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1. 发明授权

US6070761A Vial loading method and apparatus for intelligent admixture and delivery of intravenous drugs 失效
标题翻译：用于智能混合和递送静脉注射药物的小瓶装载方法和装置
公开(公告)号：US6070761A
公开(公告)日：2000-06-06
申请号：US916886
申请日：1997-08-22
申请人： Nicole D. Bloom , Dean L. Kamen , Richard Lanigan , Charles M. Grinnell , Kevin Grant
发明人： Nicole D. Bloom , Dean L. Kamen , Richard Lanigan , Charles M. Grinnell , Kevin Grant
IPC分类号： A61J3/00 , A61J7/00 , B65B3/00
CPC分类号： A61J3/002 , G06F19/3468
摘要： The present invention is directed toward a vial-loading mechanism for a system that prepares and delivers one or more IV drugs to a patient. The vial-loading mechanism is used to load a vial onto a cassette spike and includes a vertical support member located adjacent to the spike. A holding assembly holds at least one vial. The holding assembly is mounted to the support member so as to be positionable between an upper position for loading a vial and a lower position for piercing the vial with a spike. The holding assembly has an arcuate-shaped holding member for holding the vial. A catch is provided with an engagement unit for securing the holding assembly in the lower position. This arrangement provides an easy way to add, retain, and remove vials from the system and protects the clinicians that do this from contacting the spikes and hurting themselves.
摘要翻译：本发明涉及一种用于向患者制备和递送一种或多种IV药物的系统的小瓶装载机构。小瓶加载机构用于将小瓶装载到盒钉上，并且包括邻近尖峰定位的垂直支撑构件。保持组件容纳至少一个小瓶。保持组件安装到支撑构件上，以便可以在用于装载小瓶的上部位置和用于用尖钉刺穿小瓶的下部位置之间定位。保持组件具有用于保持小瓶的弓形保持构件。卡扣具有用于将保持组件固定在较低位置的接合单元。这种安排提供了一种简单的方法来添加，保留和从系统中移除小瓶，并保护临床医生不要接触尖峰并伤害自己。

2. 发明授权

US06234997B1 System and method for mixing and delivering intravenous drugs 有权
标题翻译：静脉注射药物混合体系及方法
公开(公告)号：US06234997B1
公开(公告)日：2001-05-22
申请号：US09359237
申请日：1999-07-22
申请人： Dean L. Kamen , Charles M. Grinnell , Marc A. Mandro , Dennis Gilbreath , Kevin Grant , Jason A. Demers , William T. Larkins , Robert Manning , Richard Lanigan
发明人： Dean L. Kamen , Charles M. Grinnell , Marc A. Mandro , Dennis Gilbreath , Kevin Grant , Jason A. Demers , William T. Larkins , Robert Manning , Richard Lanigan
IPC分类号： A61M3700
CPC分类号： A61M5/142 , A61M5/1409 , A61M5/1413 , A61M5/14224 , A61M5/16809 , A61M5/16827 , A61M5/16831 , A61M5/16854 , A61M5/16877 , A61M5/365 , A61M5/5086 , A61M39/24 , A61M2005/1402 , A61M2005/1403 , A61M2005/14208 , A61M2205/123 , A61M2205/128 , A61M2205/35 , A61M2205/8206 , A61M2206/22 , F16K5/0414 , F16K5/0478
摘要： A bedside-pharmacy system for the preparation and delivery of intravenous drugs. The system includes a liquid inlet for connection to a liquid supply, vial receptacles, and a liquid outlet for providing the intravenous drug in mixed, liquid form to the patient. The system may include a chamber having a variable volume, and a valve mechanism, which may be actuated to control flow between the liquid outlet, the variable-volume chamber, the vial receptacles and the liquid inlet. The system induces change in the volume of the variable-volume chamber and actuates the valve mechanism, so as to introduce liquid from the liquid inlet into the vials and reconstitute or dilute the drugs and so as to deliver the drugs to the patient. In a preferred embodiment, the liquid inlet, the vial receptacles, the variable-volume chamber, the liquid outlet and the valve mechanism (in other words, all components that come into contact with the liquid) are located in a disposable cassette, which may be received in a control unit. The system may include means for changing the chamber volume and actuating the valves so as to move the liquid repeatedly between a vial and the chamber. After the drug has been reconstituted, the system may cause the drug to be further diluted by providing an additional volume of liquid to be mixed with the drug. The system may further include a second chamber for delivery of the drug to the patient in precise quantities.
摘要翻译：用于制备和输送静脉注射药物的床旁药房系统。该系统包括用于连接到液体供应器，小瓶容器和液体出口的液体入口，用于向患者提供混合的液体形式的静脉内药物。该系统可以包括具有可变容积的腔室和阀机构，其可以被致动以控制液体出口，可变体积腔室，小瓶容器和液体入口之间的流动。该系统引起可变容积腔体积的变化并致动阀机构，从而将液体从液体入口引入小瓶中，并重新构建或稀释药物并将药物输送给患者。在优选实施例中，液体入口，瓶容器，可变容积室，液体出口和阀机构（换句话说，与液体接触的所有部件）位于一次性盒中，在控制单元中接收。该系统可以包括用于改变腔体积并致动阀的装置，以便在小瓶和腔室之间重复移动液体。药物重建后，系统可能通过提供额外体积的与药物混合的液体而使药物进一步稀释。该系统还可以包括用于以精确量将药物递送到患者的第二腔室。

