碳，放射剂，化学治疗剂或血管生成抑制剂和抗血栓形成剂。

6. 发明申请

US20110295141A1 METHODS AND SYSTEMS FOR ENDOBRONCHIAL DIAGNOSTICS 审中-公开
标题翻译：内分泌诊断的方法与系统
公开(公告)号：US20110295141A1
公开(公告)日：2011-12-01
申请号：US12954499
申请日：2010-11-24
申请人： Srikanth Radhakrishnan , Ryan Olivera , Niyazi Beyhan , Surag Mantri , Lutz Freitag
发明人： Srikanth Radhakrishnan , Ryan Olivera , Niyazi Beyhan , Surag Mantri , Lutz Freitag
IPC分类号： A61B5/08
CPC分类号： A61B5/082
摘要： A method for assessing lung function in a patient is disclosed. The method comprises isolating a lung compartment. Thereafter, in one embodiment, an inhaled gas of known composition is introduced into the lung and compared to the composition of the exhaled gas. Alternatively, accumulated CO2 content is measured within the isolated lung compartment over time, and compared to a baseline CO2 content. Alternatively, a change in pressure of an isolated lung compartment may be monitored. Alternatively, the magnitude of the range of CO2 values in an isolated lung compartment can be compared to a predetermined threshold. Any of the results obtained via these alternative embodiments may be used to determine lung function.
摘要翻译：公开了一种用于评估患者的肺功能的方法。该方法包括分离肺隔室。此后，在一个实施方案中，将已知组合物的吸入气体引入肺中并与呼出气体的组成进行比较。或者，随着时间的推移在隔离的肺隔室内测量累积的CO 2含量，并与基线CO 2含量进行比较。或者，可以监测隔离的肺隔室的压力变化。或者，可以将隔离的肺隔室中的CO 2值的范围的大小与预定阈值进行比较。通过这些替代实施方案获得的任何结果可用于确定肺功能。

7. 发明申请

US20100152616A1 DEVICES AND METHODS FOR SAFELY ACCESSING BONE MARROW AND OTHER TISSUES 审中-公开
标题翻译：用于安全地接受骨髓和其他组织的装置和方法
公开(公告)号：US20100152616A1
公开(公告)日：2010-06-17
申请号：US12699847
申请日：2010-02-03
申请人： Niyazi Beyhan , Surag Mantri , Hoang Nguyen
发明人： Niyazi Beyhan , Surag Mantri , Hoang Nguyen
IPC分类号： A61B10/00
CPC分类号： A61B10/025
摘要： A device for safely accessing bone marrow and other tissues is disclosed. Such device comprises a needle assembly, a sensor mechanism, and an actuator configured to engage with the needle assembly via the sensor mechanism to advance a tissue penetrable needle through a first tissue region and into a second tissue region. In one aspect, the first tissue region is a bone cortex and the second tissue region is a bone marrow cavity. The sensor mechanism is configured to disengage the actuator from the needle once the needle has crossed the first tissue region (e.g., bone cortex) into the second tissue region (e.g., bone marrow cavity), thereby preventing the needle from advancing further into the second tissue region. In one aspect, the sensor mechanism is mechanical and comprises a pin assembly comprising a spring-loaded pin that extends through the needle. The pin assembly is configured such that advancement of the distal tip of the spring-loaded pin past the distal tip of the needle causes the actuator to disengage from the needle. The actuator is a rotatable actuator. A catheter-based embodiment of the device can be inserted in body passageways to access tissue internally within the body.
摘要翻译：公开了一种用于安全进入骨髓和其他组织的装置。这种装置包括针组件，传感器机构和致动器，其构造成经由传感器机构与针组件接合，以将组织穿透针推进穿过第一组织区域并进入第二组织区域。在一个方面，第一组织区域是骨皮质，第二组织区域是骨髓腔。一旦针已经穿过第一组织区域（例如，骨皮质）进入第二组织区域（例如，骨髓腔），传感器机构构造成使致动器与针脱离，从而防止针进一步进入第二组织区域组织区域。在一个方面，传感器机构是机械的并且包括销组件，其包括延伸穿过针的弹簧加载销。销组件被构造成使得弹簧加载的销的远端顶端超过针的远端使得致动器与针脱离。致动器是可旋转的致动器。该装置的基于导管的实施例可以插入身体通道中以在体内内部进入组织。

