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1. 发明申请

US20130035363A1 Thalidomide Analogs 有权
标题翻译：沙利度胺类似物
公开(公告)号：US20130035363A1
公开(公告)日：2013-02-07
申请号：US13648625
申请日：2012-10-10
申请人： Nigel H. Greig , Harold Holloway , Arnold Brossi , Xiaoxiang Zhu , Tony Giordano , Qian-sheng Yu , William D. Figg
发明人： Nigel H. Greig , Harold Holloway , Arnold Brossi , Xiaoxiang Zhu , Tony Giordano , Qian-sheng Yu , William D. Figg
IPC分类号： A61K31/4035 , A61P3/04 , A61P19/02 , A61P31/04 , A61P1/00 , A61P35/00 , A61P25/00 , A61P25/28 , A61P25/16 , A61P7/04 , A61P27/02 , A61P29/00 , A61P1/04
CPC分类号： H04M1/72522 , C07D209/44 , G06F3/01 , G06F3/0346 , H04M2250/12 , H04M2250/22 , H04M2250/74
摘要： Thalidomide analogs that modulate tumor necrosis factor alpha (TNFα) activity and angiogenesis are disclosed. In particularly disclosed embodiments, the thalidomide analogs are isosteric sulfur-containing analogs. Also disclosed are methods of treating a subject with the analogs.
摘要翻译：公开了调节肿瘤坏死因子α（TNFα）活性和血管生成的沙利度胺类似物。在特别公开的实施方案中，沙利度胺类似物是等熵含硫类似物。还公开了用类似物治疗受试者的方法。

2. 发明授权

US07973057B2 Thalidomide analogs 有权
标题翻译：沙利度胺类似物
公开(公告)号：US07973057B2
公开(公告)日：2011-07-05
申请号：US10572485
申请日：2004-09-17
申请人： Nigel H. Greig , Harold Holloway , Arnold Brossi , Xiaoxiang Zhu , Tony Giordano , Qian-sheng Yu , William D. Figg
发明人： Nigel H. Greig , Harold Holloway , Arnold Brossi , Xiaoxiang Zhu , Tony Giordano , Qian-sheng Yu , William D. Figg
IPC分类号： A01N43/40 , A61K31/445
CPC分类号： C07D209/44 , C07D209/46 , C07D211/84 , C07D211/86 , C07D211/88 , C07D401/04 , C07D413/04 , C07D471/04
摘要： Thalidomide analogs that modulate tumor necrosis factor alpha (TNF-α) activity and angiogenesis are disclosed. In particularly disclosed embodiments, the thalidomide analogs are isosteric sulfur-containing analogs. Also disclosed are methods of treating a subject with the analogs.
摘要翻译：公开了调节肿瘤坏死因子α（TNF-α）活性和血管发生的沙利度胺类似物。在特别公开的实施方案中，沙利度胺类似物是等熵含硫类似物。还公开了用类似物治疗受试者的方法。

3. 发明授权

US08546430B2 Thalidomide analogs 有权
标题翻译：沙利度胺类似物
公开(公告)号：US08546430B2
公开(公告)日：2013-10-01
申请号：US13153355
申请日：2011-06-03
申请人： Nigel H. Greig , Harold Holloway , Arnold Brossi , Xiaoxiang Zhu , Tony Giordano , Qian-sheng Yu , William D. Figg
发明人： Nigel H. Greig , Harold Holloway , Arnold Brossi , Xiaoxiang Zhu , Tony Giordano , Qian-sheng Yu , William D. Figg
IPC分类号： A01N43/40 , A61K31/445
CPC分类号： C07D209/44 , C07D209/46 , C07D211/84 , C07D211/86 , C07D211/88 , C07D401/04 , C07D413/04 , C07D471/04
摘要： Thalidomide analogs that modulate tumor necrosis factor alpha (TNF-α) activity and angiogenesis are disclosed. In particularly disclosed embodiments, the thalidomide analogs are isosteric sulfur-containing analogs. Also disclosed are methods of treating a subject with the analogs.
摘要翻译：公开了调节肿瘤坏死因子α（TNF-α）活性和血管生成的沙利度胺类似物。在特别公开的实施方案中，沙利度胺类似物是等熵含硫类似物。还公开了用类似物治疗受试者的方法。