3. 发明申请

US20130178831A1 System and Method for Drug Preparation and Delivery 有权
标题翻译：药物制备和给药系统和方法
公开(公告)号：US20130178831A1
公开(公告)日：2013-07-11
申请号：US13594374
申请日：2012-08-24
申请人： Dean L. Kamen , Charles M. Grinnell , Marc A. Mandro , Dennis Gilbreath , Kevin Grant , Jason A. Demers , William T. Larkins , Robert Manning , Richard Lanigan
发明人： Dean L. Kamen , Charles M. Grinnell , Marc A. Mandro , Dennis Gilbreath , Kevin Grant , Jason A. Demers , William T. Larkins , Robert Manning , Richard Lanigan
IPC分类号： A61M5/14
CPC分类号： A61M5/142 , A61M5/1409 , A61M5/1413 , A61M5/14224 , A61M5/16809 , A61M5/16827 , A61M5/16831 , A61M5/16854 , A61M5/16877 , A61M5/365 , A61M5/5086 , A61M39/24 , A61M2005/1402 , A61M2005/1403 , A61M2005/14208 , A61M2205/123 , A61M2205/128 , A61M2205/35 , A61M2205/8206 , A61M2206/22 , F16K5/0414 , F16K5/0478
摘要： A disposable cassette for mixing a drug in a vial includes a liquid inlet for connection to a liquid supply, a first vial spike, a second vial spike, a chamber and a valve mechanism. The chamber, the first and second vial spikes, and the liquid inlet are in fluid communication with each other. The valve mechanism may be actuated to control flow between the chamber, the vial receptacles and the liquid inlet.
摘要翻译：用于在小瓶中混合药物的一次性盒包括用于连接到液体供应源的液体入口，第一小瓶尖峰，第二小瓶尖峰，室和阀机构。腔室，第一和第二小瓶尖头和液体入口彼此流体连通。可以致动阀机构以控制腔室，药瓶容器和液体入口之间的流动。

