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1. 发明申请

US20100137365A1 Long chain N-alkyl compounds and oxa-derivatives thereof 审中-公开
标题翻译：长链N-烷基化合物及其氧杂衍生物
公开(公告)号：US20100137365A1
公开(公告)日：2010-06-03
申请号：US12656370
申请日：2010-01-28
申请人： Nicole Zitzmann , Terry D. Butters , Frances M. Platt , Gary S. Jacob , Donald H. Picker , Sandra Carrouee , George W.J. Fleet , Raymond A. Dwek , David Durantel , Anand Mehta , Timothy M. Block
发明人： Nicole Zitzmann , Terry D. Butters , Frances M. Platt , Gary S. Jacob , Donald H. Picker , Sandra Carrouee , George W.J. Fleet , Raymond A. Dwek , David Durantel , Anand Mehta , Timothy M. Block
IPC分类号： A61K31/445 , A61P31/12 , A61P31/14 , C07D211/46 , C07D207/12 , C07C237/42 , A61K31/402 , A61K31/166
CPC分类号： A61K31/13 , A61K31/00 , A61K31/166 , A61K31/40 , A61K31/445 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395
摘要： Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C8-C16 alkyl group. The long chain N-alkyl compounds and oxa-substituted derivatives thereof can be used in the treatment of viral infections, in particular hepatitis B virus or hepatitis C virus, in a cell or an individual. For example, the long chain N-alkyl compounds or oxa-substituted derivatives thereof can be derived from piperidines, pyrrolidines, phenylamines, pyridines, pyrroles, or amino acids.
摘要翻译：描述了长链N-烷基氨基和亚氨基化合物，其氧杂取代的衍生物和包括这些化合物的药物组合物。长链N-烷基是C8-C16烷基。长链N-烷基化合物及其氧杂取代的衍生物可用于治疗细胞或个体中的病毒感染，特别是乙型肝炎病毒或丙型肝炎病毒。例如，长链N-烷基化合物或其氧杂取代的衍生物可衍生自哌啶，吡咯烷，苯胺，吡啶，吡咯或氨基酸。

2. 发明授权

US07816560B1 Long chain n-alkyl compounds and oxa-derivatives thereof 有权
标题翻译：长链正烷基化合物及其氧杂衍生物
公开(公告)号：US07816560B1
公开(公告)日：2010-10-19
申请号：US10031145
申请日：2000-08-10
申请人： Nicole Zitzmann , Terry D. Butters , Frances M. Platt , Gary S. Jacob , Donald H. Picker , Sandra Carrouee , George W. J. Fleet , Raymond A. Dwek , David Durantel , Anand Mehta , Timothy M. Block
发明人： Nicole Zitzmann , Terry D. Butters , Frances M. Platt , Gary S. Jacob , Donald H. Picker , Sandra Carrouee , George W. J. Fleet , Raymond A. Dwek , David Durantel , Anand Mehta , Timothy M. Block
IPC分类号： C07C211/00 , C07C303/00 , C07C307/00 , C07C309/00
CPC分类号： A61K31/13 , A61K31/00 , A61K31/166 , A61K31/40 , A61K31/445 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395
摘要： Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C8-C16 alkyl group. The long chain N-alkyl compounds and oxa-substituted derivatives thereof can be used in the treatment of viral infections, in particular hepatitis B virus or hepatitis C virus, in a cell or an individual. For example, the long chain N-alkyl compounds or oxa-substituted derivatives thereof can be derived from piperidines, pyrrolidines, phenylamines, pyridines, pyrroles, or amino acids.
摘要翻译：描述了长链N-烷基氨基和亚氨基化合物，其氧杂取代的衍生物和包括这些化合物的药物组合物。长链N-烷基是C8-C16烷基。长链N-烷基化合物及其氧杂取代的衍生物可用于治疗细胞或个体中的病毒感染，特别是乙型肝炎病毒或丙型肝炎病毒。例如，长链N-烷基化合物或其氧杂取代的衍生物可衍生自哌啶，吡咯烷，苯胺，吡啶，吡咯或氨基酸。