4. 发明申请

US20110245210A1 THALIDOMIDE ANALOGS 有权
标题翻译：噻吗啉类似物
公开(公告)号：US20110245210A1
公开(公告)日：2011-10-06
申请号：US13153355
申请日：2011-06-03
申请人： Nigel H. Greig , Harold Holloway , Arnold Brossi , Xiaoxiang Zhu , Tony Giordano , Qian-sheng Yu , William D. Figg
发明人： Nigel H. Greig , Harold Holloway , Arnold Brossi , Xiaoxiang Zhu , Tony Giordano , Qian-sheng Yu , William D. Figg
IPC分类号： A61K31/625 , A61K31/4439 , C07D401/04 , A61K31/437 , C07D471/04 , A61K31/538 , C07D413/04 , C07D211/88 , A61K31/4035 , C07D209/50 , A61P35/00
CPC分类号： C07D209/44 , C07D209/46 , C07D211/84 , C07D211/86 , C07D211/88 , C07D401/04 , C07D413/04 , C07D471/04
摘要： Thalidomide analogs that modulate tumor necrosis factor alpha (TNF-α) activity and angiogenesis are disclosed. In particularly disclosed embodiments, the thalidomide analogs are isosteric sulfur-containing analogs. Also disclosed are methods of treating a subject with the analogs.
摘要翻译：公开了调节肿瘤坏死因子α（TNF-α）活性和血管发生的沙利度胺类似物。在特别公开的实施方案中，沙利度胺类似物是同基性含硫类似物。还公开了用类似物治疗受试者的方法。

5. 发明授权

US08853253B2 Thalidomide analogs 有权
标题翻译：沙利度胺类似物
公开(公告)号：US08853253B2
公开(公告)日：2014-10-07
申请号：US13648625
申请日：2012-10-10
申请人： Nigel H. Greig , Harold Holloway , Tony Giordano , Qian-sheng Yu , William D. Figg
发明人： Nigel H. Greig , Harold Holloway , Arnold Brossi , Xiaoxiang Zhu , Tony Giordano , Qian-sheng Yu , William D. Figg
IPC分类号： A61K31/40
CPC分类号： H04M1/72522 , C07D209/44 , G06F3/01 , G06F3/0346 , H04M2250/12 , H04M2250/22 , H04M2250/74
摘要： Thalidomide analogs that modulate tumor necrosis factor alpha (TNFα) activity and angiogenesis are disclosed. In particularly disclosed embodiments, the thalidomide analogs are isosteric sulfur-containing analogs. Also disclosed are methods of treating a subject with the analogs.
摘要翻译：公开了调节肿瘤坏死因子α（TNFα）活性和血管生成的沙利度胺类似物。在特别公开的实施方案中，沙利度胺类似物是等熵含硫类似物。还公开了用类似物治疗受试者的方法。

6. 发明申请

US20060211728A1 Thalidomide analogs 有权
公开(公告)号：US20060211728A1
公开(公告)日：2006-09-21
申请号：US10572485
申请日：2004-09-17
申请人： Nigel Greig , Harold Holloway , Arnold Brossi , Xiaoxiang Zhu , Tony Giordano , Qian-sheng Yu , William Figg
发明人： Nigel Greig , Harold Holloway , Arnold Brossi , Xiaoxiang Zhu , Tony Giordano , Qian-sheng Yu , William Figg
IPC分类号： A61K31/4745 , A61K31/4709 , A61K31/454 , A61K31/4439 , C07D403/02
CPC分类号： C07D209/44 , C07D209/46 , C07D211/84 , C07D211/86 , C07D211/88 , C07D401/04 , C07D413/04 , C07D471/04
摘要： Thalidomide analogs that modulate tumor necrosis factor alpha (TNF-α) activity and angiogenesis are disclosed. In particularly disclosed embodiments, the thalidomide analogs are isosteric sulfur-containing analogs. Also disclosed are methods of treating a subject with the analogs.

7. 发明授权

US6107029A Universal method for detecting interactions between RNA molecules and RNA binding proteins 失效
标题翻译：用于检测RNA分子和RNA结合蛋白之间的相互作用的通用方法
公开(公告)号：US6107029A
公开(公告)日：2000-08-22
申请号：US690010
申请日：1996-07-31
申请人： Tony Giordano
发明人： Tony Giordano
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/68 , C12N15/00
CPC分类号： G01N33/5023 , C12Q1/68 , G01N33/5308 , G01N33/68 , C12Q1/6811 , G01N2500/02 , Y10S435/81
摘要： It has been discovered that a single set of conditions can be used to detect nearly every interaction of RNA binding proteins and RNA molecules. Prior to this discovery it was thought that each specific interaction required separate optimized conditions in order to be detected. Assays employing the disclosed universal conditions are useful for identifying RNA binding proteins that interact with specific RNA molecules of interest, detecting RNA molecules that interact with specific RNA binding proteins of interest, identifying RNA binding proteins active in certain cell types and under certain physiological conditions, identifying specific regions of an RNA molecule that interact with RNA binding proteins. Such assays are useful as a research tool for identifying targets for drug discovery, identifying altered or defective RNA/RBP interactions associated with disease conditions, and in screening assays to identify compounds that modulate RNA/RBP interactions of interest.
摘要翻译：已经发现，可以使用单一条件来检测RNA结合蛋白和RNA分子的几乎每一个相互作用。在这一发现之前，认为每个特定的相互作用需要单独的优化条件以便被检测。使用所公开的通用条件的测定可用于鉴定与感兴趣的特定RNA分子相互作用的RNA结合蛋白，检测与特定RNA结合蛋白相关的RNA分子，鉴定在某些细胞类型中和在某些生理条件下有活性的RNA结合蛋白，鉴定与RNA结合蛋白相互作用的RNA分子的特定区域。这种测定法可用作鉴定药物发现靶标，鉴定与疾病状况相关的改变或缺陷的RNA / RBP相互作用的研究工具，以及筛选测定调节感兴趣的RNA / RBP相互作用的化合物的研究工具。