4. 发明授权

US06726656B2 System for controlling flow through a line during intravenous drug delivery 有权
标题翻译：用于控制静脉内药物输送期间通过线路的流动的系统
公开(公告)号：US06726656B2
公开(公告)日：2004-04-27
申请号：US10266997
申请日：2002-10-08
申请人： Dean L. Kamen , Charles M. Grinnell , Marc A. Mandro , Dennis Gilbreath , Kevin Grant , Jason A. Demers , William T. Larkins , Robert Manning , Richard Lanigan
发明人： Dean L. Kamen , Charles M. Grinnell , Marc A. Mandro , Dennis Gilbreath , Kevin Grant , Jason A. Demers , William T. Larkins , Robert Manning , Richard Lanigan
IPC分类号： A61M3700
CPC分类号： A61M5/142 , A61M5/1409 , A61M5/1413 , A61M5/14224 , A61M5/16809 , A61M5/16827 , A61M5/16831 , A61M5/16854 , A61M5/16877 , A61M5/365 , A61M5/5086 , A61M39/24 , A61M2005/1402 , A61M2005/1403 , A61M2005/14208 , A61M2205/123 , A61M2205/128 , A61M2205/35 , A61M2205/8206 , A61M2206/22 , F16K5/0414 , F16K5/0478
摘要： A system and method for the preparation and delivery of intravenous drugs includes a liquid inlet for connection to a liquid supply and vial receptacles. The system may also include a liquid outlet for providing the intravenous drug in mixed, liquid form to the patient. The system may include a chamber having a variable volume, and a valve mechanism, which may be actuated to control flow between the liquid outlet, the variable-volume chamber, the vial receptacles and the liquid inlet. The liquid inlet, the vial receptacles, the variable-volume chamber, the liquid outlet and the valve mechanism may be located in a disposable cassette, which may be received in a control unit.
摘要翻译：用于制备和递送静脉内药物的系统和方法包括用于连接到液体供应源和小瓶容器的液体入口。该系统还可以包括用于将静脉内药物以混合的液体形式提供给患者的液体出口。该系统可以包括具有可变容积的腔室和阀机构，其可以被致动以控制液体出口，可变体积腔室，小瓶容器和液体入口之间的流动。液体入口，瓶容器，可变容积室，液体出口和阀机构可以位于可以被接收在控制单元中的一次性盒中。

5. 发明授权

US06464667B1 Method and cassette for delivering intravenous drugs 有权
标题翻译：用于递送静脉注射药物的方法和药盒
公开(公告)号：US06464667B1
公开(公告)日：2002-10-15
申请号：US09359232
申请日：1999-07-22
申请人： Dean L. Kamen , Charles M. Grinnell , Marc A. Mandro , Dennis Gilbreath , Kevin Grant , Jason A. Demers , William T. Larkins , Robert Manning , Richard Lanigan
发明人： Dean L. Kamen , Charles M. Grinnell , Marc A. Mandro , Dennis Gilbreath , Kevin Grant , Jason A. Demers , William T. Larkins , Robert Manning , Richard Lanigan
IPC分类号： A61M3700
CPC分类号： A61M5/142 , A61M5/1409 , A61M5/1413 , A61M5/14224 , A61M5/16809 , A61M5/16827 , A61M5/16831 , A61M5/16854 , A61M5/16877 , A61M5/365 , A61M5/5086 , A61M39/24 , A61M2005/1402 , A61M2005/1403 , A61M2005/14208 , A61M2205/123 , A61M2205/128 , A61M2205/35 , A61M2205/8206 , A61M2206/22 , F16K5/0414 , F16K5/0478
摘要： A bedside-pharmacy system for the preparation and delivery of intravenous drugs. The system includes a liquid inlet for connection to a liquid supply, vial receptacles, and a liquid outlet for providing the intravenous drug in mixed, liquid form to the patient. The system may include a chamber having a variable volume, and a valve mechanism, which may be actuated to control flow between the liquid outlet, the variable-volume chamber, the vial receptacles and the liquid inlet. The system induces change in the volume of the variable-volume chamber and actuates the valve mechanism, so as to introduce liquid from the liquid inlet into the vials and reconstitute or dilute the drugs and so as to deliver the drugs to the patient. In a preferred embodiment, the liquid inlet, the vial receptacles, the variable-volume chamber, the liquid outlet and the valve mechanism (in other words, all components that come into contact with the liquid) are located in a disposable cassette, which may be received in a control unit. The system may include means for changing the chamber volume and actuating the valves so as to move the liquid repeatedly between a vial and the chamber. After the drug has been reconstituted, the system may cause the drug to be further diluted by providing an additional volume of liquid to be mixed with the drug. The system may further include a second chamber for delivery of the drug to the patient in precise quantities.
摘要翻译：用于制备和输送静脉注射药物的床旁药房系统。该系统包括用于连接到液体供应器，小瓶容器和液体出口的液体入口，用于向患者提供混合的液体形式的静脉内药物。该系统可以包括具有可变容积的腔室和阀机构，其可以被致动以控制液体出口，可变体积腔室，小瓶容器和液体入口之间的流动。该系统引起可变容积腔体积的变化并致动阀机构，从而将液体从液体入口引入小瓶中，并重新构建或稀释药物并将药物输送给患者。在优选实施例中，液体入口，瓶容器，可变容积室，液体出口和阀机构（换句话说，与液体接触的所有部件）位于一次性盒中，在控制单元中接收。该系统可以包括用于改变腔体积并致动阀的装置，以便在小瓶和腔室之间重复移动液体。药物重建后，系统可能通过提供额外体积的与药物混合的液体而使药物进一步稀释。该系统还可以包括用于以精确量将药物递送到患者的第二腔室。