3. 发明授权

US09089515B2 Long chain N-alkyl compounds and oxa-derivatives thereof 有权
标题翻译：长链N-烷基化合物及其氧杂衍生物
公开(公告)号：US09089515B2
公开(公告)日：2015-07-28
申请号：US13064116
申请日：2011-03-07
申请人： Nicole Zitzmann , Terry D. Butters , Frances M. Platt , Gary S. Jacob , Donald H. Picker , Sandra Carrouee , George W. J. Fleet , Raymond A. Dwek , David Durantel , Anand Mehta , Timothy M. Block
发明人： Nicole Zitzmann , Terry D. Butters , Frances M. Platt , Gary S. Jacob , Donald H. Picker , Sandra Carrouee , George W. J. Fleet , Raymond A. Dwek , David Durantel , Anand Mehta , Timothy M. Block
IPC分类号： A61K31/45 , A61P31/12 , A61K31/13 , A61K31/00 , A61K31/166 , A61K31/40 , A61K31/445
CPC分类号： A61K31/13 , A61K31/00 , A61K31/166 , A61K31/40 , A61K31/445 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395
摘要： Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C8-C16 alkyl group. The long chain N-alkyl compounds and oxa-substituted derivatives thereof can be used in the treatment of viral infections, in particular hepatitis B virus or hepatitis C virus, in a cell or an individual. For example, the long chain N-alkyl compounds or oxa-substituted derivatives thereof can be derived from piperidines, pyrrolidines, phenylamines, pyridines, pyrroles, or amino acids.
摘要翻译：描述了长链N-烷基氨基和亚氨基化合物，其氧杂取代的衍生物和包括这些化合物的药物组合物。长链N-烷基是C8-C16烷基。长链N-烷基化合物及其氧杂取代的衍生物可用于治疗细胞或个体中的病毒感染，特别是乙型肝炎病毒或丙型肝炎病毒。例如，长链N-烷基化合物或其氧杂取代的衍生物可衍生自哌啶，吡咯烷，苯胺，吡啶，吡咯或氨基酸。

4. 发明申请

US20110184019A1 Long chain N-Alkyl compounds and oxa-derivatives thereof 有权
标题翻译：长链N-烷基化合物及其氧杂衍生物
公开(公告)号：US20110184019A1
公开(公告)日：2011-07-28
申请号：US13064116
申请日：2011-03-07
申请人： Nicole Zitzmann , Terry D. Butters , Frances M. Platt , Gary S. Jacob , Donald H. Picker , Sandra Carrouee , George W. J. Fleet , Raymond A. Dwek , David Durantel , Anand Mehta , Timothy M. Block
发明人： Nicole Zitzmann , Terry D. Butters , Frances M. Platt , Gary S. Jacob , Donald H. Picker , Sandra Carrouee , George W. J. Fleet , Raymond A. Dwek , David Durantel , Anand Mehta , Timothy M. Block
IPC分类号： A61K31/45 , C12N5/071 , A61P31/12
CPC分类号： A61K31/13 , A61K31/00 , A61K31/166 , A61K31/40 , A61K31/445 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395
摘要： Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C8-C16 alkyl group. The long chain N-alkyl compounds and oxa-substituted derivatives thereof can be used in the treatment of viral infections, in particular hepatitis B virus or hepatitis C virus, in a cell or an individual. For example, the long chain N-alkyl compounds or oxa-substituted derivatives thereof can be derived from piperidines, pyrrolidines, phenylamines, pyridines, pyrroles, or amino acids.
摘要翻译：描述了长链N-烷基氨基和亚氨基化合物，其氧杂取代的衍生物和包括这些化合物的药物组合物。长链N-烷基是C8-C16烷基。长链N-烷基化合物及其氧杂取代的衍生物可用于治疗细胞或个体中的病毒感染，特别是乙型肝炎病毒或丙型肝炎病毒。例如，长链N-烷基化合物或其氧杂取代的衍生物可衍生自哌啶，吡咯烷，苯胺，吡啶，吡咯或氨基酸。