8. 发明申请

US20120065651A1 GASTRO-INTESTINLAL COMPRESSION DEVICE 有权
标题翻译： GASTRO-INTESTINLAL压缩装置
公开(公告)号：US20120065651A1
公开(公告)日：2012-03-15
申请号：US13186429
申请日：2011-07-19
申请人： Surag Mantri , Hoang Nguyen , Niyazi Beyhan
发明人： Surag Mantri , Hoang Nguyen , Niyazi Beyhan
IPC分类号： A61B17/11
CPC分类号： A61B17/1114 , A61B2017/00818 , A61B2017/1132 , A61F5/0076 , A61F2002/044 , A61F2002/045
摘要： Devices, methods, and systems for treating Type-2 Diabetes and/or obesity by facilitating the delivery of under-digested nutrients within the gastro-intestinal tract without substantial tissue removal are disclosed. In one aspect, the gastro-intestinal tract of a patient is modified by a gastro-intestinal treatment device comprising an elongate element configured to extend within the gastro-intestinal tract, a first attachment element and a second attachment element disposed on the elongate element, wherein the first attachment element and the second attachment element are configured to attach to the gastro-intestinal tract such that a portion of the gastro-intestinal tract is compressed between the first and the second attachment elements. The length of the gastro-intestinal tract modified by the device is effectively shortened, and its surface area is reduced.
摘要翻译：公开了通过促进胃肠道内消化不良的营养物质的递送而不需要大量去除组织来治疗2型糖尿病和/或肥胖症的装置，方法和系统。在一个方面，患者的胃肠道由胃肠治疗装置改变，所述胃肠治疗装置包括构造成在胃肠道内延伸的细长元件，设置在细长元件上的第一附接元件和第二附接元件，其中所述第一附接元件和所述第二附接元件构造成附接到胃肠道，使得胃肠道的一部分在第一和第二附接元件之间被压缩。通过该装置修改的胃肠道的长度被有效地缩短，并且其表面积减小。

9. 发明申请

US20100036361A1 SYSTEM AND METHOD FOR DELIVERING MULTIPLE IMPLANTS INTO LUNG PASSAGEWAYS 审中-公开
标题翻译：将多个植入物输送到肺内穿孔的系统和方法
公开(公告)号：US20100036361A1
公开(公告)日：2010-02-11
申请号：US12474179
申请日：2009-05-28
申请人： Hoang Nguyen , Niyazi Beyhan , Son Gia
发明人： Hoang Nguyen , Niyazi Beyhan , Son Gia
IPC分类号： A61M31/00 , A61M5/315
CPC分类号： A61B17/12022 , A61B17/12104 , A61B17/12131 , A61B2090/034 , A61M37/0069
摘要： A system for delivering multiple implants into lung passageways is disclosed. The system comprises a catheter configured to receive and store a plurality of expandable implants, and an actuatable delivery tool coupled to the proximal end of the catheter. The system expels an implant of the plurality of implants with each actuation of the delivery tool. The delivery tool comprises a plunger element which extends through the catheter from the proximal to the distal end and allows the delivery tool to mechanically communicate with the implants. In one embodiment, the system comprises a spring-loaded slidable element, and a user compresses the slidable element to actuate the delivery tool. In another embodiment, the system comprises a rotation rod, and the user moves the rotation rod in a distal direction to actuate the delivery tool.
摘要翻译：公开了一种用于将多个植入物输送到肺通道中的系统。该系统包括被配置为接收和存储多个可扩展植入物的导管，以及联接到导管的近端的可致动输送工具。该系统通过递送工具的每次致动来排出多个植入物的植入物。递送工具包括柱塞元件，该柱塞元件从近端延伸到远端并允许输送工具与植入物机械连通。在一个实施例中，系统包括弹簧加载的可滑动元件，并且使用者压缩可滑动元件以致动输送工具。在另一个实施例中，系统包括旋转杆，并且使用者沿远侧方向移动旋转杆以致动输送工具。

10. 发明授权

US08870807B2 Gastro-intestinal compression device 有权
标题翻译：胃肠压缩装置
公开(公告)号：US08870807B2
公开(公告)日：2014-10-28
申请号：US13186429
申请日：2011-07-19
申请人： Surag Mantri , Hoang Nguyen , Niyazi Beyhan
发明人： Surag Mantri , Hoang Nguyen , Niyazi Beyhan
IPC分类号： A61F2/04 , A61M5/00 , A61B17/11 , A61F5/00 , A61B17/00
CPC分类号： A61B17/1114 , A61B2017/00818 , A61B2017/1132 , A61F5/0076 , A61F2002/044 , A61F2002/045
摘要： Devices, methods, and systems for treating Type-2 Diabetes and/or obesity by facilitating the delivery of under-digested nutrients within the gastro-intestinal tract without substantial tissue removal are disclosed. In one aspect, the gastro-intestinal tract of a patient is modified by a gastro-intestinal treatment device comprising an elongate element configured to extend within the gastro-intestinal tract, a first attachment element and a second attachment element disposed on the elongate element, wherein the first attachment element and the second attachment element are configured to attach to the gastro-intestinal tract such that a portion of the gastro-intestinal tract is compressed between the first and the second attachment elements. The length of the gastro-intestinal tract modified by the device is effectively shortened, and its surface area is reduced.
摘要翻译：公开了通过促进胃肠道内消化不良的营养物质的递送而不需要大量去除组织来治疗2型糖尿病和/或肥胖症的装置，方法和系统。在一个方面，患者的胃肠道由胃肠治疗装置改变，所述胃肠治疗装置包括构造成在胃肠道内延伸的细长元件，设置在细长元件上的第一附接元件和第二附接元件，其中所述第一附接元件和所述第二附接元件构造成附接到胃肠道，使得胃肠道的一部分在第一和第二附接元件之间被压缩。通过该装置修改的胃肠道的长度被有效地缩短，并且其表面积减小。

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