6. 发明授权

US06210361B1 System for delivering intravenous drugs 有权
标题翻译：递送静脉注射药物的系统
公开(公告)号：US06210361B1
公开(公告)日：2001-04-03
申请号：US09137025
申请日：1998-08-20
申请人： Dean L. Kamen , Charles M. Grinnell , Marc A. Mandro , Dennis Gilbreath , Kevin Grant , Jason A. Demers , William T. Larkins , Robert Manning , Richard Lanigan
发明人： Dean L. Kamen , Charles M. Grinnell , Marc A. Mandro , Dennis Gilbreath , Kevin Grant , Jason A. Demers , William T. Larkins , Robert Manning , Richard Lanigan
IPC分类号： A61M3700
CPC分类号： A61M5/142 , A61M5/1409 , A61M5/1413 , A61M5/14224 , A61M5/16809 , A61M5/16827 , A61M5/16831 , A61M5/16854 , A61M5/16877 , A61M5/365 , A61M5/5086 , A61M39/24 , A61M2005/1402 , A61M2005/1403 , A61M2005/14208 , A61M2205/123 , A61M2205/128 , A61M2205/35 , A61M2205/8206 , A61M2206/22 , F16K5/0414 , F16K5/0478
摘要： A bedside-pharmacy systen for the preparation and delivery of intravenous drugs. The system includes a liquid inlet for connection to a liquid supply, vial receptacles, and a liquid outlet for providing the intravenous drug in mixed, liquid form to the patient. The system may include a chamber having a variable volume, and a valve mechanism, which may be actuated to control flow between the liquid outlet, the variable-volume chamber, the vial receptacles and the liquid inlet. The system induces change in the volume of the variable-volume chamber and actuates the valve mechanism, so as to introduce liquid from the liquid inlet into the vials and reconstitute or dilute the drugs and so as to deliver the drugs to the patient. In a preferred embodiment, the liquid inlet, the vial receptacles, the variable-volume chamber, the liquid outlet and the valve mechanism (in other words, all components that come into contact with the liquid) are located in a disposable cassette, which may be received in a control unit. The system may include means for changing the chamber volume and actuating the valves so as to move the liquid repeatedly between a vial and the chamber. After the drug has been reconstituted, the system may cause the drug to be further diluted by providing an additional volume of liquid to be mixed with the drug. The system may further include a second chamber for delivery of the drug to the patient in precise quantities.
摘要翻译：用于制备和递送静脉注射药物的床旁药房系统。该系统包括用于连接到液体供应器，小瓶容器和液体出口的液体入口，用于向患者提供混合的液体形式的静脉内药物。该系统可以包括具有可变容积的腔室和阀机构，其可以被致动以控制液体出口，可变体积腔室，小瓶容器和液体入口之间的流动。该系统引起可变容积腔体积的变化并致动阀机构，从而将液体从液体入口引入小瓶中，并重新构建或稀释药物并将药物输送给患者。在优选实施例中，液体入口，瓶容器，可变容积室，液体出口和阀机构（换句话说，与液体接触的所有部件）位于一次性盒中，在控制单元中接收。该系统可以包括用于改变腔体积并致动阀的装置，以便在小瓶和腔室之间重复移动液体。药物重建后，系统可能通过提供额外体积的与药物混合的液体而使药物进一步稀释。该系统还可以包括用于以精确量将药物递送到患者的第二腔室。