5. 发明授权

US06465487B1 Inhibition of membrane-associated viral replication 有权
标题翻译：抑制膜相关病毒复制
公开(公告)号：US06465487B1
公开(公告)日：2002-10-15
申请号：US09209033
申请日：1998-12-10
申请人： Timothy M. Block , Raymond A. Dwek , Baruch S. Blumberg , Anand Mehta , Frances Platt , Terry D. Butters , Nicole Zitzmann
发明人： Timothy M. Block , Raymond A. Dwek , Baruch S. Blumberg , Anand Mehta , Frances Platt , Terry D. Butters , Nicole Zitzmann
IPC分类号： A61K31445
CPC分类号： A61K31/00 , A61K31/445 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395
摘要： Methods for inhibiting morphogenesis of host cell membrane-budding viruses and infections caused thereby using compounds that inhibit host cell glucosidase or glucosyltransferase enzymes. Methods for treating lipid storage diseases using compounds that inhibit glucosyl transferance enzymes.
摘要翻译：抑制宿主细胞膜出芽病毒的形态发生和由此引起的感染的方法使用抑制宿主细胞葡糖苷酶或葡糖基转移酶的化合物的方法。使用抑制葡糖基转移酶的化合物治疗脂质储存疾病的方法。

6. 发明授权

US06610703B1 Method for treatment of glycolipid storage diseases 失效
标题翻译：糖脂储存疾病的治疗方法
公开(公告)号：US06610703B1
公开(公告)日：2003-08-26
申请号：US09453754
申请日：1999-12-02
申请人： Gary S. Jacob , Frances M. Platt , Terry D. Butters , Raymond A. Dwek
发明人： Gary S. Jacob , Frances M. Platt , Terry D. Butters , Raymond A. Dwek
IPC分类号： A61P2500
CPC分类号： A61K31/445
摘要： A novel method is disclosed for the treatment of a patient affected with Gaucher's disease or other such glycolipid storage diseases. The method comprises administering to said patient a therapeutically effective amount of a long-chain N-alkyl derivative of deoxynojirimycin to alleviate or inhibit the glycolipid storage disease. The long-chain alkyl group has from nine to about 20 carbon atoms and preferably is nonyl or decyl.
摘要翻译：公开了用于治疗患有戈谢氏病或其他此类糖脂储存疾病的患者的新方法。该方法包括向所述患者施用治疗有效量的脱氧野尻霉素的长链N-烷基衍生物以缓解或抑制糖脂储存疾病。长链烷基具有9至约20个碳原子，优选为壬基或癸基。

7. 发明申请

US20070275998A1 DEOXYNOJIRIMYCIN AND D-ARABINITOL ANALOGS AND METHODS OF USING 有权
标题翻译：去氧吉西他滨和D-阿拉伯糖醇模拟物及其使用方法
公开(公告)号：US20070275998A1
公开(公告)日：2007-11-29
申请号：US11752015
申请日：2007-05-22
申请人： Terry D. Butters , Raymond A. Dwek , George W.J. Fleet
发明人： Terry D. Butters , Raymond A. Dwek , George W.J. Fleet
IPC分类号： A61K31/445 , A61K31/655 , C07D211/54
CPC分类号： C07D211/48 , C07D211/46
摘要： A compound of Formula I are provided: wherein R is: R1 is a substituted or unsubstituted alkyl group; W1-4 are independently selected from hydrogen, substituted or unsubstituted alkyl groups, substituted or unsubstituted haloalkyl groups, substituted or unsubstituted alkanoyl groups, substituted or unsubstituted aroyl groups, or substituted or unsubstituted haloalkanoyl groups; X1-5 are independently selected from H, NO2, N3, and NH2;Y is absent or is a substituted or unsubstituted C1-alkyl group, other than carbonyl; Z is selected from a bond or NH, provided that when Z is a bond, Y is absent, and provided that when Z is NH, Y is a substituted or unsubstituted C1-alkyl group, other than carbonyl. Also provided are D-arabinitol compounds, methods for preparing such compounds and compositions of such compounds, and methods of using such compounds.
摘要翻译：提供式I化合物：其中R是：R 1是取代或未取代的烷基; 取代或未取代的烷基，取代或未取代的烷基，取代或未取代的烷酰基，取代或未取代的芳酰基，或取代或未取代的卤代烷酰基; X 1-5独立地选自H，NO 2，N 3和NH 2; Y是不存在或是不是羰基的取代或未取代的C 1 - 烷基; Z选自键或NH，条件是当Z为键时，Y不存在，条件是当Z为NH时，Y为取代或未取代的C 1 - 烷基，除羰。还提供了D-阿拉伯糖醇化合物，制备这些化合物的方法和这些化合物的组合物，以及使用这些化合物的方法。