8. 发明授权

US06872850B2 Small molecule inhibitors of secretion of proteins encoded by ARE-mRNAs 失效
标题翻译：由ARE-mRNA编码的蛋白质分泌的小分子抑制剂
公开(公告)号：US06872850B2
公开(公告)日：2005-03-29
申请号：US10117955
申请日：2002-04-08
申请人： Tony Giordano , Michael A. Sturgess
发明人： Tony Giordano , Michael A. Sturgess
IPC分类号： C07C281/18 , C07D213/56 , C07D217/06 , C07D295/185 , C07C243/12
CPC分类号： C07D295/185 , C07C281/18 , C07D213/56 , C07D217/06
摘要： The invention features compounds that inhibit secretion of a protein encoded by an ARE-mRNA or that modulate regulation of an ARE-mRNA. These compounds are useful for the treatment or prevention of conditions involving proteins encoded by ARE-mRNAs, such as TNFα.
摘要翻译：本发明具有抑制由ARE-mRNA编码的蛋白质分泌或调节ARE-mRNA调节的化合物。这些化合物可用于治疗或预防涉及由ARE-mRNA（例如TNFα）编码的蛋白质的病症。

9. 发明授权

US06465176B1 Method for identifying compounds RNA/RNA binding protein interactions 失效
标题翻译：识别化合物RNA / RNA结合蛋白相互作用的方法
公开(公告)号：US06465176B1
公开(公告)日：2002-10-15
申请号：US09165868
申请日：1998-10-02
申请人： Tony Giordano , Deborah L. Beach , Gretchen L. Temeles
发明人： Tony Giordano , Deborah L. Beach , Gretchen L. Temeles
IPC分类号： C12Q168
CPC分类号： C12Q1/6811 , C12Q2522/101
摘要： Disclosed are nucleic acid sequences which, when present in an RNA molecule, bind to RNA binding proteins. These nucleic acid sequences are present in untranslated regions of certain mRNA. They can be used in assays to identify compounds that affect the interaction of RNA containing the nucleic acid sequence, such as the source mRNA, and RNA binding proteins. The disclosed nucleic acid sequences can also be used to identify RNA binding proteins that can interact with the sequences. An assay for identifying compounds that affect interaction of RNA containing one of the disclosed nucleic acid sequences and RNA binding proteins is also disclosed. The assay involves detecting interactions between RNA binding proteins and an RNA molecule containing one of the disclosed nucleic acid sequences in the presence of a test compound and in the absence of the test compound. A difference in the detected interaction in the presence and absence of the test compound indicates that the compound affects the interaction. The identified compounds can be used to affect the interaction of RNA binding proteins with mRNA containing the nucleic acid sequences or related sequences.
摘要翻译：公开了当存在于RNA分子中时与RNA结合蛋白结合的核酸序列。这些核酸序列存在于某些mRNA的非翻译区。它们可用于测定以鉴定影响含有核酸序列的RNA（例如源mRNA）和RNA结合蛋白的相互作用的化合物。所公开的核酸序列也可用于鉴定可与序列相互作用的RNA结合蛋白。还公开了用于鉴定影响所述公开的核酸序列和RNA结合蛋白之一的RNA的相互作用的化合物的测定法。该测定涉及检测RNA结合蛋白和含有所述公开的核酸序列之一的RNA分子在测试化合物存在下和在不存在测试化合物的情况下的相互作用。测试化合物存在和不存在时检测到的相互作用的差异表明该化合物影响相互作用。所鉴定的化合物可用于影响RNA结合蛋白与含有核酸序列或相关序列的mRNA的相互作用。

10. 发明授权

US5859227A RNA sequences which interact with RNA-binding proteins 失效
标题翻译：与RNA结合蛋白相互作用的RNA序列
公开(公告)号：US5859227A
公开(公告)日：1999-01-12
申请号：US803260
申请日：1997-02-20
申请人： Tony Giordano , Deborah L. Beach , David Jacobs
发明人： Tony Giordano , Deborah L. Beach , David Jacobs
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/68 , C07H21/02 , C07H21/04
CPC分类号： G01N33/5023 , C12Q1/68 , G01N33/5308 , G01N33/68 , C12Q1/6811 , G01N2500/02
摘要： Disclosed is a method for identifying possible binding sites for RNA binding proteins in nucleic acid sequences, and confirming the identity of such prospective binding sites by detection of interaction between the prospective binding site and RNA binding proteins. Also disclosed are specific binding sites of RNA binding proteins which have been identified using this method.
摘要翻译：公开了一种用于鉴定核酸序列中RNA结合蛋白的可能结合位点的方法，并通过检测前瞻性结合位点和RNA结合蛋白之间的相互作用来确认这种前瞻性结合位点的身份。还公开了已经使用该方法鉴定的RNA结合蛋白的特异性结合位点。

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