7. 发明授权

US08968244B2 System and method for drug preparation and delivery 有权
标题翻译：药物制备和给药的系统和方法
公开(公告)号：US08968244B2
公开(公告)日：2015-03-03
申请号：US13594374
申请日：2012-08-24
申请人： Dean L. Kamen , Charles M. Grinnell , Marc A. Mandro , Dennis Gilbreath , Kevin Grant , Jason A. Demers , William T. Larkins , Robert Manning , Richard Lanigan
发明人： Dean L. Kamen , Charles M. Grinnell , Marc A. Mandro , Dennis Gilbreath , Kevin Grant , Jason A. Demers , William T. Larkins , Robert Manning , Richard Lanigan
IPC分类号： A61M1/00 , A61M5/14 , A61M5/142 , A61M5/168 , A61M5/36 , A61M39/24 , F16K5/04
CPC分类号： A61M5/142 , A61M5/1409 , A61M5/1413 , A61M5/14224 , A61M5/16809 , A61M5/16827 , A61M5/16831 , A61M5/16854 , A61M5/16877 , A61M5/365 , A61M5/5086 , A61M39/24 , A61M2005/1402 , A61M2005/1403 , A61M2005/14208 , A61M2205/123 , A61M2205/128 , A61M2205/35 , A61M2205/8206 , A61M2206/22 , F16K5/0414 , F16K5/0478
摘要： A disposable cassette for mixing a drug in a vial includes a liquid inlet for connection to a liquid supply, a first vial spike, a second vial spike, a chamber and a valve mechanism. The chamber, the first and second vial spikes, and the liquid inlet are in fluid communication with each other. The valve mechanism may be actuated to control flow between the chamber, the vial receptacles and the liquid inlet.
摘要翻译：用于在小瓶中混合药物的一次性盒包括用于连接到液体供应源的液体入口，第一小瓶尖峰，第二小瓶尖峰，室和阀机构。腔室，第一和第二小瓶尖头和液体入口彼此流体连通。可以致动阀机构以控制腔室，药瓶容器和液体入口之间的流动。

8. 发明授权

US6092249A Constant pressure seating system 失效
标题翻译：恒压座椅系统
公开(公告)号：US6092249A
公开(公告)日：2000-07-25
申请号：US863674
申请日：1997-05-27
申请人： Dean L. Kamen , Charles M. Grinnell , Michael T. Bush , Gustavo Y. Buhacoff
发明人： Dean L. Kamen , Charles M. Grinnell , Michael T. Bush , Gustavo Y. Buhacoff
IPC分类号： A47C4/54 , A47C23/00 , A47C27/10 , A47C27/14 , A47C27/18 , A61G5/10 , A61G7/057
CPC分类号： A47C23/002 , A47C27/081 , A47C27/088 , A47C27/10 , A47C27/148 , A47C27/18 , A47C31/126 , A47C4/54 , A47C7/021 , A47C7/022 , A61G5/1045 , A61G7/05769 , A61G2203/34
摘要： A cushion system for supporting a body such as a seated person at risk of developing pressure sores. An array of one or more foam members is biased such that each foam member exhibits a substantially constant force per unit area when supporting the body. The bias may be passive, by choice of foam characteristics, and additionally, may be applied actively by providing a gas to the foam and controlling the pressure of the gas in response to the pressure conditions at the interface with the supported body.
摘要翻译：用于支撑身体的坐垫系统，例如有开发压疮风险的就座者。一个或多个泡沫构件的阵列被偏置，使得当支撑身体时，每个泡沫构件表现出基本上恒定的每单位面积的力。通过选择泡沫特性，偏压可以是被动的，并且另外，可以通过向泡沫提供气体并且响应于与被支撑体的界面处的压力条件来控制气体的压力来主动应用。