8. 发明授权

US5786369A Method of inhibiting the surface expression of glycolipid receptors for bacteria 失效
标题翻译：抑制细菌糖脂受体表面表达的方法
公开(公告)号：US5786369A
公开(公告)日：1998-07-28
申请号：US650558
申请日：1996-05-20
申请人： Frances M. Platt , Gabrielle R. Neises , Raymond A. Dwek , Terry D. Butters
发明人： Frances M. Platt , Gabrielle R. Neises , Raymond A. Dwek , Terry D. Butters
IPC分类号： A61K31/131 , A61K31/445 , C07D211/46
CPC分类号： A61K31/131 , C07D211/46
摘要： A method is disclosed for inhibiting the surface expression of glycolipid receptors for bacteria by subjecting bacteria cells to an inhibitory effective amount of an N-alkyl derivative of 1,5-dideoxy-1,5-imino-D-glucitol in which said alkyl contains from 2-8 carbon atoms.
摘要翻译：公开了通过使细菌细胞抑制有效量的1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇的N-烷基衍生物来抑制细菌的糖脂受体表面表达的方法，其中所述烷基含 2-8个碳原子。

9. 发明授权

US5472969A Method of inhibiting glycolipid synthesis 失效
标题翻译：抑制糖脂合成的方法
公开(公告)号：US5472969A
公开(公告)日：1995-12-05
申请号：US321718
申请日：1994-10-12
申请人： Frances M. Platt , Gabrielle R. Neises , Raymond A. Dwek , Terry D. Butters
发明人： Frances M. Platt , Gabrielle R. Neises , Raymond A. Dwek , Terry D. Butters
IPC分类号： A61K31/131 , A61K31/445 , C07D211/46
CPC分类号： A61K31/131 , C07D211/46
摘要： A method is disclosed for inhibiting the biosynthesis of glycolipids in cells capable of producing glycolipids comprising subjecting said cells to a glycolipid inhibitory effective amount of an N-alkyl derivative of 1,5-dideoxy-1,5-imino-D-glucitol in which said alkyl contains from 2-8 carbon atoms.
摘要翻译：公开了一种抑制能够产生糖脂的细胞中糖脂生物合成的方法，包括使所述细胞经受糖脂抑制有效量的1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇的N-烷基衍生物，其中所述烷基含有2-8个碳原子。

10. 发明授权

US5798366A Method for treatment of CNS-involved lysosomal storage diseases 失效
标题翻译： CNS相关溶酶体贮积病治疗方法
公开(公告)号：US5798366A
公开(公告)日：1998-08-25
申请号：US782321
申请日：1997-01-13
申请人： Frances M. Platt , Gabrielle R. Neises , Raymond A. Dwek , Terry D. Butters
发明人： Frances M. Platt , Gabrielle R. Neises , Raymond A. Dwek , Terry D. Butters
IPC分类号： C07H15/12 , A61K31/445 , A61K31/70 , A61K31/7028 , A61P3/00 , A61P25/00
CPC分类号： A61K31/7004 , A61K31/445 , A61K31/70 , A61K31/7012
摘要： A method is disclosed for the in vivo treatment of patients having a lysosomal storage disease with a significant central nervous system (CNS) involvement. Said method comprises administration to said patient a small but storage-inhibitory effective amount of an N-alkyl derivative of a 1,5-iminosugar in which said alkyl group contains from about 2 to about 8 carbon atoms and said 1,5-iminosugar is 1,5-dideoxy-1,5-imino-D-glucitol, or 1,5-dideoxy-1,5-imino-D-galactitol, or an O-acylated pro-drug of said 1,5-iminosugar. In an illustrative example, CNS storage of GM2 ganglioside is inhibited in Tay-Sachs mice by administration of 1,5-(butylimino)-1,5-dideoxy-D-glucitol.
摘要翻译：公开了一种用于体内治疗具有显着的中枢神经系统（CNS）参与的溶酶体贮积病的患者的方法。所述方法包括向所述患者施用小的但储存抑制的有效量的1,5-亚氨基二糖的N-烷基衍生物，其中所述烷基含有约2至约8个碳原子，所述1,5-亚氨基二糖是 1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇或1,5-二脱氧-1,5-亚氨基-D-半乳糖醇，或所述1,5-亚氨基二糖的O-酰化前体药。在说明性实例中，通过施用1,5-（丁基亚氨基）-1,5-二脱氧-D-葡萄糖醇，在Tay-Sachs小鼠中GM2神经节苷脂的CNS储存被抑制。

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