9. 发明授权

US5772637A Intravenous-line flow-control system 失效
标题翻译：静脉血流控制系统
公开(公告)号：US5772637A
公开(公告)日：1998-06-30
申请号：US472212
申请日：1995-06-07
申请人： R. Kurt Heinzmann , Richard Lanigan , Peter Lund , Dean L. Kamen , William T. Larkins , Robert Manning
发明人： R. Kurt Heinzmann , Richard Lanigan , Peter Lund , Dean L. Kamen , William T. Larkins , Robert Manning
IPC分类号： A61M5/14 , A61M5/142 , A61M5/168 , A61M5/36 , A61M39/28 , A61M5/00
CPC分类号： A61M5/1413 , A61M39/281 , A61M5/14224 , A61M2205/128 , A61M2205/14 , A61M2205/35 , A61M2205/8206 , A61M2205/8262 , A61M5/16809 , A61M5/16831 , A61M5/365 , Y10S128/12
摘要： An intravenous-line flow-control system for receiving a disposable cassette disposed in the intravenous line. The system prevents the free flow of intravenous fluid through the cassette when the cassette is removed from the system. The system includes a control unit having a door or similar structure for holding the cassette against a receiving surface. The control unit includes a stepper motor and a transmission member for turning a rotatable control valve on the cassette in order to restrict variably the flow of fluid through the cassette. When the door is being opened but while the cassette is still held against the receiving surface, a motor-disengagement mechanism moves at least the transmission member, and preferably the stepper motor as well, from a first position, from which the control valve may be engaged by the transmission member, to a second position, in which the transmission member is disengaged from the control valve. Preferably, the motor-disengagement mechanism includes a button on the handle of a door-opening mechanism, and by pushing the button the transmission member and the stepper motor are moved to the second position. In addition, when the door is being opened but while the cassette is still held against the receiving surface, a shut-off mechanism engages the cassette's control valve and turns the control valve to its closed position. The control unit may use alternative power supplies and include links for communicating with other control units.
摘要翻译：一种用于接收设置在静脉内管线中的一次性盒的静脉内线路流量控制系统。当盒子从系统中取出时，该系统防止静脉注射液自由流过盒子。该系统包括具有门或类似结构的控制单元，用于将盒子保持在接收表面上。控制单元包括步进电动机和用于转动盒上的可旋转控制阀的传动构件，以便可变地限制通过盒的流体的流动。当门被打开时，但是当盒子仍然保持在接收表面上时，电动机脱离机构至少将传动构件（优选地步进电动机）从第一位置移动，控制阀可以从该第一位置移动由传动构件接合到传动构件与控制阀分离的第二位置。优选地，电动机脱离机构包括门打开机构的把手上的按钮，并且通过按压按钮，传动构件和步进电动机被移动到第二位置。此外，当门打开时，但是当盒子仍然靠在接收表面上时，切断机构接合盒的控制阀并将控制阀转动到其关闭位置。控制单元可以使用替代电源，并且包括用于与其他控制单元通信的链接。

10. 发明授权

US6077246A Medical irrigation pump and system 有权
标题翻译：医用灌溉泵及系统
公开(公告)号：US6077246A
公开(公告)日：2000-06-20
申请号：US362946
申请日：1999-07-28
申请人： Karen E. Kullas , Glen French , Joan Kinniburgh , Augustus Felix , Philip Tessier , Dean L. Kamen , Bradley Miller , Kevin Grant
发明人： Karen E. Kullas , Glen French , Joan Kinniburgh , Augustus Felix , Philip Tessier , Dean L. Kamen , Bradley Miller , Kevin Grant
IPC分类号： A61M1/00 , A61M3/02
CPC分类号： A61M1/0058 , A61M2205/12 , A61M2205/6018 , A61M2205/6036 , A61M3/0258
摘要： A medical irrigation pump and pump system utilize a permanent non-sterile drive motor capable of operating disposable sterile single use pump units each of which is specifically designed for a particular medical procedure. The pump units have housings which are adapted to be interchangeable within the permanent controller system. Only the sterilized and disposable pump units come into contact with the fluid pathway during pumping. A pattern of bumps on each pump unit is unique for the medical procedure for which the pump unit was designed. The pattern of bumps engages switches on the controller, enabling the controller to identify what type of pump unit has been installed. After automatically identifying the type of pump unit and the intended medical procedure, the controller automatically selects a default motor speed that will provide an appropriate fluid pressure for that particular procedure. Buttons on a control panel also enable the user to manually adjust the pressure delivered by the pump. The orientation of the pump unit during the loading procedure allows easy purging of all air from the pump unit before the pump is started.
摘要翻译：医疗灌溉泵和泵系统利用能够运行一次性无菌单次使用的泵单元的永久性非无菌驱动马达，每个泵单元专门针对特定医疗程序设计。泵单元具有适于在永久控制器系统内可互换的壳体。在泵送期间，只有灭菌和一次性泵单元与流体通道接触。每个泵单元上的凸起图案对于设计泵单元的医疗程序是独一无二的。凸块的图案与控制器上的开关接合，使控制器能够识别已安装什么类型的泵单元。在自动识别泵单元类型和预期医疗程序之后，控制器自动选择一个默认的电机速度，该速度将为该特定程序提供适当的流体压力。控制面板上的按钮也使用户能够手动调节泵输送的压力。在装载过程中，泵装置的方向可以在泵启动之前从泵装置清除所有空气。

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